• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2003.10a
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• pp.329-332
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• 2003

Aquaculture have been important role to supply food resources for mankind. However, competitive power of domestic mariculture industry was declined due to increase of labor and feed expenditures, and quantity import of low-priced livefishes from the developing underdeveloped nations in North and South East Asia. Mass production and quality enhancement can be pointed out to overcome such an industrial environment in this decade. To meet these requirement, movable mariculture base remodeling feasible vessel of chemical tanker or crude oil carrier has been proposed for more advanced mariculture management system by using deep seawater from about 200m which is sustainablely clean, nutrient-rich and cold seawater. Deep seawater can be applied for control of seawater temperature for mariculture base and cultivation phytoplankton and seaweed as feed. Besides mariculture, strategic marketing can be implemented by raw water and ice of deep seawater. Feasibility of applying deep seawater was considered after evaluating general movable mariculture base and management system.

• Food Science and Biotechnology
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• v.18 no.1
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• pp.84-88
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• 2009

Cathepsin S is a cysteine protease that affects extracellular matrix remodeling. Recently, several studies have reported that cathepsin S is involved in obesity. Both mouse and human adipose cells produce this enzyme in the early phase of adipocyte differentiation, where it degrades fibronectin. Cathepsin S gene expression is elevated in the adipose tissue of obese mice as compared to that of lean mice. Paecilomyces tenuipes water extracts (PTW) are shown to have an inhibitory effect on cathepsin S activity. In this study, Z-Val-Val-Arg-MCA was used as a cathepsin S-specific substrate in order to examine inhibitory effect of PTW. Supplementing 3T3-L1 cell media with PTW clearly reduced lipid droplet accumulation and cathepsin S-induced adipogenesis. Furthermore, PTW decreased weight gain, subcutaneous adipose tissue growth, the level of serum triglyceride, and total cholesterol in mice fed a high-fat diet. These data suggest that PTW work against adipose cathepsin S and presumably contribute to anti-obese activities.

• Korean Journal of Animal Reproduction
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• v.24 no.1
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• pp.59-67
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• 2000

This study was investigated the developmental potential of bovine embryos following nuclear transfer with bovine fetal fibroblasts (BFF). BFF were isolated from a male 45-day-old-fetus. Non-starved BFF labeled with MitoTracker were transferred into perivitelline space of enucleated oocytes. BFF-oocyte units were fused by electric pulse, and then fused oocytes were activated with calcium ionophore A23187 and subsequently 6-dimethylaminopurine (6-DMAP). The resulting zygotes were placed into CRlaa bovine embryo culture medium. Transfer of the nucleus into enucleated oocyte led to premature chromosome condensation, swelling and pronucleus formation. Remodeled oocytes were developed to the mitotic and 2-cell stage at 18 to 26 h after nuclear transfer. The incidence of in vitro development to the blastocyst stages was 21% of fused oocytes. Mitochondria of BFF eliminated rapidly and were not detected at 8 h after fusion. These results suggest that BFF can be successfully reprogrammed in enucleated bovine oocytes, and that reconstructed embryos can develop to the blastocyst stage.

• Journal of The Korea Institute of Healthcare Architecture
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• v.23 no.3
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• pp.19-27
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• 2017

Purpose: The characteristics of site plan and space configuration of public dentistry through examining the public dental healthcare centers for the disabled in Korea and comparison between them are necessary for the development of planning of the dental healthcare system. This study has been started to provide basic informations such as nationwide distribution, site relationship, and space configuration for the planning of public dental hospital architecture. Methods: Literature review of publicness and public dental healthcare and investigation on current status of public dental healthcare center for the disabled in Korea have been conducted. The site plan and space configuration of eight public healthcare centers for the disabled have been analyzed. Results: The result of this study can be summarized in three points. The first one is that public dentistry in Korea are distributed public dental hospital for the disabled in Seoul and public dental healthcare centers for the disabled in eight provinces. The second one is that the types of the dental healthcare center for the disabled are divided with remodeling type which is diverted from existed dental or medical out patient clinic space or independent building type which is planned with a new and exclusive usage for the disabled. The third one is that the space configuration of dental healthcare center for the disabled is needed more required programs, larger treatment unit space, and more private clinic space than typical dental treatment plan. Implications: This study is the starting point for the research of public dentistry and it is necessary to analyze the dental prevention and dental public policy to develop the public dental healthcare system.

• Journal of the Korea Convergence Society
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• v.2 no.3
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• pp.33-38
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• 2011

This study is find out the how promotion is handled by understanding the notion and the characteristics of the underpass market in the underground space by comparing those of other ours. However, the underpass market of suwon needs to remodeling. Most of all, there are problems on not having enough ensured environment.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.36 no.1
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• pp.25-29
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• 2014

The purpose of this study is to report on five cases treated with bone graft using recombinant human bone morphogenetic protein-2 (rhBMP-2) on jaw defects after cyst enucleation. We performed bone graft with BMP (rhBMP-2+${\beta}$-tricalcium phosphate/hydroxyapatite) wrapped with a collagen sponge on jaw defects after cyst enucleation. Postoperative panoramic radiographs were taken periodically. After 1 to 12 months, bone remodeling was observed in the jaw defect area. In our cases, there were few signs or symptoms of recurrence of the cyst during the follow-up period.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2023.05a
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• pp.7-9
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• 2023

The domestic law establishes a sea trial prohibited area and stipulates that a sea trial is prohibited in this area. However, depending on the user, the term is used interchangeably with on-board test after repaired, In particular, ships undergoing test called a sea trial after remodeling and repairing ships at repair shipyards do not comply with these regulations. By this study, we would like to look at the relevant laws and regulations to see if these ships can be interpreted as sea trial, and suggest the necessity of managing repaired test ships with risks comparable to those of sea trial ships.

• Journal of Chest Surgery
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• v.56 no.5
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• pp.295-303
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• 2023

Background: The use of Adriamycin (ADR), also known as doxorubicin, as a chemotherapy agent is limited by its detrimental adverse effects, especially cardiotoxicity. Recent studies have emphasized the crucial role of angiotensin II (Ang-II) in the development of ADR-induced cardiomyopathy. This study aimed to explore the potential cardioprotective effects of losartan in a rat model of ADR-induced cardiomyopathy. Methods: Male Sprague-Dawley rats were randomly divided into 3 groups: a control group (group C), an ADR-treated group (ADR 5 mg/kg/wk for 3 weeks via intraperitoneal injections; group A), and co-treatment of ADR with losartan group (same dose of ADR and losartan; 10 mg/kg/day per oral for 3 weeks; group L). Western blot analysis was conducted to demonstrate changes in brain natriuretic peptide, collagen 1, tumor necrosis factor (TNF)-α, interleukin-6, matrix metalloproteinase (MMP)-2, B-cell leukemia/lymphoma (Bcl)-2, Bcl-2-associated X (Bax), and caspase-3 protein expression levels in left ventricular (LV) tissues from each group. Results: Losartan administration reduced LV hypertrophy, collagen content, and the expression of pro-inflammatory factors TNF-α and MMP-2 in LV tissue. In addition, losartan led to a decrease in the expression of the pro-apoptotic proteins Bax and caspase-3 and an increase in the expression of the anti-apoptotic protein Bcl-2. Moreover, losartan treatment induced a reduction in the apoptotic area compared to group A. Conclusion: In an ADR-induced cardiomyopathy rat model, co-administration of ADR with losartan presented cardioprotective effects by attenuating LV hypertrophy, pro-inflammatory factors, and apoptosis in LV tissue.

• Proceedings of the Korea Concrete Institute Conference
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• 2004.11a
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• pp.595-602
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• 2004

In this study, the roughness of fracture surfaces in cementitious material has been characterized by roughness number (RN). A systematic experimental investigation was carried out to examine the dependency of fracture parameters on the aggregate sizes as well as the loading rates. Three aggregate sizes (0.1875 in, 0.5 in, and 0.75 in) and two loading rates (slow and fast loading rate) were used. A total of 52 compression tests and 53 tension tests were performed. All fracture parameters exhibited an increase, to varying degrees, when aggregates were added to the mortar matrix. The fracture surfaces of the specimens were digitized and analyzed. Fracture roughness was monotonically increased as maximum aggregate sizes increase.

• Journal of the Earthquake Engineering Society of Korea
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• v.23 no.2
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• pp.109-117
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• 2019

In this study, a design procedure for the practical application of the dampers to building structures under earthquake loads was presented by using earthquake response spectrum. Nonlinear time history results using a 10 story building structure installed with damper verified the effectiveness of the proposed procedure by showing that the structural response could be reduced to the target performance level for seismic loads. Since the proposed design procedures are based on response spectrum seismic analysis result of the original structure, the capacity, location and the number of damper and the consequent response reduction effects can be preliminarily determined without performing the nonlinear time history analysis.