• Journal of Biomedical Engineering Research
• /
• v.34 no.2
• /
• pp.69-72
• /
• 2013

The goal of this study is to develop test method for evaluating the drug eluting properties of drug eluting stents (DES). PBS and the detergent solutions, presented by each DES manufacturer, were used for drug release of DES coated with paclitaxel, zotarolimus and everolimus. The drugs which are coating DES were not released by PBS but released by the detergent solutions, finally paclitaxel 83.38%, zotarolimus 103.85% and everolimus 115.78%. It seems that the use of the detergents is necessary in order to release the drugs because those drugs are extremely hydrophobic. In conclusion, using of detergent solutions presented by each manufacturer were suitable for evaluating the drug eluting property of drug eluting stent.

• Archives of Pharmacal Research
• /
• v.10 no.2
• /
• pp.88-93
• /
• 1987

Chitosan ($\beta$-D-glucosaminan) is chemically prepared from chitin (N-acetyl-$\beta$- D-glucosaminan) which is an unutilized natural resource. We now report on the suitability of the chitosan matrix for use as vehicles for the controlled release of drugs. Salicylic acid and aspirin were used as model drugs in this study. The permeation of salicylic acid in the chitosan membranes was determined in a glass diffusion cell with two compartments of equal volume. Drug release studies on the devices were conducted in a beaker containing 5% sodium hydroxide solution. Partition coefficient (Kd) value for acetate membrane (472) is much greater than that for fluoro-perchlorate chitosan membrane (282). Higher Kd value for acetate chitosan membrane appears to be inconsisstent with the bulk salicylic acid concentration. The permeability constants of fluoro-perchlorate and acetate chisotan membranes for salicylic acid were 3.139 ${\times}10^{-7}cm^2$ min up to 60 min and that of 30% aspirin in the devices was 4.739${\times}10^{-7}cm^2$sec upto 60 min. As the loading dose of aspirin in a chitosan device increased, water up-take of chitosan device increased, but in case of salicylic acid it decreased. The release rate increased with increase in the molecular volume of the drugs. Thses result suggest that the release mechanism may be controlled mainly by diffusion through pores.

• Journal of Pharmaceutical Investigation
• /
• v.11 no.3
• /
• pp.14-20
• /
• 1981

One of the major objectives in the developments of a progesterone I.U.D. is to prepare devices which release drug at a constant rate for extended periods. A constant release rate is achived by maintaining drug concentration at a constant valve via the introduction of rate limiting membrane to solute diffusion at the surface of the devices. In this study, progesterone dispersed at monolithic device were prepared from polyhydroxy ethyl methacrylate. Constant release rate were obtained with device which were soaked in on ethanol-hexan solution. The release rate was dependant upon the concentration of the ethanolic solution in the soaking solution. This devices offer significant potential for futher development of hydrogel in the intrauterine contraception device for controlled release of progesterone.

• Journal of the Korean Society of Propulsion Engineers
• /
• v.10 no.3
• /
• pp.99-108
• /
• 2006

Aerospace applications use pyrotechnic devices with many different functions. Functional shock, safety, overall system cost issue, and availability of new technologies, however, question the continued use of these mechanisms on aerospace applications. Release device is an important example of a task usually executed by pyrotechnic mechanisms. Many aerospace applications like satellite solar panels deployment or weather balloon separation need a release device. Several incidents, where pyrotechnic mechanisms could be responsible for spacecraft failure, have been encouraging new designs for these devices. The Frangibolt is a non explosive device which comprises a commercially available bolt and a small collar made of shape memory alloy (SMA) that replace conventional explosive bolt systems. This paper presents the modeling and simulation of Frangiblot by the change of bolt size and notch geometry. This analysis may contribute to improve the Frangibolt design.

• Journal of Pharmaceutical Investigation
• /
• v.23 no.4
• /
• pp.207-211
• /
• 1993

Reservoir type devices were designed for long-term implantable drug delivery system. The reservoir type device was prepared with the polymethacrylic acid gel coated with polyurethane membrane. Release controlling agent (RCA) were employed to control drug release from devices via generation of micropores in the membranes. The polyurethane membrane functioned as a rate controlling barrier. The drug release pattern of hydrogel demonstrated zero order kinetics. The release rate of drugs could be regulated by varying hydrophobicity/hydrophilicity and content of the RCA, as well as the thickness of the polyurethane membrane. The release of drugs from this system was governed by pore mechanism via simple diffusion and osmotic pressure.

• Proceedings of the Korean Society of Propulsion Engineers Conference
• /
• 2006.11a
• /
• pp.3-6
• /
• 2006

In this study, 3D Design and the Structural Analysis using FEM are conducted for developing the Release Devices. On these bases the prototype devices are made and the reliability has been improved through many environmental tests.

• YAKHAK HOEJI
• /
• v.30 no.6
• /
• pp.306-310
• /
• 1986

The release of heparin from monolithic devices composed of different ratios of polyethylene oxide(PEO MW 20,000) and polydimethylsiloxane was investigated. Water soluble PEO plended into the polydimethylsiloxane proved a controlled release of heparin. The release rate of heparin could be controlled by varying the content of PEO and loading dose of heparin. The release rate of heparin from the devices increased as the content of PEO and heparin in the devices increased. The release rate of heparin from devices were related to nature of solute(ionic strength) and temperature. The release mechanism may be associated with the creation of pore or domine through the devices the water-uptake and the change in the physical structure of the polydimethysiloxane network.

• Proceedings of the KIEE Conference
• /
• 2002.07b
• /
• pp.1061-1063
• /
• 2002

In this paper, the characteristics of the pyro unit applied to rocket release device in KSR-Ill are analyzed by experimental results, which are the current and voltage waveforms of the battery used as energy source. The precision design approach of the rocket release device can be achieved since the behavior and the required energy of the pyro are identified through the results.

• Journal of the Korean Society for Aeronautical & Space Sciences
• /
• v.38 no.4
• /
• pp.321-326
• /
• 2010

The non-explosive release device using jack mechanism is designed and fabricated for the small satellite. As a triggering actuator for the release device, a piezo rotory motor with torque of more than $1.7kgf{\cdot}cm$ is employed to guarantee stable activation. For performance tests of separation device, we conducted release time test, preload test and shock test. The device was operated within 1.172sec and activated stably under load of 45kgf. Maximum shock was measured as 18G that is much less than the pyro-separation device produces. We confirmed the possibility as a satellite separation device through above presented tests.

• Polymer(Korea)
• /
• v.25 no.3
• /
• pp.334-342
• /
• 2001

Gentamicin sulfate (GS)-loaded poly(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV) devices were prepared for controlled-release of antibiotics. In this study, the effects of thickness, hydroxyvalerate (HV) content, initial drug-loading ratio, and additive content on the release profile have been investigated. The morphology of devices was examined with scanning electron microscope (SEM) before and after in vitro release; their highly porous surface and cross-sectional were observed. It could be suggested that device would be affected by the packing of the HV and additive content, which would depend on their structure. A high performance liquid chromatography (HPLC) was used to detect and quantify the release of GS from the device. The drug release from all the devices showed biphasic release patterns, and some matrices released the incorporated antibiotic throughout 30 days with a near zero-order release rate. The release patterns were shown to be changed by altering the thickness, copolymer ratio, and additive content.