• Korean Journal of Clinical Pharmacy
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• v.5 no.2
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• pp.75-84
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• 1995

Drug delivery by red cells was established to maintain the release of drugs in the blood. The entrapment method by amphotericin B was re-examined and evaluated for obtaining the suitable entrapping conditions without hemolysis. The amphotericin B treatment below $10{\mu}g/ml$ induced the non-hemolysis to entrap daunorubicin into red cells within 10min. Under these conditions intracellular ATP level was decreased as $18\%$. Membrane fluidity and the shape factor of red cells were maintained. To maintain intracellular ATP, ATP and sodium pyruvate were added during the entrapment procedure because hemolysis during the release test would reflect the loss of intracellular ATP that would be postulate the decrease of the viability invivo. Consequently, the addition of ATP in the reaction solution can raise the intracellular level of ATP.

• Proceedings of the KSME Conference
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• 2001.11b
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• pp.853-858
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• 2001

The knowledge of flame structure is essential for control of combustion instability phenomena. Some results of an experimental study on mechanism of naturally occurring combustion oscillations with a single dominant frequency are presented. Tests were conducted in a laboratory-scale dump combustor at atmospheric pressure. Sound level meter was used to track the pressure wave inside the combustor. The observed instability was a longitudinal mode with a frequency of $\sim341.8Hz$. Instability map was obtained at the condition of inlet temperature of $360^{\circ}C$, mean velocities of $8.5\sim10.8m/s$ and well premixed mixture. It showed that combustion instability was susceptible to occur in the lean conditions. In this study, unstable flame was observed from stoichiometric to 0.7 in overall equivalence ratio. At selected unstable conditions, phase-resolved OH chemiluminescence images were captured to investigate flame structure with various mean velocities. As mean velocity is increased, the flame grows and global heat release was changed. Due to these effects, combustion instability can be maintained at more lean air-fuel ratio. Also, these results give an insight to the controlling mechanism for an increasing heat release at maximum pressure.

• Korean Journal Plant Pathology
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• v.3 no.2
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• pp.120-123
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• 1987

Four types of spore trap (Kim's original, improved Kim's original, Yoshino's original and mixed type of Kim's and Yoshino's original) were evaluated for their efficacy to "estimate the amount of spores released from leaf blast lesions under the natural conditions. It was found that all four types had one or two defects in allowance for adequate sporulation/release, spore catch or spore counting. Thus, an improved type of spore trap was devised considering that it could cover the defects mentioned above. As a result, newly developed spore trap was quite satisfactory in above mentioned aspects and it could be used for pursuit of spore release phase under the natural conditions.

• Journal of ILASS-Korea
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• v.20 no.4
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• pp.254-260
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• 2015

The objective of this study is to investigate the effect of multi-hole nozzle on the performance of small CRDI engine. Combustion and exhaust emission characteristics of engine were studied by using CFD simulation with ECFM-3Z combustion model. The conditions of simulation were varied with nozzle geometry, injection timing and injection quantity. In addition, the results were compared in terms of combustion pressure, rate of heat release, $NO_x$ and soot emissions. It was found that combustion pressure was increased when injection timing was advanced. The rate of heat release of 6 hole nozzle was higher than that of 12 hole nozzle since the quantity of fuel impinged at the bottom of piston rim was different under different injection timing conditions. In the case of $NO_x$ emission, 6 hole nozzle generated more $NO_x$ emission than 12 hole nozzle. On the other hand, in the case of soot emission, 12 hole nozzle showed higher value than 6 hole nozzle because injected fuel droplets from multi-hole nozzle were coalesced.

• Korean Journal of Applied Biomechanics
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• v.23 no.1
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• pp.1-9
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• 2013

The purpose of this study was to provide information on athletes' characteristics and advantages and disadvantages by analyzing the kinematic factors having a decisive influence on competitive abilities such as release conditions in the delivery phase on major Korean javelin athletes. Two supported javelin throwers of the Korean national team participated in this study. The total average time required of the delivery phase was 0.31(${\pm}0.016$). The athletes' release angle was 33.2 to 41.7 degrees. The attack angle varied widely from -3.5 to 5.9 degrees. The Javelin heights of Subject A and B were 95.9 and 89.2%Ht. The average stride length were 180.6 and 176.7cm. The center of mass velocity of LFD and REL was relatively low in all the subjects. The average deceleration rates of center of mass velocity of Subject A and B were 57.2 and 48.9%lose. The left knee angles of Subject A and B were 160.1 and 155.5 degrees in LFD, 153.0 and 164.0 degrees in REL. The joint velocity of upper limb segments was relatively low in all the subjects. The maximum average wrist velocity of Subject A and B was 18.2 and 16.3 m/s in REL.

• Journal of the Korean Society of Combustion
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• v.22 no.1
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• pp.32-38
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• 2017

This paper shows the dynamics of the Burke-Schumann flame. To show flame dynamics, this paper measures the flame surface and heat release rate. The flame shape is divided into three types with forcing frequencies. When the forcing frequency is lower than 120 Hz, the upper region of flame is cut. The flame is stagnant with 220 to 280 Hz forcing frequencies. The rest conditions of forcing frequencies make the connected wave shape of flame. The heat release rate is expressed by the flame transfer function. The gain of the flame transfer function is similar with the oscillation magnitude of the flame area except for flame cutting conditions. The flame is cut because the fuel is not supplied to upper flame region.

• Corrosion Science and Technology
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• v.14 no.4
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• pp.166-171
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• 2015

Knowledge of how metal releases from the stainless steels used in food processing applications and cooking utensils is essential within the framework of human health risk assessment. A new European standard test protocol for testing metal release in food contact materials made from metals and alloys has recently been published by the Council of Europe. The major difference from earlier test protocols is the use of citric acid as the worst-case food simulant. The objectives of this study were to assess the effect of citric acid at acidic, neutral, and alkaline solution pH on the extent of metal release for stainless steel grades AISI 304 and 316, commonly used as food contact materials. Both grades released lower amounts of metals than the specific release limits when they were tested according to test guidelines. The released amounts of metals were assessed by means of graphite furnace atomic absorption spectroscopy, and changes in the outermost surface composition were determined using X-ray photoelectron spectroscopy. The results demonstrate that both the pH and the complexation capacity of the solutions affected the extent of metal release from stainless steel and are discussed from a mechanistic perspective. The outermost surface oxide was significantly enriched in chromium upon exposure to citric acid, indicating rapid passivation by the acid. This study elucidates the effect of several possible mechanisms, including complex ion- and ligand-induced metal release, that govern the process of metal release from stainless steel under passive conditions in solutions that contain citric acid.

• Korean Journal of Weed Science
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• v.10 no.2
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• pp.122-129
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• 1990

The herbicide $^{14}C$-butachlot[N-(butoxymethyl)-2-chloro-2', 6'-diethylacetanilide] labelled uniformly in benzene ring was incorporated in alginate-based granules to get controlled release properties. The influence of kaoline addition on the formulation characteristics and release profiles were evaluated under a closed dark and an opened sunlight condition. Incorporation efficiency of $^{14}C$-butachlor in alginate-kaoline matrices was over 91.8%. Formulation yield was decreased with increase of kaoline concentration. The release rate from all the granules prepared with alginate was slower than that from the commercial granule impregnated in zeolite. The release rate from the granule containing kaoline was decreased as the kaoline content was increased under both conditions. Losses of butachlor from the leacheate solution of the alginate-kaoline matrices under an opened sunlight condition was diminished by increasing the kaoline content.

• Archives of Pharmacal Research
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• v.28 no.4
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• pp.493-501
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• 2005

Effect of solvents on physical characteristics and release characteristics of monolithic acetaminophen (APAP) hydroxypropylmethylcellulose (HPMC) matrix granules and tablets were examined. Various types and amounts of solvents were employed for granulation and coating. APAP and other excipients were mixed and were then wet-granulated in a high-speed mixer. The dried granules were then directly compressed and film-coated with low viscosity grade HPMC. As the amount of water increased, the size of granules also increased, showing more spherical and regular shape. However, manufacturing problems such as capping and lamination in tableting occurred when water was used alone as a granulating solvent. The physical properties of HPMC matrix granules were not affected by the batch size. The initial release rate as well as the amount of APAP dissolved had a tendency to decrease as the water level increased. Addition of nonaqueous solvent like ethanol to water resulted in good physical properties of granules. When compared to water/ethanol as a coating solvent, the release rate of film-coated HPMC matrix tablets was more sensitive to the conditions of coating and drying in methylene chloride/ethanol. Most of all, monolithic HPMC matrix tablet when granulated in ethanol/water showed dual release with about $50\%$ drug release immediately within few minutes followed by extended release. It was evident that the type and amount of solvents (mainly water and ethanol) were very important for wet granulation and film-coating of monolithic HPMC matrix tablet, because the plastic deforming and fragmenting properties of material were changed by the different strengths of the different solvents.

• Journal of Pharmaceutical Investigation
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• v.23 no.1
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• pp.19-26
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• 1993

The purpose of this paper is to explore the possible applicability of alginate beads as an oral controlled release system of polymeric drugs. Cellulase was used as a model polymeric drug. The release of cellulase from alginate beads was moderately affected by the ratio of cellulase to sodium alginate and strongly affected by $CaCl_2$ concentration. However, the release was not particularly affected by the other factors such as sodium alginate concentration and curing time. The drug was not released from alginate beads at pH 1.2, but was released continuously up to 8 hr at pH 6.8. At pH 6.8, the beads were swollen highly up to 3 hr, thereafter, were eroded into the bulk solution up to 6 hr, completely. Drug release from the beads can be caused due to diffusion and erosion of the matrix. Activity of cellulase was reduced when alginate beads containing cellulase were stored in simulated gastric juice. Further investigation would be necessary to improve the acid resistance of the beads. Since the release of cellulase as a model polymeric drug could be controlled by the regulation of the preparation conditions of alginate beads, the alginate beads may be used for a potential oral controlled release system of such polymeric drugs as polypeptide drugs.