• 대한한의학원전학회지
• /
• 제27권4호
• /
• pp.153-169
• /
• 2014

Objectives : This paper was motivated by the discovery that there is a regimen which is more realistic and can be used in practical life with deep consideration of Dangye's thought through Judangye's book Gyeokchiyeoron. Methods : First, after looking into the movement of the heart through the contents of natural science underlying Dangye's regimen thought, this paper intends to examine regimens by dividing them into a regimen of food, regimen of sexual desire, and regimen for infancy and the elderly according to age on the basis of the contents included in Gyeokchiyeoron. Results : As for food, Dangye argued that it's necessary that people should avoid overeating and savory taste and observe the proper time for eating, and as for sexual desire, Dangye argued that people should control themselves from bodily and mental aspects. In addition, this paper could learn that as for infants, what matter are eating, clothes to wear, their mother's role, and education while as for the elderly, what matter are taking good care of the spleen and stomach, and children's filial piety, and the elderly should awaken themselves to sound mentality. Conclusions : Through the research on Gyeokchiyeoron, this paper was able to learn that Dangye-argued regimen includes a regimen of food, sexual desire, and a regimen for infants and the elderly; in addition, this paper could learn that there are some parts of Dangye-argued regimen contents, which anyone can easily apply in reality.

• 한국임상약학회지
• /
• 제33권1호
• /
• pp.1-7
• /
• 2023

Background: Along with the increase in the elderly population, concerns about polypharmacy, which can cause medication-related problems, are increasing. This study aimed to find out the association between drug-related factors and readmission in elderly patients within 30 days after discharge. Methods: Data of patients aged ≥65 years who were discharged from the respiratory medicine ward of a tertiary hospital between January and March 2016 were retrospectively obtained. The medication regimen complexity at discharge was calculated using the medication regimen complexity index (MRCI) score, comorbidity status was assessed using the Charlson comorbidity index (CCI), potentially inappropriate medications (PIMs) were evaluated based on the Beer 2019 criteria, and adverse drug events (ADEs) were examined using the ADE reporting system. Multivariable logistic regression analysis was used to evaluate the effect of medication-related problems on hospital readmission after controlling for other variables. Results: Of the 206 patients included, 84 (40.8%) used PIMs, 31 (15%) had ADEs, and 32 (15.5%) were readmitted. The mean age, total medications, MRCI, CCI, and PIMs in the readmission group were significantly higher than those in the non-readmission group. Age significantly decreased the risk of readmission (odds ratio [OR], 0.89; 95% confidence interval [CI], 0.84-0.96) after adjusting for sex, length of hospital stay, and ADEs. The use of PIMs (OR, 2.38; 95% CI, 1.10-5.16) and increased CCI (OR, 1.50; 95% CI, 1.16-1.93) and MRCI (OR, 1.04; 95% CI, 1.01-1.07) were associated with an increased occurrence of readmission. Conclusion: PIMs were associated with a significantly greater risk for readmission than MRCI.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권7호
• /
• pp.3277-3280
• /
• 2016

Background: Gastric cancer is considered the fourth most common cancer and second most common cause of cancer-related mortalities worldwide. Gastric cancer develops more frequently among elderly. The oxaliplatin/5FU/leucovorin (FOLFOX) regimen has shown a notable activity against gastric cancer. Aim: To evaluate the responses and complications of FOLFOX-4 regimen as first line chemotherapy in elderly patients with advanced gastric cancer. Materials and Methods: From October 2014 to November 2015, a total of 21 patients with metastatic or local AGC (advanced gastric cancer) were analyzed. All patients were administered a FOLFOX-4 regimen consisting of a 2h infusion of oxaliplatin $85mg/m^2$ (day 1), continuous infusion of $1000mg/m^2$ 5-Fu in 24h., and leucovorin $200mg/m^2$ in 2h infusion as a first-line chemotherapy. Results: A total of 18 patients were assessable for efficacy and toxicity. One of 18 patients achieved a complete response, and 12 had partial responses, giving an overall response rate of 72.6%. Three (16%) patients demonstrated stable disease and 2 (12%) progression. The median progression free survival was 7.3 months, and the median overall survival was 11.9 months. One patient had grade 3 neuropathy. No other grade 3 or 4 NCI-CTC were seen. Conclusions: The FOLFOX-4 regimen used in our study was both active and acceptable for AGC in elderly patients as neoadjuvant and main therapy.

• Journal of Yeungnam Medical Science
• /
• 제35권1호
• /
• pp.76-83
• /
• 2018

Background: Elderly patients with multiple myeloma (MM) are vulnerable to adverse events (AEs). This study evaluated adherence to chemotherapy and treatment outcomes in elderly patients treated with a frontline bortezomib (BTZ), melphalan, and prednisone (VMP) regimen and regimens without BTZ. Methods: One-hundred and forty elderly patients who were diagnosed with MM from March 2007 to March 2015 were included in this retrospective study. To evaluate regimen adherence, patients who were treated with more than 4 cycles were assigned to the good adherence group. Results: Among the 140 patients, 71 were treated with a frontline VMP and 69 with non-BTZ regimens. The median age was 71 years (range, 65-90 years). The VMP group showed a higher complete response rate than the non-BTZ group: 26.8% vs. 7.2%. More patients in the VMP group achieved ${\geq}$very good partial response (VGPR) and ${\geq}PR$. In the VMP group, 27 patients (38.0%) received less than 4 cycles. The VMP good adherence group showed a higher 3-year overall survival (OS) rate (70.9%) than the poor adherence group (60.2%, p=0.059). In the multivariate analysis, treatment with ${\geq}4$ cycles of VMP was a favorable factor for OS. Conclusion: A good adherence to a frontline VMP regimen resulted in favorable long-term survival. Adequate management of AEs will be needed to achieve favorable outcomes in elderly patients with MM.

• 동서간호학연구지
• /
• 제7권1호
• /
• pp.7-17
• /
• 2002

This study attempted to develop fundamental data for East nursing intervention of nourish of life and health care from chronic disease augmented on the elderly. I understood that a point of nursing view and knowledges have limited to progress of life of quality on the oldman. In this context, this study was aimed to find out a possible of Eastern Nursing Sciences for the management of nourish of life and health care on the elderly and to suggest a distinct frame of Korean nursing intervention method which is unique. From the literature, this study identified that there are needed to intervene of livelihood of nourish of life, such as food and clothing, a feeling of moderation, moving and living(activity, sleeping, recumbency), sex for healthy and quality of life on the oldman. To propose, I suggested the traditional health method physically as Nursing intervention, such as Qi Kyong, Tae Kuk Kyun, Yuk Ja Kyoul, Oh Keum Hee etc and Moxibustion. Through there understand and percept importance and need of nourish of life on the elderly on results of literature view, as above, concrete East Nursing intervention of nourish of life on the elderly will be researched. Hence, we are needed to regain and to adapt Korean traditional health method which is the first draft on Korean Nursing tightly.

• 대한간호학회지
• /
• 제48권3호
• /
• pp.279-288
• /
• 2018

Purpose: The purpose of this study was to examine the effects of breathing exercises performed using panflutes in elderly patients undergoing spinal surgery. Methods: The study design was a nonequivalent control group non-synchronized pre-post test. The study included 24 patients in both the experimental group and the control group. The experimental group completed a daily breathing exercise regimen using panflutes for 30minutes after meals, whereas the control group was provided standard preoperative education, including breathing exercises using incentive spirometers. After the exercise regimen, breathing exercise compliance, pulmonary infections, and life satisfaction were measured in both groups, and the data were analyzed using the SPSS/WIN program. Results: The compliance rate of breathing exercises was significantly higher in the experimental group. The experimental group presented no pulmonary infections in the later period, whereas the control group presented higher pulmonary infection rates in the same period. In addition, the life satisfaction score in the experimental group significantly increased. Conclusion: The breathing exercise program using panflutes for elderly patients undergoing spinal surgery enhanced their breathing exercise compliance and their daily life satisfaction in addition to reducing their pulmonary infection rates.

• 대한의료기공학회지
• /
• 제8권1호
• /
• pp.115-127
• /
• 2005

The present study aims to provide efficient regimen by means of the Oriental medicine tool to measure Yangseng developed to fit the situation of Korea. For this purpose, the elderly people aged older than 65 were selected and their level of Yangseng was compared and analyzed depending on their perception of health. From the study, following conclusions could be drawn: 1. The total subject of study were 763 consisting mostly of the illiterate and spoused with disease but without leisure activities. 2. Most of the subjects were found to have little confidence with their health. With regard to their level of Yangseng, higher points were rated in morality yangseng, followed by activities & rest, diet, mind yangseng, sleep, seasonal yangseng, exercise and sex life in order. 3. By socio-demographic characters for the group with confidence in health, there were more male than female, with spouse, disease and leisure activities currently. In the group without confidence in health, there were more female, without spouse and leisure activity but with disease presently. 4. As for the level of Yangseng in the group with confidence in health, higher points were recorded in morality yangseng, followed by activities & rest, mind yangseng, diet, sleep, exercise and sex life in order. In case of the group without confidence in health, higher points were recorded in morality yangseng, followed by activities & rest, diet, mind yangseng, sleep, exercise and sex life in order. From the above outcomes, it would be necessary to motivate the subjects to have a renewed concept for health and efficient regimen. Continued and repeated eforts should be made to fill the gap in the study using the tool to measure Yangseng of the elderly people.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권5호
• /
• pp.1837-1840
• /
• 2012

Background: In spite of the fact that platinum-based doublets are considered the standard therapy for patients with advanced non-small-cell lung cancer (NSCLC), no elderly-specific platinum based prospective phase III regimen has been explored. The aim of this retrospective singlecenter study was to evaluate the efficacy and side effects of cisplatin-based therapy specifically for the elderly. Methods: Patients receiving platinum-based treatment were divided into three groups. In the first group (GC), Gemcitabine was administrated at 1000 $mg/m^2$ on days 1, 8 and cisplatin was added at 75 $mg/m^2$ on day 1. In the second group (DC), 75 $mg/m^2$ docetaxel and cisplatin were administered on day 1. The third group (PC) received 175 mg of paclitaxel and 75 mg of cisplatin on day 1. These treatments were repeated every three weeks. Result: GC arm had 36, the DC arm 42 and the PC arm 29 patients. Grade III-IV thrombocytopenia was higher in the GC arm (21.2% received GC, 2.8% received DC, and 3.8% received PC), while sensory neuropathy was lower in patients with GC arm (3.0%, 22.2%, and 23.1% received GC, DC and PC, respectively). There were no statistically significant difference in the response rates among the three groups (p>0.05). The median Progression-free survival (PFS) was 5.0 months and the median Overall survival (OS) in each group was 7.1, 7.4 and 7.1 months, respectively (p>0.05). Conclusion: The response rate, median PFS and OS were similar among the three treatment arms. Grade III-IV thrombocytopenia was higher in the GC arm, while the GC regimen was more favorable than the other cisplatin-based treatmetns with regard to sensory neuropathy.

• Tuberculosis and Respiratory Diseases
• /
• 제82권3호
• /
• pp.211-216
• /
• 2019

Background: Docetaxel is one of the standard treatments for advanced non-small cell lung cancer. Docetaxel is usually administered in a 3-week schedule, but there is significant toxicity. In this phase II clinical study, we investigated the efficacy and safety of a 4-weekly schedule of docetaxel monotherapy, as first-line chemotherapy for advanced squamous cell carcinoma in elderly lung cancer patients. Methods: Patients with stage IIIB/ IV lung squamous-cell carcinoma age 70 or older, that had not undergone cytotoxic chemotherapy were enrolled. Patients received docetaxel $25mg/m^2$ on days 1, 8, and 15, every 4 weeks. Primary endpoint was the objective response rate (ORR). Secondary endpoints were progression-free survival (PFS), overall survival (OS), and toxicity profiles. Results: A total of 19 patients were enrolled. Among 19 patients, 17 were for evaluated efficacy and safety. In the intent-to-treat population, ORR and disease control rate (DCR) were 11.8% and 47.1%, respectively. In the response evaluable population, ORR was 16.7% and DCR was 66.7%. Median PFS and OS were 3.1 months and 3.3 months, respectively. There were three adverse grade 3/4 events. Grade 1 neutropenia was reported in one patient. Conclusion: Our data failed to demonstrate efficacy of a 4-weekly docetaxel regimen, in elderly patients with a poor performance status. However, incidence of side effects, including neutropenia, was lower than with a 3-week docetaxel regimen, as previously reported.

• 동서간호학연구지
• /
• 제14권2호
• /
• pp.8-15
• /
• 2008

Purpose: Yangsaeng is a traditional health care regimen that incorporates specific principles and methods to promote health and prevent illness, with the aim of improving the health and longevity of life. The present study assessed Yangsaeng and quality of life (QOL-BREF) in Korea. Methods: Data from 346 adults and elderly Koreans was collected by using a self-reported questionnaire. Analysis of the data included descriptive statistics, Pearson's correlation, t-test, ANOVA and Cronbach's ${\alpha}$. Results: Statistically significant differences in QOL-BREF were evident according to the age, job, religion, education level, economic status and positive thinking. Statistically significant differences were evident in Yangsaeng according to religion, education, economic status and positive thinking. Total QOL-BREF positively related to total Yangsaeng. Morality Yangsaeng, exercise Yangsaeng and sleep Yangsaeng were positively related to all QOL-BREF sub-domains. Conclusions: The Yangsaeng oriental health care regimen can improve QOL, and should be recommended as a means of health promotion and QOL in the Korean culture.