• Title/Summary/Keyword: Regulatory

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Accelerated Evolution of the Regulatory Sequences of Brain Development in the Human Genome

  • Lee, Kang Seon;Bang, Hyoeun;Choi, Jung Kyoon;Kim, Kwoneel
    • Molecules and Cells
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    • v.43 no.4
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    • pp.331-339
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    • 2020
  • Genetic modifications in noncoding regulatory regions are likely critical to human evolution. Human-accelerated noncoding elements are highly conserved noncoding regions among vertebrates but have large differences across humans, which implies human-specific regulatory potential. In this study, we found that human-accelerated noncoding elements were frequently coupled with DNase I hypersensitive sites (DHSs), together with monomethylated and trimethylated histone H3 lysine 4, which are active regulatory markers. This coupling was particularly pronounced in fetal brains relative to adult brains, non-brain fetal tissues, and embryonic stem cells. However, fetal brain DHSs were also specifically enriched in deeply conserved sequences, implying coexistence of universal maintenance and human-specific fitness in human brain development. We assessed whether this coexisting pattern was a general one by quantitatively measuring evolutionary rates of DHSs. As a result, fetal brain DHSs showed a mixed but distinct signature of regional conservation and outlier point acceleration as compared to other DHSs. This finding suggests that brain developmental sequences are selectively constrained in general, whereas specific nucleotides are under positive selection or constraint relaxation simultaneously. Hence, we hypothesize that human- or primate-specific changes to universally conserved regulatory codes of brain development may drive the accelerated, and most likely adaptive, evolution of the regulatory network of the human brain.

Influence of Envy Types, Brand Awareness, and Regulatory Focus Chronic on Favorability of Luxury Fashion Brand -Focused on Social Network Service Users- (선망(Envy)의 유형과 브랜드 인지도, 조절초점성향이 패션 명품 브랜드의 호의도에 미치는 영향 -SNS 사용자를 대상으로-)

  • Baek, Hye Suk;Hwang, Sun Jin
    • Journal of the Korean Society of Clothing and Textiles
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    • v.42 no.1
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    • pp.1-13
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    • 2018
  • The influence of the emotion of envy as a variable in the brand attitude has increased. This study validates the influence of envy types, brand awareness, and regulatory focus chronic of consumers on favorability of luxury fashion brand. This study was designed with the mixed factorial design of 2 (envy types: benign vs malicious) ${\times}$ 2 (brand awareness types: high vs low) ${\times}$ 2 (regulatory focus chronic types: promotion focus vs prevention focus). The data for this research was collected from a questionnaire distributed to 302 subjects aged between 20 and 39 in the Seoul and Gyeonggi areas; consequently, a total of 275 data were analyzed. Data were analyzed with SPSS 23 program and three-way ANOVA, Simple interaction effects and simple main effects analysis were conducted. The results of this research were as follows. First, envy type and brand awareness showed significant interaction for the favorability of a luxury fashion brand. Second, envy type, brand awareness, and consumers' regulatory focus chronic showed significant interaction on the favorability of luxury fashion brand. Based on the findings, the characteristics of consumers' regulatory focus in brand attitude must be taken into consideration by luxury fashion brand marketers. The use of SNS strategies to induce emotions of benign envy through the comparisons to close acquaintances is recommended in order to raise brand preferability.

A Study on Adaptability Inquire & Promotable Method for “A Construction Permit Consent & Use Admission Consent” (건축허가동의 및 사용승인 동의에 대한 순응도 조사 및 제고방안에 관한 연구)

  • 이수경;하동명;김태환
    • Fire Science and Engineering
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    • v.16 no.3
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    • pp.39-47
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    • 2002
  • The government is propelling regulatory reform in priority that abrogate (8,121 an item in 14,186) improve (6,065 an item in 14,186) administrative regulation. But In spite of many regulatory reform results, successive diminution of regulatory reform is low because that modification of bureaucracy's execution don't support or a concerned group of gain and loss resists. In the future, regulatory reform must perform continuously promote. At the same time, the people, enterprises & public service manage diversified a regulatory adaptation countermeasure. In this study, grasp the present condition at A Construction Permit Consent & Use Admission Consent and would present the promotable method in analysis synthetically & systematically about cognizance, recognition & observance of a administrative regulation.

The Influence of Regulatory Focus, Self-regulated Learning and Academic Burnout on Academic Achievement (조절초점, 자기조절학습 및 학업소진이 학업성취에 미치는 영향)

  • Jung, Eun-Sun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.14 no.11
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    • pp.5455-5464
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    • 2013
  • The purpose of the present study was to investigate the role of self-regulated learning and academic burnout on the relationship between regulatory focus and academic achievement. The participants of this study were 312 university students and analyses for this study was conducted by using PASW 18.0 and Amos 8.0. The major achievements were as follows; Self-regulated learning confirmed mediating variable between regulatory focus and academic burnout, and academic burnout confirmed mediating variable between self-regulated learning and academic achievement. That is, regulatory focus had some effect on academic achievement through academic burnout based on self-regulatory learning. Finally, the needs of development about the counseling and the education approaches as a special intervention was discussed, and that approaches were reflected self-regulated learning to be improved and academic burnout to be reduced. Also, limitations and implications of subsequent further study were suggested in this research.

Moderating effect of regulatory focus on public acceptance of nuclear energy

  • He, Yanling;Li, Yazhou;Xia, Dongqin;Zhang, Tingting;Wang, Yongliang;Hu, Li;Gu, Jibao;Wu, Yican
    • Nuclear Engineering and Technology
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    • v.51 no.8
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    • pp.2034-2041
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    • 2019
  • Public acceptance has become the most critical question for sustainable development of nuclear energy in recent decades. Many researches concentrated on risk and benefit perception, which were deemed as the most influential factors of Public Acceptance of Nuclear Energy (PANE). But few researches focused on psychological factors including regulatory focus. Therefore, this paper aimed to explore the moderating effect of regulatory focus on PANE based on Regulatory Focus Theory in order to find ways to increase/decrease PANE. An Internet-based survey had been carried out in China nationwide. The results indicated that trust in government was positively related to PANE and this relationship was mediated by risk and benefit perception. In addition, the strength of the associations between risk and benefit perception and PANE were moderated by regulatory focus, consisting of prevention focus and promotion focus. Prevention focus strengthened the negative relationship between risk perception and PANE, while promotion focus weakened. Moreover, promotion focus weakened the positive relationship between benefit perception and PANE, but no significant moderating effect of prevention focus was founded on the relationship between benefit perception and PANE. Some policy implications were also proposed on the basis of above-mentioned findings.

The Effect of Ethical Leadership on Leader Identification, Regulatory Focus, and Task Performance (윤리적 리더십이 리더동일시, 조절초점 및 업무성과에 미치는 영향에 관한 연구)

  • Ryou, Ki-Dong;Kim, Jeong-Sik
    • The Journal of the Korea Contents Association
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    • v.18 no.1
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    • pp.607-622
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    • 2018
  • In this study, we investigated path that influence task performance through mediation of leader identification, regulatory focus (promotion focus and prevention focus). The results of this study are summarized as follows. First, ethical leadership has a positive effect on leader identification. Second, leader identification has played a crucial role in the relationship between ethical leadership and regulatory focus, and regulatory focus also have an important mediating effect on the relationship between leader identification and task performance. These results show that leader identification, regulatory focus play as an important mediator in relationship between ethical leadership and task performance.

Development of Program for Enhancing Learners' Mathematics Learning Motivation and Analysis of Its' Effects (수학 학습 동기 증진 프로그램 개발 및 적용 효과 분석)

  • Kim, Bumi
    • School Mathematics
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    • v.18 no.2
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    • pp.397-423
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    • 2016
  • Mathematics learning motivation is an important variable which is not only the primary goal of learning mathematics but also mediates the effects of the mathematics learning. Nevertheless, the present learning environment is full of impeding factors which reduce learners' motivation to learn mathematics and mathematical self-regulatory efficacy. The purpose of this study is to offer various suggestions for program to enhance and forster mathematics learning motivation based on empirical findings and theories on motivation, self-regulatory learning, regulatory focus, reducing academic stress and math anxiety. The concrete and practical ideas are suggested in terms of mathematical self-regulatory efficacy, learners' characteristics, learning task. The analysis of the effects revealed a positive effect on mathematical self-regulatory learning.

Study on Consumer Exposure to Sun Spray and Sun Cream in South Korea

  • Oh, Mihyun;Kim, Seoyoung;Han, Jieun;Park, Sodam;Kim, Go Un;An, Susun
    • Toxicological Research
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    • v.35 no.4
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    • pp.389-394
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    • 2019
  • When conducting risk assessments of cosmetic ingredients, it is important that reliable exposure information is obtained for cosmetic products. As cosmetics are becoming more diverse, continuous effort must be made to obtain exposure data that reflect their growth and usage trends. The usage pattern of cosmetics, such as the application area and amount used, may differ by product type and also by country. We conducted a survey to compare the amount of sun spray and sun cream used in a usage environment in South Korea. The study was conducted on Haeundae Beach, one of the most popular beaches in South Korea. A total of 1,255 beachgoers participated in this study; 604 and 651 participants used the sun spray and sun cream, respectively, while sunbathing and enjoying water activities on the beach for one day. Exposure was analyzed following a probabilistic method. On comparing all subjects, it was found that the group that used sun spray (mean: 44.52 g/day) used significantly more product (p = 0.000) than those who used sun cream (mean: 20.51 g/day). By analyzing the daily exposure of sun spray and sun cream per unit body weight according to age and gender, the exposure amount of sun spray and sun cream was found to be highest among 2~9 year-old girls (mean for sun spray: 2.51 g/kg/day, p95: 5.50 g/kg/day, mean for sun cream: 0.79 g/kg/day, p95: 1.79 g/kg/day). The amount of sun spray used is approximately twice that of sun cream. Among both the sun spray and sun cream groups, the exposure amount per unit body weight was highest in girls younger than 10. These factors should be considered when conducting risk assessments of sun spray and sun cream.

The Effects of Regulatory Focus on Proactive Behavior: A Moderated Mediation Model of Work Hope and Interpersonal Justice (조절초점이 주도적 행동에 미치는 영향: 일 희망과 대인 공정성의 조절된 매개효과)

  • Park, Ji-Hwan;Jeon, Moo-Kyeong
    • Asia-Pacific Journal of Business
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    • v.13 no.3
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    • pp.261-279
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    • 2022
  • Purpose - The purpose of this study was to examine the effect of regulatory focus on proactive behavior and to examine the mediating effect of work hope between superior's regulatory focus and subordinate's proactive behavior. In addition, the purpose of this study was to investigate the moderating effect of interpersonal justice between regulatory focus and work hope, and the moderated mediating effect of work hope and interpersonal justice in the relationship between regulatory focus and proactive behavior. Design/methodology/approach - This study used data 255pairs(510people) collected from Public organizations such as gu office and private organizations that perform various tasks such as human resources, finance, accounting, marketing, and R&D. The Confirmatory Factor Analysis (CFA) and the multiple regression analysis were used in order to analyze the data. Findings - The result showed that promotion focus was positively related to proactive behavior. In addition, this study found that the relationship between promotion focus and proactive behavior was mediated by work hope. Regarding the moderating roles of perceived interpersonal justice, the results showed that perceived interpersonal justice significantly interacted with promotion focus in influencing work hope. Finally, the moderated mediation analysis showed that the indirect effect of promotion focus on proactive behavior through work hope was valid only for subordinates with high perceived interpersonal justice. Research implications or Originality - In order to increase proactive behavior, it is necessary to focus on promotion focus and to increase the positive psychology such as hope. In addition, it is necessary to increase perception of interpersonal justice.

A Study on Relationship Between Psychological Ownership & Customer Satisfaction in Service Enterprise Employees (서비스기업 종사원의 심리적 주인의식과 소비자만족에 관한 연구)

  • Lee, Jung-Lim;Kim, Hyoung-Gil;Kim, Jae-Gyun
    • Journal of Distribution Science
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    • v.14 no.3
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    • pp.93-101
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    • 2016
  • Purpose - Due to the heavy reliance on the human dependence, several factors such as attitude, behavior, emotional status and the quality of the service by the employees have been a decisive effect on the existence of a business in service industry. This study made use of the cases from the beauty salons in Korea, and tried to find out the meaningful results with following purposes. The purpose of this study is to find out the effects of psychological ownership with focusing on the employees in service industry. Therefore, this study is based on the literature reviews in the fields of psychological ownership, regulatory focus, and customer satisfaction. In particular, this study focuses on the regulatory focus with two parts. The two parts are composed of the promotion focus and prevention focus. Also, the relationship between the regulatory focus on employee and customer satisfaction was identified through empirical study. Mediating effects of regulatory focus were also studied, that is, the regulatory focus was on the relationship between psychological ownership and customer satisfaction. In conclusion, practical and intellectual implications were discussed for the growth and development in service industry. Research design, data & methodology - The survey for this study was conducted from November 15th to December 15th in 2015. The same amount of survey was given to both, the service providers and customers. For both of them, such as the service providers and customers, 260 questionnaires were distributed to them in total. After excluding the missing and unreliable responses for the exact analysis and process, 250 responses were collected and used in the research analysis. This study conducted a survey questionnaires, and the confirmatory analysis was used for the reliability and validity in this study. SPSS & AMOS programs were used for the analysis. Results - The first variable that was looked at from this study is the psychological ownership. The psychological ownership had positive effects on the performance both in improving focus and prevention focus. It indicates that this study supports the results from the previous studies. Second, the effects on the performance in improving focus and prevention focus for customer satisfaction were studied. As a result, the performance in improving focus had positive effect on customer satisfaction, but prevention focus did not have any positive effect. Third, this study looked at the mediating effect of regulatory focus on the relationship between the psychological ownership and the customer satisfaction, and only partly, they had positive effects on customer satisfaction. Conclusions - The results of this study showed that the psychological ownership has positive effects on regulatory focus both in performance improving focus and prevention focus. However, the mediating effects had partial positive effects on customer satisfaction and these results indicate that the service enterprises should focus on the employees' psychological ownership in order to maximize the customers' satisfaction.