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http://dx.doi.org/10.9718/JBER.2013.34.2.69

Development of Evaluation Method for Drug Release Propreties in Drug Eluting Stent  

Song, J.M. (Medical Device Team, Medical Device Assessment Headquarter, Korea Testing & Research institute)
Baek, H. (Medical Device Team, Medical Device Assessment Headquarter, Korea Testing & Research institute)
Lee, S.Y. (Medical Device Team, Medical Device Assessment Headquarter, Korea Testing & Research institute)
Jang, D.H. (Medical Device Team, Medical Device Assessment Headquarter, Korea Testing & Research institute)
Seo, M.Y. (Medical Device Team, Medical Device Assessment Headquarter, Korea Testing & Research institute)
Park, G.J. (Medical Device Team, Medical Device Assessment Headquarter, Korea Testing & Research institute)
Maeng, Eun-Ho (Medical Device Team, Medical Device Assessment Headquarter, Korea Testing & Research institute)
Publication Information
Journal of Biomedical Engineering Research / v.34, no.2, 2013 , pp. 69-72 More about this Journal
Abstract
The goal of this study is to develop test method for evaluating the drug eluting properties of drug eluting stents (DES). PBS and the detergent solutions, presented by each DES manufacturer, were used for drug release of DES coated with paclitaxel, zotarolimus and everolimus. The drugs which are coating DES were not released by PBS but released by the detergent solutions, finally paclitaxel 83.38%, zotarolimus 103.85% and everolimus 115.78%. It seems that the use of the detergents is necessary in order to release the drugs because those drugs are extremely hydrophobic. In conclusion, using of detergent solutions presented by each manufacturer were suitable for evaluating the drug eluting property of drug eluting stent.
Keywords
Drug eluting stent; drug release; detergent;
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