• 공업화학
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• 제10권8호
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• pp.1155-1160
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• 1999

본 스크리닝 방법론에서는 저장탱크 및 압력방출장치로부터 누출되는 기상흐름의 누출에 대한 대기분산 모델링 절차가 고려되었다. 본 연구는 화학장치 설비 중 염소 저장탱크의 누출유형에 따른 누출물의 물성자료들을 포함하는 누출원모델, 분산모델, 기상 및 지형자료들을 TSCREEN 모델에 입력시켜 염소가스의 풍하거리에 따른 1시간 평균 최대 지표면 농도를 산출함으로써 유해독성가스의 누출 예측 및 제어를 위한 스크리닝 방법론을 개발하기 위한 것이다. 연구결과로부터, 공기보다 무거운 가스의 분산유형은 누출물의 상태, 누출 조건, 누출물의 물리 화학적특성, 누출유형(연속 및 순간누출)에 영향을 받고 있으며, 특히 누출물의 초기(감압) 밀도 및 누출속도 뿐만 아니라 풍속에 커다란 영향을 받고 있음을 알 수 있다. 특히, 기상조건(대기안정도 및 풍속)에 따른 유해물질의 대기중 누출을 살펴보았다. 본 스크리닝 방법론은 보다 다종다양한 시나리오들을 선정하여 보편적으로 적용할 수 있는 Sliding Scale 방법론을 개발함으로써 정교한 해석 모델의 적용시 예비 가이드라인으로 활용될 수 있으리라 사료된다.

• 의료법학
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• 제13권1호
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• pp.359-395
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• 2012

In a broad term, health and medical data means all patient information that has been generated or circulated in government health and medical policies, such as medical research and public health, and all sorts of health and medical fields as well as patients' personal data, referred as medical data (filled out as medical record forms) by medical institutions. The kinds of health and medical data in medical records are prescribed by Articles on required medical data and the terms of recordkeeping in the Enforcement Decree of the Medical Service Act. As EMR, OCS, LIS, telemedicine and u-health emerges, sharing and protecting digital health and medical data is at issue in these days. At medical institutions, health and medical data, such as medical records, is classified as "sensitive information" and thus is protected strictly. However, due to the circulative property of information, health and medical data can be public as well as being private. The legal grounds of health and medical data as such are based on the right to informational self-determination, which is one of the fundamental rights derived from the Constitution. In there, patients' rights to refuse the collection of information, to control recordkeeping (to demand access, correction or deletion) and to control using and sharing of information are rooted. In any processing of health and medical data, such as generating, recording, storing, using or disposing, privacy can be violated in many ways, including the leakage, forgery, falsification or abuse of information. That is why laws, such as the Medical Service Act and the Personal Data Protection Law, and the Guideline for Protection of Personal Data at Medical Institutions (by the Ministry of Health and Welfare) provide for technical, physical, administrative and legal safeguards on those who handle personal data (health and medical information-processing personnel and medical institutions). The Personal Data Protection Law provides for the collection, use and sharing of personal data, and the regulation thereon, the disposal of information, the means of receiving consent, and the regulation of processing of personal data. On the contrary, health and medical data can be inspected or delivered of the copies, based on the principle of restriction on fundamental rights prescribed by the Constitution. For instance, Article 21(Access to Record) of the Medical Service Act, and the Personal Data Protection Law prescribe self-disclosure, the release of information by family members or by laws, the exchange of medical data due to patient transfer, the secondary use of medical data, such as medical research, and the release of information and the release of information required by the Personal Data Protection Law.

• Journal of Pharmaceutical Investigation
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• 제36권6호
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• pp.405-411
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• 2006

Epinastine is an antiallergic drug effective for bronchial asthma, allergic rhinitis, urticaria and dermatitis. Epinastine is topically active, direct H1-receptor antagonist and an inhibitor of the release of histamine from the mast cell. The purpose of the present study was to evaluate the bioequivalence of two epinastine hydrochloride tablets, Alesion Tablet (Boehringer Ingelheim Korea Ltd.) and S-napine tablet 10 mg(Sam Chun Dang Pharm. Co., Ltd), according to the guidelines of the Korea Food and Drug Administration(KFDA). The release of epinastine from the two epinastine formulations in vitro was tested using KP VIII Apparatus II method with various dissolution media(pH 1.2, 4.0, 6.8 buffer solution and water). Twenty six healthy male subjects, $23.35{\pm}1.57$ years in age and $66.29{\pm}10.61kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After two tablets containing 20 mg as epinastine hydrochloride was orally administered, blood was taken at predetermined time intervals and the concentrations of epinastine in serum were determined using HPLC with UV detector. The dissolution profiles of two formulations were similar at all dissolution media. In addition, the pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t.\;C_{max}$ and untransformed $T_{max}$. The results showed that the differences between two formulations based on the reference drug, Alesion tablet, were 1.50, 1.46 and -13.48% for $AUC_t,\;C_{max}\;and\;T_{max}$, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log 0.8 to log 1.25(e.g., log 0.95$\sim$log 1.12 and log 0.93$\sim$log 1.10 for $AUC_t\;and\;C_{max}$, respectively). Thus, the criteria of the KFDA bioequivalence guideline were satisfied, indicating S-napine tablet 10 mg was bioequivalent to Alesion tablet.

• 한국화재소방학회논문지
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• 제26권6호
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• pp.38-44
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• 2012

원자력발전소 화재방호의 목표는 화재 시 원자로의 안전정지 상태를 유지하여 환경으로의 방사성물질 누출을 최소화하며, 종사자 인명안전 및 재산을 보호하는데 있다. 소방시설은 발생된 화재를 조기 감지 및 진압하여 화재로 인한 피해를 완화시킬 수 있는 심층방어개념에 입각한 중요한 방어수단의 하나이다. 그러나 소방방재청에서 제시하고 있는 소방시설 설치기준이 원자력발전소에 특화되어 있지 않아 인허가 시 별도의 심의 절차가 요구되고 있다. 또한, 성능위주설계와 같은 규정은 작업자의 인구밀도가 비교적 낮은 원자력발전소에 적용하는데 어려움이 있다. 이 논문에서는 원전 화재방호와 관련된 법령의 상세 검토를 통하여 도출된 근본적인 문제점과 KEPIC FPN의 국내 원전 적용성에 대한 평가를 통하여 소방시설에 대한 기술기준에 대한 개선방향을 제시하였다.

• 한국전자통신학회논문지
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• 제15권1호
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• pp.53-60
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• 2020

차량 관련 기술 및 서비스가 고도화 중인 현재 차량 내외의 서비스 확장에 대한 필요성이 대두되고 있다. 다양한 연동 서비스를 통해서 차량 자체에 대한 서비스 제공뿐만이 아니라 외부와의 연결을 통한 사용자의 편의성 및 유용성을 향상하는 것이 중요하다. 최근 사물인터넷(IoT)으로 불리는 소형 연결기기 및 서비스 적용 및 출시가 주요 트렌드로 자리 잡고 있으며 전자 기기뿐만이 아닌 차량을 포함한 타 분야로의 확장을 통한 서비스의 고도화 및 다양화를 이루고 있다. 본 논문에서는 차량 측면에서 최근 확장되고 있는 IoT 기술에 대한 분석을 통해 향후 IoT 기술 방향성을 제시한다. 먼저 차량 서비스 및 IoT 서비스에 대한 분석을 진행하여 차량과 IoT 간 연동 서비스 출시 시 고려해야 할 사항 및 가이드라인을 제시한다. 추가로 현재 출시 중인 차량과 홈 IoT 기기 간 연동 서비스 사례들을 통해 전반적인 차량 연동 IoT 서비스에 대한 중요 시사점 및 향후 방향성에 관해서 기술한다.

• KIEAE Journal
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• 제17권2호
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• pp.35-43
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• 2017

Purpose: The purpose of this study is to find out the characteristics of service (landfill) costs (hereinafter, the "landfill costs") applied to the dissolution promotion committee and analyze the characteristics of landfill costs at the time where the dissolution of promotion body is increasing with the authority of the head of local government regarding the territory difficult with the continuous promotion by delaying or suspending the project for a prolonged period or suspending the project through the dissolution of the project body by the promotion committee and cooperative union since the flawless promotion of the maintenance project. Method: After revising the law in February 2012, the survey and analysis is made for the status of applying landfill costs and maintenance project scale of the dissolution promotion committee not confirmed in details around a total of 20 regions, including, 9 regions of redevelopment projects completed with the advance review, 7 regions of re-construction projects and 4 regions of urban environment maintenance projects from the total of 59 regions, Result: The influence on the landfill costs is shown to be greatest in the service expenses and management and supervision on this field has significance for the maintenance project perceived as private project, rather than public project, that the public management is neglected with insufficient presentation of operation criteria and so forth that it displays the tendency to lead to the discrete operation of the project body. In order to enhance the transparency of operating costs for the projects that are led by private capital, it is required to strengthen the role of public sector through enthusiastic intervention by the public sector in standardization of operation criteria, presentation of guideline and so forth.

• 한국가스학회지
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• 제13권3호
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• pp.54-60
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• 2009

산업의 발달에 따른 영향으로 에너지수요가 증가함에 따라 국내에는 에너지 산업시설(저장시설, 고압가스 배관, 충전소, 탱크로리 등)이 전국에 산재하게 되었고 사용하는 에너지의 종류도 과거 한정된 자원이 아닌 다양한 에너지원을 사용하게 되었다. 이러한 에너지시설에는 화재, 폭발 및 유독물질 누출 등 중대사고가 발생할 수 있다. 더욱이 국내의 에너지시설은 밀집되어 있어 연쇄적인 사고가 일어날 가능성이 존재한다. 이 연구에서는 기존에 설치 운영되고 있는 LPG(liquefied petroleum gas) 및 가솔린(gasoline) 충전소와 LNG(liquefied natural gas) 충전소에 대한 피해예측을 실시하고 이를 비교 분석 함으로써 국내에서 처음 시도되고 있는 가솔린 주유소 및 LPG/LNG 충전소가 병설되어 설치되는 경우의 안전성을 검토하고자 한다.

• Tuberculosis and Respiratory Diseases
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• 제81권1호
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• pp.6-12
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• 2018

The role of the treatment for latent tuberculosis infection (LTBI) has been underscored in the intermediate tuberculosis (TB) burden countries like South Korea. LTBI treatment is recommended only for patients at risk for progression to active TB-those with frequent exposure to active TB cases, and those with clinical risk factors (e.g., immunocompromised patients). Recently revised National Institute for Health and Care Excellence (NICE) guideline recommended that close contacts of individuals with active pulmonary or laryngeal TB, aged between 18 and 65 years, should undergo LTBI treatment. Various regimens for LTBI treatment were recommended in NICE, World Health Organization (WHO), and Centers for Disease Control and Prevention guidelines, and superiority of one recommended regimen over another was not yet established. Traditional 6 to 9 months of isoniazid (6H or 9H) regimen has an advantage of the most abundant evidence for clinical efficacy-60%-90% of estimated protective effect. However, 6H or 9H regimen is related with hepatotoxicity and low compliance. Four months of rifampin regimen is characterized by less hepatotoxicity and better compliance than 9H, but has few evidence of clinical efficacy. Three months of isoniazid plus rifampin was proved equivalence with 6H or 9H regimen in terms of efficacy and safety, which was recommended in NICE and WHO guidelines. The clinical efficacy of isoniazid plus rifapentine once-weekly regimen for 3 months was demonstrated recently, which is not yet introduced into South Korea.

• 디지털콘텐츠학회 논문지
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• 제11권4호
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• pp.529-536
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• 2010

최근 국내외 모바일 시장에서 스마트 디바이스에 대한 관심과 수요가 급격히 증가하고 있다. 피쳐폰과는 달리 전면에 터치스크린을 장착한 스마트 디바이스는 직관적이고 조작이 쉬운 인터페이스를 제공하고 사용자와 기기 간의 원활한 상호작용을 가능하게 한다. 하지만 전망 높은 시장에 비해 터치스크린 기반 스마트 디바이스에서 사용자 인터페이스에 대한 실증적 연구가 부족한 실정이다. 본 연구에서는 선행 연구 결과를 토대로 사용자 중심의 터치 인터페이스 개념모델을 제안하고자 한다. 최근에 출시된 스마트 디바이스 3종을 대상으로 전문가 심층면접과 사용자 관찰 결과, 스마트 디바이스에서 사용자의 인지적 행동 요소를 정의하고, 행동 요소에 알맞은 터치 인터페이스방식을 도출하여 사용자의 인지적 행동에 대한 개념모델을 제안할 수 있었다. 이 결과를 바탕으로 향후 출시될 터치스크린 기반 스마트 디바이스에서 사용자 경험을 최대화시킬 수 있는 터치 인터페이스 구현에 좋은 디자인 지침이 될 것으로 기대한다.

• 한국BIM학회 논문집
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• 제6권3호
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• pp.1-14
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• 2016

The usage of Building Information Modelling (BIM) in building projects has enabled improvement in project planning, implementation and collaboration process amongst various stakeholders within architecture, engineering and construction (AEC) industry. However, variations exist in the current practices of BIM implementation and coordination process in the industry. These variations result in inconsistent degree of BIM use across the construction industry. This inconsistency gives rise to several managerial and technological challenges such as data interoperability issues and purposeful integration and exchange of information within the BIM components. In order to tackle the issue, it is essential to analyse the different BIM approaches employed by the industry practitioners. BIM guidelines serve as a critical link between the BIM model, and its subsequent execution. They therefore provide the best reflection of BIM application and processes. This research paper aims to address the variations existing in BIM practices across the construction industry. It includes an extensive study of 21 existing, publicly available BIM-based guidelines in order to establish an understanding of the present state of practice and deduce issues and concerns related to them. All guidelines analysed in this paper are first categorised based on authorship and the release date for efficient comparison. The points of similarity and difference between them are thereby realized and outlined. In addition, the transition of project implementation process from traditional methods to BIM technology is also explained. The existence of inconsistencies in the BIM guidelines reviewed in this paper reflects the need of a BIM 'Code Compliance Check'. The Code Compliance Check will serve as a regulatory project guideline that will further improve the potential of BIM by incorporating a consistent BIM modelling methodology for the entire construction industry.