Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Survival Analysis of Biliary Tract Cancer Cases in Turkey

  • Akca, Zeki (Department, Radiation Oncology, Mersin Goverment Hospital) ;
  • Mutlu, Hasan (Department, Medical Oncology, Akdeniz University School of Medicine) ;
  • Erden, Abdulsamet (Department, Internal Medicine, Kayseri Research and Training Hospital) ;
  • Buyukcelik, Abdullah (Department, Internal Medicine, Acıbadem University School of Medicine) ;
  • Cihan, Yasemin Benderli (Department, Radiation Oncology, Kayseri Research and Training Hospital) ;
  • Goksu, Sema Sezgin (Department, Medical Oncology, Kayseri Research and Training Hospital) ;
  • Aslan, Tuncay (Department, Internal Medicine, Kayseri Research and Training Hospital) ;
  • Sezer, Emel Yaman (Department, Medical Oncology, Mersin University School of Medicine) ;
  • Inal, Ali (Department, Medical Oncology, Mersin Goverment Hospital)
  • Published : 2014.08.15
Download PDF
⟨ Previous Next ⟩

Abstract

Background: Because of the relative rarity of biliary tract cancers (BTCs), defining long term survival results is difficult. In the present study, we aimed to evaluate the survival of a series of cases in Turkey. Materials and Methods: A totally of 47 patients with billiary tract cancer from Mersin Goverment Hospital, Acibadem Kayseri Hospital and Kayseri Training and Research Hospital were analyzed retrospectively using hospital records between 2006-2012. Results: The median overall survival was $19.3{\pm}3.9$ months for all patients. The median disease free and overall survivals were $24.3{\pm}5.3$ and $44.1{\pm}12.9$ months in patients in which radical surgery was performed, but in those with with inoperable disease they were only $5.3{\pm}1.5$ and $10.7{\pm}3.2$ months, respectively. Conclusions: BTCs have a poor prognosis. Surgery with a microscopic negative margin is still the only curative treatment.

Keywords

References

  1. Ahmad Z, Arshad H, Fatima S et al (2013). Gastrointestinal, liver and biliary tract pathology: a histopathological and epidemiological perspective from Pakistan with a review of the literature. Asian Pac J Cancer Prev, 14, 6997-7005. https://doi.org/10.7314/APJCP.2013.14.11.6997
  2. Aljiffry M, Walsh MJ, Molinari M (2009). Advances in diagnosis, treatment and palliation of cholangiocarcinoma, World J Gastroenterol, 15, 4240-62. Review https://doi.org/10.3748/wjg.15.4240
  3. AndreT, Tournigand C, Rosmorduc O et al (2004). Gemcitabine combined with oxaliplatin (GEMOX) in advanced biliary tract adenocarcinoma: a GERCOR study. Ann Oncol, 15, 1339-43 https://doi.org/10.1093/annonc/mdh351
  4. Bhargava P, Jani CR, Savarese DM, O'Donnell JL, Stuart KE, Rocha Lima CM (2003). Gemcitabine and irinotecan in locally advanced or metastatic biliary cancer, preliminary report. Oncology (Williston Park), 17, 23-6
  5. Butte JM, Matsuo K, Gonen M et al (2011). Gallbladder cancer, Differences in presentation, surgical treatment, and survival in patients treated at centers in three countries. J Am Coll Surg, 212, 50-61 https://doi.org/10.1016/j.jamcollsurg.2010.09.009
  6. Chang KY, Chang JY, Yen Y (2009). Increasing incidence of intrahepatic cholangiocarcinoma and its relationship to chronic viral hepatitis. J Natl Compr Canc Netw, 7, 423-7.
  7. Cleary SP, Knoxx J, Dawson LA (2011). Carcinoma of the biliary tract. In, Blanke CD, Rodel C, Talamonti MS, editors. Gastrointestinal Oncol. Berlin, Springer, P. 251.
  8. DeOliveira ML, Cunningham SC, Cameron JL et al (2007). Cholangiocarcinoma, thirty-one-year experience with 564 patients at a single institution. Ann Surg, 245, 755-62. https://doi.org/10.1097/01.sla.0000251366.62632.d3
  9. Greene FL, Page DL, Fleming ID (2002). AJCC cancer staging manual, 6th edn. Springer, New York.
  10. Knox JJ, Hedley D, Oza A et al ( 2005). Combining gemcitabine and capecitabine in patients with advanced biliary cancer, a phase II trial. J Clin Oncol, 23, 2332-8 https://doi.org/10.1200/JCO.2005.51.008
  11. Lee BS, Hwang JH, Lee SH et al (2012). Older adults with biliary tract cancer, treatment and prognosis. J Am Geriatr Soc, 60, 1862-71 https://doi.org/10.1111/j.1532-5415.2012.04163.x
  12. Shaib YH, Davila JA, Henderson L, McGlynn KA, El-Serag HB (2007). Endoscopic and surgical therapy for intrahepatic cholangiocarcinoma in the United States, A population-based study. J Clin Gastroenterol, 41, 911-7 https://doi.org/10.1097/MCG.0b013e31802f3132
  13. Sulpice L, Rayar M, Boucher E, Pracht M, Meunier B, Boudjema K (2012). Treatment of recurrent intrahepatic cholangiocarcinoma. Br J Surg, 99, 1711-7. https://doi.org/10.1002/bjs.8953
  14. Pattanathien P, Khuntikeo N, Promthet S, Kamsa-Ard S (2013). Survival rate of extrahepatic cholangiocarcinoma patients after surgical treatment in Thailand. Asian Pac J Cancer Prev, 14, 321-4 https://doi.org/10.7314/APJCP.2013.14.1.321
  15. Sun TT, Wang JL, Fang JY (2013). Gemcitabine alone or in combination with Cisplatin for advanced biliary tract carcinomas, an overview of clinical evidence. Asian Pac J Cancer Prev, 14, 877-83. https://doi.org/10.7314/APJCP.2013.14.2.877
  16. Unal OU, Oztop I, Unek IT, Yilmaz AU (2013).Two-week combination chemotherapy with gemcitabine, high-dose folinic acid and 5 fluorouracil (GEMFUFOL) as first-line treatment of metastatic biliary tract cancers. Asian Pac J Cancer Prev, 14, 5263-7 https://doi.org/10.7314/APJCP.2013.14.9.5263
  17. Valle J, Wasan H, Palmer DH, et al (2010). Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer. N Engl J Med, 362, 1273-81 https://doi.org/10.1056/NEJMoa0908721
  18. Vauthey JN, Blumgart LH (1994). Recent advances in the management of cholangiocarcinomas. Semin Liver Dis, 14, 109-14. https://doi.org/10.1055/s-2007-1007302
  19. Woradet S, Promthet S, Songserm N, Parkin DM (2013). Factors affecting survival time of cholangiocarcinoma patients, a prospective study in Northeast Thailand. Asian Pac J Cancer Prev, 14, 1623-7. https://doi.org/10.7314/APJCP.2013.14.3.1623
  20. Zhu AX, Hong TS, Hezel AF, Kooby DA (2010). Current management of gallbladder carcinoma. Oncologist, 15, 168-81. https://doi.org/10.1634/theoncologist.2009-0302