Psychiatry investigation

Korean Neuropsychiatric Association (대한신경정신의학회)
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Increased Frontal Gamma and Posterior Delta Powers as Potential Neurophysiological Correlates Differentiating Posttraumatic Stress Disorder from Anxiety Disorders

  • Moon, Sun-Young (Department of Psychiatry, Seoul National University Hospital) ;
  • Choi, Yoo Bin (Department of Psychiatry, Seoul National University Hospital) ;
  • Jung, Hee Kyung (Department of Psychiatry, Seoul National University Hospital) ;
  • Lee, Yoonji Irene (Department of Psychiatry, Seoul National University Hospital) ;
  • Choi, Soo-Hee (Department of Psychiatry, Seoul National University Hospital)
  • Received : 2018.07.06
  • Accepted : 2018.09.30
  • Published : 2018.11.30
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Abstract

Objective Posttraumatic stress disorder (PTSD) is distinct from anxiety disorders in its etiology and clinical symptomatology, and was reclassified into trauma- and stressor-related disorders in DSM-5. This study aimed to find neurophysiological correlates differentiating PTSD from anxiety disorders using resting-state quantitative electroencephalography (qEEG). Methods Thirty-six patients with either PTSD or acute stress disorder and 79 patients with anxiety disorder were included in the analysis. qEEG data of absolute and relative powers and patients' medication status on the day of qEEG examination were obtained. Electrodes were grouped into frontal, central, and posterior regions to analyze for regional differences. General linear models were utilized to test for group differences in absolute and relative powers while controlling for medications. Results PTSD patients differed from those with anxiety disorders in overall absolute powers [F(5,327)=2.601, p=0.025]. Specifically, overall absolute delta powers [F(1,331)=4.363, p=0.037], and overall relative gamma powers [F(1,331)=3.965, p=0.047] were increased in PTSD group compared to anxiety disorder group. Post hoc analysis regarding brain regions showed that the increase in absolute delta powers were localized to the posterior region [F(1,107)=4.001, p=0.048]. Additionally, frontal absolute gamma powers [F(1,107)=4.138, p=0.044] were increased in PTSD group compared to anxiety disorder group. Conclusion Our study suggests increased overall absolute delta powers and relative gamma powers as potential markers that could differentiate PTSD from anxiety disorders. Moreover, increased frontal absolute gamma and posterior delta powers might pose as novel markers of PTSD, which may reflect its distinct symptomatology.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea (NRF)

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