• Korean Management Science Review
• /
• v.31 no.2
• /
• pp.65-70
• /
• 2014

This paper considers a single machine scheduling problem to determine release and processing times where both the release times and processing times are linearly decreasing functions of resources. The objective is to minimize the sum of the associated resource consumption cost and scheduling cost including makespan, sum of completion times, maximum lateness, or sum of lateness. This paper proves that the scheduling problem is NP-hard in the strong sense even if the release times are constant.

• Convergence Security Journal
• /
• v.10 no.1
• /
• pp.55-61
• /
• 2010

It is of great practical interest to deciding when to stop testing a software system in development phase and transfer it to the user. This decision problem called an optimal release policies. In this paper, because of the possibility of introducing new faults when correcting or modifying the software, we were researched release comparative policies which based on infinite failure NHPP model and types of interval failure times. The policies which minimize a total average software cost of development and maintenance under the constraint of satisfying a software reliability requirement can optimal software release times. In a numerical example, applied data which were patterns, if intensity function constant or increasing, decreasing, estimated software optimal release time.

• Nuclear Engineering and Technology
• /
• v.36 no.1
• /
• pp.36-46
• /
• 2004

The ISAAC fission product release calculation is based on detailed FPRAT models developed by Jaycor. For volatile fission product release calculations, either the Cubicciotti steam oxidation correlation or the NUREG-0772 correlation is used. In this study, evaluation is carried out for these volatile fission product release models. As a result, in the case of early release, the IDCOR model with an in-vessel Te release option shows the most conservative results and for the late release case, the NUREG-0772 model shows the most conservative results. Considering both early and late release, the IDCOR model with an in-vessel Te bound option is evaluated to show mitigated conservative results. In addition, a sensitivity study on detailed core nodalization is performed. In the study, 380 horizontal fuel channels in the Wolsong plant are nodalized into 12 (6 channels per loop, $3{\times}3$ Core Pass) representative channels and detailed by 16/20/24 channels. For reference accidents, LOAH and large LOCA are selected as representing high and low pressure sequences, respectively. According to the results, the original 12 channel approach with $3{\times}3$ core passes is evaluated to be sufficient as an optimal scheme.

• The Korean Journal of Pharmacology
• /
• v.28 no.2
• /
• pp.181-190
• /
• 1992

The present study was conducted to investigate the effect of opioids on catecholamine (CA) secretion evoked by a selective cholinergic nicotinic agonist, 1,1-dimethyl-4-phenyl piperazinium (DMPP) and acetylcholine from the retrogradely perfused rat adrenal glands. Methionine-enkephalin $(9.68{\times}10^{-6}\;M)$ caused a significant inhibition of CA secretion evoked by DMPP (100 uM) and $ACh\;(50\;{\mu}g)$, but had no effect on the spontaneous (basal) CA release. Morphine $(1.73{\times}10^{-5}\;M)$ attenuated considerablely the increase in CA release induced by DMPP and ACh. Morphine itself also did not affect the basal CA output. A 20 to 65% reduction of the DMPP- and ACh-evoked increase in CA release was observed after the pretreatment with methionine-enkephalin or morphine. The increase in CA release evoked by DMPP and ACh was reduced markedly by preloading with an opiate antagonist naloxone $(1.22{\times}10^{-7}\;M)$ while basal CA output was not affected by naloxone. These present experimental results suggest that the nicotinic stimulation-evoked CA release from the perfused rat adrenal gland is inhibited by endogenously released opioid peptides through activation of opiate receptors located in the adrenal gland.

• The Transactions of The Korean Institute of Electrical Engineers
• /
• v.61 no.9
• /
• pp.1358-1361
• /
• 2012

This paper presents a study on the analysis for activation time and threshold value of heat detection sensor using HRR(Heat Release Rate). And it is represented to quantity of heat to activate heat detection sensor. The experiment is conducted to measure activation time and HRR of fire detection sensor burning alcohol and n-heptane. In order to burn the alcohol and n-heptane using $43.5cm(L){\times}43.5cm(W){\times}5cm(D)$ and $33cm(L){\times}33cm(L){\times}5cm(D)$ steel pan and the quantity of alcohol and n-heptane are 2.5 L and 650 g, respectively. The results show that peak HRR are in case of alcohol 66.13 kW and in case of n-heptane 151.64 kW, respectively. Total heat releases of heat detection sensor are in case of alcohol approximately 20.7 MJ and in case of n-heptane approximately 18 MJ, respectively.

• Archives of Pharmacal Research
• /
• v.23 no.4
• /
• pp.367-373
• /
• 2000

Cholic acid, conjugated with amine-terminated poly(W-isopropylacrylamide) (abbreviated as CA/ATPNIPAAm), was synthesized by a N, N'-dicyclohexyl carbodiimide (DCC)-mediated coupling reaction. Self-assembled CA/ATPNIPAAm micelles were prepared by a diafiltration method in aqueous media. The CA/ATPNIPAAm micelles exhibited a lower critical solution temperature (LCST) at $31.5^{\circ}C$. Micelle sizes measured by photon correlation spectroscopy (PCS) were approximately 31.6 $\times$$\times$ 5.8 nm. The CA/ATPNIPAAm micelles were spherical and their thermal size transition was observed by transmission electron microscope (TEM). A fluorescence probe technique was used for determining the micelle formation behavior of CA/ATPNIPAAm in aqueous solutions using Pyrene as a hydrophobic Probe. The critical micelle concentration (CMC) was evaluated as $8.9{\times}0^{-2}$ g/L. A drug release study was performed using indomethacin (IN) as a hydrophobic model drug. The release kinetics of IN from the CA/ATPNIPAAm micelles revealed a thermo-sensitivity by the unique character of poly(N-isopropylacrylamide) i.e. the release rate was higher at $25^{\circ}C$ than at $37^{\circ}C$.

• Journal of Environmental Science International
• /
• v.15 no.4
• /
• pp.319-324
• /
• 2006

Release rate is one of the important items for the environmental impact assessment caused by radioactive materials in case of an accidental release from the nuclear facilities. In this study, the uncertainty of the estimated release rate is evaluated using Monte Carlo method. Gaussian plume model and linear programming are used for estimating the release rate of a source material. Tracer experiment is performed at the Yeoung-Kwang nuclear site to understand the dispersion characteristics. The optimized release rate was 1.56 times rather than the released source as a result of the linear programming to minimize the sum of square errors between the observed concentrations of the experiment and the calculated ones using Gaussian plume model. In the mean time, 95% confidence interval of the estimated release rate was from 1.41 to 2.53 times compared with the released rate as a result of the Monte Carlo simulation considering input variations of the Gaussian plume model. We confirm that this kind of the uncertainty evaluation for the source rate can support decision making appropriately in case of the radiological emergencies.

• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.50 no.2
• /
• pp.175-182
• /
• 2017

We examined the effects of environmental factors on zoospore release and germling growth of the green tide alga Cladophora albida under various conditions of temperature${\times}$irradiance (zoospore release), temperature${\times}$irradiance${\times}$ nutrient (germling growth), and a single factor test of salinity. Zoospore release was maximized at $30^{\circ}C$ and $100{\mu}mol\;photons\;m^{-2}s^{-1}$ in the temperature irradiance experiment and at 34 psu in the salinity experiment. Maximum germling growth was observed at $25^{\circ}C$ with $100{\mu}mol\;photons\;m^{-2}s^{-1}$ and PES (Provasoli's Enriched Seawater) in the temperature irradiance nutrient experiment, and at 34 psu in the salinity experiment. Germlings grew faster at higher irradiances for a given temperature level, and also grew faster as salinity increased over the range of 5-34 psu. Overall, optimal environmental conditions for zoospore release were $30^{\circ}C$, $100{\mu}mol\;photons\;m^{-2}s^{-1}$ and 34 psu. Maximal germling growth occurred at $25^{\circ}C$, $100{\mu}mol\;photons\;m^{-2}s^{-1}$, PES, and 34 psu. C. albida blooms are most likely to occur under these optimal environmental conditions, as plentiful zoospore release and rapid germling growth lead to population growth.

• Journal of Pharmaceutical Investigation
• /
• v.28 no.4
• /
• pp.275-282
• /
• 1998

In order to develop a desirable in vitro release which correlates well with in vivo bioavailability, hollow type suppository containing Propranolol HCl(PPH) powder in the cavity and conventional type suppository with dispersed PPH in the base were prepared. Polyvinyl alcohol (PVA) hydrogel as a base and PPH as a model drug were used for the preparation of suppository. The rates of drug release from the suppositories were studied by Paddle method, Muranish method, Dialysis tubing method and Rotating dialysis cell method. The release profiles from suppositories using the four different release tests were compared. After a rectal administration in rat, the mean $C_{max}$ of hollow type suppository was significantly lower than that of conventional type, but $T_{max}$, $AUC_{0{\to}12}$ and MRT of hollow type were significantly higher 1.6 times, 1.2 times and 1.9 times than those of conventional type, respectively. The computer program was used to simulate plasma concentration from in vitro released amounts of drug and in vivo pharmacokinetic parameters. Based on comparison of the simulated bioavailability from computer program with experimental bioavailability in rat we have found out in vitro release test which correlates well with in vivo bioavailability. Our results have shown the best correlation between in vitro release and in vivo bioavailability in PPH-PVA hydrogel hollow type suppository for the paddle method and conventional type suppository for the rotating dialysis cell method. In this work we propose that PPH-PVA hydrogel suppository shows in vitro-in vivo correlation. This data should help to optimize the formulation of the drug and provide a basis for quality control procedures.

• Archives of Pharmacal Research
• /
• v.10 no.2
• /
• pp.88-93
• /
• 1987

Chitosan ($\beta$-D-glucosaminan) is chemically prepared from chitin (N-acetyl-$\beta$- D-glucosaminan) which is an unutilized natural resource. We now report on the suitability of the chitosan matrix for use as vehicles for the controlled release of drugs. Salicylic acid and aspirin were used as model drugs in this study. The permeation of salicylic acid in the chitosan membranes was determined in a glass diffusion cell with two compartments of equal volume. Drug release studies on the devices were conducted in a beaker containing 5% sodium hydroxide solution. Partition coefficient (Kd) value for acetate membrane (472) is much greater than that for fluoro-perchlorate chitosan membrane (282). Higher Kd value for acetate chitosan membrane appears to be inconsisstent with the bulk salicylic acid concentration. The permeability constants of fluoro-perchlorate and acetate chisotan membranes for salicylic acid were 3.139 ${\times}10^{-7}cm^2$ min up to 60 min and that of 30% aspirin in the devices was 4.739${\times}10^{-7}cm^2$sec upto 60 min. As the loading dose of aspirin in a chitosan device increased, water up-take of chitosan device increased, but in case of salicylic acid it decreased. The release rate increased with increase in the molecular volume of the drugs. Thses result suggest that the release mechanism may be controlled mainly by diffusion through pores.