Browse > Article
http://dx.doi.org/10.5352/JLS.2010.20.5.670

Autoimmune Regulator Gene (Aire) is Expressed in Lymph Node Fibroblastic Reticular Cell, BLS4  

Moon, Kyoung-Mi (Department of Biomaterial Control, Dong-Eui University)
Seo, Hee-Ju (Department of Biotechnology and Bioengineering, Dong-Eui University)
Oh, Ji-Youn (Department of Biotechnology and Bioengineering, Dong-Eui University)
Lee, Jae-Seol (Department of Biotechnology and Bioengineering, Dong-Eui University)
Kim, Hae-Young (Department of Biotechnology and Bioengineering, Dong-Eui University)
Kim, Jeong-Hwan (Department of Biomaterial Control, Dong-Eui University)
Choi, Woo-Bong (Department of Biomaterial Control, Dong-Eui University)
Kim, Byung-Woo (Department of Control Blue-Bio Regional Innovation Center, Dong-Eui University)
Kim, Kwang-Hyeon (Department of Life Science and Biotechnology, Dong-Eui University)
Lee, Jong-Hwan (Department of Biomaterial Control, Dong-Eui University)
Publication Information
Journal of Life Science / v.20, no.5, 2010 , pp. 670-675 More about this Journal
Abstract
Autoimmune regulator gene (Aire) is expressed in the thymus and controls the expression of peripheral self-antigens, known as promiscuous genes. Aire and promiscuous genes are involved in T cell tolerance and autoimmunity in the thymus. Here, we identified Aire-expressing fibroblastic reticular cell (FRC), which was derived from mouse lymph node and also expressed in insulin promiscuous antigen. The expression of insulin was increased in cultured FRC over-expressed with Aire. These data suggest that Aire regulates promiscuous gene expression in FRC, and that this function might be under peripheral selection control.
Keywords
Autoimmune regulator gene (Aire); FRC; insulin promiscuous gene; peripheral selection;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Kont, V., M. Laan, K. Kisand, A. Merits, H. S. Scott, and P. Peterson. 2008. Modulation of Aire regulates the expression of tissue-restricted antigens. Mol. Immunol. 45, 25-33.   DOI
2 Lee, J. W., M. Epardaud, J. Sun, J. E. Becker, A. C. Cheng, A. R. Yonekura, J. K. Heath, and S. J. Turley. 2007. Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self. Nat. Immunol. 8, 181-190.   DOI
3 Liston, A., S. Lesage, J. Wilson, L. Peltonen, and C. C. Goodnow. 2003. Aire regulates negative selection of organ- specific T cells. Nat. Immunol. 4, 350-354.   DOI
4 Mittaz, L., C. Rossier, M. Heino, P. Peterson, K. J. Krohn, Gos A, M. A. Morris, J. Kudoh, N. Shimizu, S. E. Antonarakis, and H. S. Scott.1999. Isolation and characterization of the mouse Aire gene. Biochem. Biophys. Res. Commun. 255, 483-490.   DOI
5 Nagamine, K., P. Peterson, H. S. Scott, J. Kudoh, S. Minoshima, M. Heino, K. J. Krohn, M. D. Lalioti, P. E. Mullis, S. E. Antonarakis, K. Kawasaki, S. Asakawa, F. Ito, and N. Shimizu.1997. Positional cloning of the APECED gene. Nat. Genet. 17, 393-398.   DOI
6 Poliani, P. L., K. Kisand, V. Marrella, M. Ravanini, L. D. Notarangelo, A. Villa, P. Peterson, and F. Facchetti. 2010. Human Peripheral Lymphoid Tissues Contain Autoimmune Regulator-Expressing Dendritic Cells. Am. J. Pathol. [Epub ahead of print]
7 Ruan, Q. G., K. Tung, D. Eisenman, Y. Setiady, S. Eckenrode, B. Yi. S. Purohit, W. P. Zheng, Y. Zhang, L. Peltonen, and J. X. She. 2007. The autoimmune regulator directly controls the expression of genes critical for thymic epithelial function. J. Immunol. 178, 7173-7180.   DOI
8 Xiao, W. 2004. Advances in NF-$\kappa$B signaling transduction and transcription. Cell Mol. Immunol. 1, 425-435.
9 Zhu, M., R. K. Chin, P. A. Christiansen, J. C. Lo, X. Liu, C. Ware, U. Siebenlist, Y. X. Fu. 2006. NF-$\kappa$B2 is required for the establishment of central tolerance through an Aire-dependent pathway. J. Clin. Invest. 116, 2964-2971.   DOI
10 Gardner, J. M., A. L. Fletcher, M. S. Anderson, and S. J. Turley. 2009. AIRE in the thymus and beyond. Curr. Opin. Immunol. 21, 582-589.   DOI
11 Hara, T., T. Katakai, J. H. Lee, Y. Nambu, N. Nakajima-Nagata, H. Gonda, M. Sugai, and A. Shimizu. 2006. A transmembrane chemokine, CXC chemokine ligand 16, expressed by lymph node fibroblastic reticular cells has the potential to regulate T cell migration and adhesion. Int. Immunol. 18, 301-311.   DOI
12 Heino, M., P. Peterson, J. Kudoh, K. Nagamine, A. Lagerstedt, V. Ovod, A. Ranki, I. Rantala, M. Nieminen, J. Tuukkanen, H. S. Scott, S. E. Antonarakis, N. Shimizu, and K. Krohn. 1999. Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla. Biochem. Biophys. Res. Commun. 257, 821-825.   DOI
13 Chen, J., W. Yang, C. Yu, and Y. Li. 2008. Autoimmune regulator initiates the expression of promiscuous genes in thymic epithelial cells. Immunol. Invest. 37, 203-214.   DOI
14 Heino, M., P. Peterson, N. Sillanpaa, S. Guerin, L. Wu, G. Anderson, H. S. Scott, S. E. Antonarakis, J. Kudoh, N. Shimizu, E. J. Jenkinson, P. Naquet, and K. J. Krohn. 2000. RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse. Eur. J. Immunol. 30, 1884-1893.   DOI
15 Katakai, T., T. Hara, M. Sugai, H. Gonda, and A. Shimizu. 2004. Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J. Exp. Med. 200, 783-795.   DOI
16 Kogawa, K., S. Nagafuchi, H. Katsuta, J. Kudoh, S. Tamiya, Y. Sakai, N. Shimizu, and M. Harada. 2002. Expression of AIRE gene in peripheral monocyte/dendritic cell lineage. Immunol. Lett. 80, 195-198.   DOI
17 Gardner, J. M., J. J. Devoss, R. S. Friedman, D. J. Wong, Y. X. Tan, X. Zhou, K. P. Johannes, M. A. Su, H. Y. Chang, M. F. Krummel, and M. S. Anderson. 2008. Deletional tolerance mediated by extrathymic Aire-expressing cells. Science 321, 843-847.   DOI
18 Bjorses, P., M. Pelto-Huikko, J. Kaukonen, J. Aaltonen, L. Peltonen, and I. Ulmanen. 1999. Localization of the APECED protein in distinct nuclear structures. Hum. Mol. Genet. 8, 259-266.   DOI
19 Anderson, M. S, E. S., Venanzi, L. Klein, Z. Chen, S. P. Berzins, S. J. Turley, H. von Boehmer, R. Bronson, A. Dierich, C. Benoist, and D. Mathis. 2002. Projection of an immunological self shadow within the thymus by the aire protein. Science 298, 1348-1349.   DOI
20 Bajenoff, M., J. G. Egen, L. Y. Koo, J. P. Laugier, F. Brau, N. Glaichenhaus, and R. N. Germain. 2006. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity 25, 989-1001.   DOI