• Applied Chemistry for Engineering
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• v.10 no.8
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• pp.1155-1160
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• 1999

The screening methodology modeling, dispersion modeling procedures for continuous and instantaneous releases of the gas phase flow from the storage tank and pressure relief valve were considered. This study was performed to develop the screening methodology for prediction and control of hazardous/toxic gas releases by estimating the 1-hr average maximum ground-level concentration of $Cl_2$ gas vs. downwind distance by incorporating source term model including the general/physical properties of released material and release mode of the $Cl_2$ storage tank of the chemical plant facilities, dispersion model, and meteorological/topographical data into the TSCREEN model. As the results of the study, it was found that dispersion modes of the dense gas were affected by the state of the released material, the released conditions, physical-chemical properties of released material, and the released modes (continuous and instantaneous releases), and especially largely affected by initial (depressurized) density of the released material and release emission rate as well as the wind velocity. Especially, this study was considered to release hazardous material as meteorological data. It was thought that this screening methodology can be useful as a preliminary guideline for application of the refined analysis model by developing the generic sliding scale methodology for various senarios selected.

• The Korean Society of Law and Medicine
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• v.13 no.1
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• pp.359-395
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• 2012

In a broad term, health and medical data means all patient information that has been generated or circulated in government health and medical policies, such as medical research and public health, and all sorts of health and medical fields as well as patients' personal data, referred as medical data (filled out as medical record forms) by medical institutions. The kinds of health and medical data in medical records are prescribed by Articles on required medical data and the terms of recordkeeping in the Enforcement Decree of the Medical Service Act. As EMR, OCS, LIS, telemedicine and u-health emerges, sharing and protecting digital health and medical data is at issue in these days. At medical institutions, health and medical data, such as medical records, is classified as "sensitive information" and thus is protected strictly. However, due to the circulative property of information, health and medical data can be public as well as being private. The legal grounds of health and medical data as such are based on the right to informational self-determination, which is one of the fundamental rights derived from the Constitution. In there, patients' rights to refuse the collection of information, to control recordkeeping (to demand access, correction or deletion) and to control using and sharing of information are rooted. In any processing of health and medical data, such as generating, recording, storing, using or disposing, privacy can be violated in many ways, including the leakage, forgery, falsification or abuse of information. That is why laws, such as the Medical Service Act and the Personal Data Protection Law, and the Guideline for Protection of Personal Data at Medical Institutions (by the Ministry of Health and Welfare) provide for technical, physical, administrative and legal safeguards on those who handle personal data (health and medical information-processing personnel and medical institutions). The Personal Data Protection Law provides for the collection, use and sharing of personal data, and the regulation thereon, the disposal of information, the means of receiving consent, and the regulation of processing of personal data. On the contrary, health and medical data can be inspected or delivered of the copies, based on the principle of restriction on fundamental rights prescribed by the Constitution. For instance, Article 21(Access to Record) of the Medical Service Act, and the Personal Data Protection Law prescribe self-disclosure, the release of information by family members or by laws, the exchange of medical data due to patient transfer, the secondary use of medical data, such as medical research, and the release of information and the release of information required by the Personal Data Protection Law.

• Journal of Pharmaceutical Investigation
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• v.36 no.6
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• pp.405-411
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• 2006

Epinastine is an antiallergic drug effective for bronchial asthma, allergic rhinitis, urticaria and dermatitis. Epinastine is topically active, direct H1-receptor antagonist and an inhibitor of the release of histamine from the mast cell. The purpose of the present study was to evaluate the bioequivalence of two epinastine hydrochloride tablets, Alesion Tablet (Boehringer Ingelheim Korea Ltd.) and S-napine tablet 10 mg(Sam Chun Dang Pharm. Co., Ltd), according to the guidelines of the Korea Food and Drug Administration(KFDA). The release of epinastine from the two epinastine formulations in vitro was tested using KP VIII Apparatus II method with various dissolution media(pH 1.2, 4.0, 6.8 buffer solution and water). Twenty six healthy male subjects, $23.35{\pm}1.57$ years in age and $66.29{\pm}10.61kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After two tablets containing 20 mg as epinastine hydrochloride was orally administered, blood was taken at predetermined time intervals and the concentrations of epinastine in serum were determined using HPLC with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. In addition, the pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t.\;C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, Alesion tablet, were 1.50, 1.46 and -13.48% for $AUC_t,\;C_{max}\;and\;T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25(e.g., log 0.95$\sim$log 1.12 and log 0.93$\sim$log 1.10 for $AUC_t\;and\;C_{max}$, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating S-napine tablet 10 mg was bioequivalent to Alesion tablet.

• Fire Science and Engineering
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• v.26 no.6
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• pp.38-44
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• 2012

The purpose of fire protection for the nuclear power plants (NPPs) is to ensure safe shutdown state of the reactor, to minimize the release of radioactive materials to the environment, to provide physical safety of the on-site personnel, and to limit the property damage. Fire protection and extinguishing equipments are one of the important protection measures based on the defense-in-depth concept, which can promptly detect and control and extinguish those fires that do occur, thereby limiting fire damage. However, a separate evaluation process might be additionally necessary for the construction permit and operating license because the fire protection laws of the NEMA for installation standards of the fire protection systems is not fully characterized for the NPPs. It is also not easy to implement the regulations such as the performance based design concept for fire protection system of the NPPs which are characterized for a relatively low density of employee. This study suggests a guideline for the improvement of the technical standards for fire protection systems of the NPPs by evaluating the fundamental problems drawn by reviewing laws and regulatory guides relevant to fire protection and by evaluating the applicability of the KEPIC FPN in domestic nuclear power plants.

• The Journal of the Korea institute of electronic communication sciences
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• v.15 no.1
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• pp.53-60
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• 2020

With the major advancement of vehicle-related technologies and services, the demands for the in/out-vehicle service expansion increase significantly. The key importance of the service expansion is to provide various vehicle-centric services in addition to improve the convenience and usability of users with connectivity. Recently, Internet of Things (IoT) gains major attention for small device connectivity and service, and it widens its area to other industries including automotive to advance and diversify its services. In this paper, we investigated the technical direction of the IoT service with the analysis of IoT technologies in the perspective of the vehicle. At first, we analyzed the vehicle and IoT services in each so that we are able to suggest the service design guideline and consideration to release integrated services between vehicle and IoT. Also, we reviewed the cases of few vehicle and home IoT integration services for the major insights and future direction of the integration services.

• KIEAE Journal
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• v.17 no.2
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• pp.35-43
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• 2017

Purpose: The purpose of this study is to find out the characteristics of service (landfill) costs (hereinafter, the "landfill costs") applied to the dissolution promotion committee and analyze the characteristics of landfill costs at the time where the dissolution of promotion body is increasing with the authority of the head of local government regarding the territory difficult with the continuous promotion by delaying or suspending the project for a prolonged period or suspending the project through the dissolution of the project body by the promotion committee and cooperative union since the flawless promotion of the maintenance project. Method: After revising the law in February 2012, the survey and analysis is made for the status of applying landfill costs and maintenance project scale of the dissolution promotion committee not confirmed in details around a total of 20 regions, including, 9 regions of redevelopment projects completed with the advance review, 7 regions of re-construction projects and 4 regions of urban environment maintenance projects from the total of 59 regions, Result: The influence on the landfill costs is shown to be greatest in the service expenses and management and supervision on this field has significance for the maintenance project perceived as private project, rather than public project, that the public management is neglected with insufficient presentation of operation criteria and so forth that it displays the tendency to lead to the discrete operation of the project body. In order to enhance the transparency of operating costs for the projects that are led by private capital, it is required to strengthen the role of public sector through enthusiastic intervention by the public sector in standardization of operation criteria, presentation of guideline and so forth.

• Journal of the Korean Institute of Gas
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• v.13 no.3
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• pp.54-60
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• 2009

The advancement of industry have increased domestic energy demands and energy facilities such as storage facility, compressed gas pipe, station, and tank lorry. Also, concern about environment have diversified energy source to clean energy such as LNG. In these major energy facilities, major accident can happen to result in fire, explosion, toxic release and etc. In addition, it may cause chain accidents to the adjacent energy facilities. In this research, safety assessment was performed through the consequence analysis of LPG liquefied petroleum gas) station, gasoline station and LNG(liquiefied natural gas) station. The obtained result will be helpful to make a safety guideline of the LPG/LNG station built adjacent to the gasoline station.

• Tuberculosis and Respiratory Diseases
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• v.81 no.1
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• pp.6-12
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• 2018

The role of the treatment for latent tuberculosis infection (LTBI) has been underscored in the intermediate tuberculosis (TB) burden countries like South Korea. LTBI treatment is recommended only for patients at risk for progression to active TB-those with frequent exposure to active TB cases, and those with clinical risk factors (e.g., immunocompromised patients). Recently revised National Institute for Health and Care Excellence (NICE) guideline recommended that close contacts of individuals with active pulmonary or laryngeal TB, aged between 18 and 65 years, should undergo LTBI treatment. Various regimens for LTBI treatment were recommended in NICE, World Health Organization (WHO), and Centers for Disease Control and Prevention guidelines, and superiority of one recommended regimen over another was not yet established. Traditional 6 to 9 months of isoniazid (6H or 9H) regimen has an advantage of the most abundant evidence for clinical efficacy-60%-90% of estimated protective effect. However, 6H or 9H regimen is related with hepatotoxicity and low compliance. Four months of rifampin regimen is characterized by less hepatotoxicity and better compliance than 9H, but has few evidence of clinical efficacy. Three months of isoniazid plus rifampin was proved equivalence with 6H or 9H regimen in terms of efficacy and safety, which was recommended in NICE and WHO guidelines. The clinical efficacy of isoniazid plus rifapentine once-weekly regimen for 3 months was demonstrated recently, which is not yet introduced into South Korea.

• Journal of Digital Contents Society
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• v.11 no.4
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• pp.529-536
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• 2010

Currently many people are awfully concerned about smart device in domestic and foreign mobile market. The need of smart device has been rapidly increased. Unlike a feature phone smart devices provide us with an intuitive interface which is easy to control. They are enable to smoothly interact between user and device. Though higher market outlook, there is a lack of empirical research on user interface in touch screen based on smart device. In this paper, we propose the touch interface conceptual model concentrating on user based on the result of previous research. Materials of this research are three kinds of smart devices which are currently released. Through expert's depth interview and observation of user, user's cognitive actions in smart device are defined. Since the method of the touch interface which is suitable for the action has been derived, we have proposed the conceptual model of user's cognitive action. This research imply to offer the excellent design guideline in order to implement touch interface to optimize user experience in touch screen based on smart device to release in the future.

• Journal of KIBIM
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• v.6 no.3
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• pp.1-14
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• 2016

The usage of Building Information Modelling (BIM) in building projects has enabled improvement in project planning, implementation and collaboration process amongst various stakeholders within architecture, engineering and construction (AEC) industry. However, variations exist in the current practices of BIM implementation and coordination process in the industry. These variations result in inconsistent degree of BIM use across the construction industry. This inconsistency gives rise to several managerial and technological challenges such as data interoperability issues and purposeful integration and exchange of information within the BIM components. In order to tackle the issue, it is essential to analyse the different BIM approaches employed by the industry practitioners. BIM guidelines serve as a critical link between the BIM model, and its subsequent execution. They therefore provide the best reflection of BIM application and processes. This research paper aims to address the variations existing in BIM practices across the construction industry. It includes an extensive study of 21 existing, publicly available BIM-based guidelines in order to establish an understanding of the present state of practice and deduce issues and concerns related to them. All guidelines analysed in this paper are first categorised based on authorship and the release date for efficient comparison. The points of similarity and difference between them are thereby realized and outlined. In addition, the transition of project implementation process from traditional methods to BIM technology is also explained. The existence of inconsistencies in the BIM guidelines reviewed in this paper reflects the need of a BIM 'Code Compliance Check'. The Code Compliance Check will serve as a regulatory project guideline that will further improve the potential of BIM by incorporating a consistent BIM modelling methodology for the entire construction industry.