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http://dx.doi.org/10.14253/acn.2022.24.2.35

Diagnosis of complex regional pain syndrome  

Kim, Young-Do (Department of Neurology, Incheon St. Mary's Hospital, The Catholic University of Korea College of Medicine)
Publication Information
Annals of Clinical Neurophysiology / v.24, no.2, 2022 , pp. 35-45 More about this Journal
Abstract
Complex regional pain syndrome (CRPS) is a chronic regional pain disorder that most frequently affects the limbs. It is characterized by hyperalgesia, allodynia, edema, motor disturbance, and vasomotor instability, and typically occurs following surgery or trauma. In type-I CRPS there is no confirmed nerve injury, while peripheral nerve injury is present in type-II CRPS. The multifactorial pathophysiological etiology of CRPS includes inflammation, autoimmune responses, abnormal cytokine production, autonomic dysfunction, altered blood flow, psychological factors, and central cortical reorganization. There are no specific laboratory diagnostic tools for CRPS, and so it is diagnosed clinically. The Budapest criteria are currently the most-accepted diagnostic criteria.
Keywords
Complex regional pain syndrome; Reflex sympathetic dystrophy; Causalgia;
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1 Bruehl S, Harden RN, Galer BS, Saltz S, Bertram M, Backonja M, et al. External validation of IASP diagnostic criteria for complex regional pain syndrome and proposed research diagnostic criteria. International Association for the Study of Pain. Pain 1999;81:147-154.   DOI
2 Birklein F, Sittl R, Spitzer A, Claus D, Neundorfer B, Handwerker HO. Sudomotor function in sympathetic reflex dystrophy. Pain 1997;69:49-54.   DOI
3 Ringer R, Wertli M, Bachmann LM, Buck FM, Brunner F. Concordance of qualitative bone scintigraphy results with presence of clinical complex regional pain syndrome 1: meta-analysis of test accuracy studies. Eur J Pain 2012;16:1347-1356.   DOI
4 Misidou C, Papagoras C. Complex regional pain syndrome: an update. Mediterr J Rheumatol 2019;30:16-25.   DOI
5 Todorova J, Dantchev N, Petrova G. Complex regional pain syndrome acceptance and the alternative denominations in the medical literature. Med Princ Pract 2013;22:295-300.   DOI
6 Ott S, Maihofner C. Signs and symptoms in 1,043 patients with complex regional pain syndrome. J Pain 2018;19:599-611.   DOI
7 Evans JH. Notes on the folklore and legends associated with the Kentish megaliths. Folklore 1946;57:36-43.   DOI
8 Moseley GL. Graded motor imagery for pathologic pain: a randomized controlled trial. Neurology 2006;67:2129-2134.   DOI
9 Sandroni P, Benrud-Larson LM, McClelland RL, Low PA. Complex regional pain syndrome type I: incidence and prevalence in Olmsted county, a population-based study. Pain 2003;103:199-207.   DOI
10 de Mos M, de Bruijn AG, Huygen FJ, Dieleman JP, Stricker BH, Sturkenboom MC. The incidence of complex regional pain syndrome: a population-based study. Pain 2007;129:12-20.   DOI
11 Harden RN, Bruehl S, Stanton-Hicks M, Wilson PR. Proposed new diagnostic criteria for complex regional pain syndrome. Pain Med 2007;8:326-331.   DOI
12 Park HY, Jang YE, Oh S, Lee PB. Psychological characteristics in patients with chronic complex regional pain syndrome: comparisons with patients with major depressive disorder and other types of chronic pain. J Pain Res 2020;13:389-398.   DOI
13 Turner-Stokes L, Goebel A. Complex regional pain syndrome in adults: concise guidance. Clin Med (Lond) 2011;11:596-600.   DOI
14 Sintzoff S, Sintzoff S Jr, Stallenberg B, Matos C. Imaging in reflex sympathetic dystrophy. Hand Clin 1997;13:431-442.   DOI
15 Manchikanti L. The role of radiofrequency in the management of complex regional pain syndrome. Curr Rev Pain 2000;4:437-444.   DOI
16 Gierthmuhlen J, Maier C, Baron R, Tolle T, Treede RD, Birbaumer N, et al. Sensory signs in complex regional pain syndrome and peripheral nerve injury. Pain 2012;153:765-774.   DOI
17 Karacan I, Aydin T, Ozaras N. Bone loss in the contralateral asymptomatic hand in patients with complex regional pain syndrome type 1. J Bone Miner Metab 2004;22:44-47.   DOI
18 Birklein F, Riedl B, Sieweke N, Weber M, Neundorfer B. Neurological findings in complex regional pain syndromes--analysis of 145 cases. Acta Neurol Scand 2000;101:262-269.   DOI
19 de Boer RD, Marinus J, van Hilten JJ, Huygen FJ, van Eijs F, van Kleef M, et al. Distribution of signs and symptoms of complex regional pain syndrome type I in patients meeting the diagnostic criteria of the International Association for the Study of Pain. Eur J Pain 2011;15:830.e1-e8.
20 Schilder JCM, Schouten AC, Perez RSGM, Huygen FJPM, Dahan A, Noldus LPJJ, et al. Motor control in complex regional pain syndrome: a kinematic analysis. Pain 2012;153:805-812.   DOI
21 Shim H, Rose J, Halle S, Shekane P. Complex regional pain syndrome: a narrative review for the practising clinician. Br J Anaesth 2019;123:e424-e433.   DOI
22 Roganovic Z, Mandic-Gajic G. Pain syndromes after missile-caused peripheral nerve lesions: part 1--clinical characteristics. Neurosurgery 2006;59:1226-1236; discussion 1236-1237.   DOI
23 Sherman RA, Karstetter KW, Damiano M, Evans CB. Stability of temperature asymmetries in reflex sympathetic dystrophy over time and changes in pain. Clin J Pain 1994;10:71-77.   DOI
24 Bussa M, Guttilla D, Lucia M, Mascaro A, Rinaldi S. Complex regional pain syndrome type I: a comprehensive review. Acta Anaesthesiol Scand 2015;59:685-697.   DOI
25 Li WW, Guo TZ, Shi X, Birklein F, Schlereth T, Kingery WS, et al. Neuropeptide regulation of adaptive immunity in the tibia fracture model of complex regional pain syndrome. J Neuroinflammation 2018;15:105.   DOI
26 Dirckx M, Stronks DL, van Bodegraven-Hof EA, Wesseldijk F, Groeneweg JG, Huygen FJ. Inflammation in cold complex regional pain syndrome. Acta Anaesthesiol Scand 2015;59:733-739.   DOI
27 Littlejohn G. Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome. Nat Rev Rheumatol 2015;11:639-648.   DOI
28 Birklein F, Drummond PD, Li W, Schlereth T, Albrecht N, Finch PM, et al. Activation of cutaneous immune responses in complex regional pain syndrome. J Pain 2014;15:485-495.
29 Gherardini G, Curinga G, Colella G, Freda N, Rauso R. Calcitonin gene-related peptide and thermal injury: review of literature. Eplasty 2009;9:e30.
30 Snijdelaar DG, Dirksen R, Slappendel R, Crul BJ. Substance P. Eur J Pain 2000;4:121-135.   DOI
31 Sumitani M, Shibata M, Sakaue G, Mashimo T. Development of comprehensive diagnostic criteria for complex regional pain syndrome in the Japanese population. Pain 2010;150:243-249.   DOI
32 Weber M, Birklein F, Neundorfer B, Schmelz M. Facilitated neurogenic inflammation in complex regional pain syndrome. Pain 2001;91:251-257.   DOI
33 van Velzen GA, Rombouts SA, van Buchem MA, Marinus J, van Hilten JJ. Is the brain of complex regional pain syndrome patients truly different? Eur J Pain 2016;20:1622-1633.   DOI
34 Russo MA, Georgius P, Pires AS, Heng B, Allwright M, Guennewig B, et al. Novel immune biomarkers in complex regional pain syndrome. J Neuroimmunol 2020;347:577330.   DOI
35 Harden NR, Bruehl S, Perez RSGM, Birklein F, Marinus J, Maihofner C, et al. Validation of proposed diagnostic criteria (the "Budapest Criteria") for complex regional pain syndrome. Pain 2010;150:268-274.   DOI
36 Beerthuizen A, Stronks DL, Van't Spijker A, Yaksh A, Hanraets BM, Klein J, et al. Demographic and medical parameters in the development of complex regional pain syndrome type 1 (CRPS1): prospective study on 596 patients with a fracture. Pain 2012;153:1187-1192.   DOI
37 Jo YH, Kim K, Lee BG, Kim JH, Lee CH, Lee KH. Incidence of and risk factors for complex regional pain syndrome type 1 after surgery for distal radius fractures: a population-based study. Sci Rep 2019;9:4871.   DOI
38 Littlejohn GO. Reflex sympathetic dystrophy in adolescents: lessons for adults. Arthritis Rheum 2004;51:151-153.   DOI
39 Choi YS, Lee MG, Lee HM, Lee CJ, Jo JY, Jeon SY, et al. Epidemiology of complex regional pain syndrome: a retrospective chart review of 150 Korean patients. J Korean Med Sci 2008;23:772-775.   DOI
40 van Velzen GAJ, Huygen FJPM, van Kleef M, van Eijs FV, Marinus J, van Hilten JJ. Sex matters in complex regional pain syndrome. Eur J Pain 2019;23:1108-1116.   DOI
41 Marinus J, Moseley GL, Birklein F, Baron R, Maihofner C, Kingery WS, et al. Clinical features and pathophysiology of complex regional pain syndrome. Lancet Neurol 2011;10:637-648.   DOI
42 Crijns TJ, van der Gronde BATD, Ring D, Leung N. Complex regional pain syndrome after distal radius fracture is uncommon and is often associated with fibromyalgia. Clin Orthop Relat Res 2018;476:744-750.   DOI
43 Knudsen LF, Terkelsen AJ, Drummond PD, Birklein F. Complex regional pain syndrome: a focus on the autonomic nervous system. Clin Auton Res 2019;29:457-467.   DOI
44 Janig W, Levine JD, Michaelis M. Interactions of sympathetic and primary afferent neurons following nerve injury and tissue trauma. Prog Brain Res 1996;113:161-184.   DOI
45 Di Pietro F, McAuley JH, Parkitny L, Lotze M, Wand BM, Moseley GL, et al. Primary motor cortex function in complex regional pain syndrome: a systematic review and meta-analysis. J Pain 2013;14:1270-1288.   DOI
46 Maihofner C, Neundorfer B, Birklein F, Handwerker HO. Mislocalization of tactile stimulation in patients with complex regional pain syndrome. J Neurol 2006;253:772-779.   DOI
47 Moseley GL. Distorted body image in complex regional pain syndrome. Neurology 2005;65:773.   DOI
48 de Rooij AM, de Mos M, Sturkenboom MC, Marinus J, van den Maagdenberg AM, van Hilten JJ. Familial occurrence of complex regional pain syndrome. Eur J Pain 2009;13:171-177.   DOI
49 van de Beek WJ, van Hilten JJ, Roep BO. HLA-DQ1 associated with reflex sympathetic dystrophy. Neurology 2000;55:457-458.   DOI
50 Higashimoto T, Baldwin EE, Gold JI, Boles RG. Reflex sympathetic dystrophy: complex regional pain syndrome type I in children with mitochondrial disease and maternal inheritance. Arch Dis Child 2008;93:390-397.   DOI
51 Veldman PH, Reynen HM, Arntz IE, Goris RJ. Signs and symptoms of reflex sympathetic dystrophy: prospective study of 829 patients. Lancet 1993;342:1012-1016.   DOI
52 Wasner G, Schattschneider J, Heckmann K, Maier C, Baron R. Vascular abnormalities in reflex sympathetic dystrophy (CRPS I): mechanisms and diagnostic value. Brain 2001;124(Pt 3):587-599.   DOI
53 Bruehl S, Harden RN, Galer BS, Saltz S, Backonja M, Stanton-Hicks M. Complex regional pain syndrome: are there distinct subtypes and sequential stages of the syndrome? Pain 2002;95(1-2):119-124.   DOI
54 Harden RN, Bruehl S, Galer BS, Saltz S, Bertram M, Backonja M, et al. Complex regional pain syndrome: are the IASP diagnostic criteria valid and sufficiently comprehensive? Pain 1999;83:211-219.   DOI
55 Furlan AD, Lui PW, Mailis A. Chemical sympathectomy for neuropathic pain: does it work? Case report and systematic literature review. Clin J Pain 2001;17:327-336.   DOI
56 Borchers AT, Gershwin ME. Complex regional pain syndrome: a comprehensive and critical review. Autoimmun Rev 2014;13:242-265.   DOI
57 Kang JE, Kim YC, Lee SC, Kim JH. Relationship between complex regional pain syndrome and working life: a Korean study. J Korean Med Sci 2012;27:929-933.   DOI
58 Eldufani J, Elahmer N, Blaise G. A medical mystery of complex regional pain syndrome. Heliyon 2020;6:e03329.   DOI
59 Eberle T, Doganci B, Kramer HH, Geber C, Fechir M, Magerl W, et al. Warm and cold complex regional pain syndromes: differences beyond skin temperature? Neurology 2009;72:505-512.   DOI
60 Elsharydah A, Loo NH, Minhajuddin A, Kandil ES. Complex regional pain syndrome type 1 predictors-epidemiological perspective from a national database analysis. J Clin Anesth 2017;39:34-37.   DOI
61 Rommel O, Gehling M, Dertwinkel R, Witscher K, Zenz M, Malin JP, et al. Hemisensory impairment in patients with complex regional pain syndrome. Pain 1999;80:95-101.   DOI
62 Galer BS, Butler S, Jensen MP. Case reports and hypothesis: a neglect-like syndrome may be responsible for the motor disturbance in reflex sympathetic dystrophy (complex regional pain syndrome-1). J Pain Symptom Manage 1995;10:385-391.   DOI
63 de Mos M, Huygen FJ, van der Hoeven-Borgman M, Dieleman JP, Ch Stricker BH, Sturkenboom MC. Outcome of the complex regional pain syndrome. Clin J Pain 2009;25:590-597.   DOI
64 Mailis A, Wade J. Profile of Caucasian women with possible genetic predisposition to reflex sympathetic dystrophy: a pilot study. Clin J Pain 1994;10:210-217.   DOI
65 Speck V, Schlereth T, Birklein F, Maihofner C. Increased prevalence of posttraumatic stress disorder in CRPS. Eur J Pain 2017;21:466-473.   DOI
66 Raja SN, Grabow TS. Complex regional pain syndrome I (reflex sympathetic dystrophy). Anesthesiology 2002;96:1254-1260.   DOI
67 Treede RD, Rief W, Barke A, Aziz Q, Bennett MI, Benoliel R, et al. Chronic pain as a symptom or a disease: the IASP classification of chronic pain for the international classification of diseases (ICD11). Pain 2019;160:19-27.   DOI
68 Reinders MF, Geertzen JH, Dijkstra PU. Complex regional pain syndrome type I: use of the International Association for the Study of Pain diagnostic criteria defined in 1994. Clin J Pain 2002;18:207-215.   DOI
69 Uceyler N, Eberle T, Rolke R, Birklein F, Sommer C. Differential expression patterns of cytokines in complex regional pain syndrome. Pain 2007;132:195-205.   DOI
70 Birklein F, Riedl B, Neundorfer B, Handwerker HO. Sympathetic vasoconstrictor reflex pattern in patients with complex regional pain syndrome. Pain 1998;75:93-100.   DOI
71 Oh SW, Choi SU, Park M, Shin JH. Validity of the Budapest criteria for poststroke complex regional pain syndrome. Clin J Pain 2019;35:831-835.   DOI
72 Albazaz R, Wong YT, Homer-Vanniasinkam S. Complex regional pain syndrome: a review. Ann Vasc Surg 2008;22:297-306.   DOI
73 Goldsmith DP, Vivino FB, Eichenfield AH, Athreya BH, Heyman S. Nuclear imaging and clinical features of childhood reflex neurovascular dystrophy: comparison with adults. Arthritis Rheum 1989;32:480-485.   DOI
74 Price DD, Long S, Wilsey B, Rafii A. Analysis of peak magnitude and duration of analgesia produced by local anesthetics injected into sympathetic ganglia of complex regional pain syndrome patients. Clin J Pain 1998;14:216-226.   DOI