• 한국주거학회논문집
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• 제15권5호
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• pp.21-32
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• 2004

The purpose of this study is to interpret Gaudi's philosophy of architecture through an analysis of the design characteristics in his remodeling of Casa Battlo. A review of the literature related to Casa Battlo as well as a field study in Barcelona to see the building were made for this study. The conclusions were as follows; Casa Battle is one of the best examples of Gaudi's attempts at creating a surreal atmosphere and should be evaluated in light of the following considerations: 1) Casa Battle as a remodeled house presented its own restrictions to Gaudi that he overcame by introducing characteristic design elements into the remodeling process; 2) the achievement, a perfect sculpture expressing continuity through a gorgeous colour scheme using different materials and design motifs with a dynamic spiral shape, originated from Gaudi's observations of nature and his experiences working in modeling studios; 3) a visualized embodiment of Gaudi's naturalism and functionalism through the impression of perpetual movement and continuity as formative symbols of genesis, life, death, and transmigration of the soul, originated from Gaudi's personal experiences of the early deaths of several close family members; 4) the design is meant to show the same processes of creation used by nature rather than a mere imitation of nature. Gaudi was not only a person dedicated obsessively to his profession as an architect, but also a rationalist fundamentally in the way he operated. It was expected that this study could be employed as a small stimulus to challenge the paradigm of housing remodeling projects -a hot issue in today's Korea- especially in their philosophical aspect.

• Korean Journal of Radiology
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• 제22권10호
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• pp.1619-1627
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• 2021

Objective: This study used cardiac magnetic resonance imaging (MRI) to compare the characteristics of left ventricular remodeling in patients with primary aldosteronism (PA) with those of patients with essential hypertension (EH) and healthy controls (HCs). Materials and Methods: This prospective study enrolled 35 patients with PA, in addition to 35 age- and sex-matched patients with EH, and 35 age- and sex-matched HCs, all of whom underwent comprehensive clinical and cardiac MRI examinations. The analysis of variance was used to detect the differences in the characteristics of left ventricular remodeling among the three groups. Univariable and multivariable linear regression analyses were used to determine the relationships between left ventricular remodeling and the physiological variables. Results: The left ventricular end-diastolic volume index (EDVi) (mean ± standard deviation [SD]: 85.1 ± 13.0 mL/m² for PA, 75.9 ± 14.3 mL/m² for EH, and 77.3 ± 12.8 mL/m² for HC; p = 0.010), left ventricular end-systolic volume index (ESVi) (mean ± SD: 35.2 ± 9.8 mL/m² for PA, 30.7 ± 8.1 mL/m² for EH, and 29.5 ± 7.0 mL/m² for HC; p = 0.013), left ventricular mass index (mean ± SD: 65.8 ± 16.5 g/m² for PA, 56.9 ± 12.1 g/m² for EH, and 44.1 ± 8.9 g/m² for HC; p < 0.001), and native T1 (mean ± SD: 1224 ± 39 ms for PA, 1201 ± 47 ms for EH, and 1200 ± 44 ms for HC; p = 0.041) values were higher in the PA group compared to the EH and HC groups. Multivariable linear regression demonstrated that log (plasma aldosterone-to-renin ratio) was independently correlated with EDVi and ESVi. Plasma aldosterone was independently correlated with native T1. Conclusion: Patients with PA showed a greater degree of ventricular hypertrophy and enlargement, as well as myocardial fibrosis, compared to those with EH. Cardiac MRI T1 mapping can detect left ventricular myocardial fibrosis in patients with PA.

• IMMUNE NETWORK
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• 제9권6호
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• pp.274-284
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• 2009

Background: Swiprosin-1 was identified in human CD8+ lymphocytes, mature B cells and non-lymphonoid tissue. We have recently reported that swiprosin-1 is expressed in mast cells and up-regulated in both in vitro and in vivo. Methods: The expression of cytokines and swiprosin-1 were determined by by real time PCR and conventional PCR. Pharmacological inhibitors were treated to investigate potential mechanism of swiprosin-1 in mast cell activation. Actin content was evaluated by confocal microscopy and flow cytometry. Results: The swiprosin-1 augmented PMA/A23187-induced expression of cytokines and release of histamine. However, knock-down of swiprosin-1 showed only a modest effect on PMA/A23187-induced cytokine expression, suggesting that swiprosin-1 has gain-of-function characteristics. Swiprosin-1 was found in microvilli-like membrane protrusions and highly co-localized with F-actin. Importantly, either disruption of actin by cytochalasin B or inhibition of PI3 kinase, an enzyme involved in actin remodeling, by wortmannin blocked cytokine expression only in swiprosin-1-overexpressing cells. Conclusion: These results suggest that swiprosin-1 modulates mast cell activation potentially through actin regulation.

• 교육시설 논문지
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• 제25권3호
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• pp.13-24
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• 2018

Unlike other educational spaces in school facilities, restrooms have remained unpleasant spaces without reflecting the change in social awareness and students' lifestyle. In the process of the 'School Restroom Environment Remodeling Project in Seoul' by means of "user participatory design method", this study aimed to suggest a design of the school restroom environment responding to the different needs of actual users, who are students and school staffs. By surveying them, it was revealed that they have a variety of respective behavioral patterns and spatial needs according to their status, gender, age and working period. Implications of this study are as follows; First, it is necessary to establish a separate restroom facility standards that respond to the characteristics of elementary school students. Second, there should be an expansive approach to widely accommodate with the users' needs that were found out through 'user participation', more than just repairing pre-existing space. Third, it needs to have critical review of the maintenance and operation system itself as well as the improvement of the school restroom environment.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 추계학술대회논문집B
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• pp.529-532
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• 2001

The purposes of the present study are to investigate hemodynamic characteristics and to define shear-sensitive remodeling in the stenosed coronary models. Two models for the compensatory remodelling used for this research are a pre-stenotic dilation and a post-stenotic dilation models for the computer simulation. The peak wall shear stress on the post-stenotic model is higher than that of the pre-stenotic model. Two recirculation zones are generated in the pre-stenotic model, and the zones in the pre-stenotic model are smaller than those in the post-stenotic model. Variation of the wall shear stress in the pre-stenotic model is lower than that in the post-stenotic model. In computer simulation with the post-stenotic model, higher temporal and spatial shear fluctuation and stress suggested shear-sensitive remodeling. Shear-sensitive remodeling may be associated with the increased risk of plaque rupture, the underlying cause of acute coronary syndromes, and sudden cardiac death.

• 한국구조물진단유지관리공학회 논문집
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• 제11권3호
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• pp.77-86
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• 2007

건축물의 증가와 자원의 효율적인 활용의 목적으로 기존 건축물에 대한 리모델링이 주목을 받고 있다. 리모델링 공사로 인해 세대간 병합을 위해 기존 벽에 개구부를 설치하는 경우 개구부의 영향을 파악 하는 것을 목적으로 철근콘크리트 전단벽의 정적가력 실험을 실시했다. 그 결과 개구부 유무에 따른 파괴현상은 벽판에 형성된 압축지주의 단면적이 감소함으로써 다르게 나타났다. 특히 최대 내력은 개구부 설치에 따라 약 35%정도 감소되는 특성을 보였다. 이러한 경향은 강성 및 에너지 소산능력에서도 유사하게 나타났다.

• 한국주거학회논문집
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• 제20권6호
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• pp.31-38
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• 2009

The purpose of this study is to investigate remodelling that meets the characteristics, intention and needs of antiquated apartment in Gwangju. For this study, firstly, we observed the current status and residents of old-aged apartments and attempted interview. Secondly, we used ethnographical interview of participating and observation methods based on cultural anthropology. The needed for this study was obtained by the questionnaires with 273 answer sheet. The data analyzing method was the statistic program SPSS. This study targeted more than 10-year-old seven apartment complexes which had above 10 stories. In respect of other needs of remodelling, it was very difficult to obtain uniform remodeling on which the whole residents agreed. As old-aged apartment could not be remodelled uniformly, remodeling types should be specified according to different complexes, buildings and units. Joint plans should be prepared for buildings or common space according to different steps of aging before joint remodelling and houses should be individually or jointly remodelled after joint plan is prepared. Current apartment remodelling is designed to increase economic values, but remodelling is more necessary for the residents with low-income. So, financial burden should be minimized and gradually remodelling apartment for improvement of residential environment is to be preferred.

• 한국농촌건축학회논문집
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• 제16권4호
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• pp.51-58
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• 2014

This study is to clarify the actual condition of the plan of high schools in the rural area. Recently, many high schools are remodeling the buildings and facilities based on departmental system. This study, through analyzing on 5 remodeling cases of high school in gyeongnam area. This article discuses about the basic characteristics of the plan composition and the education program of 5 high schools. This study is showing the variation before and after remodeling and space organization types. The results of this study are summarized as follows; We studied 5 high schools in 2012~2013 of them, which located in the rural area. We studied the location of department classrooms, teachers' labs and home bases of them. 1) Most of them take horizontal zoning system in the department classrooms. 2) The number of teachers' labs were increased in most of floors. On the other hand, most of Labs' area were decreased. Every department classroom zone has one teachers' lab. 3) Sample schools took much more spaces of home-base and media-space than before.

• 대한건축학회논문집:계획계
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• 제34권9호
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• pp.43-54
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• 2018

Recently, residents' community center is trying to combine with various program and facilities as the residents self-government program's development. This is due to the reduction of administrative tasks, the computerization of programs, the importance of community participation activities, the activation of community, and the increase of welfare projects. Therefore, previous studies on program complexity have been actively carried out. Nevertheless, spaces and programs studies of considering regional characteristics are lacking. Therefore, the community centers' program and spaces need to change. Therefore, this study propose an improvement direction through analyzing the situation of the residents' community center. For this study, the precedent research and institutional limitations are examined. In addition, this study selected and analyzed the 15 local community center. Thirdly, interviews were conducted with users and officials of the 5 residents' community centers on major changes. Finally, This study suggests direction of program improvement and architectural design direction. As a result of this study, integrated management measures with overlapping agencies should be sought. Surplus space will have to be rearranged into a new program through prior examination. Above all, the proposed remodeling guidelines require user requirements to be reflected and designed with the residents.

• The Korean Journal of Physiology and Pharmacology
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• 제20권6호
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• pp.641-647
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• 2016

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by vascular remodeling of pulmonary arteries (PAs) and increased vascular resistance in the lung. Monocrotaline (MCT), a toxic alkaloid, is widely used for developing rat models of PAH caused by injury to pulmonary endothelial cells; however, characteristics of vascular functions in MCT-induced PAH vary and are not fully understood. Here, we investigated hypoxic pulmonary vasoconstriction (HPV) responses and effects of various vasoconstrictors with isolated/perfused lungs of MCT-induced PAH (PAH-MCT) rats. Using hematoxylin and eosin staining, we confirmed vascular remodeling (i.e., medial thickening of PA) and right ventricle hypertrophy in PAH-MCT rats. The basal pulmonary arterial pressure (PAP) and PAP increase by a raised flow rate (40 mL/min) were higher in the PAH-MCT than in the control rats. In addition, both high $K^+$ (40 mM KCl)- and angiotensin II-induced PAP increases were higher in the PAH-MCT than in the control rats. Surprisingly, application of a nitric oxide synthase inhibitor, L-$N^G$-Nitroarginine methyl ester (L-NAME), induced a marked PAP increase in the PAH-MCT rats, suggesting that endothelial functions were recovered in the three-week PAH-MCT rats. In addition, the medial thickening of the PA was similar to that in chronic hypoxia-induced PAH (PAH-CH) rats. However, the HPV response (i.e., PAP increased by acute hypoxia) was not affected in the MCT rats, whereas HPV disappeared in the PAH-CH rats. These results showed that vascular contractility and HPV remain robust in the MCT-induced PAH rat model with vascular remodeling.