• Korean Journal of Applied Biomechanics
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• v.21 no.5
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• pp.645-652
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• 2011

The purpose of this study was to analyze, in real time, the glide motion and release motion of domestic athletes and gold and bronze medalists employing the glide technique for the men's shot put at the Daegu World Athletic Championship in 2011. In the glide motion, the Korean athletes had a relatively high body center and shot put heights and lager stretching angles for their hips and knees. In the delivery phase, which shifts to the release phase, the Korean athletes showed slower vertical body center and shot put speeds, and they changed the phase, to the release phase by using a small body angle. In the release phase, the Korean athletes showed differences in their projection speeds and vertical body center speeds. The world-famous players showed high angle speeds, which refer to the composition of the rotation force at the moment of release (body, hip, and shoulder line). In the release phase, the Korean athletes did not have fully stretched hip and knee angles, which might have negatively influenced the vertical speed. Because the Korean athletes showed relatively low projection heights and projection angles. it was found that they need to enhance the muscular power of their, throwing arms and lower limbs.

• Bulletin of the Korean Chemical Society
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• v.29 no.2
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• pp.422-426
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• 2008

Hemodialysis graft coated with paclitaxel prevents stenosis; however, large initial burst release of paclitaxel causes many negative effects such as drug toxicity and inefficient drug loss. Therefore we developed and tested a novel coating method, double dipping, to provide controlled and sustained release of paclitaxel locally. Expanded polytetrafluoroethylene (ePTFE) grafts were dipped twice into a solution of several different paclitaxel concentrations. In vitro release tests of the double dipping method showed that early burst release could be somewhat retarded and followed by sustained release for a long time. We observed the effect of paclitaxel coating by double dipping in porcine model of arterio-venous (AV) grafts between the common carotid artery and the external jugular vein. 12 weeks after constructing AV grafts, cross sections of the graft venous anastomosis were obtained and analyzed. Paclitaxel coated ePTFE grafts by double dipping were observed to prevent neointimal hyperplasia and therefore reduced stenosis of the arteriovenous hemodialysis grafts, especially at the graft venous anastomosis sites. Our results demonstrate that second dipping of ePTFE graft, which was already coated once with paclitaxel, washes off the drug on a surface of the graft and affects the ratio of paclitaxel on the surface to that of the inner space, possibly by diffusion: thus the early burst of drug can be somewhat reduced.

• YAKHAK HOEJI
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• v.37 no.5
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• pp.511-519
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• 1993

The short and variabke transit of drug throught GI tracj and the inter-and intra-subject variations of the transit restrict the sustained drug absorption after oral adminstration. These restrictions may be solved by retaining the dosage forms in the stomach. Then the dosage form will act as a platform which releases the drug slowly and makes the GI absorption occur for a long time. In this study, as the platforms, PVP hydrogels were synthesized by chemical and y-irradiation method in the cylindrical test tube. The chemical method means the synthesis of the hydrogel by heating the mixed solution of N-vinyl-2-pyrrolidone [monomer], acrylated albumin [crosslinking agent], 2, 2'-agobis(2-methylpropionitrile) [initiator] and proxyphylline [drug] at $65^{\circ}C$ for 5 hr. The $\gamma$-irradiation method means the synthesis of the hydrogel by irradiation with $^{60}$ Co $\gamma$-ray of the mixed solution of the monomer, acrylated albumin, and flurbiprofen [drug] at room temperature with total 0.2 Mrad for 3 hr. Our intention is to design the hydrogel tablet (diameter : 1.20 cm, thickness : 0.60 cm) which swells in the gastric fluid after oral administration to such a size that passing through the pylorus could be inhibited during the period of drug release. After releasing drug, the hydrogel should be degraded by the enzymeatic digestion in the stomach, or by hydrolysis and eventually solubilized. Thus, in votro tests were performed to examine the factors that affect swelling and drug release from the PVP hydrogels. Experimental results show that the hydrogels swell to a size larger than the diameter of the pylorus(l.3$\pm$0.7 cm) and the hydrogel prepared by the chemical method is digested by pepsin. But the hydrogel prepared by the $\gamma$-irradiation method was not digested by the pepsin and just collapsed with time. Thus, the swelling of the hydrogel synthesized by $\gamma$-irradiation was independent albumin acrylation time and pepsin concentration. But drug content and radiation dose affected the swelling and drug release kinetics of the hydrogel. Drug release from the hydrigels was prolonged up to about 24 hr. Therefore, it was concluded that by adjusting these factors, the albumin-crosslinked PVP hydrogel synthesized by $\gamma$-irradiation method is expected to be retained in the stomach for up to 60hr and be a potential platform of drugs for long-term GI absorption.

• Journal of Korean Port Research
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• v.9 no.1
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• pp.45-56
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• 1995

Investigation of the physical behavior of dredged material disposal in coastal water includes estimations of water column concentration in the receiving water, exposure time, the initial deposition pattern as well as thickness of material at the dumping fields near the estuary area. Calculation based on vertical setting and horizontal advection of single particles ignore the effects of bulk properties of the disposed material, vertical and horizontal diffusion, and material dilution due to the entrainment of ambient water during descent. This paper focuses on the spatial and temporal changes in the dumping fields for the water column and bottom at a hypothetically confined coastal water, where the ambient time-invariant velocity and density profiles are applied, within the initial time period following the instantaneous release of the dredged material. This model accounts the behavior of material after release divided into three phases: convective descent, dynamic collapse and long-term passive dispersion

• MALSORI
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• no.15_18
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• pp.19-34
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• 1989

There is general agreement that voice onset time (VOT) is functionally related with the glottal opening at the moment of the oral release of a stop. However, systematic investigations of tempo 8n4 the place of articulation as affecting the glottal opening and VOT have relatively neglected. Various instrumental techniques were used to verify the claim with BrEng and korean speakers, under controlled experimental conditions, tempo being one of them. It was found that voiceless aspiration (i.e. VOT) is not simply a function of the glottal area at the moment of the oral release of a stop as it is normally defined in the existing literature. Within a given place of articulation and across temper VOT was generally insignificantly related to the glottal area. It is inferred that the glottal adduction onset time for the following vowel is actively control led by the speaker to meet aerodynamic requirements in relation to class (i.e. aspirated and unaspirated) and tempo. Some possible underlying physiological mechanisms for various phonetic aspects of intervocalic stops, associated with the glottal area and VOT, were discussed.

• Communications for Statistical Applications and Methods
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• v.12 no.3
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• pp.697-704
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• 2005

Computer software has gradually become an indispensable elements in many aspects of our daily lives and an important factor in numerous systems. In recent years, it is not unusual that the software cost is more than the hardware cost in many situations. In addition to the costs of developing software, the repair cost resulting from the software failures are even more significant. In this paper, a cost model with warranty cost, time to remove each fault detected in the software system, and delivery delay cost is developed. We use a software reliability model based on non-homogeneous Poisson process (NHPP). We discuss the optimal release policies to minimize the expected total software cost. Numerical examples are provided to illustrate the results.

• Proceedings of the KSR Conference
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• 2004.06a
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• pp.277-283
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• 2004

The time to ignition, heat release rate characteristics and carbon monoxide yield of fiber reinforced and sandwich phenol resin were investigated with cone calorimeter. The fire characteristics of unsaturated polyester, mostly being applied to the existing passenger train, and phenolic resin were compared. Thermal gravimetric analysis(TGA) was used to monitor the degree of thermal decomposition for the phenolic resin. According to the cone calorimeter data, the time to ignition, heat release rate and CO yield was faster and higher as the external heat flux increase. Under the same heat flux, the time to ignition of sandwich type phenolic resin was shorter than that of fiber reinforced. The result of comparison between unsaturated polyester and phenolic resin was that phenolic resin was shown to have better fire resistance than that of unsaturated polyester.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1991.10a
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• pp.405-421
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• 1991

In this paper, faults existing in a software system is classified into three types; simple, degenerative and regenerative faults. The reliability functions and failure rates of both a software module and system which have a mixture of such faults are obtained and the expected number of failures in the system after time T is also derived. Using the formulas obtained, a cost-reliability model and an efficient algorithm for optimal software release time are proposed via nonlinear programming formulation ; minimizing the total test cost with constraints on the failure rates of each module. Application of this model to several cases are presented and it appears to be more realistic.

• Journal of the military operations research society of Korea
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• v.22 no.2
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• pp.153-165
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• 1996

This paper presents an order releasing algorithm for an AMS. Order release policy determine order releasing time to shop floor so as to improve order management and shop performance. The proposed order releasing algorithm can cope with the dynamic environment of orders(e.g. change or cancel of order) flexibly and fastly, by processing individual order and exchanging the information(e.g. compeletion time or lateness of order, etc) with customer. And the objective of the order releasing algorithm is the observance of the due-date, therefore, it can provide customer with a reliability of order. Computer simulation is used to obtain the makespan of order which is the input data of the order releasing algorithm. The eight candidate part dispatching rules are simulated to selected an effective part dispatching rule for the computer simulation. By using the best effective part dispatching rule, the computer simulation is conducted to determine order releasing time.

• Journal of Pharmaceutical Investigation
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• v.40 no.5
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• pp.297-304
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• 2010

The present work focuses on preparation of olanzapine, orally dispersing tablets by direct compression method. Effect of super disintegrant crospovidone, disintegration time, drug content on in vitro release has been studied. A factorial design was employed in formulating a prompt dispersible tablet. The selected independent variables crospovidone and fmelt showed significant effect on dependent variables i.e. disintegration time and percent drug dissolved. Disintegration time and percent drug dissolved decreased with increase in the level of crospovidone. The similarity factor $f_2$ was found to be 97.48 for the developed formulation indicating the release was similar to that of the marketed formulation. Pharmacokinetics of olanzapine after single-dose oral administration of orally disintegrating tablet in normal volunteers were evaluated and the results showed that PK parameters (Cmax, Tmax, AUC) of the designed ODT matrix were similar to those of commercial product, Zyprexa Zydis$^{(R)}$ as a reference.