• The Korean Journal of Pain
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• 제22권3호
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• pp.216-223
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• 2009

Background: There have been limited reports on the effectiveness of 5% lidocaine patches (L5Ps) for treating a few types of chronic pain. We utilized L5Ps for chronic pain patients with various diagnoses and who had incompletely responded to their current treatment regimen. This study aimed at describing the results of a retrospective review of an open-label L5P trial to assess L5Ps' effectiveness and safety for treating various chronic pain patients. Methods: The chronic pain patients with pain lasting longer than 6-month duration were offered a 2-week L5P treatment trial. The patients were maintained on their other analgesic regimens. The treatment effect was measured according to the change from the baseline visual analog scale (VAS) to the week 2 VAS. After a 2-week trial, the patients were asked if they perceived pain improvement with L5Ps by using a four-item Pain Relief Scale (1 = a lot of relief, 2 = slight relief, 3 = no change, 4 = worse pain). Results: In the combined patient population (n = 177), 2-week treatment with the L5Ps significantly improved the week 2 VAS (P = 0.000). Significant improvement in the VAS was reported by the chronic pain patients with postherpetic neuralgia, intercostal neuralgia, degenerative osteoarthritis at knee joint, and other maladies. A higher proportion of the chronic pain patients reported improving their pain by the L5Ps. Seven patients experienced mild or moderate patch-related adverse events. Conclusions: The L5P provided clinically meaningful pain relief in some refractory chronic pain patients without any severe adverse events.

• 한국산학기술학회논문지
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• 제19권4호
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• pp.229-238
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• 2018

본 연구의 목적은 자살시도를 한 중학생의 스트레스 인자와 주관적 행복감의 관계에서 잠으로 피로회복, 주관적 건강인지를 이용하여 다중매개효과 차이를 파악하고자 함이다. 2016년(제 12차) 청소년건강형태온라인조사 원시자료에서 최근 12개월 동안 자살시도를 한 적이 있는 중학생 820명을 대상으로 IBM SPSS 23과 IBM SPSS AMOS 23 프로그램을 이용하여, 경로분석, 부트스트래핑, 팬텀변수, 다중집단분석으로 분석하였다. 연구결과 스트레스 인지와 주관적 행복감의 관계에서 잠으로 피로회복과 주관적 건강인지는 간접효과(${\beta}=-.12$, p=.003)가 통계적으로 유의하였다. 스트레스 인지와 주관적 행복감의 관계에서 잠으로 피로회복 간접효과는 -.05(p=.004), 주관적 건강인지 간접효과는 -.09(p=.004)로, 두 변수의 간접효과 크기 차이는 주관적 건강인지가 잠으로 피로회복보다 -.02(p=.028) 효과크기가 큰 것으로 나타났다. 남 여 중학생 집단별 경로 간 효과 크기의 차이를 본 결과 남학생집단(${\beta}=.44$, p<.001)이 여학생집단(${\beta}=.23$, p<.001) 보다 효과가 큰 것으로 나타났다. 연구결과를 바탕으로 자살시도 중학생의 행복감 증진에 도움이 되는 스트레스인지, 잠으로 피로회복, 주관적 건강인지 내용이 포함된 교육 프로그램의 개발 및 적용되어야 할 것이다.

• 융합정보논문지
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• 제10권5호
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• pp.75-82
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• 2020

본 연구는 치매안심센터의 치매환자 보호자에게 미충족 치매정보를, 종사자에게는 프로그램에 대한 효과성을 파악하기 위한 서술적 조사연구이다. 대상자는 S시 25개 자치구의 치매안심센터에서 보호자 114명, 종사자 217명을 대상으로 하였으며, 기간은 2019년 11월 1일부터 2020월 1월 30일까지이다. 연구도구 중 미충족 치매정보는 7문항의 Likert 5점 척도, 위기관리수준은 6항목, 10문항의 Likert 5점 척도로 구성된 설문지를 사용하였다. 연구결과 우울한 보호자가 그렇지 않은 보호자에 비해 미충족 치매정보를 경험할 비율이 12.3배 높은 것으로 나타났다(p<.001). 위기관리수준이 미흡하다고 인식한 종사자일수록 프로그램 효과성이 8.98배 높게인식하였으며(p=.004), 사회복지사가 간호사에 비해 2.81배나 높게인식하였다(p=.091). 결론적으로, 치매안심센터 서비스 수준을 단기간에 최고로 만들기 위한 일방적 정책보다 지역사회 주민들과 다양한 의견교환을 통해 그들의 필요를 충족해 나가는 쌍방향 운영이 필요하다.

• Asia Marketing Journal
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• 제16권1호
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• pp.101-116
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• 2014

In the year 2013, Warren Buffett was named one of the most influential people of the year by TIME magazine. When people are exposed to such news, they show strong interest in who the influential people are and how those people became so successful. Likewise, people show strong attachment to other prominent figures as well. This social phenomenon indicates that people perceive well-known persona like business leaders, TV stars or sports stars etc. as human brands of intangible assets. As the role of these human brands is becoming more important, people tend to develop stronger attachment toward them. Another notable modern social phenomenon is people's pursuit of life-satisfaction and social well-being. People desire to increase their quality of life by having quality time with family and friends, and also by building attachment towards celebrities, sports stars, and so on. The main objective of this study is to examine how attachment toward human brands affects quality of life. While existing studies on human brands examined antecedents of attachment, e.g., some needs fulfillment such as A-R-C needs (autonomy, relatedness and competence needs) fulfillment, this study focuses on the outcome variables of attachment, e.g., how attachment toward human brands affects stress relief and life satisfaction through self-efficacy. Based on previous research, we divided human brands into two types: heroes and celebrities. Heroes are defined as people who have considerable and lasting importance on both societal and individual levels, and celebrities are defined as people who are well-known but have little or no short-term impact on society and individual levels. This study focuses on how attachment toward each type of human brands, celebrities and heroes, affects the quality of life or well-being. This study focuses on three important outcome variables; stress relief, life satisfaction, and self-efficacy, (three variables) which have been recently gaining importance, especially in the domain of positive psychology. Major findings from the present study show that although celebrities draw attachment from people by providing fun and entertainment or providing stress relief, they have weak influences on the wellbeing or efficacy of individuals at a deeper level. In contrast, attachment toward heroes helps people live better by providing meaning and positively influencing life satisfaction through self-efficacy (Frankl 1997). These results are consistent with the main tenet of 'positive psychology' which seeks "to find and nurture genius and talent and to make normal life more fulfilling" (Seligman and Csikszentmihalyi 2000). Considering the fact that certain celebrities are perceived as heroes to some, we can conclude that celebrities can become heroes if they provide meaning and value to the lives of people. This study contributes to the research stream of human brands since the most current leading research (e.g., Thomson 2006) indicated the need to look at the resulting effect of attachment on life satisfaction through self-efficacy. Another important contribution is that we empirically documented the different effects of celebrities and heroes. As expected, this study shows that heroes more deeply influence the lives of individuals in the long term while celebrities do so rather shallowly in the short term. The issues of the influence of heroes on the individuals' lives need to be further investigated in relation with the perspective of positive psychology.

• 대한기계학회논문집
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• 제3권2호
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• pp.43-47
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• 1979

This paper presents the effect of stress relief annealing on mechanical properties in single Vee-groove welding joint. In this experiment, the investigation of annealing effect on mechanical properties of test material carried out by changing the annealing temperature from $600^{\circ}C$ to $900^{\circ}C$ under the given conditions. The results pbtained by this study are as follows: (1) Under the constant welding conditions, the tensile strength of test welded joint decrease in accordance with the increase of annealing temperature. The experimental results show that the reduction rate of tensile strength is about 35.09% of base metal strength. (2) Microhafdness distribution of welded joint bring about the maximum hardness near the bended line of welding joint. (3) Izod impact energy of welded joint in increase in according to the rise of annealing temperature and the peak energy of impact test occurs at $800^{\circ}C$

• The Korean Journal of Pain
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• 제27권4호
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• pp.334-338
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• 2014

Background: Lumbar transforaminal epidural steroid injections (TFESIs) are performed to provide symptom relief in patients with radicular pain. Recent articles suggested that injected volume itself have analgesic effects and higher volumes are associated with better outcomes. To date, few studies have been conducted to investigate the effects of volume. Therefore, well-designed controlled studies were necessary to confirm the effect of volume itself on pain relief. The purpose of this study was to examine the effectiveness of a forceful saline injection on lumbar TFESI using non-particulate steroids. Methods: Fifty consecutive patients with lumbar radicular pain were enrolled. The participants were allocated into one of two groups: dexamethasone with volume (Group DV) and dexamethasone alone (Group DO). The volume was delivered by a forceful injection of 5ml of normal saline. The primary end-point for this study was a VAS pain score and modified MacNab score indicating the rate of effectiveness at the four-week follow-up. Results: There were no significant post-procedural VAS differences between two groups (P = .252). The effectiveness rate among the patients was 47.8% in DV group, 34.8% in DO group, measured by modified MacNab score. The difference was not statistically significant (P = .117). Conclusions: A forceful saline injection did not have a significant effect during the treatment of radicular pain. Further studies with greater volumes and with additional techniques would offer a more conclusive perspective.

• The Korean Journal of Pain
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• 제14권1호
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• pp.68-75
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• 2001

Background: Thoracotomy is the operation that produces the most postoperative pain, necessitating the highest requirements for postoperative analgesics. The common methods of treating postthoracotomy pain are the use of thoracic epidural analgesia, intemittent or continuous intercostal nerve blocks, intravenous narcotics and cryoanalgesia. We designed to assess the analgesic effect of epidural analgesia, cryoanalgesia and the combined analgesia in thoracic surgery. Methods: A prospective study was carried out in 59 patients undergoing elective thoracotomy for parenchymal disease. Patients were randomized into three groups: C (cryoanalgesia), CE (cryoanalgesia and thoracic epidural analgesia), E (epidural analgesia). All patients had standard anesthesia with endotracheal intubation using a double lumen endotracheal tube, and one-lung ventilation. Subjective pain relief was assessed on a visual analog scale. Analgesic requirements, complications and the degree of satisfaction were evaluated during the 7 days following surgery. Results: Subjective pain relief was significantly better in Group CE and Group E in comparison with Group C (P < 0.05). Cryoanalgesia provided a better pain score on the 6th and 7th POD than the early postoperative periods. Analgesic requirements were higher in Group C than in the Group CE and Group E during the first POD. The incidence of side effects was similar in Group CE and Group E. Conclusions: If we can reduce the concentration of fentanyl and local anesthetics in combined analgesia of epidural and cryoanalgesia, the disadvantages of each method would be overcome and would be a better method of postthoracotomy pain control.

• 약학회지
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• 제55권1호
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• pp.1-10
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• 2011

Mastic is a bleed resin formed in pistacia lentiscus tree extract form the anacatdiaceae family. Mastic is used as a food ingredient in the Mediteraanean resin, and has been used by local inhabitants as a traditional medicine for relief of upper abdominal discomfort, dyspepsiaand peptic ulcer. Clinically, mastic has been effective in the treatment of benign gastric and duodenal, ulcers, giving symptomatic relief and endoscopically proven healing. In this study, to enhance activiteies of poorly water soluble Mastic with oils, surfactants and cosurfactants and then the mixure was microemulsified in aqueous media under condition of gentle agitation and digestive motility that would be encountered in the gastrointestinal tract. Formulation development and screening were based on phase diagrams and characteristics of resultant microemulsion. For optimum mastic formulation, microemulsions with various ratio (w/w%) of mastics, oils, surfactants and cosurfactants were prepared and their solubility was evaluated by monitoring particles size in their buffer through visual asessment and electrophoretic light scattering spectrophotomerter (ELS). In vitro activity of self microemulsified mastic (SME mastic) was determined by minimum ingibition concentration (MIC) test against a panel of Helicobacter pylori (H. pylori) clinical strains. Additionally, in vivo activity of SME masitc was investigated us mouse infected by CH275 of H. pylori. The mean diameter of SME mastic was less then 100 nm in water and SME mastic was showed similar antiboisis effect compared to tometronidazole, clarithromycin and omeproazole. Consequently, SME mastic would be effective system to exterminate H. pylori. If mastic were dose with combined treatment, mastic might augur well for effect of H. pylori eradication as good remedy.

• 디지털융복합연구
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• 제14권6호
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• pp.271-283
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• 2016

본 연구는 체계적 문헌고찰과 메타분석을 이용하여 향기요법 간호중재의 통증완화에 대한 효과를 산출하고자 하였다. 연구출처는 KERIS, KISS, DBpia, Cochrane Library, Ovid-Medline와 Pubmed를 통해서 2000년부터 2014년까지 출판된 연구로 총 20개의 연구에 1029명의 대상자를 메타분석하였다. 연구대상이 되는 주요어는 PICO와 아로마, 향기, 향흡입, 향마사지, 아로마테라피, 통증, 통증관리 등이다. 메타분석결과를 살펴보면, 향기요법 간호중재의 통증완화에 대한 효과는 전체 효과뿐만 아니라 하위요인에서도 통계학적으로 유의한 차이를 나타내었다. 연구결과를 바탕으로 향기요법 간호중재가 통증완화 효과를 나타냈 수 있다는 근거자료를 확보하기 위해서는 추후연구가 필요하다고 사료된다.

• 동의생리병리학회지
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• 제25권1호
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• pp.132-137
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• 2011

Bee venom acupuncture (BVA), as a kind of herbal acupuncture, involved injecting diluted bee venom into acupoints and is used for pain, osteoarthritis and rheumatoid arthritis patients. BVA is growing in popularity, especially in Korea, and is used primarily for pain relief in many kinds of diseases. However, the effect of bee venom anti-inflammatory related action in lipopolysaccharide (LPS) induced chondrocyte stress have not been reported yet. The aim of this study was to investigate the effect of bee venom of cell viability and inflammatory cytokine in rat articular chondrocyte cultures stimulated with lipopolysaccharide. Inflammation was induced in rat chondrocytes by treatment with $10{\mu}g/m{\ell}$ LPS. The change of cell viability were decreased in chondrocytes after treatment with lipopolysaccharide. The cell viability revealed that BV exerted no significant cytotoxicity in the rat chondrocyte. Bee venom inhibited decreased cell viability in the presence of lipopolysaccharide ($10{\mu}g/m{\ell}$) in a dose dependent manner(0.1, 0.5, 1.0 and $5.0{\mu}g/m{\ell}$) at bee venom(p<0.05). Tumor necrosis factor (TNF)-${\alpha}$ production in the presence of lipopolysaccharide($1{\mu}g/m{\ell}$) was also inhibited in a dose dependent manner (p<0.05 from bee venom $0.1{\mu}g/m{\ell}$). Interleukin (IL)-6 production in the presence of lipopolysaccharide ($10{\mu}g/m{\ell}$) was inhibited as well (p<0.05 at bee venom 0.1, 0.5, 1.0 and $5.0{\mu}g/m{\ell}$, respectively). Our results demonstrate that bee venom was a anti-inflammatory agent of chondrocytes. Bee venom may exert its anti inflammatory effects through inhibition of TNF-${\alpha}$ and IL-6 synthesis, and may then pain relief and reduce the articular destruction.