• Korean Journal of Clinical Pharmacy
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• v.30 no.1
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• pp.36-43
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• 2020

Background: Tacrolimus, a calcineurin inhibitor, is an immunosuppressant used in post-transplantation maintenance therapy. The drug has a narrow therapeutic range and requires periodic therapeutic drug monitoring. Although many studies have reported the effects of intrapatient variability of tacrolimus on survival, rejection, and complications in renal transplant recipients, very few studies have reported these effects in liver transplant recipients. The purpose of this study was to evaluate the effect of intrapatient variability of tacrolimus on clinical outcomes after liver transplantation. Methods: Intrapatient variability was calculated using individual, averaged tacrolimus concentrations. Patients were divided into two groups according to their median variability value: high-variability and low-variability groups. The rate of deviation from the therapeutic range, incidence of acute rejection, post-transplant diabetes, incidence of infection, and estimated glomerular filtration rate (eGFR) after transplantation were compared between the groups. Results: Of the total patients (n=82), the high-variability group (n=41) exhibited significantly greater deviation from the therapeutic range (65.92% vs. 56.84%; p<0.001). There was no significant difference in acute rejection or post-transplantation diabetes incidence or eGFR; however, the number of infection in the first 6 months was significantly lower in the low-variability group (0.4 vs. 0.9 times; p=0.039). Multiple linear regression analysis showed that the number of infection significantly increased as intrapatient variability increased (p=0.015). Conclusion: High intrapatient variability in tacrolimus concentrations was strongly associated with an increased frequency of deviation from the suggested therapeutic range and an increased number of infection.

• The Journal of the Acoustical Society of Korea
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• v.20 no.2
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• pp.27-34
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• 2001

Utterance verification is used in variable vocabulary word recognition to reject the word that does not belong to in-vocabulary word or does not belong to correctly recognized word. Utterance verification is an important technology to design a user-friendly speech recognition system. We propose a new utterance verification algorithm for no-training utterance verification system based on the minimum verification error. First, using PBW (Phonetically Balanced Words) DB (445 words), we create no-training anti-phoneme models which include many PLUs(Phoneme Like Units), so anti-phoneme models have the minimum verification error. Then, for OOV (Out-Of-Vocabulary) rejection, the phoneme-based confidence measure which uses the likelihood between phoneme model (null hypothesis) and anti-phoneme model (alternative hypothesis) is normalized by null hypothesis, so the phoneme-based confidence measure tends to be more robust to OOV rejection. And, the word-based confidence measure which uses the phoneme-based confidence measure has been shown to provide improved detection of near-misses in speech recognition as well as better discrimination between in-vocabularys and OOVs. Using our proposed anti-model and confidence measure, we achieve significant performance improvement; CA (Correctly Accept for In-Vocabulary) is about 89％, and CR (Correctly Reject for OOV) is about 90％, improving about 15-21％ in ERR (Error Reduction Rate).

• Journal of Korean Physical Therapy Science
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• v.10 no.1
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• pp.206-211
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• 2003

The purpose of this study is the effect of massage therapy on the human autonomic nerve system by heart rate variability spectral analysis. This study were to effect autonomic nerve system before and after massage therapy in 12 health peoples. The effect of massage therapy were assessments through Heart Rate Variability (HRV; SA-2000E, Medicare, Korea) before and after the massage therapy by same massage therapist. Statistical techniques for data analysis were applied paired t-test. The 0.05 level of significance was used as the critical level for rejection of the null hypotheses for the study. On the basis of the results analyzed in this study, conclusions were drawn as follows; Rest Heart Rate was significantly decreased before and after massage therapy, but other variable were no statistical significances. These results suggest that massage therapy maybe be effective in reducing heart rate and activity in valgal tone.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.46 no.4
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• pp.148-156
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• 2009

This paper presents a new image rejection algorithm based on the analysis of the distortion of a single-frequency continuous-wave (CW) signal due to the I/Q mismatch. Existing methods estimated the gain mismatch and phase mismatch on RF receivers and compensated them However, this paper shows that the circular trajectory of a single-frequency CW signal is distorted elliptic-type trajectory due to the I/Q mismatch. Utilizing the analysis, we propose a I/Q mismatch compensation method. It has two processing steps. In the first processing step, the generated signal is rotated to align the major axis of the elliptic-type trajectory diagram with the x-axis. In the second processing step, the Q-channel signal in the regenerated signal is scaled to align the regenerated signal with the transmitted single-frequency CW signal. Simulation results show that a receiver using the proposed image rejection algorithm can achieve an image rejection ratio of more than 70dB. And, simulation results show that the bit error rate performances of receivers using the proposed image rejection algorithm are almost the same as those of conventional coherent demodulators, even in fading channels.

• Journal of the Korean Professional Engineers Association
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• v.32 no.2
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• pp.99-109
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• 1999

The dried sea tangle added for soup prepatation to improved the taste in Korean and Japaness for long time. Attempts were made to develop the best procedures for extraction and removal of alginate by ultrafiltration and diafiltration. The summerized results of this study are as follows: 1) For hot water extraction in temperature range of 60～100$^{\circ}C$ for 4 hours, the higher temperature resulted higher yields in solids and protein. 2) Optimum sea tangle hot water extraction condition were 60～65$^{\circ}C$ for 1 hour which was cheap operating cost and high yield of good taste components. 3) The membrane flux was more higher GR 51 PP. and increase of flow rate permeate flow rate was accordingly increased. but limiting flow volume was 3.7 l/min. 4) It was found that ultration was relatively of higher recovery rate, solid and taste components, and low rejection coefficient rate than diafiltration.

• Membrane Journal
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• v.9 no.3
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• pp.178-184
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• 1999

A periodic backflushing was performed to reduce the membrane fouling of ultrafiltration for wastewater, and the effect and the optimum condition were investigated in this study. The alumina¬ceramic tubular membrane with pore size of 0.02${\mu}m$ was used for the wastewater treated by coagulation and sedimentation from two paper plants, of which A plant made toilet paper by recycling milk paper cartons and B plant recycled corrugated cardboards. And the effect of periodic backflushing to membrane fouling and quality of permeate were studied with a constant backflushing time of 3 sec. As results of measuring SS, TDS, and COD of source and permeate, the rejection rate of SS showed the highest value at the backflushing period of 15 see, which was the shortest time in these experiments, in case of waste¬water discharged from A plant. However, the rejection rate of COD had the highest value at the period of 30 sec for wastewater from both A and B plant. Then, the rejection rate of TDS was almost same at 30 and 60 sec for A plant wastewater, and the highest at 60 see for B plant. The effect of periodic back¬flushing to membrane fouling was investigated by change of permeate flux according to operating time. The permeate flux decreased slowly at the operation with backflushing, and was higher compared with that without backflushing in both case of A and B wastewater. But, the optimum period with the highest flux of A wastewater was different from that of B, because SS and COD of A was higher than those of Band TDS of B was higher than that of A.

• Journal of Aquaculture
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• v.15 no.2
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• pp.79-86
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• 2002

This study is the first attempt to understand the feeding physiology of a sea-urchin larva on a red-tide dinoflagellate. Fifteen day old larvae of S. intermedius capture C. polykrikoides cells by localized reversal of ciliary beats. No failure to transporte the algal cells from theciliated band to mouth and no rejection at the mouth suggest that C. polykrikoides has no feeding deterrence to S. intermedius larvae. The trend obtained for the clearance rate of S. intermedius larvae is similar to that of other sea urchin larvae. Thus, the clearance rate decreased as the algal concentration increased. Maximum clearance rate of S. intermedius on C. polykrikoides was 17.7 $\mu l$/larva/hr. Ingestion rate rapidly increased at lower algal concentrations and saturated at higher concentrations. There was no inhibition in ingestion rate at the highest prey concentration of ca. 3000 cells/ml. Maximum ingestion rate of S. intermedius on C. polykrikoides was 131 ngC/larva/d, which is higher than that reported for the larvae of the mussel Mytilus gal-lotrovincialis, but lower than that of the ciliate Strombidinopsis sp. The grazing rate, calculated by combining the field data on algal abundances with experimental data on ingestion rate, suggests that due to its low abundance, sea urchin Iarva has no significant grazing impact on C. polykrikoides population.

• Asian-Australasian Journal of Animal Sciences
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• v.22 no.1
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• pp.20-25
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• 2009

Xenotransplantation of pig organs into humans is a potential solution for the shortage of donor organs for transplantation. However, multiple immune barriers preclude its clinical application. In particular, the initial type of rejection in xenotransplantation is an acute cellular rejection by host $CD8^+$ cytotoxic T lymphocyte (CTL) cells that react to donor major histocompatibility complex (MHC) class I. The human cytomegalovirus (HCMV) glycoprotein Unique Short (US) 2 specifically targets MHC class I heavy chains to relocate them from the endoplasmic reticulum (ER) membrane to the cytosol, where they are degraded by the proteasome. In this study we transfected the US2 gene into minipig fetal fibroblasts and established four US2 clonal cell lines. The integration of US2 into transgenic fetal cells was confirmed using PCR and Southern blot assay. The reduction of Swine Leukocyte Antigen (SLA)-I by US2 was also detected using Flow cytometry assay (FACS). The FACS analysis of the US2 clonal cell lines demonstrated a substantial reduction in SLA-I surface expression. The level (44% to 76%) of SLA-I expression in US2 clonal cell lines was decreased relative to the control. In cytotoxicity assay the rate of $CD8^+$ T cell-mediated cytotoxicity was significantly reduced to 23.8${\pm}$15.1% compared to the control (59.8${\pm}$8.4%, p<0.05). In conclusion, US2 can directly protect against $CD8^+$-mediated cell lysis. These results indicate that the expression of US2 in pig cells may provide a new approach to overcome the CTL-mediated immune rejection in xenotransplantation.

• Journal of Korean Society of Water and Wastewater
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• v.29 no.2
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• pp.203-209
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• 2015

The purpose of this study is to estimate the applicability of a stable anaerobic digester using a separator membrane to the preprocessing thickening process. The results of the experiments showed about a 47.16% weight loss rate for the sludge under anaerobic condition, and about 41.17% under intermittent aeration condition. The concentrations of rejection water were $SCOD_{Cr}$ 25 mg/L, T-N 16.6 mg/L, and T-P 1.4 mg/L on the average under the intermittent aeration condition, which were lower than the concentrations of rejection water under an anaerobic condition. As for the factors affecting the reduction of the flux, correlation analyses of TTF, MLSS, $SCOD_{Cr}$, and $EPS_{Protein}$, $EPS_{Polysacchride}$ resulted in -0.97, -0.95, -0.84 and -0.86, -0.95, respectively, which showed that TTF had the highest correlation to the reduction of the flux. In addition, it was concluded that MLSS, $SCOD_{Cr}$ and $EPS_{Protein}$, $EPS_{Polysacchride}$ also have close correlations. The results are considered to show that, in the case of the process using a tubular membrane in the preprocessing process of an anaerobic digester, an intermittent aeration condition of the thickener considering the contamination of the membrane and load of rejection water is appropriate for the stable preprocessing process.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.6
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• pp.1141-1149
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• 2007

This paper describes two major techniques; image processing and gas vent insert and rejection control, for efficient gas vent exchange and holes detecting on the shoes mold. The key idea is to detect holes on the mold to select which holes to insert and to reject automatically guide center of hole's position. This allows us to save labor time while minimizing defective rate of PU shoes mold forming and production costs for gas vent exchange such as insertion and rejection.. Our experimental results have demonstrated that the hole's detection and gasvent exchange mechanism are more efficient and provide accurate mechanism to mitigate risks of vent injection/rejection failures.