• Journal of Ginseng Research
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• v.2 no.1
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• pp.35-57
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• 1977

Seasenal absorption of inorganic nutrients and dry matter Production were studied with four-year-old ginseng plant. The residuary amounts of the nutrients supplied to ginseng Plantation were decreased with lime elapsed. The decreasing rate was greater in chemical plots than in Yacto Plots. The amounts of manure applied in this current year and growth in dry matter production of ginseng showed no signficant difference. The amounts of mineral nutrients per unit dry matter were proportional to the amounts of supplied with chemical fertilizer in the early period of growing season but with Yacto in the late season of growing. Seasonal changes of nitrogen, Phosphorus and Potassium contents per unit dry weight in each organ were high in the middle of May. They decreased sharply in the middle of June and then slowly decreased in both leaves and stems but gradually increased in roots. The absorption ratio of nitrogen to Phosphorus (N/P) was high, and that of nitrogen to Potassium (N/K) was few. The amounts of nitrogen, phosphorus and Potassium in leaves became lower with increasing the relative light intensity, but in stems, the concentrations were different with the kind of mineral nutrients. The requisite amounts of mineral nutrient of ginseng plant were 8.3∼9.9 kg of nitrogen, 1.2∼1.5 kg of phosphorus, 6.4∼7.9 kg of potassium Per 10 a for five years.

• Food Science and Preservation
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• v.21 no.1
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• pp.25-33
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• 2014

The effects of the ice pack and aluminum coated board in the corrugated boxes for maintaining the quality of fresh oriental melons (Cucumis melo var. makuwa) were investigated. The harvested oriental melons were stored at a temperature of $30^{\circ}C$ for 21 days after placing them in the corrugated boxes treated with control, including ice pack and aluminum coated board. The treatment with the ice pack and aluminum coated board was identified to have maintained the relative low temperature in the corrugated box against the high temperature from the environment. For the storage study of the oriental melon, the treatments with the ice pack and aluminum coated board reduced the respiration rate, the development of external color, and total weight loss. All treatments were also effective in maintaining the firmness and decreasing the decay ratio of the oriental melon as compared to those that were controlled. However, the value of total soluble solids regarding the fruit was insignificantly affected by the ice pack treatment. The results indicated that the application of the ice pack and aluminum coated board in the corrugated box played an important role in maintaining the quality of oriental melons during storage. The combination with the ice pack and aluminum coated board had more effective values on the storage qualities for oriental melons than that with the ice pack only. Based on the results of this study, the ice pack and aluminum coated board were the useful treatments for reducing the loss of quality of the fresh oriental melons in high temperature storage conditions.

• Archives of Pharmacal Research
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• v.28 no.5
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• pp.626-635
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• 2005

Liposome as a carrier of topotecan (TPT), a promising anticancer drug, has been reported in attempt to improve the stability and antitumor activity of TPT. However, the biodistr ibution pattern of TPT liposome in vivo and PEG-modified liposome containing TPT have not been studied systemically. In this paper, the in vitro stability and in vivo biodistribution behavior of several liposomes containing TPT with different lipid compositions and PEG-modification were studied. Compared with the 'fluid' liposome (S-Lip) composed of soybean phosphatidylcholine (SPC), the 'solid' liposome (H-Lip) composed of hydrogenated soybean phosphatidylcholine HSPC decreased the leaking efficiency of TPT from liposome and enhanced the stability of liposome in fetal bovine serum (FBS) or human blood plasma (HBP). The results of biodistribution studies in S$_{180}$ tumor-bearing mice showed that liposomal encapsulation increased the concentrations of total TPT and the ratio of lactone form in plasma. Compared with free TPT, S-Lip and H-Lip resulted in 5- and 19- fold increase in the area under the curve (AUC$_{0\rightarrow\propto}$), respectively. PEG- modified H-Lip (H-PEG) showed 3.7-fold increase in AUC$_{0\rightarrow\propto}$ compared with H-Lip, but there was no significant increase in t$_{1/2}$ and AUC$_{0\rightarrow\propto}$ for PEG-modified S-Lip (S-PEG) compared with S-Lip. Moreover, the liposomal encapsulation changed the biodistribution behavior, and H-Lip and H-PEG dramatically increased the accumulation of TPT in tumor, and the relative tumor uptake ratios were 3.4 and 4.3 compared with free drug, respectively. There was also a marked increase in the distribution of TPT in lung when the drug was encapsulated into H-Lip and H-PEG. Moreover, H-PEG decreased the accumulation of TPT in bore marrow compared with unmodified H-Lip. All these results indicated that the membrane fluidity of liposome has an important effect on in vitro stability and in vivo biodistribution pattern of liposomes containing TPT, and PEG-modified 'solid' liposome may be an efficient carrier of TPT.

• Journal of the East Asian Society of Dietary Life
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• v.15 no.5
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• pp.549-557
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• 2005

Effects of Acanthopanax senticosus extract (AS) on blood sugar content and serum lipid profiles of streptozotocin-induced diabetic rats were investigated. Experimental groups were classified into four groups, that is, normal control (NC) group, diabetic mellitus (DM) group, AS-fed group and DMAS-fed group. The AS group showed lower feed efficiency than the NC group, but the efficiency of DMAS group was higher than DM group. DMAS group showed the decreased water intake and urine by $45.5\%$ and $23.7\%$ respectively, compared with DM group. Compared with DM group, DMAS group decreased blood sugar by $46.9\%$ and triglyceride by $17.8\%$, total cholesterol by $10.0\%$ and LDL cholesterol by $22.0\%$ in serum, but increased serum HDL cholesterol by $14.4\%$ The relative percentage of liver or kidney per body weight, and the serum ALT activity in DMAS group were lower than those of DM group. There were no significant differences in hepatic glutathione(GSH) contents and total xanthine oxidase(XOD) activities among experimental groups. The hepatic lipid peroxide(LPO) content in DMAS group decreased by $54.6\%$ compared with that in DM group. The XOD (O type) and the ratio of O type to total type of both STZ-treated groups (DM and DMAS) were higher than those of NC group, but less conversion of D to O type was observed in DMAS group than in DM group. There was no significant difference in GST activity between NC and AS, but STZ-treated groups showed lower glutathione S-transferase(GST) activity than NC. In conclusion, it seems that AS reduces blood sugar by inhibiting the activity of xanthine oxidase type O as an oxygen-free radical generating system which induces the tissue damage. Antidiabetic effect of AS may regulate diabetes-induced high lipid profiles in blood.

• Journal of the Korean Chemical Society
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• v.35 no.3
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• pp.240-248
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• 1991

The regioselectivity in the nitrosation of seven N-methyl-N'-substituted phenylureas ($CH_3NHCONHC_6H_4-G$; G = H, p-CH$_3$, m-CH$_3$, m-CH$_3$O, p-F, m-F, m-Br) was examined using NaNO$_2$ and 4 different acids (diluted HCl, HCOOH, CH$_3$COOH, CF$_3$COOH). In all cases, the two regioisomeric products, N-nitroso-N-methyl-N'-substituted phenylureas (A) and N'-nitroso-N-methyl-N'-substituted phenylureas (B) were observed to be formed as major products and product ratios were determined by the integration of their methyl peaks in $^1$H-NMR. Electron donating substitutent(G) on phenyl of the ureas generally led to increase the ratio of B to A. The data have revealed that the relative sensitivity of the nitrosonium species (HONO, HCOONO, CH$_3$COONO, CF$_3$COONO) toward the change of electron density on nitrogen with phenyl substitutents are 1.00 : 0.93 : 0.78 : > ∼ 0.7.

• Journal of Korean Neurosurgical Society
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• v.52 no.1
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• pp.14-20
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• 2012

Objective : Intracranial meningiomas are primarily benign tumors with a good prognosis. Although WHO grade II meningiomas are rare (2-10%), WHO grade II meningiomas have higher recurrence and mortality rates than benign. We evaluated the patient recurrence rate and investigated the prognostic factors of WHO grade II meningiomas. Methods : Between 1993 and 2005, 55 patients were diagnosed with WHO grade II meningiomas in our hospital. WHO grade II meningiomas (n=55) were compared with other WHO grades meningiomas (I, n=373; and III, n=20). The patients had a median age of 48.4 years (range, 14-17 years), a male-to-female ratio of 26 : 29, and a mean follow-up time of 45 months (range, 3-175 months). Results : In WHO grade II meningiomas, only the extent of resection was a significant prognostic factor. Post-operative radiotherapy had no significant influence on tumor recurrence (p=0.053). The relative risk of recurrence was significantly higher in WHO grade II meningiomas with incomplete resection (10/27, RR=37%) than in WHO grade II meningiomas with complete resection (4/28, RR=14%) regardless of post-operative radiotherapy. In the incomplete resection group, Simpson grade III or IV had a significantly high risk of recurrence regardless of post-operative RT (n=3, RR=100%) However, if the degree of resection was Simpson grade II, the recurrence rate was similar to the complete resection group even though post-operative RT was not performed. Conclusion : Complete resection was the most powerful independent predictive factor of the recurrence rate in WHO grade II meningiomas. Post-operative adjuvant RT was not a significant factor in this study.

• Korean Journal of Agricultural Science
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• v.25 no.2
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• pp.260-270
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• 1998

The field tests were performed to suggest the rational method for stability evaluation of soft clay. The behavior of settlement-displacement obtained by field monitoring system was to compare and analyze the results of the observationed method, and to investigate the complex behavior of soft clay with filling height. The results of this study are summarized as follows. 1. The horizontal displacement was suddenly increased when physical properties of soft clay showed maximum values and the part of the turning point. The values of these properties were available to the fundamental data for stability evaluation. The shear deformation appeared that difference of the horizontal displacement was maximum values. 2. Although the stability of embankment by step filling showed the unstable part over the failure standard line, the embankment was confirmed stable. So the evaluation of the stability of embankment is reasonable to use the inclination of curve than failure standard line. 3. The horizontal displacement and relative settlement were increased as same ratio at improvement ground. Estimation of shear deformation using Terzaghi's modified bearing capacity should consider the relations of embankment load and undrained shear strength at nonimprovement ground, and minimum safety factor is recommended to use larger than 1.2. 4. Excess pore water pressure was increased with increasing of filling height and decreased with maintain the filling height. The embankment was unstable when filling height was exceed the evaluation standard line, and the behavior of excess pore water pressure and horizontal displacement could use as a standard of judgement of the filling velocity control because their behavior were agree with each other.

• Journal of Life Science
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• v.25 no.7
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• pp.765-772
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• 2015

The aim of this study was to determine the effect of decursin (D) and decursinol angelate (DA) against bisphenol A (BPA) toxicity in a rat two-generation study. Adult rats were divided into the following three groups: (1) control, (2) BPA, and (3) BPA+D/DA. The D and DA treatment of F0 parents increased the terminal body weight and relative adult organ weights (testes, kidneys, spleen, and liver) when compared with the BPA group. A significant decrease in sperm count was found in the BPA+D/DA (7.69%) and BPA (64.70%, p<0.01) groups, when compared with the sperm count in the control group. No offspring were obtained in the F1 generation of the BPA (50 mg/kg/day) group, but the addition of D/DA in the BPA+D/DA group significantly restored fertility (55.78%) and gestation indices (98.87%) in the F1 generation. No significant differences were found in the fertility index between the control (75.02%) and the BPA+D/DA (78.11%) groups in the two-generation study, when compared with the one-generation study. The viability ratio during lactation in the D/DA group was also similar to that of the control group. These data indicate that D/DA (50 mg/kg/day) administered over two generations causes significant positive changes in reproductive or developmental parameters.

• The Korean Journal of Food And Nutrition
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• v.16 no.4
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• pp.340-346
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• 2003

The diet food used in this test was composed of the total 16 kinds, such as refined water, herb extract, pomegranate extract, polydextrose and isomalto-oligosaccharide etc. Edible fiber as a major component in dietary food was contained to 2.60%(w/w) level. But the calorie was 104.57kca1/100g, contrast of control domestic saengshick product was 368.06kca1. As a result, calorie of dietary food sample was very low level. Vitamin and mineral as a minor component were determined 5, 6 kinds, respectively. On the other hand, dietary effect of body weight loss was determined about 14%(w/w) at animal test result used for rats during 4 weeks. The reason of dietary effect could confirmed from change of plasma neutral lipids, total cholesterol and HDL-cholesterol concentration. Increasing ratio of these in the general diet and dietary diet feeding groups during 4 weeks were 10.55, 6.90, 9.82% and 6.11, 3.85, 6.11%, respectively. from these results, decrease reason of body weight could confirmed the relative relationship with plasma lipids and cholesterol concentration. But plasma plasma glucose and insulin concentration have not positive relativity.

• Journal of Korea Water Resources Association
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• v.48 no.4
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• pp.245-255
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• 2015

This study used high density network of integrated meteorological sensor, which are operated by SK Planet, with KMA weather stations to estimate the quantitative precipitation field in Seoul area. We introduced SK Planet network and analyzed quality of the observed data for 3 months data from 1 July to 30 September 2013. As the quality analysis result, we checked most SK Planet stations observed similar with previous KMA stations. We developed the real-time quality check and adjustment method to reduce the error effect for hydrological application by missing and outlier value and we confirmed the developed method can be corrected the missing and outlier value. Through this method, we used the 190 stations(KMA 34 stations, SK Planet 156 stations) that missing ratio is less than 20% and the effect of the outlier was the smallest for quantitative precipitation estimation. Moreover, we evaluated reproducibility of rainfall field high density rain gauge network has $3km^2$/gauge. As the result, the spatial relative frequency of rainfall field using SK Planet and KMA stations is similar with radar rainfall field. And, it supplement the blank of KMA observation network. Especially, through this research we will take advantage of the density of the network to estimate rainfall field which can be considered as a very good approximation of the true value.