• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.4853-4858
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• 2015

Background: Colorectal cancer is the most common gastrointestinal cancer in Oman with an increasing incidence. We here report the presenting features, treatment outcomes and survival in a University hospital in Oman and compare our data with regional and international studies. Materials and Methods: Medical records of patients with colorectal cancer were reviewed retrospectively between June 2000 and December 2013 and were followed until June 2014. Results: A total of 162 patients were diagnosed with colorectal cancer. The majority were males (58.6%), with a median age of 56 years. Rectum was involved in 29.6% of patients, followed by ascending and sigmoid colon. The majority of patients had stage III (42.6%) and stage IV (32.7%) disease at presentation. K-Ras status was checked for 79 patients, and 41 (51.9%) featured the wild type. Median relapse free survival was 22 months. Median overall survival for all patients was 43 months. Observed 5 year overall survival (OS) for stages I, II and III was 100%, 60% and 60% respectively. On Log rank univariate analysis, age, BMI, diabetes, hypertension, metformin use, stage, clinical nodal status for rectal cancer, pathological T and nodal status, site of metastasis, surgical intervention, chemotherapy, radiotherapy, chemotherapy regimen, no of cycles of chemotherapy, response, RFS, site of recurrence and administration of $2^{nd}$ line chemotherapy were significant factors affecting OS. On Cox regression multivariate analysis none of the factors independently affected the OS. Conclusions: The majority of patients present with advanced disease and at young age. The survival rates are comparable to the published regional and international literature.

• 지역연구
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• 제34권1호
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• pp.49-60
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• 2018

본 연구의 목적은 청년 1인 가구 증가와 함께 나타나는 주거 문제의 원인을 분석하는 것이다. 본 연구에서는 생애 주기 가설을 기반으로 주택 수요 함수를 추정하였다. 추정 결과, 청년 1인 가구의 주택 수요와 항상소득 잔차로 인한 주택 수요가 다른 집단에 비해 유의미하게 낮게 나타났다. 이는 청년 1인 가구의 주택 소비에 항상소득이 충분히 실현되지 못하고 있으며, 이를 뒷받침할 금융 시장의 역할이 미비함을 의미한다. 본 연구에서는 항상소득 실현의 어려움과 주택 금융 부족을 청년 1인 가구 주택 수요 불균형 현상의 원인으로 분석하였다. 따라서 청년 1인 가구의 주택 문제를 해결하기 위해 항상소득과 현재 주택 수요의 균형을 유도하는 정책이 도입되어야 한다.

• 한국지역지리학회지
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• 제4권2호
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• pp.95-117
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• 1998

관광지 주민들이 갖는 태도는 관광지의 전체적인 이미지 형성에 커다란 영향을 끼치고, 관광객의 견인에 있어서도 관광지의 자연 환경이나 기후, 그리고 관광지 시설과 함께 매우 중요한 요인의 하나가 되고 있다. 본 연구의 목적은 광주 전남 지역의 4 사례 지역 관광지 주민들을 대상으로 관광 개발 이후 나타나는 경제적 사회적 문화적 및 환경적 영향 등에 관한 관광지 주민들의 태도를 구명해 보고 자 한다. 본 연구 결과에서 나타난 주요 내용을 요약하면 다음과 같다. 첫째, 관광의 경제적 효과에 대해서는 대체로 긍정적 반응을 보이지만 사회적 영향에 대한 결과는 청소년 관련 교육 문제와 범죄율 증가에 영향을 끼친다는 부정적 입장을, 그리고 문화적 영향에 대해서는 긍정적 측면과 미래 지향적 바램을 동시에 나타내었고, 환경적 영향에 대해서는 환경 보호에 큰 관심을 보였다. 둘째, 관광 개발과 관련한 우선 순위로는 관광 개발로 인한 수입 증대를 가장 중시하였고, 다음으로 긍정적인 이미지 부여를 위한 역사적 문화적 전시(람)회 필요, 스레기 투기자에 대한 처벌 강화, 지역 발전을 위한 관광 개발과 투지 필요 등의 순으로 나타났다.

• Advances in nano research
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• 제5권2호
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• pp.127-140
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• 2017

Metal nanoparticles have been intensively studied within the past decade. Nano-sized materials have been an important subject in basic and applied sciences. Zinc oxide nanoparticles have received considerable attention due to their unique antibacterial, antifungal, and UV filtering properties, high catalytic and photochemical activity. In this study, microbiological aspects of scale formation in PVC pipelines bacteria and fungi were isolated. In the emerging issue of increased multi-resistant properties in water borne pathogens, zinc oxide (ZnO) nanoparticle are being used increasingly as antimicrobial agents. Thus, the minimum bactericidal concentration (MBC) and minimum fungal concentration of ZnO nanoparticles towards pathogens microbe were examined in this study. The results obtained suggested that ZnO nanoparticles exhibit a good anti fungal activity than bactericidal effect towards all pathogens tested in in-vitro disc diffusion method (170 ppm, 100 ppm and 30 ppm). ZnO nanoparticles can be a potential antimicrobial agent due to its low cost of production and high effectiveness in antimicrobial properties, which may find wide applications in various industries to address safety issues. Stable ZnO nanoparticles were prepared and their shape and size distribution characterized by Dynamic light scattering (35.7 nm) and transmission electron microscopic TEM study for morphology identification (20 nm), UV-visible spectroscopy (230 nm), X-ray diffraction (FWHM of more intense peak corresponding to 101 planes located at $36.33^{\circ}$ using Scherrer's formula), FT-IR (Amines, Alcohols, Carbonyl and Nitrate ions), Zeta potential (-28.8). The antimicrobial activity of ZnO nanoparticles was investigated against Bacteria and Fungi present in drinking water PVC pipelines biofilm. In these tests, Muller Hinton agar plates were used and ZnO nanoparticles of various concentrations were supplemented in solid medium.

• Journal of Microbiology and Biotechnology
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• 제26권11호
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• pp.1836-1844
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• 2016

Adipogenesis is one of the cellular processes and a highly controlled program. Nowadays, inhibition of adipogenesis has received attention as an effective way to regulate obesity. In the current study, we investigated the inhibition effect of a chloroform extract of Pleurotus eryngii var. ferulae 'Beesan No. 2' (CEBT) on adipogenesis in 3T3-L1 murine preadipocytes. Pleurotus eryngii var. ferulae is one of many varieties of King oyster mushroom and has been reported to have various biological activities, including antitumor and anti-inflammation effects. Biological activities of 'Beesan No. 2', a new cultivar of Pleurotus eryngii var. ferulae, have not yet been reported. In this study, we found that CEBT suppressed adipogenesis in 3T3-L1 cells through inhibition of key adipogenic transcription factors, such as peroxisome proliferatoractivated receptor ${\gamma}$ and CCAAT/enhancer binding protein ${\alpha}$. Additionally, CEBT reduced the expression of the IRS/PI3K/Akt signaling pathway and its downstream factors, including mammalian target of rapamycin and p70S6 kinase, which stimulate adipogenesis. Furthermore, ${\beta}-catenin$, a suppressor of adipogenesis, was increased in CEBT-treated cells. These results indicate that Pleurotus eryngii var. ferulae 'Beesan No. 2' effectively inhibited adipogenesis, so this mushroom has potential as an anti-obesity food and drug.

• Safety and Health at Work
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• 제13권4호
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• pp.421-428
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• 2022

Background: The exposure to solar ultraviolet radiation is a significant risk factor generally underestimated by outdoor workers and employers. Several studies have pointed out that occupational solar exposure increased eye and skin diseases with a considerable impact on the lives and productivity of affected workers. The main purpose of this study was to evaluate the effectiveness against ultraviolet radiation of some measures recently undertaken for the protection of lifeguards in a coastal area of Tuscany. Methods: Different shading structures (gazebos and beach umbrella) were tested during a sunny summer's day on a sandy beach by means of two radiometers; the UV protection offered by some T-shirts used by lifeguards was also tested in the laboratory with a spectrophotometer. Results: The analysed shading structures strongly reduced the ultraviolet radiation by up to 90%, however a not always negligible diffuse radiation is also present in the shade, requiring further protective measures (T-shirt, sunglasses, sunscreen, etc.); the tested T-shirts showed a very good-excellent protection according to the Australian/New Zealand standard. Conclusion: Results obtained in this study suggest how the adoption and dissemination of good practices, including those tested, could be particularly effective as a primary prevention for lifeguards who are subjected to very high levels of radiation for long periods.

• Investigative Magnetic Resonance Imaging
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• 제17권1호
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• pp.19-25
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• 2013

목적: 신장 혈중산소치의존 자기공명영상은 신장 산소공급의 평가로 사용되고 있다. 3T 자기공명영상에서 신장의 정상 $R2^*$ 값을 재고, 성별과 위치에 따른 $R2^*$ 값의 차이를 평가하고자 하였다. 대상과 방법: 24명의 건강한 자원자를 대상으로 3.0T 에서 혈중산소치의존 자기공명영상을 시행하였다. $T2^*$ 맵을 생성한 다음에 $R2^*$ 값을 계산하였고, 신피질과 신수질, 남녀 그리고 좌우 신장에 대한 $R2^*$값의 통계적 차이를 평가하였다. 양측 신장 내에서도 위치에 따른 $R2^*$값의 차이도 평가하였다. 결과: 모든 대상에서 혈중산소치의존 자기공명영상은 성공적이었으며, $R2^*$의 측정에 방해되는 인공물은 없었다. 3.0T에서의 평균 $R2^*$는 피질에서 $17.1{\pm}2.60s^{-1}$ 였으며 수질에서는 $27.7{\pm}4.83s^{-1}$ 였다 (p < 0.001). 남자의 수질의 $R2^*$ 값이 여자보다 통계적으로 유의하게 높았으나 (p=0.025), 좌우신이나 신장 내에서의 $R2^*$값의 통계적 차이는 없었다 (p=0.197). 결론: 3.0T에서 신장 혈중산소치의존 자기공명영상은 효과적으로 시행될 수 있었다. 정상인에서 상대적인 신수질의 저산소증이 존재하였고, 이 결과는 병리적인 환경에서 신장 평가에서의 기준치로 사용될 수 있을 것으로 생각된다.

• Asian-Australasian Journal of Animal Sciences
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• 제6권4호
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• pp.555-559
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• 1993

Studies at freezing point depression (FPD) for goat milk are described in this paper. The 432 samples of raw goat milk collected in a period of two years and analysed by the use of an electronic cryoscope gave a mean value of FPD: $-0.565{\pm}0.01^{\circ}C$. Statistical significant differences were found between the morning and evening milk. The evening milk showed better quality considering the lactose and others dissolved solutes. Among the Brown, Saanen and Anglo-nubian goats, the greatest increase in FPD, occurred in the Anglo-nubian breed. The statistical analysis revealed a significant breed difference (p<0.05), when climate variation was observed. The superior and inferior values found to the FPD of the caprine milk (-0.545 to $-0.585^{\circ}C$), is important in establishing regional rules, to improve the quality control criteria and legal interpretation of standards found in the pertinent legislation. The results are also important to improve herd management so that one can increase the animal production which will affect the technological composition, and the nutritional characteristics of the resultant products.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제11권2호
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• pp.1005-1018
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• 2017

This paper proposes an App Visualization (AppV) based on IoT Self-diagnosis Micro Control Unit (ISMCU) for accident prevention. It collects a current status of a vehicle through a sensor, visualizes it on a smart phone and prevents vehicles from accident. The AppV consists of 5 components. First, a Sensor Layer (SL) judges noxious gas from a current vehicle and a driver's driving habit by collecting data from various sensors such as an Accelerator Position Sensor, an O2 sensor, an Oil Pressure Sensor, etc. and computing the concentration of the CO collected by a semiconductor gas sensor. Second, a Wireless Sensor Communication Layer (WSCL) supports Zigbee, Wi-Fi, and Bluetooth protocol so that it may transfer the sensor data collected in the SL to ISMCU and the data in the ISMCU to a Mobile. Third, an ISMCU integrates the transferred sensor information and transfers the integrated result to a Mobile. Fourth, a Mobile App Block Programming Tool (MABPT) is an independent App generation tool that changes to visual data just the vehicle information which drivers want from a smart phone. Fifth, an Embedded Module (EM) records the data collected through a Smart Phone real time in a Cloud Server. Therefore, because the AppV checks a vehicle' fault and bad driving habits that are not known from sensors and performs self-diagnosis through a mobile, it can reduce time and cost spending on accidents caused by a vehicle's fault and noxious gas emitted to the outside.

• 생명과학회지
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• 제20권5호
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• pp.670-675
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• 2010

Autoimmune regulator gene (Aire)는 흉선에서 발현되며 promiscuous genes으로 알려진 흉선에서 자가항원 발현을 조절한다. Aire 와 promiscuous genes은 흉선에서 T세포 tolerance와 자가면역에 관여한다. 말초 조직 즉 림프절에서 Aire의 역할을 알아보고자 림프절 구성 세포중 하나인 fibroblastic reticular cell (FRC)을 분리 확립하였다. 마우스 림프절로부터 분리된 FRC에서 Aire의 발현을 확인하였고 또한 promiscuous antigen인 insulin의 발현도 확인하였다. Aire 과발현 플라스미드로 형질전환 후 배양 FRC에서 Insulin의 발현이 증가하였다. 이것은 Aire가 FRC에서 promiscuous gene의 발현을 조절한다는 것을 보여주며 peripheral selection과 연관되어 있을 수 있다는 것을 제시한다.