• Journal of The Korea Institute of Healthcare Architecture
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• v.16 no.3
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• pp.27-36
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• 2010

Recently general hospitals in Korea have been actively remodeled. Remodeling is required to extend the hospitals' area and to meet the new medical demand. Eventually it aims for achieving ideal healing environment. Seoul National University Bundang Hospital has also developed the schematic design to open the new hospital in 2012. This large scale of extension is the first step in its expected remodeling cycle. It is essential for the extension of hospital to create an architectural system on the basis of function, and to keep the balance with both the existing buildings and natural context simultaneously. To connect the existing hospital and the new hospital, a hospital street should be designed to make it function as a main pedestrian spine. Space design marketing of general hospital is effective in promoting the hospital image. It can be realized by emphasizing hospital identity through combining cultural program and commercial facilities. Developing hospital design should be encouraged under the EBD (Evidence Based Design) concept spread in USA.

• Journal of The Korea Institute of Healthcare Architecture
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• v.3 no.5
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• pp.97-105
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• 1997

According as the medical demands have been high, ward dept, in general Hospital become more specifying. One thing of its sample is Children ward in general Hospitals and Children's medical demand become increasing. Therefore, this study aims to represent the standard for the architectural planning of the children ward in general Hospital. For it, the present conditions and space programs of 4 general Hospitals were investigated, analyzed. And to present children ward's functional programs, plans of the 2 domestic children hospitals and foreign children hospitals were analyzed. Then one children ward in general hospital was selected, architectural remodeing process was performed by the whole those sources.

• Korean Journal of Radiology
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• v.24 no.9
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• pp.827-837
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• 2023

Objective: To investigate the predictive value of radiomics features based on cardiac magnetic resonance (CMR) cine images for left ventricular adverse remodeling (LVAR) after acute ST-segment elevation myocardial infarction (STEMI). Materials and Methods: We conducted a retrospective, single-center, cohort study involving 244 patients (random-split into 170 and 74 for training and testing, respectively) having an acute STEMI (88.5% males, 57.0 ± 10.3 years of age) who underwent CMR examination at one week and six months after percutaneous coronary intervention. LVAR was defined as a 20% increase in left ventricular end-diastolic volume 6 months after acute STEMI. Radiomics features were extracted from the oneweek CMR cine images using the least absolute shrinkage and selection operator regression (LASSO) analysis. The predictive performance of the selected features was evaluated using receiver operating characteristic curve analysis and the area under the curve (AUC). Results: Nine radiomics features with non-zero coefficients were included in the LASSO regression of the radiomics score (RAD score). Infarct size (odds ratio [OR]: 1.04 (1.00-1.07); P = 0.031) and RAD score (OR: 3.43 (2.34-5.28); P < 0.001) were independent predictors of LVAR. The RAD score predicted LVAR, with an AUC (95% confidence interval [CI]) of 0.82 (0.75-0.89) in the training set and 0.75 (0.62-0.89) in the testing set. Combining the RAD score with infarct size yielded favorable performance in predicting LVAR, with an AUC of 0.84 (0.72-0.95). Moreover, the addition of the RAD score to the left ventricular ejection fraction (LVEF) significantly increased the AUC from 0.68 (0.52-0.84) to 0.82 (0.70-0.93) (P = 0.018), which was also comparable to the prediction provided by the combined microvascular obstruction, infarct size, and LVEF with an AUC of 0.79 (0.65-0.94) (P = 0.727). Conclusion: Radiomics analysis using non-contrast cine CMR can predict LVAR after STEMI independently and incrementally to LVEF and may provide an alternative to traditional CMR parameters.

• Journal of The Korea Institute of Healthcare Architecture
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• v.16 no.2
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• pp.65-75
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• 2010

Space transformation of hospital architecture happens more rapidly than other types such as school and office buildings. This requirement is caused by medical demand, service transformation, technical development and equipment changes. Grand scale extension and rapid change in hospital architecture affects whole planning; therefore, it is important to design in the macro perspective such like Life Cycle. Grand scale extension is difficult process to rebuild growth and transfer of hospital architecture and to adapt to the future change. That's why simple planning gives limits to some departments in a short-term and brings another reform such as more extension or interior renovation in a long-term. This study surveys various space transformation and grand scale extension of EB hospital extended recently, and it is to find planning condition in extension.

• 대한생식의학회:학술대회논문집
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• 1999.11a
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• pp.71.1-71.1
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• 1999

• BMB Reports
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• v.47 no.7
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• pp.388-392
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• 2014

Berberine, a type of isoquinoline alkaloid isolated from Chinese medicinal herbs, has been reported to have various pharmacological activities. Studies have demonstrated that berberine has beneficial effects on vascular remodeling and alleviates restenosis after vascular injury. However, its mechanism of action on vascular smooth muscle cell migration is not fully understood. We therefore investigated the effect of berberine on human aortic smooth muscle cell (HASMC) migration. Boyden chamber assay was performed to show that berberine inhibited HASMC migration dose-dependently. Real-time PCR and Western blotting analyses showed that levels of matrix metalloproteinase (MMP)-2, MMP-9, and urokinase-type plasminogen activator (u-PA) were reduced by berberine at both the mRNA and protein levels. Western blotting assay further confirmed that activities of c-Fos, c-Jun, and NF-${\kappa}B$ were significantly attenuated. These results suggest that berberine effectively inhibited HASMC migration, possibly by down-regulating MMP-2, MMP-9, and u-PA; and interrupting AP-1 and NF-${\kappa}B$ mediated signaling pathways.

• Clinical and Experimental Reproductive Medicine
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• v.29 no.4
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• pp.323-335
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• 2002

Object: The present study was accomplished to obtain a gene expression profile of the luminal epithelium during embryo apposition in comparison of implantation (1M) and interimplantation (INTER) sites. Material and Method: The mouse uterine luminal epithelium from IM and INTER sites were sampled on day 4.5 (Day of vaginal plug = day 0.5) by Laser Captured Microdissection (LCM). RNA was extracted from LCM captured epithelium, amplified, labeled and hybridized to microarrays. Results from microarray hybridization were analyzed by Significance Analysis of Microarrays (SAM) method. Differential expression of some genes was confirmed by LCM followed by RT-PCR. Results: Comparison of IM and INTER sites by SAM identified 73 genes most highly ranked at IM, while 13 genes at the INTER sites, within the estimated false discovery rate (FDR) of 0.163. Among 73 genes at IM, 20 were EST/unknown function, and the remain 53 were categorized to the structural, cell cycle, gene/protein expression, immune reaction, invasion, metabolism, oxidative stress, and signal transduction. Of the 24 structural genes, 14 were related especially to extracellular matrix and tissue remodeling. Meanwhile, among 13 genes up-regulated at INTER, 8 genes were EST/unknown function, and the rest 5 were related to metabolism, signal transduction, and gene/protein expression. Among these 58 (53+5) genes with known functions, 13 genes (22.4%) were related with $Ca^{2+}$ for their function. Conclusions: Results of the present study suggest that 1) active tissue remodeling is occurring at the IM sites during embryo apposition, 2) the INTER sites are relatively quiescent than IM sites, and 3) the $Ca^{2+}$ may be a crucial for apposition. Search for human homologue of those genes expressed in the mouse luminal epithelium during apposition will help to understand the implantation process and/or implantation failure in humans.

• Korean Institute of Interior Design Journal
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• v.14 no.1
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• pp.100-108
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• 2005

If remodeling is defined as activities that restore the overall function of a building up to the standards currently demanded rather than as a simple replacement or repair of old facilities and equipment, the main task of remodeling should be the reduction in differences between areas, establishment of a functional linkage between departments and setup of a smooth circulation system. Therefore, this study is an analysis of remodeling strategies and construction processes to resolve major tasks of remodeling. Through this research we acquire concluding remarks. 1) The remodeling strategies of equipment-intensive areas can be divided into two measures: utilizing the existing buildings (the main buildings) the most, and of concentrated relocation in the new buildings. The former method is advantageous in that the main building serves as a center in hospital layouts because concentrated placement of the diagnosis/ treatment area and the supply area benefit the overall operation in terms of functions. However, the measure has limits in that it is difficult to install the facilities and equipment of the new demands due to the low ceilings, which serve as a potential challenge in future growth and changes. 2) The latter measure is the one in which equipment-intensive areas and the areas that are absolutely short of space are first placed in the new buildings while other areas (the outpatient area, the administration area and the miscellaneous areas) are in the existing building (main building). Given the possibility of development In the future, concentrated placement in the new buildings can be said to be more effective order to actively address future growth and changes.

• Korean Journal of Radiology
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• v.20 no.5
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• pp.729-738
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• 2019

Objective: To assess the effects of iterative model reconstruction (IMR) on image quality for demonstrating non-calcific high-risk plaque characteristics of coronary arteries. Materials and Methods: This study included 66 patients (53 men and 13 women; aged 39-76 years; mean age, 55 ± 13 years) having single-vessel disease with predominantly non-calcified plaques evaluated using prospective electrocardiogram-gated 256-slice CT angiography. Paired image sets were created using two types of reconstruction: hybrid iterative reconstruction (HIR) and IMR. Plaque characteristics were compared using the two algorithms. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of the images and the CNR between the plaque and adjacent adipose tissue were also compared between the two reformatted methods. Results: Seventy-seven predominantly non-calcified plaques were detected. Forty plaques showed napkin-ring sign with the IMR reformatted method, while nineteen plaques demonstrated napkin-ring sign with HIR. There was no statistically significant difference in the presentation of positive remodeling, low attenuation plaque, and spotty calcification between the HIR and IMR reconstructed methods (all p > 0.5); however, there was a statistically significant difference in the ability to discern the napkin-ring sign between the two algorithms (χ² = 12.12, p < 0.001). The image noise of IMR was lower than that of HIR (10 ± 2 HU versus 12 ± 2 HU; p < 0.01), and the SNR and CNR of the images and the CNR between plaques and surrounding adipose tissues on IMR were better than those on HIR (p < 0.01). Conclusion: IMR can significantly improve image quality compared with HIR for the demonstration of coronary artery and atherosclerotic plaques using a 256-slice CT.

• Korean Circulation Journal
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• v.53 no.6
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• pp.406-417
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• 2023

Background and Objectives: Pathophysiological changes of right ventricle (RV) after repair of tetralogy of Fallot (TOF) are coupled with a highly compliant low-pressure pulmonary artery (PA) system. This study aimed to determine whether pulmonary vascular function was associated with RV parameters and exercise capacity, and its impact on RV remodeling after pulmonary valve replacement. Methods: In a total of 48 patients over 18 years of age with repaired TOF, pulmonary arterial elastance (Ea), RV volume data, and RV-PA coupling ratio were calculated and analyzed in relation to exercise capacity. Results: Patients with a low Ea showed a more severe pulmonary regurgitation volume index, greater RV end-diastolic volume index, and greater effective RV stroke volume (p=0.039, p=0.013, and p=0.011, respectively). Patients with a high Ea had lower exercise capacity than those with a low Ea (peak oxygen consumption [peak VO₂] rate: 25.8±7.7 vs. 34.3±5.5 mL/kg/min, respectively, p=0.003), while peak VO₂ was inversely correlated with Ea and mean PA pressure (p=0.004 and p=0.004, respectively). In the univariate analysis, a higher preoperative RV end-diastolic volume index and RV end-systolic volume index, left ventricular end-systolic volume index, and higher RV-PA coupling ratio were risk factors for suboptimal outcomes. Preoperative RV volume and RV-PA coupling ratio reflecting the adaptive PA system response are important factors in optimal postoperative results. Conclusions: We found that PA vascular dysfunction, presenting as elevated Ea in TOF, may contribute to exercise intolerance. However, Ea was inversely correlated with pulmonary regurgitation (PR) severity, which may prevent PR, RV dilatation, and left ventricular dilatation in the absence of significant pulmonary stenosis.