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http://dx.doi.org/10.5352/JLS.2015.25.7.765

Recovery from the Two-generation Reproductive Toxicity in Sprague-Dawley Rats by Treatment with Decursin and Decursinol Angelate  

Kim, Kang Min (Department of Pharmacy, Kyungsung University)
Ok, Seon (Department of Pharmacy, Kyungsung University)
Go, Youn Suk (Department of Pharmacy, Kyungsung University)
Kang, Jae Seon (Department of Pharmacy, Kyungsung University)
Publication Information
Journal of Life Science / v.25, no.7, 2015 , pp. 765-772 More about this Journal
Abstract
The aim of this study was to determine the effect of decursin (D) and decursinol angelate (DA) against bisphenol A (BPA) toxicity in a rat two-generation study. Adult rats were divided into the following three groups: (1) control, (2) BPA, and (3) BPA+D/DA. The D and DA treatment of F0 parents increased the terminal body weight and relative adult organ weights (testes, kidneys, spleen, and liver) when compared with the BPA group. A significant decrease in sperm count was found in the BPA+D/DA (7.69%) and BPA (64.70%, p<0.01) groups, when compared with the sperm count in the control group. No offspring were obtained in the F1 generation of the BPA (50 mg/kg/day) group, but the addition of D/DA in the BPA+D/DA group significantly restored fertility (55.78%) and gestation indices (98.87%) in the F1 generation. No significant differences were found in the fertility index between the control (75.02%) and the BPA+D/DA (78.11%) groups in the two-generation study, when compared with the one-generation study. The viability ratio during lactation in the D/DA group was also similar to that of the control group. These data indicate that D/DA (50 mg/kg/day) administered over two generations causes significant positive changes in reproductive or developmental parameters.
Keywords
Angelica gigas Nakai; decursin; decursinol angelate; reproductive toxicity; two-generation;
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