• 대한수의학회지
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• 제39권4호
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• pp.838-845
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• 1999

To determine the prognostic factors for survival of dogs infected with canine parvovirus, clinical and laboratory data of 35 dogs with clinical signs compatible with canine parvoviral enteritis admitted to the Veterinary Medical Teaching Hospital, Seoul National University during the period 1997-1998 were collected. Dogs were grouped by some major covariates, which can be considered as guides to the relative prognosis of dogs in the different subgroups. The Kaplan-Meier survival analysis and Weibull proportional hazard model were used to estimate overall survival, evaluate the comparability between groups, and identify potential prognostic factors. The overall survival rate for all dogs was 45.7% over the study period, and the Kaplan-Meier estimate of one week survival was 0.4989. Gender was the most favorable prognosis ; male dog (median, 6 days) had significantly higher risk of dying than female dog (median, 17 days ; p = 0.0023). In addition to gender, age was significantly associated with survival, with juvenile dogs less than 6-month-old having higher risk (p = 0.0359). Dogs that vaccinated with complete protocol (p = 0.0374) and those of having higher value of mean corpuscular volume (p = 0.0346) were found to be of prognostic importance. The 7 dogs in which white blood cell count of less than 2000 had shorter median survival time (3 days) than the remaining 28 dogs (8 days), but no statistical significance was found between leukopenic and survival. The distribution of packed cell volume and hemoglobin measurement was such that the overall risk of dying in the two groups was comparable. Further studies are needed to more accurately assess these results.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1413-1418
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• 2012

Background: Previous studies generally indicate that synchronous bilateral breast cancers (SBBC) have an equivalent or moderately poorer survival compared with unilateral cases. The prognostic characteristics of SBBC would be relevant when planning adjuvant therapies and follow-up medical surveillance. The frequency of SBBC among early breast cancers in clinical settings in Australia and New Zealand was investigated, plus their prognostic significance, using the Breast Cancer Audit Database of the Society of Breast Surgeons of Australia and New Zealand, which covered an estimated 60% of early invasive lesions in those countries. Design: Rate ratios (95% confidence limits) of SBBC were investigated among 35,370 female breast cancer cases by age of woman, histology type, grade, tumour diameter, nodal status, lymphatic/vascular invasion and oestrogen receptor status. Univariate and multivariable disease-specific survival analyses were undertaken. Results: 2.3% of cases were found to be SBBC (i.e., diagnoses occurring within 3 months). The figure increased from 1.4% in women less than 40 years to 4.1% in those aged 80 years or more. Disease-specific survivals did not vary by SBBC status (p=0.206). After adjusting for age, histology type, diameter, grade, nodal status, lymphatic/vascular invasion, and oestrogen receptor status, the relative risk of breast cancer death for SBBC was 1.17 (95% CL: 0.91, 1.51). After adjusting for favourable prognostic factors more common in SBBC cases (i.e., histology type, grade, lymphatic/vascular invasion, and oestrogen receptor status), the relative risk of breast cancer death for SBBC was 1.42 (95% CL: 1.10, 1.82). After adjusting for unfavourable prognostic factors more common in SBBC cases (i.e., older age and large tumour diameter), the relative risk of breast cancer death for SBBC was 0.98 (95% CL: 0.76, 1.26). Conclusions: Results confirm previous findings of an equivalent or moderately poorer survival for SBBC but indicate that SBBC status is likely to be an important prognostic indicator for some cases.

• Journal of Preventive Medicine and Public Health
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• 제37권1호
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• pp.26-36
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• 2004

Objective : To examine the association between hospital procedure volume and treatment outcomes following allogeneic bone marrow transplantation (allo-BMT). Methods : Out of 1,050 patients who received allo-BMTs between 1998 and 2000 in 21 Korean hospitals, 752 with first allo-BMT and complete data were included in this study. Study subjects were divided into the following three groups according to cumulative hospital experience of all-BMTs during the study period: low (<30 cases), medium (30-49) and high ($\geq$50 cases) volume. Patient outcome was defined as early survival at day 100 and one-year survival. Multiple logistic regression analyses were performed to examine the association between hospital experience and survival at day 100 and one year. Results : When the low volume group was defined as the reference group, the adjusted relative risks (RR) of survival at day 100 for the high volume group were 2.46(95% CI, 1.13-5.36) for all patients, 2.61(1.04-6.57) for those with leukemia, and 2.20(0.47-10.32) for those with aplastic anemia. For one-year survival, adjusted RR for the high volume group were 2.52(1.40-4.51) for all patients, 1.99 (1.01-3.93) for leukemia, and 6.50(1.57-26.80) for aplastic anemia. None of the RR for the medium volume group was statistically significant. Patient factors showing significant relationship with survival were donor-recipient relation, human leukocyte antigen matching status, time from diagnosis to transplant, and disease stage. Conclusions : The study results suggest that the cumulative experience of hospitals in providing allo-BMT is positively associated with patient survival.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6025-6027
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• 2014

Background: Because of the relative rarity of biliary tract cancers (BTCs), defining long term survival results is difficult. In the present study, we aimed to evaluate the survival of a series of cases in Turkey. Materials and Methods: A totally of 47 patients with billiary tract cancer from Mersin Goverment Hospital, Acibadem Kayseri Hospital and Kayseri Training and Research Hospital were analyzed retrospectively using hospital records between 2006-2012. Results: The median overall survival was $19.3{\pm}3.9$ months for all patients. The median disease free and overall survivals were $24.3{\pm}5.3$ and $44.1{\pm}12.9$ months in patients in which radical surgery was performed, but in those with with inoperable disease they were only $5.3{\pm}1.5$ and $10.7{\pm}3.2$ months, respectively. Conclusions: BTCs have a poor prognosis. Surgery with a microscopic negative margin is still the only curative treatment.

• 한국콘텐츠학회논문지
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• 제19권2호
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• pp.591-604
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• 2019

본 연구는 IMF 이후의 시대성 내부에서 경쟁의 논리가 내면화되고 정교해지는 과정을 서바이벌 프로그램의 계보를 통해서 점검하기 위한 것이다. IMF 사태에 대한 극복의 서사가 공동체주의와 개인의 성공 사이에서 충분히 화해 가능한 서사 모델들을 발견했다면, 거꾸로 포스트 IMF는 경쟁과 관련된 특유의 정서적 구조를 드러내는 재난적 리얼리티에 기초하고 있다. 따라서 본 연구는 재난적 리얼리티를 서바이벌의 형식과 그러한 형식에 내포된 서사적 구조를 통해서 구성되어가는 과정을 살펴보는 것이기도 하다. 본 연구는 서바이벌 프로그램의 변화와 그에 따른 서사적 변화를 추적하기 위한 통시적인 흐름을 재구성하였다. 힐링-멘토의 시기에 상대적으로 서바이벌 프로그램은 쇠퇴하는 것처럼 보이지만 오히려 힐링-멘토 담론에 내포되어 있는 자기계발의 논리를 통해서 새로운 과도기를 마련한 것처럼 보인다. 사회나 구조보다도 개인의 자기계발 논리에 경유하면서, 서바이벌에 내재된 경쟁의 리얼리티는 더 이상 공동체 내부의 도덕주의나 정서적 화해를 위해서 작동하지 않아도 되는 것이다. 서바이벌 프로그램은 공동체 내부의 큰 공감을 지향하기보다는 좁은 자기 취향의 영역에 경쟁을 위임함으로써 환상적인 대리만족을 수행하게 된다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권12호
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• pp.4839-4842
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• 2014

Background: Although the Cox's proportional hazard model is the popular approach for survival analysis to investigate significant risk factors of cancer patient survival, it is not appropriate in the case of log-term disease free survival. Recently, cure rate models have been introduced to distinguish between clinical determinants of cure and variables associated with the time to event of interest. The aim of this study was to use a cure rate model to determine the clinical associated factors for cure rates of patients with breast cancer (BC). Materials and Methods: This prospective cohort study covered 305 patients with BC, admitted at Shahid Faiazbakhsh Hospital, Tehran, during 2006 to 2008 and followed until April 2012. Cases of patient death were confirmed by telephone contact. For data analysis, a non-mixed cure rate model with Poisson distribution and negative binomial distribution were employed. All analyses were carried out using a developed Macro in WinBugs. Deviance information criteria (DIC) were employed to find the best model. Results: The overall 1-year, 3-year and 5-year relative survival rates were 97%, 89% and 74%. Metastasis and stage of BC were the significant factors, but age was significant only in negative binomial model. The DIC also showed that the negative binomial model had a better fit. Conclusions: This study indicated that, metastasis and stage of BC were identified as the clinical criteria for cure rates. There are limited studies on BC survival which employed these cure rate models to identify the clinical factors associated with cure. These models are better than Cox, in the case of long-term survival.

• Journal of Microbiology and Biotechnology
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• 제28권10호
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• pp.1736-1748
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• 2018

Brucella abortus can survive and replicate within host macrophages, and great efforts have been made to demonstrate the genes involved in pathogenicity, such as internalization, in Brucella research. Here, intracellular responses were compared between THP-1 macrophage cells stimulated with B. abortus wild-type and four mutants (C1, C10, C27, and C32) using microarray to demonstrate the role of genes related to intracellular survival and replication. These mutants were generated by deleting genes encoding BAB_RS13225 (4-hydrobenzoate 3-monooxygenase, PHBH), BAB_RS00455 (heme exporter protein cytochrome C, CcmC), BAB_RS03675 (exopolyphosphatase, PPX), and BAB_RS13225 (peptidase M24). The results showed that mutants C1 and C10 induced significant suppression of survival levels and cytokine expression relative to wild-type in the THP-1 macrophage cells. These findings suggest that the BAB_RS13225 and BAB_RS00455 genes play important roles in survival within human macrophages. Conversely, mutants C27 and C32 induced significantly higher survival level than wild-type in the cells inhibiting cellular signal transduction. It is assumed that the BAB_RS03675 and BAB_RS13225 genes play a role in cellular resistance to B. abortus. Therefore, the disrupted genes are involved in B. abortus intracellular growth, and especially in its survival, and they could be effective targets for understanding the intracellular bacterium, B. abortus.

• 생태와환경
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• 제45권4호
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• pp.420-443
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• 2012

An Individual-Based Model (IBM) was developed by employing natural and toxic survival rates of individuals to elucidate the community responses of benthic macroin-vertebrates to anthropogenic disturbance in the streams. Experimental models (dose-response and relative sensitivity) and mathematical models (power law and negative exponential distribution) were applied to determinate the individual survival rates due to acute toxicity in stressful conditions. A power law was additionally used to present the natural survival rate. Life events, covering movement, exposure to contaminants, death and reproduction, were simulated in the IBM at the individual level in small (1 m) and short (1 week) scales to produce species abundance distributions (SADs) at the community level in large (5 km) and long (1~2 years) scales. Consequently, the SADs, such as geometric series, log-series, and log-normal distribution, were accordingly observed at severely (Biological Monitoring Working Party (BMWP<10), intermediately (BMWP<40) and weakly (BMWP${\geq}50$) polluted sites. The results from a power law and negative exponential distribution were suitably fitted to the field data across the different levels of pollution, according to the Kolmogorov-Smirnov test. The IBMs incorporating natural and toxic survival rates in individuals were useful for presenting community responses to disturbances and could be utilized as an integrative tool to elucidate community establishment processes in benthic macroin-vertebrates in the streams.

• KDI Journal of Economic Policy
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• 제31권2호
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• pp.195-234
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• 2009

본 연구에서는 Hummels and Klenow (2005)의 분석방식을 이용하여 1990년대 이후 우리나라의 대중국 수출에 있어서의 수출의 다양도 및 집약도의 상대적인 기여도를 고찰하고 있다. 본 연구에서 수출 다양도란 우리나라를 제외한 대중국 전체 수출국의 수출품목 대비 우리나라의 대중국 수출품목의 비중을 의미한다. 한편, 수출 집약도는 우리나라의 대중국 수출품목 기준으로 우리나라를 제외한 대중국 전체 수출국 대비 우리나라 수출의 비중으로 정의한다. 분석 결과에 의하면, 최근 1990년대 이후 우리나라의 대중국 수출 확대의 주요인은 수출 집약도의 증가였던 것으로 나타난다. 이러한 결과는 중장기적인 수출 호조세의 지속을 위해서는 수출 다양도보다는 수출 집약도가 더 중요한 요인이라는 $Besede{\check{s}}$ and Prusa(2007), Helpman, Melitz, and Rubinstein(2007) 등의 분석과 일치된 결과이다. 수출 다양도의 경우, 무역자유화 초기에 해당되는 1990년대 초반에는 빠르게 증가하나 이후에는 부품 및 자본재 등 일부 품목을 제외하고는 오히려 다소 하락하는 추세를 나타냈다. 한편, 부품과 자본재가 전반적으로 1차 산품, 소비재 등 여타 상품군들에 비해 수출의 지속성(survival)이 높은 것으로 나타난다. 1차 산품, 소비재 등의 경우 수출 개시 후 4년 이내에 전체의 약 75% 수준의 품목이 수출을 중단하는 것으로 분석된 반면, 부품과 자본재는 기술 수준의 구분 없이 1992~2007년 기간 중 지속적으로 수출이 이루어진 품목의 비중이 15% 수준에 이른다. 이러한 분석 결과는 국제분업구조의 진전이 수출의 지속성에 지대한 영향을 미칠 수 있음을 시사한다.

• 생물환경조절학회지
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• 제31권3호
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• pp.212-220
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• 2022

장미의 단일 마디 삽목의 경우 온도, 상대 습도 및 광과 같은 환경 관리가 생산성에 영향을 미친다. 기온과 상대습도가 삽목 성공률과 묘 소질에 미치는 영향을 조사하기 위해 장미(Rosa hybrida) 'Maisie' 품종과 투명한 플라스틱 박스를 이용하였으며 인공조명(white LED, PPFD 104.0µmol·m^-2·s^-1)을 이용하여 전 기간 밀폐 조건에서 삽목 시 가장 효과적인 소엽수와 광주기 조건을 구명하고자 하였다. 첫 번째 실험은 밀폐 기간을 달리하여 총 6주 동안 진행되었다. 밀폐 기간이 길어질수록 뿌리수와 가장 긴뿌리의 길이가 감소하였다. 그러나 밀폐 기간에 따른 생존율, 신초발생률, 발근율에 유의한 차이가 없었다. 두 번째 실험에서는 삽수 생존율과 신초발생률이 광주기(0/24, 2/22, 4/20, 8/16, 16/8h)와 삽수 소엽의 개수(0, 2, 4)에 의해 영향을 받는 것으로 나타났다. 생존율은 명기 16시간, 소엽 4개 처리구에서 가장 높았다. 생존율과 신초발생률을 에너지 효율과 함께 고려한 결과, 소엽을 2개 또는 4개 붙인 삽수를 이용하여 하루 8시간 광을 조사하는 것이 가장 효과적인 것으로 판단되었다.