• Korean Journal of Radiology
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• 제22권7호
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• pp.1152-1162
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• 2021

Objective: This study aimed to determine whether there are regional differences in the blood-brain barrier (BBB) permeability of cognitively normal elderly participants and to identify factors influencing BBB permeability with a clinically feasible, 10-minute dynamic contrast-enhanced (DCE) MRI protocol. Materials and Methods: This IRB-approved prospective study recruited 35 cognitively normal adults (26 women; mean age, 64.5 ± 5.6 years) who underwent DCE T1-weighted imaging. Permeability maps (K_trans) were coregistered with masks to calculate the mean regional values. The paired t test and Friedman test were used to compare Ktrans between different regions. The relationships between K_trans and the factors of age, sex, education, cognition score, vascular risk burden, vascular factors on imaging, and medial temporal lobar atrophy were assessed using Pearson correlation and the Spearman rank test. Results: The mean permeability rates of the right and left hippocampi, as assessed with automatic segmentation, were 0.529 ± 0.472 and 0.585 ± 0.515 (K_trans, x 10^-3 min^-1), respectively. Concerning the deep gray matter, the K_trans of the thalamus was significantly greater than those of the putamen and hippocampus (p = 0.007, p = 0.041). Regarding the white matter, the K_trans value of the occipital white matter was significantly greater than those of the frontal, cingulate, and temporal white matter (p < 0.0001, p = 0.0007, p = 0.0002). The variations in K_trans across brain regions were not related to age, cognitive score, vascular risk burden, vascular risk factors on imaging, or medial temporal lobar atrophy in the study group. Conclusion: Our study demonstrated regional differences in BBB permeability (K_trans) in cognitively normal elderly adults using a clinically acceptable 10-minutes DCE imaging protocol. The regional differences suggest that the integrity of the BBB varies across the brains of cognitively normal elderly adults. We recommend considering regional differences in K_trans values when evaluating BBB permeability in patients with neurodegenerative diseases.

• 디지털융복합연구
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• 제13권8호
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• pp.419-429
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• 2015

본 연구는 고지혈증 유병률의 지역 간 변이 정도와 위험 요인을 규명하여 지역별 특성에 맞는 고지혈증 관리 사업을 지원하기 위한 기초자료를 제공하기 위해 수행되었다. 이를 위해 질병관리본부의 2012년도 시군구 지역사회건강조사 249건의 자료를 이용하여 단순 상관관계 분석, 단계적 회귀분석, 의사결정나무 등의 기법으로 분석하였다. 249개 시군구 지역의 고지혈증 유병률은 9.2%였고, 변동계수는 28.3%였다. 남동부 해안지역에 비해 수도권과 내륙지방의 고지혈증 유병률이 높았다. 의사결정나무 모형이 회귀모형에 비해 예측력이 좋았는데, 지역의 임금근로자 비율, 스트레스 인지율, 고혈압, 협심증, 관절염 유병률이 높은 지역일수록 고지혈증 유병률이 높은 것으로 나타났다. 따라서 사회 역학적 관점에서 지역사회의 개입이 가능한 지점을 중심으로 고지혈증 유병률을 감소시키기 위한 전략 마련이 필요하다.

• 대한지리학회지
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• 제37권5호
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• pp.536-550
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• 2002

이 연구는 7년 동안의 수문, 기후, 수질자료를 이용하여 펜실바니아 38개 유역 수질의 공간적 변이 패턴을 고찰하였다. 연구기간동안 도시적, 농업적 토지이용이 많은 유역에서 농도의 변이가 심하게 나타났다. 질소의 농도는 농업적 토지이용과. 인의 농도는 도시적 토지이용과 상관관계가 높게 나타났다. 주성분분석을 통해 이들의 농도 변이를 설명하는 주요 성분 셋이 - 토지 지형관련, 기후관련, 규모 - 도출되었다. 부분 여분 분석을 통해 기후, 토지, 지형의 복합적인 영향이 질소 농도 변이의 28.1%를 설명하고 있으며, 순수한 토지 변수의 영향이 인 농도의 41.8 o/o를 설명하고 있음을 알 수 있었다. 주 전체적인 차원에서 농도변이의 뚜렷한 지리적 패턴-북서부지역의 낮은 농도와 남동부지역의 높은 농도-이 나타나고 있으며, 이는 지역적 규모에서 수문, 기후, 토지이용, 지형 등 여러 가지 환경변수의 복합적인 상호관련성을 반영하고 있다.

• 한국대기환경학회지
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• 제31권2호
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• pp.181-194
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• 2015

Spatial-temporal meteorological features of the Ulsan metropolitan region (UMR) were analyzed using observations and high-resolution numerical modeling. Long-term trend analysis (1970~2013) showed a significant increase of $0.033^{\circ}Cyr^{-1}$ in the 5-year moving average temperature, although detailed short-term features varied, whereas wind speed and relative humidity over the same period displayed clear decreases of $-0.007ms^{-1}$ and $-0.29%yr^{-1}$, respectively. These trends indicate the effects of regional climate change and urbanization in the UMR. Seasonal variations averaged for the most recent three years, 2011~2013, showed that temperatures in three different regions (urban/industrial, suburban, coastal areas) of the UMR had similar seasonality, but significant differences among them were observed for a certain season. Urban and industrial complex regions were characterized by relatively higher temperatures with large differences (max.: $3.6^{\circ}C$) from that in the coastal area in summer. For wind speed, strong values in the range from 3.3 to $3.9ms^{-1}$ occurred in the coastal areas, with large differences clearly shown between the three regions in September and October. Diurnal variations of temperature were characterized by pronounced differences during the daytime (in summer) or nighttime (in winter) between the three regions. Results from the WRF modeling performed for four months of 2012 showed large variations in gridaverage temperature and winds in the UMR, which displayed significant changes by season. Especially, a clear temperature rise in the urban center was identified in July ($0.6^{\circ}C$ higher than nearby urban areas), and overall, relatively weak winds were simulated over urban and inland suburban regions in all seasons.

• 한국대기환경학회지
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• 제17권6호
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• pp.451-461
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• 2001

Backward trajectories were calculated from five urban areas in Korea in 1999 in order to assess the effects of long-range transport on the air quality variations on an annual basis. The five areas selected were Seoul, Mokpo, Cheju, Pohang, and Kangnung, which are evenly distributed along the shoreline in Korea. Meteorological fields used in the work were prepared by the Korea Meteorological Administration using the RDAPS(Regional Data Assimilation and Prediction System) with grid spacing of 40 km and 12-h intervals(0000 and 1200 UTC). Upwind regions around the Korean Peninsula were divided into five sectors including the region to the northeast(I), northern China (II), southern China(III), the northwestern Pacific(IV), and Japan(V). The influence of air flow from these sectors on the variations of carbon monoxide concentrations in the selected areas was investigated. The results showed that the influences of Sectors II and III were persistent although some influences of adjacent sectors were observed according to the location of the areas. In general, the concentration of carbon monoxide tended to go up under the influence of Sectors II and III but tended to go down under the influence of Sector I. However, the influences of other sectors were rather mixed. The importance of the long-range transport was examined when the whole country was uniformly influenced by Sectors II and III with strong synoptic winds. The effects of long-range transport were large in Mokpo and Cheju, close to Sectors II and III, where the local emissions were considered small. The effects of local emissions were significant in Pohang and Seoul; such effect was more distinct in Pohang located farther from Sectors II and III.

• 한국대기환경학회지
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• 제23권6호
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• pp.631-639
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• 2007

We examined diurnal and seasonal variations of ozone ($O_3$) concentrations and its relation to meteorological parameters observed at the Ieodo Ocean Research Station ($32.07^{\circ}N$, $125.10^{\circ}E$, 36 m above sea level) during June 2003 and May 2005. Over the 2-year period, the mean ozone concentration was $49.5{\pm}15.5\;ppbv$. Ozone concentrations show great variability with a monthly mean up to 68.2 ppbv in May 2005 and seasonal variations with being highest in spring and fall, and lowest in summer. However, the amplitude of diurnal variation was less than ${\sim}4\;ppbv$ with a maximum at $3{\sim}4\;p.m.$ and minimum at $7{\sim}8\;a.m.$ HYSPLIT backward air trajectory indicated that the air masses with higher ozone came from the north or northwest and those with lower ozone arrived mainly via southerly or southeasterly. Ozone distributions at Ieodo Ocean Research Station were observed to be significantly impacted by long-range transport and regional scale air circulation.

• Animal Bioscience
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• 제34권7호
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• pp.1235-1242
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• 2021

Objective: The purpose of this study was to identify through infrared thermal imaging technology the facial surface temperature (FST) of laying hens in response to the variations in their thermal environment, and to identify the regional differences in FST to determine the most stable and reliable facial regions for monitoring of thermoregulatory status in chickens. Methods: Thirty Hy-Line Brown hens (25-week-old) were sequentially exposed to three different thermal conditions; optimal (OT, 22℃±2℃), low (LT, 10℃±4℃), and high temperature (HT, 30℃±2℃). The mean values of FST in five facial regions including around the eyes, earlobes, wattles, beak and nose, and comb were recorded through infrared thermography. The maximum FST (MFST) was also identified among the five face-selective regions, and its relationship with temperature-humidity index (THI) was established to identify the range of MFST in response to the variations in their thermal environment. Results: Hens exposed to OT condition at 15:00 displayed a higher temperature at wattles and around the eyes compared to other regions (p<0.001). However, under LT condition at 05:00 to 08:00, around the eyes surface temperature showed the highest value (p<0.01). In HT, wattles temperature tended to show the highest temperature over almost time intervals. Main distribution regions of MFST were wattles (63.3%) and around the eyes (16.7%) in OT, around the eyes (50%) in LT, and wattles (62.2%) and comb (18.3%) in HT. The regression equation between MFST and THI was estimated as MFST = 35.37+0.2383×THI (R² = 0.44; p<0.001). Conclusion: The FST and the frequency of MFST in each facial region of laying hens responded sensitively to the variations in the thermal environment. The findings of this experiment provide useful information about the effect of the thermal conditions on the specific facial regions, thus offering an opportunity to stress and welfare assessment in poultry research and industry.

• 대한간호학회지
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• 제53권4호
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• pp.426-438
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• 2023

Purpose: Walking practice is a representative indicator of the level of physical activity of local residents. Although the world health organization addressed reduction in prevalence of insufficient physical activity as a global target, the rate of walking practice in Korea has not improved and there are large regional disparities. Therefore, this study aimed to explore the spatial variations of walking practice and its associated factors in Korea. Methods: A secondary analysis was conducted using Community Health Outcome and Health Determinants Database 1.3 from Korea Centers for Disease Control and Prevention. A total of 229 districts was included in the analysis. We compared the ordinary least squares (OLS) and the geographically weighted regression (GWR) to explore the associated factors of walking practice. MGWR 2.2.1 software was used to explore the spatial distribution of walking practice and modeling the GWR. Results: Walking practice had spatial variations across the country. The results showed that the GWR model had better accommodation of spatial autocorrelation than the OLS model. The GWR results indicated that different predictors of walking practice across regions of Korea. Conclusion: The findings of this study may provide insight to nursing researchers, health professionals, and policy makers in planning health programs to promote walking practices in their respective communities.

• 한국대기환경학회지
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• 제34권2호
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• pp.294-305
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• 2018

Quantitative assessment on the impact from North Korean emissions to surface particulate matter(PM) concentration in the Seoul Metropolitan Area (SMA), South Korea is conducted using a 3-dimensional chemistry transport model. Transboundary transport of air pollutants and their precursors are important to understand regional air quality in East Asian countries. As North Korea locates in the middle of main transport pathways of Chinese pollutants, quantifiable estimation of its impact is essential for policy making in South Korean air quality management. In this study, the Community Multiscale Air Quality Modeling System is utilized to simulate regional air quality and its sensitivity, using the Comprehensive Regional Emissions inventory for Atmospheric Transport Experiment 2015 and the Clean Air Policy Support System 2013 emissions inventories for North and South Korea, respectively. Contributions were estimated by a brute force method, perturbing 50% of North and South Korean emissions. Simulations demonstrate that North Korean emissions contribute $3.89{\mu}g/m^3$ of annual surface PM concentrations in the SMA, which accounts 14.7% of the region's average. Impacts are dominant in nitrate and organic carbon (OC) concentrations, attributing almost 40% of SMA OC concentration during January and February. Clear seasonal variations are also found in North Korean emissions contribution to South Korea (and vice versa) due to seasonal characteristics of synoptic weather, especially by the change of seasonal flow patterns.

• 한국수산과학회지
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• 제44권3호
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• pp.298-307
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• 2011

The species composition and distributions of subtidal marine algae on the east coast of Korea were studied. We examined all species found in permanent quadrats at three depths (3 m, 5 m and 10 m) at Sacheon between October 2008 and December 2009. Coverage and frequency data were collected monthly via underwater photography and analyzed using a modified photo quadrat method. Of the 82 species identified, 10 were chlorophytes, 21 were phaeophytes, 50 were rhodophytes, and one was a seagrass. The largest number of species (59) was found 10 m deep, while the fewest (39) species were present at 5 m. A total 17 species (two green, five brown, and 10 red algae) occurred at all three depths. The vertical distribution of the study site was characterized by the melobesioidean algae, Ulva pertusa, Sargassum confusum, Phyllospadix iwatensis, and Codium arabicum at 3 m deep, melobesioidean algae and U. pertusa at 5 m deep, and Corallina pilulifera, Prionitis cornea, Chondracanthus tenellus and melobesioidean algae at 10 m deep. Given that coralline algae such as melobesioidean algae and C. pilulifera play important roles in coastal ecosystems, thorough studies on the spatial and temporal variations of coralline algae and the dynamics of marine algal communities on the east coast of Korea are now required.