• Journal of Animal Science and Technology
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• v.63 no.4
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• pp.934-953
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• 2021

Ciglitazone is a member of the thiazolidinedione family, and specifically binds to peroxisome proliferator-activated receptor-γ (PPARγ), thereby promoting adipocyte differentiation. We hypothesized that ciglitazone as a PPARγ ligand in the absence of an adipocyte differentiation cocktail would increase adiponectin and adipogenic gene expression in bovine satellite cells (BSC). Muscle-derived BSCs were isolated from six, 18-month-old Yanbian Yellow Cattle. The BSC were cultured for 96 h in differentiation medium containing 5 µM ciglitazone (CL), 10 µM ciglitazone (CM), or 20 µM ciglitazone (CH). Control (CON) BSC were cultured only in a differentiation medium (containing 2% horse serum). The presence of myogenin, desmin, and paired box 7 (Pax7) proteins was confirmed in the BSC by immunofluorescence staining. The CL, CM, and CH treatments produced higher concentrations of triacylglycerol and lipid droplet accumulation in myotubes than those of the CON treatment. Ciglitazone treatments significantly increased the relative expression of PPARγ, CCAAT/enhancer-binding protein alpha (C/EBPα), C/EBPβ, fatty acid synthase, stearoyl-CoA desaturase, and perilipin 2. Ciglitazone treatments increased gene expression of Pax3 and Pax7 and decreased expression of myogenic differentiation-1, myogenin, myogenic regulatory factor-5, and myogenin-4 (p < 0.01). Adiponectin concentration caused by ciglitazone treatments was significantly greater than CON (p < 0.01). RNA sequencing showed that 281 differentially expressed genes (DEGs) were found in the treatments of ciglitazone. DEGs gene ontology (GO) analysis showed that the top 10 GO enrichment significantly changed the biological processes such as protein trimerization, negative regulation of cell proliferation, adipocytes differentiation, and cellular response to external stimulus. Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that DEGs were involved in the p53 signaling pathway, PPAR signaling pathway, biosynthesis of amino acids, tumor necrosis factor signaling pathway, non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, and Wnt signaling pathway. These results indicate that ciglitazone acts as PPARγ agonist, effectively increases the adiponectin concentration and adipogenic gene expression, and stimulates the conversion of BSC to adipocyte-like cells in the absence of adipocyte differentiation cocktail.

• Proceedings of the Korea Technology Innovation Society Conference
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• 1998.05a
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• pp.23-23
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• 1998

1980년대 이후 계속된 디지털 기술의 발전과 영상처리 기술의 발전은 전통적으로 엄격히 분리 운영되어 온 통신과 방송의 융합화를 촉진하고 있으며, 기존의 미디어 질서를 근본적으로 변화시키고 있다. 이미 통신망과 방송망이 융합하여 하나의 망을 통해 방송서비스와 통신서비스를 동시 제공하는 것이 가능해지고 있으며, VOD, 인터넷방송, FM 방송전파를 통한 무선호출서비스 등 새로운 서비스가 등장하고 있다. 사업자측면에서는 통신사업자와 방송사업자가 상대영역에 진입하거나 M&A를 통해 양 분야의 서비스를 동시에 제공하는 사례가 증가되고 있다. 이에 따라 미국, 영국, 일본 등 선진국뿐만 아니라 EU 차원에서도 최근의 기술발전 추세와 산업계의 동향을 반영하여 통신사업자와 방송사업자간 상호진입 허용, 규제기구의 통합 등 기존의 규제제도를 전면적으로 재검토하고 있다. 미국의 1996년 통신법 개정, EU의 대체인프라스트럭쳐 자유화정책, 영국과 일본에서의 CATV망을 통한 통신서비스제공 허용 등이 그 대표적인 사례이다. 그러나 이러한 세계적인 흐름과 비교하여 볼 때 우리나라의 법/제도 정비 및 정책적 대응은 매우 미진한 상태이다. 현행법은 아직까지 통신망과 방송망간 융합, 사업자간 융합을 엄격히 규제하고 있으며, 서비스의 규제방식 등 통신·방송 융합시대에 대비한 규제제도 정비가 아직까지 미흡한 실정이다. 본 고에서는 통신·방송 융합의 배경과 전개과정, 국내외 융합추진 현황을 살펴보고, 통신·방송 융합 현상에 따른 규제제도상의 과제를 제시하고자 하였다.

• Journal of Biomedical Engineering Research
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• v.38 no.3
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• pp.89-94
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• 2017

In order to improve national competitiveness through technological research and development, the government puts in R&D budget every year and manages to improve the R&D results. Accordingly, various R&D project management methods have applied for successful advancement of technology and product. TRL is a measurement system developed by NASA to assess the maturity of technology since the 1970s. To apply medical device, the characteristics such as regulation, clinical trials are considered as a significant influence. In this study, we would like to derive PMI(performance measures index) for medical device R&D projects by using TRL and stage-gate model. As a result of this study, it is possible to use the PMI for decision making and evaluation in the R&D projects and believed that the objectivity can be ensured by the approval or certification of regulatory authority.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2002.11a
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• pp.45-57
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• 2002

Since a new entrant in the telecommunications market requires time in order to construct its own network, a requirement on the incumbent operator to implement carrier selection and pre-selection can enable a new entrant to immediately attract customers and earn revenue. Carrier selection can normally be accomplished in two ways, on a call-by-call basis or through carrel pre-selection. Call-by-call selection allows customers to choose a new entrant rather than the incumbent carrier using a specific code designated to the new carrier each time a call is made. Carrier Pre-Selection, on the other hand, allows customers directly connect to the network of one provider to have access automatically to another company's services when they pick up the phone to make certain types of calls. The carrier pre-selection option is generally considered to be a second regulatory step following the implementation of the call-by-call carrier selection option. Carrier pre-selection with the ability to override on a call-by-call basis for long distance, international, local, and fixed-to-mobile calls has now been implemented in many EU countries. This paper attempts to identify the issues in introducing CPS and to draw policy implications from other countries' experiences.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2003.11a
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• pp.41-53
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• 2003

The issues on the interconnection of telecommunications network are recently prevailed in the IT industry. In this study, we classify the network interconnection system into two categories: two way-same price model and two way-different price model. The purpose of this paper is to analyze economic characteristics of optimal settlement system according to each model. One of the most important policy implications we derive through this study is that symmetry between enterprises is required for policy maker or regulatory agency to set an efficient settlement system under two way-same price model, but that symmetry is not necessarily required under two way-same price model.

• The Journal of Industrial Distribution & Business
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• v.13 no.8
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• pp.29-50
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• 2022

Purpose - This study aims to investigate factors affecting Chatbot service acceptance attitude. For wide use of Chatbot service, firms need to find barriers or obstacles for customers, if any, not to use Chatbot service. Research design, data, and methodology - We apply value-based accept model to investigate the quality of Chatbot, to verify the meaning of service value of Chatbot and to find the relationship among variables. To test hypotheses, we conducted survey. We collected 300 questionnaires. SPSS version 2.0 is used. Regression analysis, moderating effect test is conducted. Results - 4 Qualities of Chatbot, Ease of use, Usefulness, Enjoyment, Interaction are affecting acceptance attitude, and 5 service values, only interaction does not affect emotion. Trust, Specialty, Necessity, Social, Emotion moderating Chatbot service to accepting attitude. Regarding moderating effects by personal characteristics and personal tendency, innovation resistance, innovativeness, and social effects are turned to have influence while regulatory focus, construal level does not have moderating force. Also, the auxiliary service like Chatbot service affects customers' evaluation on the main service quality. Conclusions - Service firms adopt Chatbot service for various purposes. The results imply that customers are generally recognize the merits of Chatbot, but there are some barriers such as innovation resistance characteristic especially uncomfortable.

• Journal of Radiopharmaceuticals and Molecular Probes
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• v.9 no.1
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• pp.49-55
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• 2023

Tumors are encircled by various non-cancerous cell types in the extracellular matrix, including fibroblasts, endothelial cells, immune cells, and cytokines. Fibroblasts are the most critical cells in the tumor stroma and play an important role in tumor development, which has been highlighted in some epithelial cancers. Many studies have shown a tight connection between cancerous cells and fibroblasts in the last decade. Regulatory factors secreted into the tumor environment by special fibroblast cells, cancer-associated fibroblasts (CAFs), play an important role in tumor and vessel development, metastasis, and therapy resistance. This review addresses the development of FAP inhibitors, emphasizing the first, second, and latest generations. First-generation inhibitors exhibit low selectivity and chemical stability, encouraging researchers to develop new scaffolds based on preclinical and clinical data. Second-generation enzymes such as UAMC-1110 demonstrated enhanced FAP binding and better selectivity. Targeted treatment and diagnostic imaging have become possible by further developing radionuclide-labeled fibroblast activation protein inhibitors (FAPIs). Although all three FAPIs (01, 02, and 04) showed excellent preclinical and clinical findings. The final optimization of these FAPI scaffolds resulted in FAPI-46 with the highest tumor-to-background ratio and better binding affinity.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.50 no.2
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• pp.153-161
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• 2024

Vitamin D is a fat-soluble vitamin that is mainly produced in the skin by UV rays. Along with melatonin, it is a representative chronobiotic substance, and the skin plays an important role in distinguishing between day and night. However, vitamin D cannot be used directly in cosmetics because it is a vitamin that acts as a coenzyme and plays a hormonal role in regulating the expression of various types of genes. Therefore, it was to investigate the skin efficacy of provitamin D (7-dehydrocholesterol), a vitamin D precursor that can be used in cosmetics. Our findings reveal that pro vitamin D can effectively inhibit the expression of tyrosinase, the melanin-producing enzyme, thereby attenuating melanin synthesis. This skin tone regulatory effect has been corroborated in vitro using artificial skin models. Additionally, pro vitamin D demonstrated anti-inflammatory properties by suppressing the expression of TNFa and, upon conversion to vitamin D through UV exposure, it was observed to induce the production of the antimicrobial peptide CAMP (LL-37). The inhibitory effect of pro vitamin D on melanin production appears to be a result of it reducing the UV absorption capacity of melanin, thereby inducing the conversion of pro D to vitamin D. Utilizing pro vitamin D in cosmetic formulations could not only modulate skin tone and enhance skin immunity but also expect to contribute to other cutaneous benefits as anti-aging and barrier function improvement with everyday UV exposure. This multifaceted efficacy positions pro vitamin D as a promising ingredient in advancing the formulation of skin care products.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.18 no.4
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• pp.165-175
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• 2023

In venture creation research, studying 'entrepreneurial leadership' is important for uncovering and comprehending the underlying causal process in innovative behavior performance. Although previous studies provide that entrepreneurial leadership enhances followers' innovative behavior, there is few research on entrepreneurial leadership and followers' characteristics interaction. The present study's focus is paradoxical effects of entrepreneurial leadership on self-efficacy and innovative behavior. On the basis of individual regulatory focus, this study suggests that interaction effects of entrepreneurial leadership and followers' regulatory focus differed in promotion view and prevention view followers' innovative behavior. To strengthen the casual mechanism, this study conducted in priming experiment method using employees in SMEs. This study used a 2(entrepreneurial leadership vs. control) x 2 (regulatory focus: promotion vs. prevention) between-participants design. The results of this study provide that (1) Individuals in promotion focus especially benefited from entrepreneurial leadership in terms of its effect on their self-efficacy and innovative behavior; (2) whereas entrepreneurial leadership was negatively related to self-efficacy and innovative behavior of followers' prevention focus. In sum, results of the present study supporting evidence for hypotheses, combined effect of entrepreneurial leadership and regulatory focus on innovative behavior through self-efficacy. Experimental results confirmed hypotheses of this study, revealing that promotion focus show more innovative behavior than prevention focus when their leaders' leadership style is entrepreneurial leadership. Also, the paradoxical effect of entrepreneurial leadership and regulatory focus of followers on innovative behavior was mediated by followers' self-efficacy. This study helps explain how leaders' entrepreneurial leadership boost followers' innovative behavior, particularly for those employees who have promotion focus. The current study contributes to the theory of entrepreneurial leadership and regulatory focus and innovation literature. Findings of this study shed light on the organizational processes that shape innovative behavior in venture/startup corporations and provide contributions for venture business field.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.10 no.6
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• pp.215-223
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• 2015

Recently, in OECD countries, youth unemployment has become one of the most serious problems in society. Entrepreneurship creates innovative new companies that create more jobs than big traditional companies. In addition, entrepreneurship develops creative human resources leading to fertile ground for new technology and business innovation. Recently, regulatory theory has drawn a lot of attention and interest in the literature of psychology and marketing management. However, the theory has not been applied to the study of entrepreneurship. In this article, we try to examine the relationship among regulatory focus, entrepreneurial orientation, and entrepreneurial intentions of korean college students who show their interests in entrepreneurship. From our empirical study, we find the followings. First, promotion focus thriving on optimism, taking risks, and trying new actively affect positively on entrepreneurial orientation and entrepreneurial intention. Second, prevention focus concentrating on security, fulfilling responsibilities and maintaining efficiency does not always affect negatively on entrepreneurial orientation and entrepreneurial intention. In other words, prevention-focused students do not always have bad impression on entrepreneurship and may consider entrepreneurship as viable career path similar to average college students. Third, our empirical findings are consistent with previous studies that entrepreneurial intention is positively affected by entrepreneurial orientation.