• 생약학회지
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• 제15권3호
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• pp.121-127
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• 1984

Attempts were to investigate the effects of 'Bojungikgi-tang' on the digestive system, blood pressure and diuresis. The results showed that relaxing action was shown on the isolated ileum in mice and that strong antagonistic actions were seen on $BaCl_2$, acetylcholine and histamine-induced contraction of the ileum in mice and guinea-pigs that the relaxing effect of the intestinal smooth muscle was recognized. Inhibitory effects on transport rate in the small intestine of mice and castor oil-induced catharsis in mice were noted. Inhibitory action on the secretion of gastric juice, pH ascending effect and decreasing effect of the free acidity and total acidity were recognized. Continuous hypotensive action was seen, but when the vagus nerve was cut, hypotensive action was remarkably decreased. The diuretic effect was also recognized.

• 생약학회지
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• 제19권2호
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• pp.141-151
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• 1988

The sedative, antipyretic, analgesic and anticonvulsive action, action on the isolated ileum in mice, retricting action on edema, action on blood pressure and respiration of Sipmidojuksan were evaluated. The results were as follows; sedative effects were recognized by the unbalanced effects of spontaneous momentum by wheel cage method, muscle relaxing action by rotor rod method and prolongation of sleeping hours. In mice, a significant antipyretic effect to endotoxin was recognized. Significant anagesic effects by acetic acid and Randall-Sellito method were recognized. Significant anticonvulsive effects to strychnine and picrotoxin were recognized. Spontaneous momentum of isolated ileum in mice was restricted, and relaxing effects on smooth muscle of digestive organ were noted by anti-acetylcholine, anti-barium chloride and anti-histamine effects. Significant antiedemic effects to carrageenin and histamine were recognized. Dilatation of blood vessels and decrease of blood pressure were noted.

• 동의생리병리학회지
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• 제27권6호
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• pp.809-817
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• 2013

The aim of this study was to evaluate the mechanism of vasodilation of Lespedezea cuneata(LC) in rabbit common carotid artery and cavernosal smooth muscle. LC relaxed arterial strips precontracted with norepinephrine and cavernosal strips precontracted with phenylephrine. The arterial relaxation effects of LC was endothelium-dependent. $N{\omega}$-nitro-L-arginine(L-NNA), NOS inhibitor, methylene blue(MB), cGMP inhibitor, indomethacin(IM), cyclo-oxygenase inhibitor and tetraethylammonium chloride(TEA), KCa-channel blocker attenuate the relaxation responses of LC in arterial strips. In $Ca^{2+}$-free krebs-ringer solution, pretreatment of LC extract significantly reduced the contraction induced by addition $Ca^{2+}$. L-NNA reduced LC extract-induced relaxation in cavernosal strips, but IM, TEA and MB didn't affect LC extract-induced relaxation. When LC extract was applicated on human umbilical vein endothelial cell, the nitric oxide concentration was increased. We conclude that in rabbit common carotid artery, LC may suppress influx of extra-cellular $Ca^{2+}$ through the release of endothelium derived relaxing factor including nitric oxide, prostacyclin, endothelium derived hyperpolarizing factor. And LC exerts a relaxing effect on corpus cavernosum through activating the NO.

• 한국멀티미디어학회논문지
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• 제19권4호
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• pp.756-764
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• 2016

In this paper, we present electroencephalography (EEG)-based power spectra analysis and auditory stimuli methods as coping mechanisms for disgust affection and phobia. Disgust affection is a negative emotion generated from trying to eliminate something harmful to one. It is usually related to mental illnesses such as obsessive-compulsive disorder, specifically phobia and depression. In our experiments, participants watched videos on horrible body mutilation and disgusting creatures, with either the original sound track or relaxing and exciting music as auditory stimulation. After watching the videos with original sound track, the participants watched the same video with a different audio background, such as soothing or cheerful music. We analyzed the EEG data utilizing relative power spectra and examined survey results of the participants. The results demonstrated that disgust affection is decreased when participants watched the video with relaxing or exciting music instead of the original soundtracks. Moreover, we confirmed that human's brainwave reacts according to types of audio and sources of disgust affection.

• 생약학회지
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• 제17권3호
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• pp.215-222
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• 1986

Although the 'Insamyangwee-tang' has been widely used in clinical purposes in the oriental medicine, its clinical efficacy is only documentated for the cases of gastritis, gastric ulcer and enteritis, but the experimental study on these has not been undertaken. So, to investigate the clinical efficacy of 'Insamyangwee-tang' comparing with animal experiments, This study was carried out. The results showed that relaxing action was shown on the isolated ileum in mice and that strong antagonistic actions were seen on $BaCl_2$, acetylcholine and histamine induced contraction of the ileum in mice, rats, rabbits and guinea-pigs that the relaxing effect of the intestinal smooth muscle was recognized. Inhibitory effects on transport rate in the small intestine of mice. Strong antagonistic actions were seen on acetylcholine induced contraction of duodenum in rats and remarkably inhibiting actions were seen of duodenum in rats. Inhibitory action on the secretion of gastric juice and pepsin, anti-ulceration effect was recognized.

• 대한한의학방제학회지
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• 제18권2호
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• pp.15-23
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• 2010

The spice phenomenon therapy is to adhibit aromatic herbs or materials to the human body or clothing, for the purpose of preventing and treating diseases. Mankind found the fire, and found that some plants and trees give off smoke when they are burning. Then, they found that some of aromatic substances had certain actions after being absorbed through the respiratory organ, which was the beginning of the spice phenomenon therapy. The spice phenomenon therapy is effective to relieve the exterior syndrome, to eliminate dampness, to regulate Qi flow, and to induce resuscitation. It has two actions. One is that the aromas that permeated the body, refreshes the mind, stimulates the appetite, strengthens the spleen and the stomach, and makes a relaxing sleep. The other is that the aromatic substances, absorbed into the human body, have pharmacological actions. The volatile aromatic substances have various pharmacological actions such as stimulating cranial nerves, dilating cardiac blood vessels, promoting gastric secretion, relaxing and sleep-inducing. It has been proved that the spice phenomenon therapy is anti-inflammatory and anti-microbial and is effective to dilate cerebral blood vessels and to ease the pain. It is expected to be studied more aggressively.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2009년도 춘계 학술발표회
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• pp.677-685
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• 2009

연구대상 사면에 대해 정밀한 현장조사 및 안정성 검토를 실시한 결과 다음과 같은 결론을 얻었다. 1. 연구 대상 사면의 붕괴 원인은 암석 자체의 풍화, 근본적으로 내재해 있는 단층, 과다한 발파로 인한 균열 등이 복합적으로 작용하여 발생된 것으로 판단된다. 2. 해석 결과 연구 대상 사면은 평면파괴의 우려가 있는 것으로 나타났다. 3. 한계평형해석 결과를 이용하여 보강력을 결정하였다. 4. 보강대책으로는 Rock Anchor, Rock Bolt, 구배완화를 비교 검토한 결과 구배완화가 연구 대상 사면에 가장 적합한 공법이라고 판단되었다.

• 한국감성과학회:학술대회논문집
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• 한국감성과학회 1998년도 춘계학술발표 논문집
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• pp.75-80
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• 1998

본 연구는 얼굴근전도(facial EMG)가 다양한 시각자극에 의해서 유발된 감성을 평가할 수 있는가를 알아보고자 하였다. 특히 감성의 차원중 각성-이완차원에서의 차이를 얼굴근전도를 이용하여 객관적으로 측정할 수 있는가를 알아보았다. 사용된 자극은 15개의 시각자극이었다 . 각각의 자극은 30초씩 무선적으로 제시되었고, 각 자극의 제시사이마다 120초씩의 휴식기를 두었다. 매 자극제시후 피험자는 제시된 자극에 대해 각성-이완의 정도를 주관적으로 평가하였다. 실험참가자는 25명의 여자대학생이었으며, 왼쪽이마의 추미근(corrugator muscle)과 빰의 관골근(zygomatic muscle)의 얼굴근전도를 측정하였다. 측정된 얼굴근전도에 대해서 절대값을 취해 면적을 구하였다. 최대 각성(the most arousing stimulus), 최소 각성(the least arousing stimulus), 최소이완(the least relaxing stimulus), 최대이완(the most relaxing stimulus)이라고 피험자들마다 주관적으로 평가한 가극에 대한 얼굴근전도를 비교.분석하였다. 그 결과 이마의 추미근이 각성과 이완감성의 차이를 변별할 수 있었다. 즉 각성감성을 느낄수록 이마의 추미근의 활동이 증가함을 보였다. 또한 최대각성감성을 느낄때 이마의 추미근의 활동이 증가함을 보였다. 결론적으로, 얼굴근전도가 다양한 시각자극에 의해 유발된 감성의 각성-이완차원을 측정할 수 있는 좋은 지표가 될수 있음을 나타낸다.

• Journal of Ginseng Research
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• 제16권3호
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• pp.175-182
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• 1992

Intravenous administration of saponin from the root of Panax ginseng (red ginseng) lowered the blood pressure in a dose-dependent manner (10~100 mg/kg B.W) in anesthetized rats. Therefore, experiments were designed to study whether this lowering of blood pressure is associated with the release of endothelium-derived relaxing factor. Rings of thoracic aorta with and without endothelium were suspended for the measurement of isometric tension in organ chamber. All experiments were performed in the presence of indomethacin (10-5 M). Ginseng saponin (10-5~3$\times$10-4 g/ml) relaxed contractions induced by phenylephrine (10-5 M) in the aorta with endothelium but not in that without endothelium. Treatment of aortic rings with NG_monomethyl-L-arginine (L-NMMA 10-4 M for 30 min), a competive inhibitor of nitric oxide synthase and methylene blue (M.B., 3$\times$10-7 M for 30 min), an inhibitor of soluble guanylate cyclase, diminished the relaxation induced by ginseng saponin. In thoracic aortic rings from rats treated with ginseng saponin for 2 weeks intraperitoneally, the relaxation to acetylcholine was increased compared with non-ginseng treated rings. These data suggest that red ginseng saponin evokes hypotension and that vascular relaxations induced by red ginseng saponin are inediatpd by release of endothelium-derived relaxing factor.

• 한국실내디자인학회논문집
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• 제15권3호
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• pp.173-183
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• 2006

Design is inseparably related to aesthetics. In spite of that, it is difficult to explain the precise aesthetic variables that affect the aesthetic value of space or environment. Therefore, this study intended to find the relationships between aesthetic variables by perceptual and affective judgement for space design with focus on complexity and preference variables. The research found low level of 'arousing' as well as high levels of affective dimension variables 'pleasant' and 'relaxing' evoked high preference. High preference also appeared in space design cases with high unity, order, and clarity with low contrast and complexity, which are variables of perceptual dimension. Complexity, one variables of preference by Kaplan, is in an inverse proportion to space preference. Thus, space design with high complexity has high level of 'exciting' and 'arousing' affective responses and relatively low level of 'relaxing' response. Additionally, it was confirmed that the most importantly influential factor on complexity was diverse components rather than visual richness and ornamentation.