• Biomedical Science Letters
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• v.27 no.2
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• pp.77-87
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• 2021

Reflux esophagitis (RE) is a disease that stomach contents, stomach acid, and pepsin continually refluxing and is curently increasing worldwide. This study was conducted to find natural materials that can reduce side effects and effectively treat RE. Animal experiments were conducted with a 1:1 (EA1), 1:5 (EA5) ratio of Evodiae Fructus and Arecae Semen known to be effective against reflux esophagitis. As a result of confirming the total lesion of the esophageal mucosa after EA1 or EA5 treatment in reflux esophagitis animals, it showed superior improvement compared to the RE-control rats. In addition, by regulating the expression of MPO and NADPH oxidase, the activation of NF-κB was inhibited, and the expression of COX-1 and COX-2 was regulated. Moreover, its improved esophageal barrier function through regulating protein expressions of tight junction protein and MMPs/TIMPs. Taken together, a mixture of Evodiae Fructus and Arecae Semen can attenuate the damage to the esophageal mucosa that not only inactivationed the NF-κB through oxidative stress control, but also by regulating tight junctions and MMPs/TIMPs. This effect was more excellent in the 1:1 mixture (EA1) than in the Evodiae Fructus and Arecae Semen 1:5 mixture (EA5).

• Journal of Korean Society for Quality Management
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• v.50 no.2
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• pp.221-233
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• 2022

Purpose: This study investigates how the salespersons behave in coordinating the multiple communication channels during supplier integration (SI) for new product development (NPD), especially when their engineers directly collaborate with the buyer. Methods: This study conducted a qualitative study to explore the dynamics of the supplier's salespersons during SI for NPD. With the support of a consumer goods manufacturer (focal firm) in South Korea, we interviewed several managers, including purchasing and engineering, from the focal firm and salespersons from eight tier-1 suppliers of the focal firm. Results: The results found that the supplier's salespersons show two different behaviors toward managing and controlling the collaboration between their engineers and the buyer: (1) Process regulating behaviors that control the flows of information or communication between the engineers and the buyer, and (2) knowledge regulating behaviors that directly and indirectly support the engineers to be equipped with accurate and complete knowledge so that they can share the right knowledge with the buyer. Conclusion: This study contributes to academia and practitioners as follows. To academia, this study fill the gap in the literature by introducing the distinct behaviors of the supplier's salesperson in SI for NPD. To practitioner, in addition, our findings present coordination mechanisms to manage and control multiple communications within an inter-organizational collaboration.

• Korean Journal of Adult Nursing
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• v.19 no.3
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• pp.483-494
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• 2007

Purpose: The objective of the study is to describe the experience of health care activities of the menopausal women through phenomenological methodology. Methods: Seven menopausal women participated in the study. Open in-depth interviews were used to collect data, and data were analyzed by the phenomenological methods suggested by Colaizzi. Results: The data were separated into 4 categories of uncomfortable life due to physical and emotional change, building consistency in daily life through regulating a routine rhythm, recovering normality, recovering stability, and 8 clusters of themes; securing regularity in daily life, securing availability in daily life, regulating through elimination and diminishment, regulating through supplementation, being patient and control self, expressing self, review the context and exchanging views, expending a world through one's faith. Conclusion: Participants accepted menopause not as a disease but as a natural course of life and realized that menopausal health problems could be naturally settled in general health care activities in daily life.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.25 no.7
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• pp.398-405
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• 2013

Small and medium-size buildings employ a multi-distributed individual air-conditioning system that utilizes package air conditioners instead of centralized cooling systems, which can allow easier building management and maintenance, along with a diversification of facility use. Inverter driven system heat pumps have been developed to achieve not only an easy distribution control, allowing free combination of indoor units with different models and different capacities, but also wide applications to intelligent air conditioning. However, the control algorithms of the system heat pump are limited in the open literature, due to complicated operating conditions. In this paper, an inverter-driven system heat pump having two indoor units with electronic expansion valves (EEV) was simulated in the cooling mode. An integral optimum regulating controller employing the state space control method was also simulated, and applied to the system-heat pump system, to obtain efficient control of the MIMO (multi input multi output) system. The simulation model for the controller yielded satisfactory prediction results. The new control model can be successfully utilized as a basic tool in controller design.

• Journal of architectural history
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• v.12 no.1 s.33
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• pp.25-41
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• 2003

This paper is a study of Le Corbusier's trace regulateur of the 1920s, particularly its role in the design of the Villas La Roche-Jeanneret and Stein-de Monzie. It proceeds on the basis of the following three themes: first, the relation between the regulating line and the dom-ino frame; second, its status as a proportional device based not on a module system but one that defines relations; third, its function as an essential practical device in the design process. In the Villa La Roche-Jeanneret, the embedded horizontal planes of the dom-ino frame were constant, but the vortical lines of the columns were altered according to the changes in plan. Initially, a left-hand bay window formed a symmetry with the right-hand bay window, the only constant in the design process. With subsequent changes, mullion sections of the horizontal window and roof elements came to provide the reference points for the regulating line. Eventually, a regulating line different from the one that controlled the bay window and the elongated volume came to control the entrance hall of Villa La Roche, resulting in three different kinds of regulating lines in the final version. In contrast to the Villa La Roche-Jeanneret, a singular and consistent regulation line was anticipated in the earliest design stages of the Villa Stein-de Monzie. The repetition of its A:B grid and the standard $2.5m{\times}1.0m$ sliding window determined the proportions of both its plan and elevation, and thus the regulating line became 'automatic,' losing its viability as a practical tool. Though the regulating titles of the La Roche-Jeanneret look as if they were an afterthought, drawn after the design was complete, they were most active, requiring tenacity and discipline in their application. On the other hand, the seemingly 'redundant' regulating line of the Villa Stein-de Monzie gains its raison d'etre from the dom-ino frame. Its cantilevers and uninterrupted horizontal window could be used in decisive fashion because of the guarantee that the correct proportion would always be maintained. Thus we discover that Le Corbusier's discipline of the 1920s had a certain spectrum of flexibility. His 'parti' ranged from the extremely loose and malleable grid of the Villa La Roche-Jeanneret to the fixed grid of the Villa Stein-de Monzie. In different ways, these projects retain the tension between the dom-ino frame and the regulating line. For Le Corbusier, as much as the grid was an object with fixed attributes, it was also an active medium manipulated by the will of the architect.

• Journal of Nutrition and Health
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• v.34 no.4
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• pp.409-416
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• 2001

In order to evaluate the effect of habitual Na and Ca intake on blood pressure regulation, we measured the habitual dietary intakes of Na and Ca, urinary excretion of Ca, Na and K, and plasma level of renin activity, aldosterone, and indices of Ca metabolism in 27 untreated hypertensive women and 30 age-matched normal women on a free diet. Hypertensive and total subjects were divided into four groups according to habitual dietary intakes of Na and Ca as low Na-low Ca(LNLC), low Na-high Ca(LNHC), high Na-low Ca(HNLC), and high Na-high Ca(HNHC). HNLC hypertensive group showed the lowest level of plasma renin activity, 25-(OH) Vit D$_3$, calcitonin and serum total Ca, and presented the highest level of PTH and urinary excretions of Na/K and Ca/Cr. There were no significant difference in plasma level of aldosterone and urinary excretion of Na and K among four hypertensive groups. When all subjects were divided into four groups according to the same method, HNLC group showed the highest level of blood pressure with no statistical significance and the lowest level of calcitonin and total serum Ca. The above results indicated that renin-aldosterone system and Ca regulating hormone has a mutual relationship in hypertension. Na and Ca may interact each other, rather than affecting independently blood pressure control. As a result, considering the fact that daily balance of Na and Ca intakes affects Na and Ca regulating hormones and urinary excretion of Na and Ca, it may be involved in blood pressure control. These results suggest that maintaining an adequate intake of Ca with less intake of Na may prevent from the risk of hypertension. (Korean J Nutrition 34(4) : 409~416, 2001)

• Journal of Korea Water Resources Association
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• v.45 no.7
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• pp.675-684
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• 2012

Recently, a heavy rainfall under climate change causes the flood exceeded river's conveyance. Flood control methods under the limited river width are the increase of embankment, the construction of storage pockets and diversion channel, the dredging of river bed. Hwasun flood control reservoir of washland is designed as the storage pockets and the regulating gate for the control of water level. In this study, the propriety of design was investigated through hydraulic experiments for the circumstances to exclude the constant flood discharge during operation period. In the results, the over flow rate of side weir exceeded the flow of design and indicated to be able to discharge the designed flow in the regulating gate opened 1.1 m. The high velocity 7.1 m/s behind the gate has investigated to reduce under 3.3 m/s by the baffle block.

• Proceedings of the IEEK Conference
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• 2001.06a
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• pp.133-136
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• 2001

In this work, the problem of regulating and tracking available bit rate (ABR) traffic in ATM network. The issue of providing control signals to throttled sources at distant location from bottlenecked node is of particular interest. Network modeling and design of controller is outlined. To obtain optimal control, receding horizon control (RHC) theory is applied. Simulation results are presented in views of regulation and tracking problems with or without constraints.

• Proceedings of the IEEK Conference
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• 2002.06e
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• pp.63-66
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• 2002

This paper has been studied the parallel resonant inverter which controlling the constant power and tracking the load resonant frequency with PLL is possible, in order to minimize switching losses. The current-fed full-bridge type parallel resonant inverter of an induction heating system was composed of IGBT in switching device. For regulating the output power of an induction heating system, the Fuzzy controller is used. The Fuzzy controller makes the control signal for a stable power regulating control and when reference is changed, it is superior to adaptability. It has been evaluated a stable behavior for a noise with switching and a load disturbance.

• Journal of Integrative Natural Science
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• v.16 no.2
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• pp.69-74
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• 2023

In Dictyostelium , there are 15 Ras subfamilies, including 11 Ras, 3 Rap, 1 Rheb. The Ras proteins are involved in regulating various cell processes as switch proteins. The functions of many Ras proteins have been identified, but some of Ras proteins have not yet been identified. Here, we focused on identifying the roles of RasW among them. To investigate the functions of RasW in cell morphology, cell migration, and development in Dictyostelium , we compared the phenotypes of wild-type cells and rasW null cells. rasW null cells showed a larger, more spread-out morphology and reduced cell motility compared to wild-type cells. There was no significant difference between wild-type cells and rasW null cells during multicellular developmental process. These results suggest that RasW is involved in regulating cell morphology and cell migration in Dictyostelium.