• Imaging Science in Dentistry
• /
• 제53권1호
• /
• pp.1-9
• /
• 2023

Purpose: The aim of this study was to evaluate 3-dimensional cone-beam computed tomography (CBCT) images of alveolar bone changes in patients who underwent minimally invasive periodontal surgery-namely, the pinhole surgical technique (PST). Materials and Methods: Alveolar bone height was measured and compared on CBCT images of 254 teeth from 23 consecutive patients with Miller class I, II, or III recession who had undergone PST. No patient with active periodontal disease was selected for surgery. Two different methods were used to assess the alveolar bone changes postoperatively. In both methods, the distance between the apex of the tooth and the mid-buccal alveolar crestal bone on pre- and post-surgical CBCT studies was measured. Results: An average alveolar bone gain >0.5 mm following PST was identified using CBCT(P=0.05). None of the demographic variables, including sex, age, and time since surgery, had any significant effect on bone gain during follow-up, which ranged from 8 months to 3 years. Conclusion: PST appears to be a promising treatment modality for recession that results in stable clinical outcomes and may lead to some level of resolution on the bone level. More long-term studies must be done to evaluate the impact of this novel technique on bone remodeling and to assess sustained bone levels within a larger study population.

• Journal of Microbiology and Biotechnology
• /
• 제17권10호
• /
• pp.1661-1669
• /
• 2007

Gamma-aminobutyric acid (GABA) is a non-protein amino acid. It is well known for its role as an inhibitory neurotransmitter of developing and operating nervous systems in brains. In this study, a novel function of GABA in the healing process of cutaneous wounds was presented regarding anti-inflammation and fibroblast cell proliferation. The cell proliferation activity of GABA was verified through an MTT assay using murine fibroblast NIH3T3 cells. It was observed that GABA significantly inhibited the mRNA expression of iNOS, IL-$1{\beta}$, and TNF-${\alpha}$ in LPS-stimulated RAW 264.7 cells. To evaluate in vivo activity of GABA in wound healing, excisional open wounds were made on the dorsal sides of Sprague-Dawley rats under anesthesia, and the healing of the wounds was apparently assessed. The molecular aspects of the healing process were also investigated by hematoxylineosin staining of the healed skin, displaying the degrees of re-epithelialization and linear alignment of the granulation tissue, and immunostaining and RT-PCR analyses of fibroblast growth factor and platelet-derived growth factor, implying extracellular matrix synthesis and remodeling of the skin. The GABA treatment was effective to accelerate the healing process by suppressing inflammation and stimulating re-epithelialization, compared with the epidermal growth factor treatment. The healing effect of GABA was remarkable at the early stage of wound healing, which resulted in significant reduction of the whole healing period.

• 한국화재소방학회논문지
• /
• 제32권4호
• /
• pp.86-94
• /
• 2018

제천 스포츠센터 화재로 29명이 사망하고 40명이 부상을 입었다. 이 논문에서는 스포츠센터 화재 사례에 대해 다수 사상자가 발생한 요인을 분석하기 위해 저자의 화재조사 결과를 토대로 건물과 설비의 구조적인 요인을 분석하고 있다. 건물과 설비의 구조적인 요인은 필로티 구조의 주차장, 필로티 주차장과 로비 사이 방화구획 미비, 필로티 주차장에 스프링클러설비 미설치, 1층 주계단에 방화문 미설치, 옥상에 소화수조 미설치, 2층 주출입구에 벽체 매립형 방화문 설치, EPS실 및 배관 피트 층별 방화구획 부실, 배수배관 연결부의 누수, 화물용 승강기의 승강로와 실내에 면하는 벽체에 합판 설치, 폐쇄형 옥상구조로 개조, 주차장 반자 안쪽 천장에 스티로폼 단열재 부착, 2층 여탕 무창층 강화유리 구조, 드라이비트 외벽으로 분석하였다.

• Maxillofacial Plastic and Reconstructive Surgery
• /
• 제20권3호
• /
• pp.217-227
• /
• 1998

Calcium sulfate(plaster of Paris) has been used in dental and orthopedic surgery for about 100 years. It is well known that the plaster is bioresorbable, biocompatible, defect conformable and moldable. The purpose of this study is to evaluate two effects of calcium sulfate on bone regeneration, that is, the effects of graft materials and barrier for bone regeneration. Cortical bone defects were formed for recipient site on the femurs of 19 Sprague-Dawley rats. The autogenous particulated bone and calcium sulfate were grafted to the defects. Calcium sulfate paste, $Gore-Tex^R$ membrane(W.L. GORE & ASSOCIATES LTD., U.S.A.) and rubber sheet were used for the shielding materials. The results were as follows : 1. Calcium sulfate that had been grafted in the cortical bone defect was almost resorbed before bone remodeling, resultantly had little effect on bone regeneration. 2. Resoption process of calcium sulfate grafted on the bone grafting area tends to be accelerated, as being divided into numerous small particles progressively. Under the situation where the calcium sulfate was protected, with the coverage of fascia, $Gore-Tex^R$ membrane or rubber sheet, new bone formation was confirmed with presence of calcium sulfate particles over 6 weeks after grafting. 3. In the case of calcium sulfate covered with membrane, distinct bone formation was observed on the marrow space of femur adjacent to the plaster mass. 4. Rubber shielded plaster group revealed new bone trabeculae under the rubber sheet, but it showed ischemic degeneration of superficial cortical bone.

• 한국주거학회:학술대회논문집
• /
• 한국주거학회 2009년도 추계학술발표대회 논문집
• /
• pp.213-216
• /
• 2009

The purpose of this study is analyzing temporal flow about 20 detailed performance items in the "Housing Performance Grading Indication System". This study try to figure out situations according grade in detailed performance item and to analyze change item about 112 cases(2 cases in 2006, 15 cases in 2007, 46 cases in 2008, 49 cases in 2009), from January 9, 2006 which system is undertaken, to October, 2009. This system consists of 5 main performance section, 14 performance categories and 20 detailed performance items. 5 main performance parts are Noise and Acoustics(Light-weight impact sound control, heavy-weight impact sound control, sound control of toilet, sound control of party wall), Long-life(flexibility, remodeling & maintenance, durability), Landscape & Indoor Environment(landscape, formaldehyde control & ventilation, daylighting, thermal environment), Welfare & Barrier-free(playground and community center, welfare space, barrier-free design), Fire Safety(fire safety, safe place, fire-resisting quality). Total efficiency about housing can understand systematically of 20 perfomance items though this research.

• 한국농촌건축학회논문집
• /
• 제17권1호
• /
• pp.65-72
• /
• 2015

Recently the concerns of aging & care according to the aged Society were on the increase about Home for the elderly facility. In order to moment, the purpose of this study is to analyze planning direction and Architectural Environments in medium and small scale Elderly Care Facilities. This survey are used to investigate with latest building data, which is Long-term Care Insurance Code for the Elderly was started on July 2008 in Korea. The results of this paper are as follows. First, various type of home for the elderly and the elderly group homes are spread out, attached to day care center type, nursing home type, city region type, countryside rural type, near the university and remodeling type. Secondly, per capita room area-$6.32m^2$ are sufficient in regal comparison with $6.6m^2$. Thirdly, Sunlight environments is inappropriate condition as south direction proportion-41.95%. According to the present situation various facility type and model for our baby boomers generation should be more developed with preemptive systems of senior welfare concept.

• 한국농촌건축학회논문집
• /
• 제17권4호
• /
• pp.75-82
• /
• 2015

The elderly rate in South Korea in 2015 is over 13.1%. Especially, the elderly rate in rural area is high. Senior community project in rural that is being promoted by the government. This study's purpose is to provide the reserch group-home for the elderly in Japan rural area. And this paper provided planning of group-home for the elderly in Korea rural area. For this study, respective 5senior housing of Korea and Japan were chosen as respresenting two nations, and every manager was interviewed on housing pattern. This study suggests the planning material as following. First, the effectiveness of the group-home are big. Especially, the elderly was far healthier. Design point is public space(living room, small living room, etc). Maybe, healthy group-home concept is that would be design by Korean traditional housing. Also important public space design is that would be inner courtyard-house, wood floor, Deachong, etc. Two group-homes will construct elderly welfare facilities in between. Otherwise that is need layout of a big public space. In the case of vacant house can used by considering of scale, structure, site condition. Closed school can used through so easy remodeling too. More often than not complex type(hospital, community heath center) was appeared in Japan rural area. In the case of Korea, recommend complex type in community health center and public building. In this case, considering communication, access, contact, group-home keeps on ground floor. In this paper, we hope to take a lesson from group-home planning source for the elderly in Korea rural area.

• Anatomy and Cell Biology
• /
• 제56권4호
• /
• pp.518-525
• /
• 2023

Septin4 belong to a family of polymerizing GTP-binding proteins that are required for many cellular functions, such as membrane compartmentalization, vesicular trafficking, mitosis, and cytoskeletal remodeling. Since, Septin4 is expressed specifically in the testis, we aimed to determine the association between Septin4 gene expression with sperm quality, DNA damage, and stress oxidative level in infertile patients. The present study included 60 semen samples that grouped into three groups: normozoospermia (n=20), asthenozoospermia (n=20), astheno-teratozoospermia (n=20). Initially, semen parameters were analyzed by using the World Health Organization protocol. The mRNA expression of Septin4 in sperm was examined using reverse transcription-polymerase chain reaction. Oxidative stress markers, i.e., total antioxidant capacity, superoxide dismutase, catalase, glutathione peroxidase, and malondialdehyde, were determined by ELISA kit. The current study showed a statistically significant highly positive correlation in Septin4 gene expression with sperm motility, normal morphology, viability, capacity, and sperm mitochondrial membrane potential (MMP). However, it showed significant negative correlation with sperm DNA fragmentation. Septin4 had a significant correlation with stress oxidative factor and antioxidant enzyme levels. In conclusion, Septin4 gene expression provides clinical useful information for the diagnosis of male infertility. It might be a marker for discrimination between fertile and infertile patients. The current study showed a statistically significant highly positive correlation in Septin4 gene expression with sperm motility, normal morphology, viability, capacity, and sperm MMP. However, it shows significant negative correlation with sperm DNA fragmentation. Septin4 had a significant correlation with stress oxidative factor and antioxidant enzyme levels.

• International Journal of Oral Biology
• /
• 제39권3호
• /
• pp.145-151
• /
• 2014

During bone remodeling, there is requirement of differentiation of osteoblastic cells. Previously, we identified proteins differentially expressed in soft tissue during bone healing. Of these proteins, we focused the effect of LTF on differentiation of osteoblast. In order to analyze the osteogenic ability of LTF, we treated conditioned media collected from human LTF-stably transfected HEK293T cells into osteoblastic MC3T3-E1. The results showed that the activity and expression of alkaline phosphatase were increased in MC3T3-E1 cells treated with conditioned media containing LTF in dose- and time-dependent manner. At the same time, we observed the significant increase of the expression of osteoblastic genes, such as ALP, BSP, COL1A1, and OCN, and along with matrix mineralization genes, such as DMP1 and DMP2, in LTF conditioned media-treated groups. Moreover, the result of treating recombinant human LTF directly into osteoblastic MC3T3-E1 showed the same pattern of treating conditioned media containing LTF. Our study demonstrated that LTF constitutively enhances osteoblastic differentiation via induction of osteoblastic genes and activation of matrix mineralization in MC3T3-E1 cells.

• Journal of Trauma and Injury
• /
• 제22권1호
• /
• pp.51-56
• /
• 2009

Purpose: The purpose of this study was to investigate environmental factors contributing to childhood home slip-down injuries. Methods: Among a total of 2,812 injured children in our Customer Injury Surveillance System (CISS), we performed a prospective study on 262 children with home slip-down injuries who visited the pediatric emergency department of Asan Medical Center between March 2008 and February 2009. We made a frequency analysis on parameters such as activities just before the accident, the presence of any obstacles or lubricant materials, specific home place in the home where the injuries occurred, flooring materials on which the slip-down happened, additional objects hit after slip down, the site and kind of injury, the duration of therapy, and the disposition. Results: Walking was the most common activity just before the injury. Because rooms and bathrooms were most common places in the home for slip down injuries, laminated papers/ vinyl floor coverings and tiles were the most common flooring materials used in the places where the injuries occured. Most commonly, no obstacles caused the children to slip down, but the furniture, stairs, doorsills, wetness, or soapy fluid followed after that. Over half of the children who slipped (58%) also collided with other than the floor itself after the slip-down, most common objects hit were the edges of the furniture, and doorsills, followed by stairways. The head and neck were the most commonly injured sites, and a laceration was the most common kind of injury. Most children needed less than 1 week of therapy, only 4 children (1.53%) admitted. There were no mortalities. Conclusion: The environmental factors contributing to slip-down injuries were the bathroom, laminated papers/vinyl floors, the furniture, stairs, doorsills, and wetness or soapy fluid. Especially, the furniture, stairs, and doorsills can be both primary obstacles and secondary collision objects. For the safety of our children, we must consider these factors on housing, when decorating or remodeling our house.