[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.1007/s10059-009-0111-2

Biology of Glioma Cancer Stem Cells

Park, Deric M. (University of Pittsburgh Cancer Institute)
Rich, Jeremy N. (Department of Stem Cell Biology and Regenerative Medicine Cleveland Clinic)

Abstract

Gliomas, much like other cancers, are composed of a heterogeneous mix of neoplastic and non-neoplastic cells that include both native and recruited cells. There is extensive diversity among the tumor cells, with differing capacity for In vitro and in vivo growth, a property intimately linked to the cell's differentiation status. Those cells that are undifferentiated, self-renewing, with the capacity for developing tumors (tumorigenic) cells are designated by some as cancer stem cells, because of the stem-like properties. These cells may be a critical therapeutic target. However the exact identity and cell(s) of origin of the socalled glioma cancer stem cell remain elusive. Here we review the current understanding of glioma cancer stem cell biology.

Keywords

brain tumor; cancer stem cell; glioma; glioblastoma;

Citations & Related Records

Times Cited By Web Of Science : 32 (Related Records In Web of Science)

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5	(2009) Oncology letters Expression of a-disintegrin and metalloproteinase 10 correlates with grade of malignancy in human glioma / 9 (5) , 2157
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9	(2015) Cell death and differentiation The LIM-only transcription factor LMO2 determines tumorigenic and angiogenic traits in glioma stem cells / 22 (9) , 1517
7	(2009) Neuro-oncology Hypoxia in the glioblastoma microenvironment: shaping the phenotype of cancer stem-like cells / 19 (7) , 887
23	(2009) Journal of materials chemistry. B, Materials for biology and medicine Paramagnetic albumin decorated CuInS2/ZnS QDs for CD133+ glioma bimodal MR/fluorescence targeted imaging / 4 (23) , 4110
9	(2009) Epigenomics An update on the epigenetics of glioblastomas / 8 (9) , 1289
6	(2009) Laboratory investigation Notch3 Signaling-Mediated Melanoma-Endothelial Crosstalk Regulates Melanoma Stem-Like Cell Homeostasis and Niche Morphogenesis / 97 (6) , 725
20	(2017) Oncotarget The p38 signaling pathway mediates quiescence of glioma stem cells by regulating epidermal growth factor receptor trafficking / 8 (20) , 33316
3	(2017) Molecular Oncology TRIM 8 regulates stemness in glioblastoma through PIAS 3‐ STAT 3 / 11 (3) , 280
2	(2009) Cell journal (Yakhteh) Targetome Analysis Revealed Involvement of MiR-126 in Neurotrophin Signaling Pathway: A Possible Role in Prevention of Glioma Development / 20 (2) , 150
None	(2009) Molecular imaging The Development and Applications of a Dual Optical Imaging System for Studying Glioma Stem Cells / 18 (None) , 153601211987089
None	(2019) Frontiers in molecular neuroscience Dexamethasone in Glioblastoma Multiforme Therapy: Mechanisms and Controversies / 12 (None) , 65
2	(2009) Oncology letters MMP-2 expression and correlation with pathology and MRI of glioma / 17 (2) , 1826
1	(2009) Scientific reports Retinoid receptor turnover mediated by sumoylation, ubiquitination and the valosin-containing protein is disrupted in glioblastoma / 9 (1) , 16250
7	(2009) Acta neurochirurgica Radiotherapy versus combination radiotherapy-bevacizumab for the treatment of recurrent high-grade glioma: a systematic review / 163 (7) , 1921
20	(2009) International journal of molecular sciences PIM1 Inhibition Affects Glioblastoma Stem Cell Behavior and Kills Glioblastoma Stem-like Cells / 22 (20) , 11126