• 한국식품영양과학회지
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• 제33권10호
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• pp.1748-1752
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• 2004

숙지황은 제조방법에 따라 각각 그 제조과정의 기준을 달리하고 있어 건지황을 증숙하는 횟수에 따라 5-HMF와 당류의 함량변화를 분석하여 어느 증숙단계가 바람직한지를 검토하고 그 외에 총질소, 조지방, 회분 등을 측정하였다. 건지황에서 는 5-HMF가 나타나지 않았고, 숙지황에서 증수(증수)에 따라 1증에서 6증까지 는 5-HMF의 함량이 서서히 증가하다가 7증에서 크게 증가하였다. 당류는 건지황에서 이당류인 sucrose와 단당류인 fructose 및 glucose가 함유되었으나 증숙과정을 거친 후(1증∼9증) sucrose가 나타나지 않았고, fructose와 glucose의 함량이 크게 증가하였다. 총질소는 건지 황과 증숙과정 을 거 친 숙지 황에서 큰 변화가 없었으며, 조지방의 경우 증숙과정을 거치는 동안 서서히 감소하였다. 회분은 대한약전(제8개정)의 기준(6.0%이하)에 적합하였다. 숙지황의 품질관리를 위한 지표로서 5-HMF함량이 대한약전(제8개정)의 기준(0.1% 이상)에 적합한 증숙과정은 본 연구에서는 7증 이상임을 알 수 있었다. 또한, 숙지황은 그 제조방법에 따라 그 성상 및 성분의 함량이 변화하므로 제조기준으로서 증숙단계를 어느 한 단계로 규정하기보다는 지표성분인 5-HMF가 0.1% 이상인 제조과정이 어느 단계에 해당되는 것인지를 파악하여 제품을 생산하는 것이 바람직하다고 사료된다.

• 한국약용작물학회지
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• 제26권1호
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• pp.1-7
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• 2018

Background: Rehmanniae radix preparata (RRP) has been used as a traditional medicine and is one of the most important oriental herbal medicines. However, the physical characteristics of RRP are not suitable for use in industry. The present study was under-taken to determined the preparation method of RRP powder and the physicochemical characteristics of RRP powder by milling under different pre-freezing temperatures. Methods and Results: Moisture content, powder yield, particle size, bulk density, compressive stress, extraction yield, and 5-HMF content of PRR powders by milling with pre-freezing temperatures (-20, -40, -60, and $-80^{\circ}C$) were analyzed, and correlation among these factors was determined. Powder yield increased and particle size decreased in a pre-freezing temperature-dependent manner from -20 to $-60^{\circ}C$. The Hausner ratio increased from 1.186 to 1.225 with decreasing temperature from -20 to $-80^{\circ}C$, whereas compressive stress showed the opposite trend. Extraction yield and 5-HMF content were not significantly different between RRP powder. Significant correlations were observed among pre-freezing temperature and physical characteristics (e.g., yield, particle size, Hausner ratio, and compressive stress). Conclusions: These results suggest that the pre-freezing temperature is an important factor affecting the physical characteristics of PRR powder and applicable to the industrial production of RRP powder.

• 한국식품조리과학회지
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• 제28권1호
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• pp.1-8
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• 2012

This study was performed to evaluate the quality characteristics of yanggeng prepared with different amounts of Rehmanniae radix Preparata (RRP) concentrate. Moisture, acidity, soluble solids, and reducing sugar contents of the control were the lowest, followed in order by the 3%, 6%, and 9% RRP addition. The pH of 9% RRP added yanggeng was the lowest, followed in order by the 6% and 3% additions. The lightness value of the Hunter color system decreased based on the amount of RRP concentrate added to yanggeng. In the texture analysis, the hardness and cohesiveness of the 9% RRP added yanggeng were the highest among the treatments. Total phenol content was the highest in 9% RRP added yanggeng. Antioxidant activities such as DPPH radical scavenging activity and hydroxyl radical scavenging activity, were the highest in the 9% RRP added yanggeng. In the sensory evaluation for yanggeng, the sensory scores for overall preference and texture were the highest in the 6% RRP added yanggeng The result was suggested that the optimum amount of RRP concentrate to add to yanggeng was 6%.

• 대한한의학방제학회지
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• 제20권1호
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• pp.123-132
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• 2012

Objectives : The purpose of this study is to find out herb-pair prototype composed of Zanthoxyli Fructus, to examine compatibility regulation between them and to classify them into seven features of compatibility. Methods : To search usages of Zanthoxyli Fructus compatibility, we have investigated the classics of herb and prescription such as "五十二病方"(Fifty-two kinds of Diseases), "黃帝內經"(The Medical Classic of Yellow Emperor), "傷寒論"(Treatise on Febrile Caused by Cold), "金匱要略"(Synopsis of Prescriptions of The Golden), "附廣肘后方"(Handbook of Prescriptions for Emergencies), "本草綱目"(Compendium of Materia Medica), "得配本草"(Deukbae Materia Medica). Results : In these books Zanthoxyli Fructus was paired with below herbs; 桂(Cinnamomi Cortex), 薑(Zingiberis Rhizoma), 吳茱萸(Evodiae Fructus), 細辛(Asari Radix), 茴香(Foeniculi Fructus), 肉荳蔲(Cistanches Herba), 釜下土(Terba Flava Usta), 益智仁(Alpinae Oxyphyllae Fructus), 飴(Saccharum Granorum), 葱白(Allii Radix), 梨(Pyrus), 牙皂(Gleditsia Fructus), 杏仁(Armeniacae Amarum Semen), 蕎麥粉(Fagopyrum esculentum Moench), 胡粉(Minium), 白朮(Atractylodis Rhizoma White), 蒼朮(Atractylodis Rhizoma), 麻子仁(Cannabis Fructus), 大麥蘗(Hordei Fructus Germiniatus), 麴(Massa Medicata Fermentata), 生地黃(Rehmanniae Radix), 茯苓(Poria), 牡蛎(Ostreae Concha), 白礬(Alumen), 雄黃(Realgar), 烏頭(Aconiti Radix), 附子(Aconiti Lateralis Preparata Radix). Conclusions : Zanthoxyli Fructus herb-pair classified by seven features of compatibility are as follows; 1. Mutual reinforcement compatibility with : Cinnamomi Cortex, Zingiberis Rhizoma, Evodiae Fructus, Asari Radix, Foeniculi Fructus, Cistanches Herba, Terba Flava Usta, Alpinae Oxyphyllae Fructus, Saccharum Granorum, Allii Radix, Pyrus, Gleditsia Fructus. 2. Mutual assistance compatibility with : Armeniacae Amarum Semen, Fagopyrum esculentum Moench, Minium, Atractylodis Rhizoma White, Atractylodis Rhizoma, Cannabis Fructus, Hordei Fructus Germiniatus, Massa Medicata Fermentata, Rehmanniae Radix, Poria, Ostreae Concha, Alumen. 3. Mutual restraint compatibility with: Realgar, Aconiti Radix, Aconiti Lateralis Preparata Radix) 4. Mutual detoxication compatibility with: 桑汁(Juice of Mori Folium), 桑根汁(Juice of Morus Cortex), 大蒜(Allii Bulbus), 薺苨(Remotiflori Radix), 桂汁(Juice of Cinnamomi Cortex).

• 생약학회지
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• 제53권3호
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• pp.170-180
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• 2022

Polycyclic aromatic hydrocarbons(PAHs) contents were analyzed by measuring benz(a)anthracene(BaA), chrysene(Chr), benzo(b)fluoranthene(BbF) and benzo(a)pyrene(BaP), and the related risk characterization was conducted for 113 samples out of 14 different agricultural products used for food and medicine. Detection rate of PAHs was 90.3% as a whole, and the highest one was 80.5% for BaP. The detection rate of BaP exceeding the maximum permitted concentration of Rehmanniae Radix Preparata and Rehmanniae Radix, 5.0 ㎍/kg was 1.8%, and the detection rates of BaA, Chr and BbF were within the range of 2.7~10.6%. The highest average concentration of BaA was 3.41 ㎍/kg detected from Lycii Fructus, while those of Chr, BbF, BaP and PAH4(sum of detected BaA, Chr, BbF and BaP) were 5.00, 1.79, 2.36, 12.36 ㎍/kg, respectively, detected from Rehmanniae Radix Preparata. As for the risk characterization on PAHs, the overall MOE(Margin of Exposure) values were measured within the range of 10⁵~10⁷, which is unlikely to cause direct health concerns, but the worring values of MOE were measured 6.57×10⁴ for BaP and 6.10×10⁴ for PAH4 from Rehmanniae Radix Preparata, which may require an improvement plan to reduce BaP contents.

• 대한한방소아과학회지
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• 제33권3호
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• pp.56-68
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• 2019

Objectives The purpose of this study to analyze the effect of Korean medicine therapy of Attention deficit hyperactivity disorders. Methods Electronic research articles were selected by using NDSL, OASIS, KISS, KMBASE, K-portal, Pubmed, Cochrane, and Ebscohost. Results We analyzed fifteen studies about Korean medicine treatment of Attention deficit hyperactivity disorders. There are eleven studies on the acupuncture treatment, and the most commonly used acupoints were GV20 and EX-HN1. There are eight studies on the herb medicine treatment. The most commonly used herbal materials are Root of Rehmanniae Radix et Rhizoma Preparata, Root of Rehmanniae Radix et Rhizoma Preparata, Sclerotium of Poria cocos Wolf, and Rhizome of Acori Gramineri Rhizoma. Syncope and hematomas were common side effects of the acupuncture treatment. Also, the acupuncture needle can be stuck or bent during the treatment. In most studies, Attention deficit hyperactivity disorders was improved when treated with Korean medicine. Conclusions More studies are needed to demonstrate the effectiveness of Korean medicine in Attention deficit hyperactivity disorders. This study can be used for various studies of Attention deficit hyperactivity disorders.

• KSBB Journal
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• 제18권2호
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• pp.90-93
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• 2003

쌍화탕의 재료로 사용되는 9가지 한약재에 함유된 6가지 인체에 유해한 중금속 함유량은 생강과 당귀의 경우 식약청 기준치인 30ppm의 1.47배와 1.24배 이었고 기타 한약재는 기준치와 거의 동등하거나5% 이내에서 초과하였다. 가장 간단한 수치법인 물세 척 만으로 중금속이 20-38% 제거되었고 따라서 모든 실험 대상 약재 에 대하여 중금속 함량을 식약청 기준치보다 낮출 수 있었다.

• 생약학회지
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• 제30권4호
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• pp.363-367
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• 1999

Palmultang(PMT) consists of Ginseng Radix Alba, Atractylodis Rhizoma Alba, Hoelen, Glycyrrhizae Radix, Rehmanniae Radix Preparata, Paeoniae Radix, Cnidii Rhizoma and Angelicae Gigantis Radix. PMT enhanced the lucigenin chemiluminescence and the engulfment of fluorescein-conjugated E. coli particles and inhibited the production of nitric oxide in murine peritoneal macrophage. PMT enhanced the production of ${\gamma}-interferon$, interleukin-2 and the cell viability in murine thymocyte, but did not affect the production of interleukin-4. These results indicate that PMT enhances the phagocytosis of macrophage via the stimulation of ${\gamma}-interferon$ production in $T_H1$ cells and the reduction of nitric oxide production in peritoneal macrophage.

• 한국식품영양과학회지
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• 제44권3호
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• pp.386-392
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• 2015

본 연구는 숙지황 분말을 이용한 기능성 면류를 제조하기 위해서 숙지황 분말을 밀가루에 0, 2.5, 5, 7.5% 첨가하여 제조한 국수의 품질 특성 및 항산화성을 조사하였다. 숙지황 분말 첨가가 증가함에 따라 국수의 중량, 부피, 함수율은 감소하였고 탁도는 증가하였다. 색도는 숙지황 분말의 첨가량이 증가할수록 L값과 b값은 감소하고 a값은 증가하는 경향을 나타내었다. 수분 함량은 숙지황 분말의 첨가량이 증가할수록 감소하였다. 숙지황 분말 첨가량이 증가할수록 국수의 경도는 증가하였고, 탄력성, 응집성, 검성 및 씹힘성은 감소하였다. 숙지황 분말의 첨가 농도가 증가함에 따라 아밀로그래프상의 호화개시 온도는 증가하였고, 최고 점도와 최종 점도는 감소하였다. 숙지황 분말 첨가 농도가 높아질수록 polyphenol 함량은 증가하였고, DPPH radical 소거능에서 $IC_{50}$값이 감소하였으므로 숙지황 분말 첨가량이 증가할수록 항산화능이 높아지는 것을 알 수 있었다. 관능검사 결과 숙지황 분말 2.5% 첨가 국수가 전체적인 기호도 및 구입의사에서 가장 높게 평가되었다. 이상의 결과로 볼 때 숙지황 분말을 첨가한 기능성 국수의 개발이 가능하였고 기능성을 고려하였을 때는 숙지황 분말 7.5% 첨가가 가장 그 항산화 활성이 우수하였다. 하지만 제품 개발 특성상 관능적 특성을 크게 고려하였을 때, 숙지황 분말을 2.5% 첨가하여 국수를 제조하는 것이 가장 적합한 것으로 사료된다.

• 대한한방소아과학회지
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• 제32권4호
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• pp.103-112
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• 2018

Objectives The purpose of this study is to provide clinical evidences on effectiveness of herbal medicine treatment regarding pediatric growth based on recent clinical studies. Methods Selected 17 clinical studies since January 1998 to June 2018 from the Journal of Pediatrics of Korean Medicine and OASIS Traditional Medicine Knowledge Portal were reviewed. Results Medications that strengthening spleen and stomach (健脾胃藥), digestant (消導藥), supplementing kidneys (補 腎藥), and lungs (補肺藥) were frequently used. Frequently used herbs were Hoelen (茯?), Citri Pericarpium (陳皮), Glycyrrhizae Radix (甘草), Atractylodis Rhizoma Alba (白朮), Dioscoreae Rhizoma (山藥), Angelicae Gigantis Radix (當歸), Amomi Fructus (砂仁), Rehmanniae Radix Preparata (熟地黃). Conclusions This study showed that Korean herb medicine treatment can be effective for pediatric growth.