• BMB Reports
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• 제52권12호
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• pp.718-727
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• 2019

Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell transplant. Functional NK cells may impact engraftment success of life-saving procedures such as bone marrow transplantation in human SCID patients. Therefore, in animal models, a T cell-/B cell-/NK cell+ environment provides a valuable tool for understanding the function of the innate immune system and for developing targeted NK therapies against human immune diseases. In this review, we focus on underlying mechanisms of human SCID, recent progress in the development of SCID animal models, and utilization of SCID pig model in biomedical sciences. Numerous physiologies in pig are comparable to those in human such as immune system, X-linked heritability, typical T-B+NK- cellular phenotype, and anatomy. Due to analogous features of pig to those of human, studies have found that immunodeficient pig is the most appropriate model for human SCID.

• 설비공학논문집
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• 제20권7호
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• pp.447-454
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• 2008

The regenerative evaporative cooler(REC) is to cool a stream of air using evaporative cooling effect without an increase in the humidity ratio. In the regenerative evaporative cooler, the air can be cooled down to a temperature lower than its inlet wet-bulb temperature. Besides the cooling performance, for practical application of the regenerative evaporative cooler, the compactness of the system is also a very important factor to be considered. In this respect, three different configurations, i.e., the flat plate type, the corrugated plate type, and the finned channel type are investigated and compared for the most compact configuration. The optimal structure of each configuration is obtained individually to minimize the volume for a given effectiveness within a limit of the pressure drop. Comparing the three optimal structures, the finned channel type is found to give the most compact structure among the considered configurations. The volume of the regenerative cooler can be reduced to 1/8 by adopting the finned channel type as compared to that of the flat plate type.

• BMB Reports
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• 제52권11호
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• pp.625-634
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• 2019

Severe combined immunodeficiency (SCID) is a group of inherited disorders characterized by compromised T lymphocyte differentiation related to abnormal development of other lymphocytes [i.e., B and/or natural killer (NK) cells], leading to death early in life unless treated immediately with hematopoietic stem cell transplant. Functional NK cells may impact engraftment success of life-saving procedures such as bone marrow transplantation in human SCID patients. Therefore, in animal models, a T cell-/B cell-/NK cell＋ environment provides a valuable tool for understanding the function of the innate immune system and for developing targeted NK therapies against human immune diseases. In this review, we focus on underlying mechanisms of human SCID, recent progress in the development of SCID animal models, and utilization of SCID pig model in biomedical sciences. Numerous physiologies in pig are comparable to those in human such as immune system, X-linked heritability, typical T-B＋NK- cellular phenotype, and anatomy. Due to analogous features of pig to those of human, studies have found that immunodeficient pig is the most appropriate model for human SCID.

• 자동차안전학회지
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• 제12권2호
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• pp.7-13
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• 2020

Recently, there is a big issue of downsizing on brake system according to fuel efficiency and regenerative braking cooperation control. Especially, small cars have improved in a variety ways such as electric vehicle and smart car compared to previous small cars. So, small brake system is strongly required in the car industry. A new small brake system for light compact vehicles was proposed in this paper. For this system, the solid type disc and caliper were newly developed. And the important design factors were considered to reduce brake size. First, we calculated the temperature rise of disc through heat capacity formula and CAE analysis. Second, we analyzed the housing and carrier stiffness of caliper to select the reasonable condition. Finally, the superiorities of the developed brake system were verified by heat capacity, consumption liquid level, braking feeling, judder, wear test and regenerative braking cooperation control analysis. A developed brake system is expected to be useful for brake system of light compact platform.

• Journal of the Optical Society of Korea
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• 제17권5호
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• pp.357-361
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• 2013

A regenerative Er-doped fiber amplifier system for a high-repetition-rate optical pulse train is investigated for the first time. A signal pulse train with a wavelength tuning range of 18 nm is produced by a passive mode-locked fiber laser based on a nonlinear polarization rotation technique. In order to realize the amplification, an optical delay-line is used to achieve time match between the pulses' interval and the period of pulse running through the regenerative amplifier. The 16 dB gain is obtained for an input pulse train with a launching power of -30.4 dBm, a center wavelength of 1563.4 nm and a repetition rate of 15.3 MHz. The output properties of signal pulses with different center wavelengths are also discussed. The pulse amplification is found to be different from the regenerative amplification system for CW signals.

• 한국컴퓨터산업학회논문지
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• 제5권4호
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• pp.503-510
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• 2004

이 논문은 모듈 프로그램 안에서 전문가 시스템 소프트웨어 유지 보수에 관한 기존 논문을 분석하고 건설 라인 공정의 문제점을 표준 시스템을 적용, 전문가 시스템으로 해결하는 과정에서 전문가 시스템 소프트웨어 프로그램의 재생성 모듈을 기술하였다. 끝으로 CES(Construction Expert System)라는 프로그램 타입 시스템을 적용 검증했고 전문가 시스템 소프트웨어 프로그램을 통해 대형 건설 과정의 유지 보수에 대한 프레임을 제시하였다.

• 조명전기설비학회논문지
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• 제24권9호
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• pp.85-96
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• 2010

The recent environmental protection trend requires more strict energy saving, therefore every transportation system should reduce energy consumption to the minimum value. High-efficiency operation system, energy saving and $CO_2$ emissions shall be addressed as important issues in railway system. These issues are the most essential factors of railway, compared to major public transportation system. Recently, saving energy in the electric railway system has been studied. The efficient use of regenerated energy is considered to save energy. Namely, Using regenerative energy is that to store the energy generated during braking and discharge it again when a vehicle accelerates. Reusing energy stores and discharges energy, consequently enables a complete exchange of energy between vehicles, even if they are not braking and accelerating at precisely the same time, as is most frequently the case in everyday service. This paper analyzes effects of energy saving and $CO_2$-cut by using regenerative energy of electric vehicles.

• 한국분무공학회지
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• 제9권2호
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• pp.18-23
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• 2004

An experimental studies of conventional gasoline fuel pump were carried out to obtain fundamental data fur liquid phase LPG injection(LPLi) system. A regenerative type and a roller-vane type of pumps were investigated in various operational condition. The experiments were performed to obtain flow rate of LPG fuel as a function of pressure differences and temperatures. The regenerative pump had too low flow rate at some experimental conditions to use this pump system for LPLi fuel supply system. On the other hand, the roller-vane type pump can be applied to the system only if its check valve is modified. Cavitation might occur in this system which can result in system noise, flow rate variation, and pump durability problem. To solve these problems the system is needed to increase $NPSH_{re}$(required net positive suction head).

• 한국철도학회:학술대회논문집
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• 한국철도학회 2008년도 춘계학술대회 논문집
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• pp.505-511
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• 2008

when electric traction system used DC 1500V runs on decline of rail road track and slows down, dc voltage goes beyond regular voltage. In this case extra power is forcibly wasted by resister because rectifier of substation and electric train including power converter and so on are out of order. This paper described a DC electric railway system, which can generate the excessive DC power form DC bus line to AC source in substation for traction system. The purpose of this study was the development of the regenerative inverter system which suppress extra DC-line voltage and regenerate the energy instead of using a resister. That is Developed regenerative inverter system returns the regenerative energy from the DC line voltage to the utility. In addition, the inverter can be compensate the harmonics caused by the power conversion devices used in the DC traction system.

• Biomolecules & Therapeutics
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• 제28권1호
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• pp.34-44
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• 2020

Mesenchymal stem cells (MSCs) have been proposed as an alternative therapy to be applied into several pathologies of the nervous system. These cells can be obtained from adipose tissue, umbilical cord blood and bone marrow, among other tissues, and have remarkable therapeutic properties. MSCs can be isolated with high yield, which adds to their ability to differentiate into non-mesodermal cell types including neuronal lineage both in vivo and in vitro. They are able to restore damaged neural tissue, thus being suitable for the treatment of neural injuries, and possess immunosuppressive activity, which may be useful for the treatment of neurological disorders of inflammatory etiology. Although the long-term safety of MSC-based therapies remains unclear, a large amount of both pre-clinical and clinical trials have shown functional improvements in animal models of nervous system diseases following transplantation of MSCs. In fact, there are several ongoing clinical trials evaluating the possible benefits this cell-based therapy could provide to patients with neurological damage, as well as their clinical limitations. In this review we focus on the potential of MSCs as a therapeutic tool to treat neurological disorders, summarizing the state of the art of this topic and the most recent clinical studies.