• Investigative Magnetic Resonance Imaging
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• v.19 no.1
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• pp.10-18
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• 2015

Background and Purpose: The association between the low emotional regulation and the brain structural change of major depressive disorder (MDD) has been proposed, but the voxel-based morphometry (VBM) studies on female MDD are rare. The purpose of the present study was to show the regional volume changes of gray matter (GM) in female patients with MDD by optimized VBM. Methods: To control subjects homogeneity, twenty female MDD patients and age, sex matched 21 normal controls were included for the VBM analysis. To identify the change of regional gray matter volume (GMV), the optimized VBM was performed with T1 MRIs. The amounts of gray/white matter and intracranial cavity volumes (ICV) were measured. The analysis of covariance (ANCOVA) and partial correlation analyses covariate with age and ICV were applied for VBM. Results: The age and ICV distributions were similar between the two groups. In the ANCOVA, the total GMV of MDD was smaller than that of normal controls. In the VBM, regional GMV was relatively decreased in the limbic system (amygdalae, ambient gyri, hippocampi heads, subiculum, posterior parahippocampal gyri, pulvinar nuclei, dorsal posterior cingulate gyri, and left pregenual cingulate gyrus). The lingual gyri, short insular gyri, right fusiform gyrus, and right inferior frontal gyrus were also showed decreased regional GMV. Conclusion: The results of this study indicate that the female MDD is mainly associated with the structural deficits of the limbic system and limbic system related cortices, which were known to the center of emotions.

• Anxiety and mood
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• v.4 no.2
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• pp.148-156
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• 2008

Objective : Although cognitive-behavior therapy (CBT) is effective in patients with panic disorder, its the-rapeutic mechanism of action in the brain remains unclear. This study was performed to investigate regional blood flow changes associated with successful completion of CBT in drug-naive patients with panic disorder. Method : The regional blood flow in 4 patients with panic disorder was compared to that in 11 healthy controls before and after a 12-week group CBT using $^{99m}Tc$-ECD SPECT imaging. Psychopathology was assessed using Panic Disorder Severity Scale. Data were analyzed using software for statistical parametric mapping (SPM2). Results : Before CBT, significantly decreased blood flow was found in the parietal and occipital area in panic patients than normal volunteers. In all the patients who showed remission after CBT, increased blood flow was detected in the right cingulate gyrus, left lingual gyrus, and left superior parietal lobule, whereas decreased blood flow was seen in the left inferior temporal gyrus. Conclusion : These results suggested that CBT is effective for panic disorder and change the activity of cingulate gyrus and left temporal gyrus, a part of the brain areas associated with fear in panic disorder.

• Anxiety and mood
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• v.4 no.2
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• pp.127-134
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• 2008

Objective : This study examined whether major depressive disorder patients with anxiety traits displayed abnormal electroencephalographic (EEG) alpha asymmetries. Methods : Resting EEG was recorded in 11 outpatients with major depressive disorder (6 of whom had a high anxiety trait while 5 exhibited a low anxiety trait) and 6 controls. Results : In contrast to the controls, within the major depressive disorder patient group, comorbid anxiety disorder showed alpha asymmetry indicative of less activation over right than over left temporal sites. Patients diagnosed with major depressive disorder but no anxiety disorder showed a reduced temporal alpha asymmetry, supporting the potential importance of evaluating anxiety in studies of regional brain activation, in depressed patients. Conclusion : These findings suggest that anxiety is associated with brain hypoactivation, especially with right temporal hypoactivation.

• Korean Security Journal
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• no.54
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• pp.77-99
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• 2018

This study is designed to examine the relationship between the social safety net and the 'satisfaction level of safety life' conducted by local governments and to examine the effects of anarchy on the indicators. To do this, 300 people were sampled using the random sample method in the metropolitan area using the population of residents in the metropolitan area in 2017, and a total of 276 copies were extracted except 24 copies in the final analysis. Regression analysis and path analysis were conducted through structural equation modeling. Bootstrapping was performed to investigate the significance of the mediator effect. In summary, 'CPTED' has a positive effect on 'disorder' and 'safety life satisfaction', but 'municipal safety education' has a positive effect on 'safety life satisfaction' Respectively. 'Local disorder' has a negative effect on 'safety life satisfaction'. As a result of path analysis, the same effect was found. In order to examine mediating effect, bootstrapping showed that regional disorder was mediated only in 'CPTED' and 'safety life'. This result suggests that there is a need for change in the safety education of the community and it supports the precedent study that it is an effective means of safety net for the safety life of the CPTED community in the community. It is one of the nation's most important policies to prepare measures for the safety of the people. The local governments should also ensure the safety of local residents. In this study, the relationship between the local safety net and the disorder and safety life satisfaction was investigated.

• The Journal of Internal Korean Medicine
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• v.39 no.5
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• pp.895-903
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• 2018

Objectives: This study reports on the efficacy of using integrative Korean medical treatments for Type 1 complex regional pain syndrome (CRPS). Methods: A 48-year-old female patient with Type 1 R/O CRPS was treated with herbal medicines, acupuncture, and pharmacopuncture for 38 days. The chief complaints were severe burning pain, general weakness, sleep disorder, and aggressive and depressed mood. The treatment effect was evaluated by measuring the numerical rating scale (NRS) of pain, improvement of the quality of sleep, and change in mood status. Results: After the hospital treatment, the patient's pain was controlled and the NRS score was decreased. Sleep and mood disorder also improved. Conclusions: The integrative Korean medical treatments appeared to be effective in reducing Type 1 CRPS symptoms. Further clinical research of patients with CRPS is needed.

• Annals of Clinical Neurophysiology
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• v.24 no.2
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• pp.35-45
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• 2022

Complex regional pain syndrome (CRPS) is a chronic regional pain disorder that most frequently affects the limbs. It is characterized by hyperalgesia, allodynia, edema, motor disturbance, and vasomotor instability, and typically occurs following surgery or trauma. In type-I CRPS there is no confirmed nerve injury, while peripheral nerve injury is present in type-II CRPS. The multifactorial pathophysiological etiology of CRPS includes inflammation, autoimmune responses, abnormal cytokine production, autonomic dysfunction, altered blood flow, psychological factors, and central cortical reorganization. There are no specific laboratory diagnostic tools for CRPS, and so it is diagnosed clinically. The Budapest criteria are currently the most-accepted diagnostic criteria.

• Korean Journal of Biological Psychiatry
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• v.22 no.1
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• pp.20-27
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• 2015

Objectives It is increasingly thought that the human cerebellum plays an important role in emotion and cognition. Although recent evidence suggests that the cerebellum may also be implicated in fear learning, only a limited number of studies have investigated the cerebellar abnormalities in panic disorder. The aim of this study was to evaluate the cerebellar gray matter deficits and their clinical correlations among patients with panic disorder. Methods Using a voxel-based morphometry approach with a high-resolution spatially unbiased infratentorial template, regional cerebellar gray matter density was compared between 23 patients with panic disorder and 33 healthy individuals. Results The gray matter density in the right posterior-superior (lobule Crus I) and left posterior-inferior (lobules Crus II, VIIb, VIIIa) cerebellum was significantly reduced in the panic disorder group compared to healthy individuals (p < 0.05, false discovery rate corrected, extent threshold = 100 voxels). Additionally, the gray matter reduction in the left posterior-inferior cerebellum (lobule VIIIa) was significantly associated with greater panic symptom severity (r = -0.55, p = 0.007). Conclusions Our findings suggest that the gray matter deficits in the posterior cerebellum may be involved in the pathogenesis of panic disorder. Further studies are needed to provide a comprehensive understanding of the cerebro-cerebellar network in panic disorder.

• Psychiatry investigation
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• v.15 no.11
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• pp.1087-1093
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• 2018

Objective Posttraumatic stress disorder (PTSD) is distinct from anxiety disorders in its etiology and clinical symptomatology, and was reclassified into trauma- and stressor-related disorders in DSM-5. This study aimed to find neurophysiological correlates differentiating PTSD from anxiety disorders using resting-state quantitative electroencephalography (qEEG). Methods Thirty-six patients with either PTSD or acute stress disorder and 79 patients with anxiety disorder were included in the analysis. qEEG data of absolute and relative powers and patients' medication status on the day of qEEG examination were obtained. Electrodes were grouped into frontal, central, and posterior regions to analyze for regional differences. General linear models were utilized to test for group differences in absolute and relative powers while controlling for medications. Results PTSD patients differed from those with anxiety disorders in overall absolute powers [F(5,327)=2.601, p=0.025]. Specifically, overall absolute delta powers [F(1,331)=4.363, p=0.037], and overall relative gamma powers [F(1,331)=3.965, p=0.047] were increased in PTSD group compared to anxiety disorder group. Post hoc analysis regarding brain regions showed that the increase in absolute delta powers were localized to the posterior region [F(1,107)=4.001, p=0.048]. Additionally, frontal absolute gamma powers [F(1,107)=4.138, p=0.044] were increased in PTSD group compared to anxiety disorder group. Conclusion Our study suggests increased overall absolute delta powers and relative gamma powers as potential markers that could differentiate PTSD from anxiety disorders. Moreover, increased frontal absolute gamma and posterior delta powers might pose as novel markers of PTSD, which may reflect its distinct symptomatology.

• Journal of Acupuncture Research
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• v.29 no.4
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• pp.93-97
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• 2012

Complex regional pain syndrome type 1(CRPS 1) is a neuropathic pain disorder that accompanies severe pain and motor deficit as well as changes in the skin in the extremities. The pathophysiology of CRPS 1 is still not exactly elucidated. However, the general consensus of involvement of inflammatory mediators in the development of CRPS 1 is amply made. On the basis that placental extract successfully inhibited the production of inflammatory cytokines and mediators in several experimental models, we have tried a long-term weekly injection of placental extract into acupuncture points to a CRPS 1 patient suffering pain and immobilization of shoulder joint. The results say that placental extract effectively resolved pain, restored skin color and improved immobilization of shoulder joint in the CRPS 1 patient.

• Korean Journal of Psychosomatic Medicine
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• v.18 no.2
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• pp.57-61
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• 2010

The complex regional pain syndrome(CRPS) is a painful and disabling disorder that can affect one or more extremities. Unfortunately, knowledge concerning its natural history and mechanism remains very limited. Many current rationales in treatment of CRPS are mainly dependent on efficacy originate in other common conditions of neuropathic pain. This article introduces various treatments for CRPS, but few studies of high methodological quality have been carried out into the effects of those treatments. I think early recognition and a multidisciplinary approach to management seems important in obtaining a good outcome.