• 혜화의학회지
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• 제9권2호
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• pp.173-182
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• 2001

1. $\ll$Graphical Materia Medica$\gg$ is first book that writes about Rehmanniae Radix Preparat. $\ll$Shen nong's herbal$\gg$ is only written about Rehmanniae Radix. 2. After the $\ll$Decoction Materia Medica$\gg$, orintal dortors use Rehmanniae Radix's effect is removing heat from the blood and Rehmanniae Radix's effect is enriching the blood. 3. Rehmanniae Radix Preparat is kinds of durgs for enriching the blood, because Rehmanniae Radix Preparat's effect do nourishing yin and supplementing blood. Therefore, Rehmanniae Radix Preparat is uesd simple recipe or Rehmanniae Radix Preparat is used with another herbs that shows so good effect of hematogenous functions at laboratory work. 4. Bone marrow is doing hematogenesis. That has relation to Rehmanniae Radix Preparat's effect is replenishing bone marrow, it's channel tropisms are liver kidney channels. 5. Rehmanniae Radix Preparat's guide component is 5-HMF, but effective component has relation with hematogenesis is mannitol of saccharides. And we need more reserch about Rehmanniae Radix Preparat.

• 대한한의학회지
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• 제23권2호
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• pp.78-87
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• 2002

Objectives : The aim of this study was to investigate the effects of Ginseng Radix (Panax ginseng C.A. MEY.), Zizyphi Spinosae Semen (Zizyphus spinosa HU.) and Rehmanniae Radix Preparat (Rehmannia glutinosa LIBOSCH.) on the serotonin- immunoreactivity cells in the Caudal raphe nuclei, Rostal raphe nuclei and hippocampus of the mouse brain. Methods : The mice were stressed by restraining for one hour and treated with herbal medicine by oral feeding. The mice were killed after one hour and observed by electron microscope after immunohistochemical staining. Results : In the caudal raphe nuclei of the medulla oblongata, the highest number of 5-HT immunoreactivity cells were observed at the Zizyphi Spinosae Semen-treated group, while the lowest level among the herbs treatment group was shown at the Ginseng Radix group. In the hippocampus, serotonin-immunoreactive cells were expressed significantly at the CA3 area while the lowest level of it was shown at the control group. In the midbrain, immunoreactive cells were expressed higher than other groups, while observed at the lowest level in the control group. Conclusions : The extracts of Zizyphi Spinosae Semen, Rehmanniae Radix Preparat and Ginseng Radix show a certain degree of effect on the change of serotonin immunoreactive neurons as an index of nerve disorder.

• 대한본초학회지
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• 제20권4호
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• pp.61-67
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• 2005

Objectives : Obese and osteoporosis are diseases characterized by bone loss and morbidity with osteoporotic fracture is increasing in elderly. The present study was carried out to determine the effects of Rehmanniae Radix Preparat(RRP) on the postmenopausal obese. Methods : The variance of body weight, femoral bone weight, serum level of cholesterol and microscopic view of tibia were investigated. Animals were observed for 8 weeks, and vehicle and extracts of prescriptions were administered ad libitum. Results : Body weight increased significantly in 6 weeks after ovariectomy, and the weight of RRP administered group decreased significantly. RRP decreased the serum level of cholesterol. Conclusions : According to above results, RRP can be used for prevention and curing the postmenopausal obese.

• 대한한의학회지
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• 제27권3호
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• pp.77-87
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• 2006

Objectives: The present study was carried out to investigate the preventive effects of Samgijiwhang-Tang(SJT) on streptozotocin(STZ)-induced diabetic nephropathy. Methods: SIT was given to rats through oral administration. The experimental animals were divided into a normal group of rats, a control group of STZ-induced diabetic rats, and a sample group with SIT administration. Rehmanniae Radix Preparat is combined in the original prescription of SIT, but in this experiment, Rehmanniae Radix was combined instead of Rehmanniae Radix Preparat to compare the effects of anti-diabetic nephropathy. Experimental diabetic nephropathy was induced by the injection of STZ(60mg/kg) in the rat via the peritoneum. The effect of SIT on STZ-induced diabetic nephropathy was observed by measuring the serum level of creatinine and BUN, in addition to urine secretion of albumin for 24 hours and the level of glucose found in the urine. Anti-oxidative stress of SIT administration in a living body was estimated by measuring lipid peroxide and GSH content in the cortex of kidneys. Results: STZ induced an increase of serum creatinine, urine glucose and renal cortical lipid peroxidation was lowered by Rehmanniae Radix Preparat combined SIT administration. Conclusions: The SIT treatment showed a protective effect on the rat diabetic nephropathy model, and action mechanism of the effect was thought to be concerned with anti-oxidative stress.

• 동의생리병리학회지
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• 제16권6호
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• pp.1117-1121
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• 2002

To test the protective effect of herbal medicine on myocardial damage against oxygen free radical-induced myocardiotoxicity, cytotoxicity was examined using MTT, Beating rate and DNA synthesis assay in the presence of water extract of three kinds of Radix Rehmanniae. Myocardial toxicity was evaluated in neonatal rat myocardiocytes in cultures. The results of these experiments were obtained as follows : Xanthine oxydase/hypoxanthine resulted in a decrease in viability, beating rate and DNA synthesis in cultured myocardial cells. Radix Rehmanniae Recens(生地黃, RRR) water extract shows effects of protection from the cardiocyte toxicity induced by xanthine oxydase/hypoxanthine treatment such as increases in beating rate. Radix Rehmanniae Preparat(熟地黃, RRP) water extract shows effects of protection from the cardiocyte toxicity induced by xanthine oxydase/hypoxanthine treatment such as increases in DNA synthesis. These results show that xanthine oxydase/hypoxanthine elicits toxic effects in cultured myocardial cells derived from neonatal rat, and suggest that water extract of three kinds of Radix Rehmanniae is very effective in the prevention of xanthine oxydase/hypoxanthine-induced cardiotoxicity.

• 동의생리병리학회지
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• 제21권6호
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• pp.1569-1575
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• 2007

In oriental medicine, Sukjihwang (SJH, Rehmanniae radix preparat) has been used as one of the key ingredients for the prescription of several herbal decoctions and applied clinically for the treatment of several diseases including nervous system and cardiovascular disease. Here, possible growth-promoting effects of SJH on injured spinal cord axons were investigated in the rats. SJH administration increased levels of active form of ERK1/2 protein and Cdc2 proteins in the injured spinal cord tissue. Anterograde DiI-tracing of corticospinal tract axons showed that SJH-treatment enhanced axonal arborization in the injury area and extensive axonal extension into the caudal area. In SJH-treated group, glial scar formed after spinal cord injury was confined in a smaller area compared to the control group, and the trabecula structure was well observed within the injury cavity. Furthermore, increased proliferation and migration of astrocytes in the injury cavity were observed by SJH treatment. Thus, these present data provide a biological evidence on potential importance of SJH therapy for the treatment of injured spinal cord.

• 동의생리병리학회지
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• 제17권1호
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• pp.113-117
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• 2003

This study was performed to investigate the anti-depression effect of herbal extracts (Rehmanniae Radix Preparat, Corni Fructus, Lycii Fructus, Pinelliae Rhizoma, Nelumbinis Semen) in the chronic mild stressed rat. After adaptation period for 2 weeks, each herbal extract was administered to the rats divided 5 groups. For comparison, St. John's wart was administered to another group in the same environment. The chronic mild stress was induced to rats by overnight illumination for 2 days before the forced swimming test. Struggling time, first latency and rest duration were calculated during the forced swimming test to evaluate the anti-depressant effect. The results were as follows: 1. In the result of evaluation of the struggling time, there was no significance in Pinelliae Rhizoma (-1.1%), Corni Fructus (-3.9%), Rehmanniae Radix Preparat (15.2%), Lycii Fructus (4.9%), St. John's wart (25.2%). There was a significant increase only in Nelumbinis Semen (43.9%) (P=0.0037). 2. In the result of evaluation of the first latency time, there was no significance in Lycii Fructus (-21.37%), Rehmanniae Radix Preparat (38.4%), Pinelliae Rhizoma (65.5%), Corni Fructus (29.2%), St. John's wart (75.8%). There was a significant increase only in Nelumbinis Semen (90.2%) (P=0.0116). 3. In the result of evaluation of the first rest duration, there was no change in St. John's wart, and Decrease was shown in Pinelliae Rhizoma (62.4%), Corni Fructus (31.6%) Rehmanniae Radix Preparat (63.1 %), Lycii Fructus (12.4%), Nelumbinis Semen (59.0%), but there was no significance in all. 4. Nelumbinis Semen is considered to have a superior anti-depression effect than the other herbal extracts, and to have a superior and-depression effect than St. John's wart being used commonly.

• 혜화의학회지
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• 제8권2호
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• pp.191-210
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• 2000

The Literatual Study on Treatment of Toothbleeding Through the literatual study on treatment of toothbleeding, we concluded as follows, 1. The causes of the toothbleeding are divided into heat of stomach (胃熱) and deficiency of renal (腎虛). If caused by heat of stomach, the treatment methods are Ryang-Hyul-Ji-Hyul(凉血止血), Cheong-Yul-Sa-Hwa(淸熱瀉火). If caused by deficiency of renal, the treatment methods are Ryang-Hyul-Ji-Hyul(凉血止血), Ja-Eum-Gang-Hwa(滋陰降火). 2. The medications are several - taking a medicine for internal use(內服法), keeping with one's mouth full of an infusion and spoutting it Haamsoobup(含漱法), and others like taking a medicine for external use(外用法) only. 3. The treatment drugs divided by medication are as follows : Taking a medicine for internal use : Cheongwesan(淸胃散), Gamroeum(甘露飮), Joweseunggitang(調胃承氣湯), Seogagjihwangtang(犀角地黃湯), Yugmijihwangtang(六味地黃湯), Palrnihwan(八味丸), Soansinhwan(小安腎丸) etc... Haamsoobup : Gudogeum(救毒飮), Jihwangtang(地黃湯), Mangchosan(莽章散) etc... Taking a medicine for external use : Pilseungsan(必勝散), Rogposan(綠包散, Hyunggeousan(荊槐散), Bingoksan(氷玉散), Sahyangsan(麝香散), Ulgeumsan(鬱金散), Yongnoisan(龍腦激) are used. 4. A coposition of the medication : Cheong-Yul medicine(淸熱藥), Bo-IK medicine(補益藥), Ji-Hyul medicine(止血藥), Gae-Gyu medicine(開竅藥), Su-sap medicine(收澁藥) are mainly used. Cheong-Yul medicine : Rehmanniae Radix(鮮地黃), Moutan Cotex(牧丹皮), Coptidis Rhizoma(黃連), Scutellariae Radix(黃芩) Bo-Ik medicine : Glycyrrhizae Radix(甘草), Angelicae gigantis Radix(當歸), Rehmanniae Radix Preparat(熟地黃), Ginseng Radix(人蔘) Ji-Hyul medicine : Biotae Cacumen(側柏葉), Sophorae Flos(槐花), Typhae Pollen(蒲黃) Gae-Gyu medicine : Moschus(麝香), Bomeolum(氷片) Su-sap medicine : Alumem(白礬) 5. A result of the observation on the medication : Taking a medicine for internal use : Glycyrrhizae Radix, Rehmanniae Radix Preparat, Rehmanniae Radix, Moutan Cortex, Scutellariae Radix are used. Yugmijihwangtang and Cheong-Yul medicine are mainly used. Taking a medicine for external use : Alumem, Moschus, Salt(鹽), Asari herba cum Radice(細辛) are mainly used. Especially there is a method that uses a burnt drug. Haamsoobup and taking a medicine for external use : Medicines of Cheong-Yul-Ryang-Hyul(淸熱凉血) and Su-Ryum-Ji-Hyul(收斂止血) are used.

• 대한본초학회지
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• 제22권4호
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• pp.81-86
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• 2007

Objectives : The purpose of this study is to examine the antioxidant activity in the germ cells of the extract of Rehmanniae Radix Preparat (RR). Methods : The extract was studied for diphenyl-picryl-hydrazyl (DPPH) radical scavenging activity, GC-1 cell viability by a modified MTT assay, the effects on H2O2-induced cytotoxicity by MTT assay and lipid peroixidation by malondialdehyde (MDA) formation, respectively. Results : The results showed that the extract scavenged DPPH radical in a dose-dependent manner by up to 43.1%. The extract at concentrations of 100 ${\mu}g/ml$ showed peak level of 136.5% in growth of GC-1 cell. The hydrogen peroxide-induced cytotoxicity was blocked by the extract at concentrations of 10, 50 and 100 ${\mu}g/ml$. The extract (50 and 100 ${\mu}g/ml$) also displayed a dose-dependent reduction of MDA formation on hydrogen peroxide-induced lipid peroxidation. Conclusions : In conclusion, the extract of Rehmanniae Radix Preparat has strong antioxidant activity.

• Environmental Analysis Health and Toxicology
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• 제22권3호
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• pp.255-261
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• 2007

본 연구에서는 건지황을 증숙하여 제조하는 숙지황 제조과정 동안의 중금속과 농약의 안전성을 평가하였다. 숙지황을 제조할 때 건지황을 황주로 9번 증숙하는 과정동안 증숙한 한국 시료의 평균은 As는 $0.147{\pm}0.007\;mg/L$이었으며, Cd는 $0.025{\pm}0.001\;mg/L$이었고, Pb는 $0.193{\pm}0.021\;mg/L$이었다. 또한 중국 시료의 평균은 As, Cd와 Pb가 각각 $0.0145{\pm}0.014\;mg/L,\;0.023{\pm}0.002\;mg/L$와 $0.299{\pm}0.013\;mg/L$이었다. 건지황을 숙지황을 제조하는 동안 중금속의 농도는 큰 변화가 없었다. 일반 시중 숙지황 중에서 As는 우리나라 시료는 평균 $0.106{\pm}0.052\;mg/L$이었으므로 As의 허용기준 3.0mg/kg에 3.53%이었으며, 중국 시료는 $0.135{\pm}0.011\;mg/L$이었으므로 As의 허용기준에 4.50%이었다. 우리나라와 중국의 숙지황 중 Cd농도는 허용기준 0.3 mg/kg에 각각 6.66%와 5.33%였다. Pb의 허용기준은 5.0 mg/kg인데 우리나라와 중국의 숙지황 중 Pb농도는 허용기준의 5.16%와 7.86%였다. 이와 같이 우리나라와 중국의 숙지황 중 중금속의 농도가 허용기준의 $3{\sim}8%$ 수준으로 매우 낮았으며, 이는 중금속으로부터 안전하였다. 우리나라 안동과 중국 하남의 건지황 중 잔류농약으로 Aldrin, $BHC-{\alpha},\;BHC-{\beta},\;BHC-{\gamma},\;BHC-{\delta}$, Captan, Chlorfenapyr, Chlorpyrifos, DDD, DDE, DDT-o,p, DDT-p,p, Dieldrin, Endosulfan-sulfate, $Endosulfan-{\alpha},\;Endosulfan-{\beta}$, Fenitrothion, Penthoate, Permethrin, Quintozene, Tolyfluanid와 Vinclozolin 등이 검출되지 않았다. 숙지황 제조에 사용된 황주 시료에도 이들 농약이 모두 동일하게 불검출로 나타났다. 따라서 이를 이용하여 제조한 숙지황에도 이들 농약이 불검출 되었다. 따라서 본 연구에서 검토된 우리나라와 중국지역의 건지황으로 제조된 숙지황은 중금속과 잔류농약이 식품의약안전청 기준에 적합한 안전성이 확인되었다.