• Asian Pacific Journal of Cancer Prevention
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• 제15권23호
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• pp.10355-10361
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• 2015

Background: MicroRNAs (miRNAs) are small non-coding RNA molecules found in multicellular eukaryotes which are implicated in development of cancer, including cutaneous squamous cell carcinoma (cSCC). Expression is controlled by transcription factors (TFs) that bind to specific DNA sequences, thereby controlling the flow (or transcription) of genetic information from DNA to messenger RNA. Interactions result in biological signal control networks. Materials and Methods: Molecular components involved in cSCC were here assembled at abnormally expressed, related and global levels. Networks at these three levels were constructed with corresponding biological factors in term of interactions between miRNAs and target genes, TFs and miRNAs, and host genes and miRNAs. Up/down regulation or mutation of the factors were considered in the context of the regulation and significant patterns were extracted. Results: Participants of the networks were evaluated based on their expression and regulation of other factors. Sub-networks with two core TFs, TP53 and EIF2C2, as the centers are identified. These share self-adapt feedback regulation in which a mutual restraint exists. Up or down regulation of certain genes and miRNAs are discussed. Some, for example the expression of MMP13, were in line with expectation while others, including FGFR3, need further investigation of their unexpected behavior. Conclusions: The present research suggests that dozens of components, miRNAs, TFs, target genes and host genes included, unite as networks through their regulation to function systematically in human cSCC. Networks built under the currently available sources provide critical signal controlling pathways and frequent patterns. Inappropriate controlling signal flow from abnormal expression of key TFs may push the system into an incontrollable situation and therefore contributes to cSCC development.

• Journal of Families and Better Life
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• 제29권6호
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• pp.55-69
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• 2011

The purpose of this study was to explore the effects of difficult temperament and mothers' reactions to child negative emotion on child emotion regulation strategies. Mothers of 253 preschoolers(Mage=4.04yrs.) responded to questionnaires on child temperament, mothers' reactions to child negative emotion, and child emotion regulation strategy. The results of regression analysis revealed that; 1) child difficult temperament positively predicted child's aggressive or outburst/appealing strategies whereas negatively predicted avoidance/none strategy; 2) child difficult temperament was not the variable predicting positive coping strategy, but mothers' emotion-focused or problem-focused reactions predicted child positive coping strategy whereas punitive or distress reactions predicted either aggressive or avoidance/none strategy; 3) child temperament moderated the link between mothers' reactions to child's negative emotion expression and child emotion regulation strategies. In particular, children with higher difficult temperament showed higher aggressive strategy under mothers' higher distress or punitive reaction and lower emotion focused or problem focused reaction. On the other hand, children with lower difficult temperament only showed avoidance/ none strategy when mothers showed higher minimization or punitive reaction. The results of current study underscore both child temperament, mothers' reactions and their interactions in predicting child emotion regulation strategies.

• Human Ecology Research
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• 제52권1호
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• pp.1-10
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• 2014

The purpose of this study was to analyse the principles and methods of Taegyo-Singi with regard to emotion and to review basic informations on Taegyo programs for promoting prenatal development. Taegyo-Singi was analyzed as follows. First, the contents of Taegyo-Singi were classified into principles and methods of Taegyo. Second, the domains of emotion were categorized into emotional perception, emotional expression, emotional understanding, and emotional regulation based on the classification of Mayer and Salovey, and Moon. Third, the contents of Taegyo-Singi were classified into the four domains of emotion. Finally, the reliability and validity of the classification were obtained through inter-rater agreement and analysis of content validity. The results indicated that first, the principles of Taegyo presuppose parental influence on temperament formation, and that the emotional states of the mother in the prenatal and prepregnancy period is the most influential variable in a child's temperament formation. Second, the methods of Taegyo presuppose that the human mind interacts with their behavior. Therefore, through emotional support of family members, 'jon-sim (the serene mind)' and 'chung-sim (the mind from rectitude)' are the key methods of Taegyo. This means that the Korean tradition of Taegyo focused on the emotional domain of development, especially emotional regulation. This coincides with the emotion-focused temperament theory that individual differences in temperament reflect individual differences in emotion.

• Transactions of the Korean Society of Automotive Engineers
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• 제18권2호
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• pp.31-38
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• 2010

Bus manufacturers have tested and studied the dynamic collapse behavior of a bus body structure in rollover since UN ECE established ECE Regulation 66 to provide the requirement for the strength of bus structure. In spite of the costly cycles of practical tests, however, it is still a hard task to meet the rollover regulation by means of local reinforcements in the bus structure. Therefore it is necessary to develop a well designed strategy for the rollover strength implemented in the early stage of vehicle development. In this study, the suitable development method for each design stage from a component to complete body structure was considered to make a well-established development process of a bus body structure for rollover safety. For the efficient approach of the concept design stage, a numerical model based on the plastic hinge theory was used instead of detailed shell models. After setting up the concept design for the component size and geometry, the shell model was used to confirm and optimize the whole structure composition. The process developed in this study was practically used as an effective method to predict the rollover behavior of a new bus body structure.

• International Journal of Automotive Technology
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• 제2권2호
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• pp.39-45
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• 2001

Hydrogen is seen as one of the important energy vectors of the next century. Hydrogen as a renewable energy source, provides the potential for a sustainable development particularly in the transportation sector. Hydrogen driven vehicles reduce both local as well as global emissions. The laboratory of transporttechnology (University of Gent) converted a GM/Crusader V-8 engine for hydrogen use. Once the engine is optimised, it will be built in a low-floor midsize hydrogen city bus for public demonstration. For a complete control of the combustion process and to increase the resistance to backfire (explosion of the air-fuel mixture in the inlet manifold), a sequential timed multipoint injection of hydrogen and an electronic management system is chosen. The results as a function of the engine parameters (ignition timing. injection timing and duration, injection pressure) we given. Special focus is given to topics related to the use of hydrogen as a fuel: ignition characteristics (importance of electrode distance), quality of the lubricating oil (crankcase gases with high contents of hydrogen), oxygen sensors (very lean operating conditions), noise reduction (configuration and length of inlet pipes). The advantages and disadvantages of a power regulation only by the air to fuel ratio (as for diesel engines) against a throttle regulation (normal gasoline or gas regulation) are examined. Finally the goals of the development of the engine are reached: power output of 90 kW, torque of 300 Nm, extremely low emission levels and backfire-safe operation.

• Nuclear Engineering and Technology
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• 제40권5호
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• pp.349-364
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• 2008

Over the years, probabilistic risk assessment (PRA) research activities conducted at the U.S. Nuclear Regulatory Commission (NRC) have played an essential role in support of the agency's move towards risk-informed regulation. These research activities have provided the technical basis for NRC's regulatory activities in key areas; provided PRA methods, tools, and data enabling the agency to meet future challenges; supported the implementation of NRC's 1995 PRA Policy Statement by assessing key sources of risk; and supported the development of necessary technical and human resources supporting NRC's risk-informed activities. PRA research aimed at improving the NRC's understanding of risk can positively affect the agency's regulatory activities, as evidenced by three case studies involving research on fire PRA, human reliability analysis (HRA), and pressurized thermal shock (PTS) PRA. These case studies also show that such research can take a considerable amount of time, and that the incorporation of research results into regulatory practice can take even longer. The need for sustained effort and appropriate lead time is an important consideration in the development of a PRA research program aimed at helping the agency address key sources of risk for current and potential future facilities.

• Environmental and Resource Economics Review
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• 제11권2호
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• pp.233-260
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• 2002

This paper tries to analyze the efficiency structure and regulatory effects in electric power industry by using total factor productivity and indices based on cost function method. This paper performed an empirical analysis on the efficiency improvement and optimal scale taking the cost aspect in electricity industry into account. By expanding the cost structure framework, this paper proposes the analytical method regarding the needs of technology regulation and presents the empirical results which can be verified. Hence, this work can play a key role in decision-making of the national power development and regulatory policy. The empirical result indicates that the electricity industry in Korea has been in the state of economies of scale until 1980s, However, due to sustained growth of power generation, economies of scale declined and subsided after 1980s and then diseconomies of scale is shown recent years. The analysis on the effect of technology regulation shows the national large-scale base-load power plant development-oriented policy until so far contributed substantial cost effect to the electricity industry. The empirical result indicates that the reserve requirement as one of means of technology regulation policy did not contribute to the economies of scale but positive effect on the total factor productivity in Korea.

• International Journal of Internet, Broadcasting and Communication
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• 제9권2호
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• pp.27-36
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• 2017

The world's unique geographical, multilingual, multiethnic, multiracial and multi religious Himalayan country Nepal has more than 100 years history on telephony service and it has been formulating appropriate policy and regulation for the adoption of new technology, introducing the competitive market environment for the overall development of Information and Communication Technology (ICT) infrastructures and application of ICT service and tools for socio-economic transformation. The Nepalese market seems to be continuously growing and having huge demand of mobile telephony and internet subscriptions trend. The ICT infrastructure development in difficult geographical area is quite challenging and thus operators are focusing mobile telephony and mobile internet services. Nepal has been doing its best effort on formulating policy and regulation, adoption key strategies for ICT sector development and at the same time joining hands with international and regional bodies such as ITU, SAARC etc for ICT sector development. Due to geographical diversity, policy and regulatory barriers in some extent, power supply constraints and low affordability from customers on ICT tools and services, Nepal has been facing challenges on ICT infrastructure development. However, the national statistics on ICT, Networked Readiness Index and ICT Development Index show that Nepal has done quite good progress and is keeping its pace on ICT development despite the these challenges. Moreover, there seems to be quite uncovered market segments on internet service and big opportunity on ICT sector development in Nepal in the days to come.

• Journal of Korean Public Health Nursing
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• 제29권3호
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• pp.441-451
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• 2015

Purpose: This study was conducted in order to examine the multiple mediated effects of self-regulation and hopelessness between self efficacy and internet game addiction in middle school students. Methods: The participants were 458 middle school students in G City, South Korea. Multiple mediation was analyzed using Indirect SPSS macro and the bootstrapping method. Results: Significant negative correlations were observed for internet game addiction, self-efficacy, and self-regulation. Self-efficacy and self-regulation were positively correlated. Self-efficacy showed a direct effect on Internet game addiction. The results of the indirect effects of all mediators showed the mediated effect of self-regulation (estimated effect=-.11, 95% CI[-.20, -.03]) and hopelessness(estimated effect=-.06, 95% CI[-.12, -.01]). Conclusion: Based on these study results, we suggest that self-efficacy should be examined to prevent development of Internet game addiction in middle school students. It is necessary to provide Internet game addiction preventive programs focusing on changing the self-regulation and relieving the feelings of hopelessness.

• Archives of Pharmacal Research
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• 제22권1호
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• pp.1-8
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• 1999

Transforming growth factor-$\beta$ (TGF-$\beta$) is the prototypical multifunctional cytokine, participating in the regulation of vital cellular activities such as proliferation and differentiations as well as a number of basic physiological functions. The effects of TGF-$\beta$ are critically dependent on the expression and distribution of a family of TGF-$\beta$ receptors, the TGF-$\beta$ types I, II, and III. It is now known that a wide variety of human pathology can be caused by aberrant expression and function of these receptors. the coding sequence of the type II receptor (RII) appears to render it uniquely susceptible to DNA replication errors in the course of normal cell division. By virtue of its key role in the regulation of cell proliferation, TGF-$\beta$ RII should be considered as a tumor suppressor gene. High levels of mutation in the TGF-$\beta$ RII gene have been observed in a wide range of primarily epithelial malignancies, including colon and gastric cancer. It appears likely that mutation of the TGF-$\beta$ RII gene may be a very critical step in the pathway of carcinogenesis.