• Journal of Chest Surgery
• /
• 제32권11호
• /
• pp.1052-1056
• /
• 1999

The pulmonary sarcomatoid carcinoma is a rare malignant tumor, which is composed of an admixture of carcinomatous and sarcomatous components, and accounts for 0.3% of all pulmonary neoplasms. Clinicopathological features are often related to anatomical location: central endobronchial type and peripheral parenchymal type. Noninvasive diagnostic test had a low yield in detection sarcomatoid carcinoma. Metastasis to the regional lymph nodes and to distant organ is common. The prognosis is poor and the median survival is about 15 months. We report two cases of pulmonary sarcomatoid carcinoma with review of literatures.

• Journal of Chest Surgery
• /
• 제26권7호
• /
• pp.564-567
• /
• 1993

Carcinosarcoma of the lung is an admixture of cardinomatous and sarcomatous lesion and accounts for 0.3% of all pulmonary neoplasm. Clinicopathological features are often related to anatomical location : central endobronchial type and peripheral parenchymal type. Noninvasive diagnostic tests had a low yield in detection carcinosarcoma. Metastasis to regional lymph nodes and to distant organ is common. The prognosis is poor and the median survival is less than one year.Two cases of carcinosarcoma patients are reported here - one case is composed of undifferent cell carcinoma and spindle cell sarcoma in the male of 72 year old and the other case squamous cell carcinoma and spindle cell sarcoma in the male of 65 year old.

• Tuberculosis and Respiratory Diseases
• /
• 제83권1호
• /
• pp.89-95
• /
• 2020

Background: Same-day sputum microcopy is recommended in areas where sputum smear microscopy external quality assessment (EQA) is effectively implemented and sturdy. In Addis Ababa, the status of EQA and drop-out of same-day sputum smear microcopy has not yet been assessed. The objective of this study was to assess the quality of same-day sputum smear microscopy and diagnostic drop-out of presumptive tuberculosis (TB) patients in health facilities (HFs) across Addis Ababa, Ethiopia. Methods: Amulti-analysis was conducted from September 2016 to July 2017 to determine the status of external quality assessment and diagnostic drop-out of presumptive TB patients registered for same-day sputum smear microscopy. Data was coded and entered in Microsoft Excel, and subsequently transferred and analyzed using SPSS version 20.0. Results: The drop-out of same-day sputum smear microscopy was 209 (6.2%). More than 33% of the specimens collected for purposes of same-day sputum smears were of poor quality. Among the selected HFs for the study: 13 (46.4%) used filter reagents prior to sputum smear staining while 75% of the selected HFs for the study used smear microscopy services interruption in a year. The sensitivity and specificity of the HFs participating in regional quality assessment scheme for the diagnosis of TB was 97.4% and 99.6%, respectively. Conclusion: The diagnostic drop-out of same-day sputum smear microscopy was high in Addis Ababa. Strengthening EQA, competency-based laboratory professionals training on sputum smear microscopy might reduce the reading errors in sputum smear. Awareness creation of the community on the benefits gained from completion of specimen provision for the same-day approach decreases diagnostic drop-out and enhances TB control program.

• 대한핵의학회지
• /
• 제24권1호
• /
• pp.80-86
• /
• 1990

Fifty seven patients with differentiated thyroid carcinoma were performed radioactive iodine-131 whole body scans after administration of diagnostic dose $(2\sim10\;mCi)$ and therapeutic dose $(30\sim150\;mCi)$ within three months. We evaluated the state of radioactive iodine-131 uptakes in whole body scan to detect correct metastasis of thyroid carcinoma. The results are as follows: 1) In 20 of the 57 patients (35%), the therapeutic scan showed the additional uptakes that were not seen in the diagnostic scan. 2) In 9 (64.2%) of the 14 patients who had been received the thyroid ablation theraphy with I-131 previously, new additional lesions were found in the therapeutic scan but only 11 (25%) of the 32 patients who had not been received the thyroid ablation theraphy disclosed new uptake lesions (p < 0.01). 3) The additional uptake lesions of therapeutic scan were significantly more common in the bony metastatic foci (55.7%) than other areas (p < 0.01). In 11 (55%) of 20 patients, additional uptake regions were anterior neck areas (thyroid bed or regional lymph node). We conclude that diagnostic scan with $2\sim5$ mCi I-131 is inadequate in evaluating residual iodine avid tissues of patients with thyroid carcinoma. Also post-theraphy I-131 whole body scan would be important to evaluate the correct staging and prognosis of thyroid carcinoma, and to follow-up patients.

• 농촌계획
• /
• 제25권1호
• /
• pp.51-65
• /
• 2019

This study developed diagnostic system to understand the level of welfare cultural service and infrastructure in rural areas. The applicability was reviewed through the Delphi survey and the sample survey of 60 villages. The diagnostic indicators consist of three areas: the demand area, supply area, and delivery area. The demand area consists of 8 indicators, 25 indicators for welfare services and infrastructure (healthcare, social welfare) and 32 indicators for cultural services and infrastructure (culture, education, leisure sports). The service delivery area was divided into service supply area access and traffic accessibility (public transport use status and rural transport model status) by each indicator. A diagnostic system was applied to 60 villages. Services and infrastructure for rural welfare and culture were supplied more in the Si area than Gun area. The delivery area was easier to access the Gun area than Si area. In the case of traffic access, public transportation was more frequently used in the Si area than Gun area, and the rural transportation model was found to have a relatively large amount in the Gun area compared to Si area. The diagnosis system about services and infrastructure for rural welfare and culture will provide information necessary for establishment and decision making of regional development policy taking into account characteristics of rural areas in the future.

• 한국미생물·생명공학회지
• /
• 제43권1호
• /
• pp.79-83
• /
• 2015

박과는 스쿼시, 호박, 애호박, 조롱박, 오이 및 수박 등 100여 속이 넘는 속이 포함된 식물과이며, 종자의 수입량이 매우 많은 작물이다. 이들이 우리나라로 수입될 때, 규제바이러스인 Squash mosaic virus (SqMV), Cucumber green mottle mosaic virus (CGMMV) 및 Kyuri green mottle mosaic virus (KGMMV)에 대하여 검역을 수행한다. 본 연구에서는 SqMV, CGMMV 및 KGMMV를 신속·높은 감도로 검출할 수 있는 특이적 RT-PCR 및 nested PCR 프라이머 조합과 유전자변형-양성대조구 플라스미드를 개발하였다. 또한 본 연구에서 개발한 진단시스템을 2010년부터 2014년 상반기까지 현장적용하여, SqMV 47건, CGMMV 67건 및 KGMMV 17건을 검출하였다.

• 한국의학물리학회:학술대회논문집
• /
• 한국의학물리학회 2002년도 Proceedings
• /
• pp.322-323
• /
• 2002

Partial volume averaging effect of PET data influences on the accuracy of quantitative measurements of regional brain metabolism because spatial resolution of PET is limited. The purpose of this study was to evaluate the accuracy of partial volume correction carried out on $^{18}$ F-PET images using Hoffman brain phantom. $^{18}$ F-PET Hoffman phantom images were co-registered to MR slices of the same phantom. All the MR slices of the phantom were then segmented to be binary images. Each of these binary images was convolved in 2 dimensions with the spatial resolution of the PET. The original PET images were then divided by the smoothed binary images in slice-by-slice, voxel-by-voxel basis resulting in larger PET image volume in size. This enlarged partial volume corrected PET image volume was multiplied by original binary image volume to exclude extracortical region. The evaluation of partial volume corrected PET image volume was performed by region of interests (ROI) analysis applying ROIs, which were drawn on cortical regions of the original MR image slices, to corrected and original PET image volume. From the ROI analysis, range of regional mean values increases of partial volume corrected PET images was 4 to 14%, and average increase for all the ROIs was about 10% in this phantom study. Hoffman brain phantom study was useful for the objective evaluation of the partial volume correction method. This MR-based correction method would be applicable to patients in the. quantitative analysis of FDG-PET studies.

• 대한임상검사과학회지
• /
• 제54권2호
• /
• pp.79-94
• /
• 2022

COVID-19로 인한 높은 전염성과 호흡기 질환의 심각성 때문에, 전염의 확산을 더 잘 모니터링하고 예방하기 위해 경제적이고 정확한 검사가 필요하다. COVID-19 대유행의 초기 단계에서 SARS-CoV-2의 구조적 및 분자적 특성이 밝혀짐에 따라, 많은 COVID-19 진단 키트 제조업체들은 진단 테스트의 설계, 개발, 검증 및 구현에 적극적으로 투자했다. 현재, SARS-CoV-2에 대한 진단검사로써 신속한 항원, 특정 IgG 및 IgM 항체검사를 위한 면역 혈청학적 검사 그리고 분자 진단 검사가 가장 널리 사용되고 검증된 기술이다. 분자 진단 분석법은 SARS-CoV-2에 감염된 것으로 의심되는 개인에서 바이러스 RNA를 직접 검출하기 위한 gold standard이다. 항체 기반 혈청 검사는 지역사회에서 COVID-19 유병률을 결정하고 면역력을 획득한 개인을 식별하는 데 사용되는 간접 검사이다. 본 논문에서는 시판되고 FDA가 승인한 분자 및 면역학적 진단 측정을 평가하여 성능 특성을 분석하였다.

• 대한핵의학회지
• /
• 제29권1호
• /
• pp.48-53
• /
• 1995

Rb-82 dynamic PET과 이중적분법에 의한 국소 심근 혈류측정 연구를 시행하고자 실험 개를 이용한 심근 혈전증 모델에서 좌심실 입력함수에 의한 정상 및 관류결손 심근에서의 혈류를 측정하였다. 이중적분법이 선형회귀모델에 의한 혈류측정방법에 비하여 실현이 간단하고 심근내 혈류가 선형적인 가정을 배제할 수 있어 더욱 정확한 방법이 될 수 있음을 확인하였다.

• 응용통계연구
• /
• 제20권2호
• /
• pp.229-244
• /
• 2007

국내외에서 소지역 추정에 관한 많은 연구가 진행되고 있다. 보조 자료가 충분히 있는 경우 모형기반 추정법을 사용하는 것이 일반적이며 이 중에서 계층적 베이지안(Hierarchical Bayesian: HB) 추정법이 가장 좋은 것으로 알려져 있다. 그러나 보조 자료가 충분하지 않은 경우에는 모형 기반 추정법의 사용은 제한적이다. 최근 충분한 보조 자료가 없는 경우 공간 정보를 보조 자료로 사용하는 방법이 제안되었다. 본 논문에서는 공간통계량과 베이즈 접근방법을 활용한 모형기반의 소지역 통계량들을 모형 검진방법(Diagnostic method)들을 이용하여 비교 분석하였다. 분석에 사용된 자료는 2005년도 경제활동인구 조사이며 소지역(시,군,구)통계를 추정하여 비교하였다.