• Proceedings of the KSR Conference
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• 2003.05a
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• pp.580-585
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• 2003

Korean high speed train (KHST) has adopted a combined electric/ mechanic (friction) braking system. Electric brakes are consist of rheostatic brake, regenerative brake and eddy current brake and mechanical brakes are composed of disc brake, wheel disc brake and tread brake. In this paper, we introduce the braking performance test and the measuring method of mechanical brake. And disc brake performance has been reviewed by the experimental method. The on-line test of KHST has been carried out up to 260 km/h and proved that the disc braking capacity of KHST is sufficient.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.24 no.2
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• pp.121-128
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• 2012

Improvement in the energy efficiency has been studied of the desiccant cooling system by applying a vapor compression type heat pump to modify the system into a hybrid system. The cycle simulation was performed and the results were compared between a reference desiccant cooling system composed of a desiccant rotor, a sensible rotor and a regenerative evaporative cooler, and a hybrid desiccant cooling system with the sensible rotor being replaced by a heat pump. Though the electric consumption increases as much as the compressor power consumption, the total cooling capacity increases and the thermal energy input decreases by the addition of the heat pump. Therefore, the total energy efficiency can be improved if the increase in the electric consumption can be compensated with the increase in the cooling capacity and the decrease in the thermal energy input. The results showed that the total energy efficiency is optimized at a certain heat pump capacity. When the heat from the CHP plant is used for the thermal energy input, the energy consumption of the hybrid system is reduced by 20~30% compared with the reference system when the heat pump shares 30~40% of the total cooling capacity.

• The Journal of Korean Academy of Prosthodontics
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• v.30 no.2
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• pp.167-189
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• 1992

Frictional heat produced by cutting tools during dental implantation procedure may destroy the surrounding bone tissue and regenerative capacity and interfere ossointegration by formation of undifferentiated connective tissue. To study the effect of frictional heat according to various rotational speeds on the regenerative capacity of surrounding bone tissue, 13 ITI HS implants (8 mm) were inserted at 4 mongrel dogs. Temperatures were measured using thermocouple located 6 mm below from the marginal crest and 0.5 mm from the periphery of trephine mill during implant bed preparation. After 4 and 9 months, animals were sacrificed and specimens were examined using x-rays and light microscope. Results were as follows: 1. With drill speeds of 300, 800, 2,000, 3,500 rpm and saline irrigation, temperatures of surrounding bone were decreased from $-2.9^{\circ}\;to\;-1.7^{\circ}C$. Temperature rises of $2.0^{\circ}\;and\;2.1^{\circ}C$ were recorded with a drill speed of 5,000 rpm and irrigation. 2. With drill speeds of 800, 3,500, 5,000 rpm and no irrigation, temperatures of surrounding bone rose from $+1.5^{\circ}\;to\;+6.8^{\circ}C$, but maximum temperature was $40^{\circ}C$ at 5,000 rpm. 3. On radiographic examination, bone resorptions were observed at the upper half of implant of 5,000 rpm without irrigation and one case of 5,000 rpm with irrigation. 4. Osseointegration was unsuccessful in cases of 3,500, 5,000 rpm without irrigation due to fibrous connective tissue formation to the outer surface and hollow, but it was successful in a case of 800 rpm without irrigation. 5. Osseointegration was successful in cases of 300, 800, 2,000 and 3,500 rpm with irrigation. But fibrous connective tissue formation was observed at the hollow of implant inserted with 5,000 rpm with irrigation.

• Journal of Periodontal and Implant Science
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• v.53 no.6
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• pp.467-477
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• 2023

Purpose: The purpose of this study was to evaluate the regenerative capacity of stem cells combined with bone graft material and a collagen matrix in rabbit calvarial defect models according to the type and form of the scaffolds, which included type I collagen matrix and synthetic bone. Methods: Mesenchymal stem cells (MSCs) were obtained from the periosteum of participants. Four symmetrical 6-mm-diameter circular defects were made in New Zealand white rabbits using a trephine drill. The defects were grafted with (1) group 1: synthetic bone (β-tricalcium phosphate/hydroxyapatite [β-TCP/HA]) and 1×10⁵ MSCs; (2) group 2: collagen matrix and 1×10⁵ MSCs; (3) group 3: β-TCP/HA, collagen matrix covering β-TCP/HA, and 1×10⁵ MSCs; or (4) group 4: β-TCP/HA, chipped collagen matrix mixed with β-TCP/HA, and 1×10⁵ MSCs. Cellular viability and cell migration rates were analyzed. Results: Uneventful healing was achieved in all areas where the defects were made at 4 weeks, and no signs of infection were identified during the healing period or at the time of retrieval. New bone formation was more evident in groups 3 and 4 than in the other groups. A densitometric analysis of the calvarium at 8 weeks post-surgery showed the highest values in group 3. Conclusions: This study showed that the highest regeneration was found when the stem cells were applied to synthetic bone along with a collagen matrix.

• Proceedings of the Korean Society of Machine Tool Engineers Conference
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• 2000.04a
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• pp.348-354
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• 2000

An accumulator in hydraulic systems stores kinetic energy during braking action, and then that controls a hasty surge pressure. This study suggests a method ot determine the capacity of the accumulator to control surge pressure to a desired degree. A mathematical dynamic model of the system was derived and the parameters in the model were identified from experimental data. A series of computer simulation were done for the brake action. The results of the simulation work were compared with those of experiments. These results of the computer simulation and experiments shows that the proposed design method of the accumulator was verified in controlling surge pressure of the system.

• Molecules and Cells
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• v.28 no.1
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• pp.7-12
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• 2009

Gliomas, much like other cancers, are composed of a heterogeneous mix of neoplastic and non-neoplastic cells that include both native and recruited cells. There is extensive diversity among the tumor cells, with differing capacity for In vitro and in vivo growth, a property intimately linked to the cell's differentiation status. Those cells that are undifferentiated, self-renewing, with the capacity for developing tumors (tumorigenic) cells are designated by some as cancer stem cells, because of the stem-like properties. These cells may be a critical therapeutic target. However the exact identity and cell(s) of origin of the socalled glioma cancer stem cell remain elusive. Here we review the current understanding of glioma cancer stem cell biology.

• Journal of Yeungnam Medical Science
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• v.26 no.1
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• pp.1-14
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• 2009

Human bone marrow-derived mesenchymal stem cells (MSCs) are a rare population of undifferentiated cells that have the capacity of self renewal and the ability to differentiate into mesodermal phenotypes, including osteocytes, chondrocytes, and adipocytes in vitro. Recently, MSCs have been shown to reside within the connective tissue of most organs, and their surface phenotype has been well analyzed. Many reports showed that transplanted MSCs enhanced regeneration as well as functional improvement of damaged organs and tissues. The wide differentiation plasticity of MSCs was expected to contribute to their demonstrated efficacy in a wide variety of experimental animal models and in human clinical trials. However, new findings suggest that the ability of MSCs to alter the tissue microenvironment via secretion of soluble factors may contribute more significantly than their capacity for differentiation in tissue repair. This review describes what is known about the cellular characteristics and differentiation potential of MSCs, which represent a promising stem cell population for further applications in regenerative medicine.

• Animal cells and systems
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• v.16 no.6
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• pp.462-468
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• 2012

Urodeles including newt and salamander have remarkable regenerative capacity during the postembryonic life span. Some of the unique features are the formation of the well-developed wound epidermis and the active dedifferentiation process in the early phase of regeneration. These are regarded as key events for the successful regeneration since no further regenerative activity is possible without them. In this study, we investigated the role of retinoic acid (RA) in salamander limb regeneration by blocking RA synthesis using disulfiram, an inhibitor of aldehyde dehydrogenase that oxidizes retinal to RA. Disulfiram treatment resulted in delaying the limb regeneration processes via inhibition of wound epidermis formation and dedifferentiation process. When RA was administered after disulfiram treatment, the inhibitory effect of disulfiram was rescued. In addition, disulfiram treatment after the dedifferentiation stage resulted in the mild retardation of limb regeneration, suggesting that RA might also be involved in the blastema outgrowth. Furthermore, salamander MMP-9 gene expression was also inhibited by disulfiram treatment. Collectively, our findings indicate that endogenous RA may play an important role(s) in the early phase of limb regeneration by regulating the expression of molecules responsible for the modification of intracellular and extracellular environment during salamander limb regeneration.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2007.04a
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• pp.135-140
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• 2007

An analysis has been conducted of the optimal condition to maximize the specific impulse for a liquid rocket engine with film cooling. The present engine performance has been compared with the published conceptual design to be verified satisfactorily accurate. The optimal combination of film coolant flow rate and the regenerative cooling capacity has been found for maximum specific impulse. The optimal fuel pump pressure increases and the optimal film coolant flow decreases for a larger thrust engine. Higher turbine inlet temperature increases both the fuel pump pressure and the film coolant flow rate as the optimal condition. The coking temperature has the same qualitative effect as the turbine inlet temperature.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.22 no.5
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• pp.328-335
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• 2010

The purpose of this study is to make an analysis of influence on the cooling capacity and COP of a desiccant cooling system with a regenerative evaporative cooler when a direct evaporative cooler was applied to the inlet of regeneration process of this system. We used cycle simulation in order to analyze the performance of this system. From the cycle simulation, we knew that the optimal rotation time of desiccant rotor was between 160s and 220s and hardly ever affected cooling capacity of desiccant cooling system when this system was operated at the outdoor air condition of $35^{\circ}$ and 40% RH and low regeneration temperature of $60^{\circ}$. Also there was optimal area ratio of regeneration to dehumidification between 0.7 and 1.0. Our results showed that it had a small effect on the system’s cooling capacity to install direct evaporative cooler at the inlet of regeneration process.