• Asian Pacific Journal of Cancer Prevention
• /
• v.14 no.10
• /
• pp.6127-6130
• /
• 2013

This study aimed to investigate the association between p53 Arg72Pro polymorphism and the risk of human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) by conducting meta-analysis. The PubMed database was searched for relevant studies until May 30, 2013. Relevant studies were selected and data were extracted by two independent authors. Overall, subgroup, and sensitivity analyses were then conducted using the Comprehensive Meta-Analysis v2.2 software. Wild-genotype ArgArg was considered as reference [odds ratio (OR) = 1.00]. Nine studies involving 1071 HNSCC cases were obtained. Meta-analysis results indicated no association between p53 Arg72Pro polymorphism and the risk of HPV-related HNSCC: for Pro/Pro vs. Arg/Arg, OR = 1.17, 95% confidence interval (CI) = 0.70-1.98; for Arg/Pro vs. Arg/Arg, OR = 1.25, 95% CI = 0.97-1.72; and for (Pro/Pro + Arg/Pro) vs. Arg/Arg, OR = 1.28, 95% CI = 0.95-1.70. These meta-analysis results were supported by subgroup and sensitivity analysis results. In conclusions, p53 Arg72Pro polymorphism is a potential marker of HP infection-related HNSCC rather than a susceptibility gene polymorphism.

• Safety and Health at Work
• /
• v.4 no.2
• /
• pp.77-83
• /
• 2013

There is still a considerable burden of occupational diseases and injuries in the world. It is not well known which interventions can effectively reduce the exposures at work that cause this burden. The objective of this article is to summarize evidence from systematic reviews of interventions to prevent occupational diseases and injuries. We included systematic reviews of interventions to reduce the incidence of work-related cancer, dust-related diseases, occupational asthma, chronic obstructive pulmonary disease, noise induced hearing loss, back pain, and occupational injuries. We searched Medline and Embase with predefined search strategies to locate systematic reviews of these interventions. We found 23 systematic reviews of which the results are also applicable to low- and middle income countries. Effective measures to reduce exposure leading to work-related cancer, dust-related diseases, asthma, chronic obstructive pulmonary disease, noise, and injuries are available. However, better implementation of these measures is needed. Regulation, enforcement of regulation, and incentives for employers are effective interventions to achieve this goal. There is evidence that feedback and rewards for workers help in reducing occupational injuries. There is no evidence in many studies that back pain can be prevented. Personal protective equipment technically has the potential to reduce exposure but this is difficult to put into effect. There is no evidence in the studies regarding the effectiveness of education and training, preventive drugs, or health examinations. There is evidence that the implementation of technical measures enforced by regulation can prevent occupational diseases and injuries. For other interventions such as education or health examinations, there is no evidence that supports their effectiveness. More systematic reviews are needed in the area of injury prevention.

• Research in Community and Public Health Nursing
• /
• v.32 no.3
• /
• pp.325-343
• /
• 2021

Purpose: The purpose of this study is to determine the results of a meta-analysis of impulsivity variables related to self-destructive behavior of South Korean adolescents. Methods: A meta-analysis was carried out according to the Cochrane guidelines criteria and the quality of the studies was evaluated using the JBI checklist. 2,333 studies were collected through the databases of RISS, KISS, and DBpia on 'impulsivity' published from 2000 to 2020. Self-destructive behavior-related variables were largely categorized into three areas (addiction, violence, and delinquency), and six subgroups. Results: Using the correlations with impulsivity in the final 53 papers, 231 self-destructive behavior-related variables were identified. The social delinquency showed the closest relationship with impulsivity (ES=0.34, 95% CI: 0.23~0.43, p<.001), followed by addictive behavior (ES=0.28, 95% CI: 0.24~0.32, p<.001), personal delinquency (ES=0.28, 95% CI: 0.23~0.32, p<.001), violence against others, violence against self, and substance addiction. These effects were identified as ranging from magnitudes of 0.23 to 0.27 based on the criteria of Cohen. Conclusion: To improve the reliability of the results of meta-analysis, more studies on the impulsivity of adolescents should be carried out so that the results can be accumulated, and the effectiveness can be examined in-depth later.

• Journal of Digital Convergence
• /
• v.17 no.1
• /
• pp.449-456
• /
• 2019

This study attempted to improve the quality of hairstyling-related studies and provide basic data for future studies on hairstyling terms through analysis of cosmetology-related loan words used in hairstyling theses among recent cosmetology papers. For data collection to derive valid conclusions, the signatures of a total of 1,980 academic papers collected after typing in the keyword 'Hair' at the Research Information Sharing Service (http://www.riss.kr) were analyzed. The results show that researchers in hairstyling seem not to pay close attention to the correct use of foreign loan words. Therefore, the study results would be very helpful to the development of future cosmetology studies. The correct notation and use of foreign loanwords should be further encouraged.

• Journal of Family Relations
• /
• v.23 no.2
• /
• pp.133-155
• /
• 2018

Objectives: This study examined the differences in the intention of having a second child and the related factors among Chinese and Vietnamese migrant women from the perspective of adaptation theory. Methods: Data were drawn from the National Survey on Multi-Cultural Families in 2009 and 2015. Among the total 7,615 married migrant women (Korean-Chinese, Chinese-Han, Vietnamese), those within the age group 20-39 within the first 5 years of marriage who had one child were selected. A frequency analysis, chi-squared test, and logit regression analysis were performed. Results: Different ethnic groups had different reasons for having a second child and the related factors also differed between 2009 and 2015. In 2009, after controlling the related variables, the intention of Korean-Chinese and Chinese-Han married immigrant women to have a second child was higher than that of Vietnamese women, but no such difference was found in 2015. Participation in their local community, first marriage, the gender of the first child, and whether they were living with their parents-in-law were associated with the intention of migrant women having a second child in the 2009 analysis model but these factors were not significant in the 2015 analysis model. In the latter model, the household income, a variable related to economic conditions, has a positive effect on the intention of having a second child. Conclusions: The significance of this study supports adaptation theory by addressing the similarity in the childbirth intention between recently married immigrant women and Korean women.

• The Korean Journal of Pain
• /
• v.35 no.2
• /
• pp.173-182
• /
• 2022

Background: Neurokinin-1 (NK1) and calcitonin gene-related peptide (CGRP) play a vital role in pain pathogenesis, and these proteins' antagonists have attracted attention as promising pharmaceutical candidates. The authors investigated the anti-nociceptive effect of co-administration of the CGRP antagonist and an NK1 antagonist on pain models compared to conventional single regimens. Methods: C57Bl/6J mice underwent sciatic nerve ligation for the neuropathic pain model and were injected with 4% formalin into the hind paw for the inflammatory pain model. Each model was divided into four groups: vehicle, NK1 antagonist, CGRP antagonist, and combination treatment groups. The NK1 antagonist aprepitant (BIBN4096, 1 mg/kg) or the CGRP antagonist olcegepant (MK-0869, 10 mg/kg) was injected intraperitoneally. Mechanical allodynia, thermal hypersensitivity, and anxiety-related behaviors were assessed using the von Frey, hot plate, and elevated plus-maze tests. The flinching and licking responses were also evaluated after formalin injection. Results: Co-administration of aprepitant and olcegepant more significantly alleviated pain behaviors than administration of single agents or vehicle, increasing the mechanical threshold and improving the response latency. Anxiety-related behaviors were also markedly improved after dual treatment compared with either naive mice or the neuropathic pain model in the dual treatment group. Flinching frequency and licking response after formalin injection decreased significantly in the dual treatment group. Isobolographic analysis showed a meaningful additive effect between the two compounds. Conclusions: A combination pharmacological therapy comprised of multiple neuropeptide antagonists could be a more effective therapeutic strategy for alleviating neuropathic or inflammatory pain.

• Journal of Animal Science and Technology
• /
• v.65 no.2
• /
• pp.311-323
• /
• 2023

Beef consumers valued meat quality traits such as texture, tenderness, juiciness, flavor, and meat color that determining consumers' purchasing decision. Most research on meat quality has focused on marbling, a key characteristic related to meat eating quality. However, other important traits such as meat texture, tenderness, and color have not much studied in cattle. Among these traits, meat tenderness and texture of cattle are among the most important factors affecting quality evaluation of consumers. Collagen is the main component of connective tissues.It greatly affects meat tenderness. The objective of this study was to determine significant variants and candidate genes associated with collagen contents trait (total collagen) through genome-wide association studies (GWAS). Phenotypic and genomic data from 135 Hanwoo were used. The BLUPF90 family program and GRAMMAR method for GWAS were applied in this study. A total of 73 potential single nucleotide polymorphisms (SNPs) showed significant associations with collagen content. They were located in or near 108 candidate genes. TMEM135 and ME3 genes were identified to have the most significant SNPs associated with collagen contents trait. Data indicated that these genes were related to collagen. Biological processes and pathways for the prediction of biological functions of candidate genes were confirmed. We found that candidate genes were involved in positive regulation of CREB transcription factor activity and actin cytoskeleton related to tenderness and texture of beef. Three genes (CRTC3, MYO1C and MYLK4) belonging to these biological functions were related to tenderness. These results provide a basis for improving genomic characteristics of Hanwoo for the production of tender beef. Furthermore, they could be used they could be used as an index to select desired traits for consumers.

• Journal of the Korean Society for Library and Information Science
• /
• v.49 no.4
• /
• pp.125-157
• /
• 2015

In Korean Studies, there have been made many studies for finding the identity as the intrinsic academic field, because the Korean studies have complex intertwined characteristics with other fields. However, previous related studies have been mostly focused on the qualitative content analysis method related to the major Korean Studies, the study applying the bibliometric method was not conducted. Therefore, the purpose of this study is to draw intellectual structures about the domestic and overseas Korean studies academic papers applying the bibliometric methods, and to analyze content of intellectual structures by focus group interview (FGI). As the result of this study, the intellectual structure in the domestic Korean Studies had the characteristics of the Humanities, and the intellectual structure in the foreign Korean Studies had the characteristics of the Social Sciences. Also, the domestic Korean Studies encompassed a wide range of period from ancient to modern times, while the foreign Korean Studies focused on a modern and contemporary times. This study has a significance in the way that it is the first study to draw the intellectual structures in the domestic and foreign Korean Studies applying the bibliometric method, and then to carry out the comprehensive analysis through FGI with specialists in Korean Studies. However, in order to do more meaningful one-to-one comparison studies about the field of the domestic and foreign Korean Studies, many follow-up co-studies reflecting diverse opinions of many researchers in Korean Studies will be necessary.

• The Journal of Korean Physical Therapy
• /
• v.28 no.2
• /
• pp.77-87
• /
• 2016

Purpose: The purpose of the study was to review functioning components of studies for measuring functional information using International Classification of Functioning, disability and health (ICF) in Korea. Methods: A literature review was conducted and eligible studies were identified via search of RISS, KISS, DBpia, KoreaMed, PubMed, and ISI databases published from 2001 to 2015. For inclusion in this review, a study should be published in a peer-review journal, must have participation of Korean researchers and/or developed in Korea, and should provide functioning data related ICF. Descriptive studies containing only ICF concepts and review studies were also excluded. Collected functioning data in each study were analyzed using frequency based on ICF domain. Data assessment was performed by two independent reviewers. Results: Eighty publications were included in the analysis. The majority of studies collected data from clinical patients (n=38) and from the disabled (n=28). Fourteen studies assessed functioning data from the elderly and students under special education. The studies reported functioning data using various tools, including ICF itself, ICF checklist, coresets, and conventional measurement tools. Body function domain was most commonly used and the least used domain was the body structure across areas. Interestingly, increasing data related to environmental factors was observed in all studied populations. Conclusion: Functioning data was collected from four domains of ICF across professional areas. The most common collected data was body function and activity and participation for which conventional measurement tools are already available. To understand clients, components of environmental factors that might influence a person's functioning should be considered.

• Journal of Trauma and Injury
• /
• v.28 no.3
• /
• pp.182-189
• /
• 2015

Purpose: We performed a quantitative and qualitative analysis in the Journal of the Korean Society of Traumatology (JKST) by Bibliometrics to know the trends of articles. Methods: We reviewed articles in the JKST retrospectively through 1988 to 2014. Articles were classified into original articles, case reports, review articles, and also it is further classified as topics and the information related to the Department of Medicine of corresponding author. Original article was classified prospective and retrospective studies. Results: 753 studies and average of 27.9 studies per year were posted on JKST. 576 original articles (76.5%) were posted. Retrospective studies around 449 studies (78%) were posted and there were about 35 descript studies and 541 analytic studies. The most common themes were related to abdominal trauma, 144 pieces, 95 pieces following damage to the chest and the 84 pieces of special order of trauma. Emergency department had the highest case whereas general surgery came to the second place. Conclusion: Recently, there has been reduced proportion of original article in JKST. It was not possible to evaluate the Korea Citation index journals due to the fact that it does not correspond to listed register Journal of National Foundation of Korea. There will be the need for the effort to improve the maintenance of the posted article number, as well as the qualitative development of the posted articles.