References
- Al-Hajj, M., Wicha, M.S., Benito-Hernandez, A., Morrison, S.J., and Clarke, M.F. (2003). Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. USA 100, 3983-3988 https://doi.org/10.1073/pnas.0530291100
- Amariglio, N., Hirshberg, A., Scheithauer, B.W., Cohen, Y., Loewenthal, R., Trakhtenbrot, L., Paz, N., Koren-Michowitz, M., Waldman, D., Leider-Trejo, L., et al. (2009). Donor-derived brain tumor follow-ing neural stem cell transplantation in an ataxia telangiectasia patient. PLoS Med. 6, e1000029
- Androutsellis-Theotokis, A., Leker, R.R., Soldner, F., Hoeppner, D.J., Ravin, R., Poser, S.W., Rueger, M.A., Bae, S.K., Kittappa, R., and McKay, R.D. (2006). Notch signalling regulates stem cell numbers in vitro and in vitro. Nature 442, 823-826 https://doi.org/10.1038/nature04940
- Bachoo, R.M., Maher, E.A., Ligon, K.L., Sharpless, N.E., Chan, S.S., You, M.J., Tang, Y., DeFrances, J., Stover, E., Weissleder, R., et al. (2002). Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 1, 269-277 https://doi.org/10.1016/S1535-6108(02)00046-6
- Bajenaru, M.L., Zhu, Y., Hedrick, N.M., Donahoe, J., Parada, L.F., and Gutmann, D.H. (2002). Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. Mol. Cell. Biol. 22, 5100-5113 https://doi.org/10.1128/MCB.22.14.5100-5113.2002
- Bao, S., Wu, Q., McLendon, R.E., Hao, Y., Shi, Q., Hjelmeland, A.B., Dewhirst, M.W., Bigner, D.D., and Rich, J.N. (2006a). Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444, 756-760 https://doi.org/10.1038/nature05236
- Bao, S., Wu, Q., Sathornsumetee, S., Hao, Y., Li, Z., Hjelmeland, A.B., Shi, Q., McLendon, R.E., Bigner, D.D., and Rich, J.N. (2006b). Stem cell-like glioma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res. 66, 7843-7848 https://doi.org/10.1158/0008-5472.CAN-06-1010
- Bao, S., Wu, Q., Li, Z., Sathornsumetee, S., Wang, H., McLendon, R.E., Hjelmeland, A.B., and Rich, J.N. (2008). Targeting cancer stem cells through L1CAM suppresses glioma growth. Cancer Res. 68, 6043-6048 https://doi.org/10.1158/0008-5472.CAN-08-1079
- Bar, E.E., Chaudhry, A., Lin, A., Fan, X., Schreck, K., Matsui, W., Piccirillo, S., Vescovi, A.L., DiMeco, F., Olivi, A., et al. (2007). Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Stem Cells 25, 2524-2533 https://doi.org/10.1634/stemcells.2007-0166
- Beier, D., Hau, P., Proescholdt, M., Lohmeier, A., Wischhusen, J., Oefner, P.J., Aigner, L., Brawanski, A., Bogdahn, U., and Beier, C.P. (2007). CD133(+) and CD133(-) glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles. Cancer Res. 67, 4010-4015 https://doi.org/10.1158/0008-5472.CAN-06-4180
- Beier, D., Rohrl, S., Pillai, D.R., Schwarz, S., Kunz-Schughart, L.A., Leukel, P., Proescholdt, M., Brawanski, A., Bogdahn, U., Trampe-Kieslich, A., et al. (2008). Temozolomide preferentially depletes cancer stem cells in glioblastoma. Cancer Res. 68, 5706-5715 https://doi.org/10.1158/0008-5472.CAN-07-6878
- Ben-Porath, I., Thomson, M.W., Carey, V.J., Ge, R., Bell, G.W., Regev, A., and Weinberg, R.A. (2008). An embryonic stem celllike gene expression signature in poorly differentiated aggressive human tumors. Nat. Genet. 40, 499-507 https://doi.org/10.1038/ng.127
- Bonnet, D., and Dick, J.E. (1997). Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 3, 730-737 https://doi.org/10.1038/nm0797-730
- Carstensen, H., Juhler, M., Bogeskov, L., and Laursen, H. (2006). A report of nine newborns with congenital brain tumours. Childs Nerv. Syst. 22, 1427-1431 https://doi.org/10.1007/s00381-006-0115-6
- Clarke, M.F., Dick, J.E., Dirks, P.B., Eaves, C.J., Jamieson, C.H., Jones, D.L., Visvader, J., Weissman, I.L., and Wahl, G.M. (2006). Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res. 66, 9339-9344 https://doi.org/10.1158/0008-5472.CAN-06-3126
- Collins, A.T., Berry, P.A., Hyde, C., Stower, M.J., and Maitland, N.J. (2005). Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res. 65, 10946-10951 https://doi.org/10.1158/0008-5472.CAN-05-2018
- Conheim, V. (1875). Congenitales, quergestreiftes muskelsarkom der nieren. Virchows Arch. Pathol. Anat. Physiol. Klin. Med. 65, 64-69 https://doi.org/10.1007/BF01978936
- Dahlstrand, J., Collins, V.P., and Lendahl, U. (1992). Expression of the class VI intermediate filament nestin in human central nervous system tumors. Cancer Res. 52, 5334-5341
- Dalerba, P., Cho, R.W., and Clarke, M.F. (2007). Cancer stem cells: models and concepts. Ann. Rev. Med. 58, 267-284 https://doi.org/10.1146/annurev.med.58.062105.204854
- Dietrich, J., Imitola, J., and Kesari, S. (2008). Mechanisms of Disease: the role of stem cells in the biology and treatment of gliomas. Nat. Clin. Pract. 5, 393-404
- Eyler, C.E., Foo, W.C., LaFiura, K.M., McLendon, R.E., Hjelmeland, A.B., and Rich, J.N. (2008). Brain cancer stem cells display preferential sensitivity to Akt inhibition. Stem Cells 26, 3027-3036 https://doi.org/10.1634/stemcells.2007-1073
- Fidler, I.J., and Kripke, M.L. (1977). Metastasis results from preexisting variant cells within a malignant tumor. Science 197, 893-895 https://doi.org/10.1126/science.887927
- Galli, R., Binda, E., Orfanelli, U., Cipelletti, B., Gritti, A., De Vitis, S., Fiocco, R., Foroni, C., Dimeco, F., and Vescovi, A. (2004). Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res. 64, 7011-7021 https://doi.org/10.1158/0008-5472.CAN-04-1364
- Gilbertson, R.J., and Rich, J.N. (2007). Making a tumour’s bed: glioblastoma stem cells and the vascular niche. Nat. Rev. 7, 733-736 https://doi.org/10.1038/nrc2246
- Hanahan, D., and Weinberg, R.A. (2000). The hallmarks of cancer. Cell 100, 57-70 https://doi.org/10.1016/S0092-8674(00)81683-9
- Harris, H. (2004). Tumour suppression: putting on the brakes. Nature 427, 201 https://doi.org/10.1038/427201a
- Harris, H. (2005). A long view of fashions in cancer research. Bioessays 27, 833-838 https://doi.org/10.1002/bies.20263
- Hemmati, H.D., Nakano, I., Lazareff, J.A., Masterman-Smith, M., Geschwind, D.H., Bronner-Fraser, M., and Kornblum, H.I. (2003). Cancerous stem cells can arise from pediatric brain tumors. Proc. Natl. Acad. Sci. USA 100, 15178-15183 https://doi.org/10.1073/pnas.2036535100
- Holland, E.C., Celestino, J., Dai, C., Schaefer, L., Sawaya, R.E., and Fuller, G.N. (2000). Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat. Genet. 25, 55-57 https://doi.org/10.1038/75596
- Horbinski, C., Mintz, A., Engh, J., Lieberman, F., Hamilton, R.L., and Park, D.M. (2009). Post-therapeutic changes in the molecular profile of glioblastomas. J. Clin. Oncol. 27, No 15S, 93
- Ignatova, T.N., Kukekov, V.G., Laywell, E.D., Suslov, O.N., Vrionis, F.D., and Steindler, D.A. (2002). Human cortical glial tumors contain neural stem-like cells expressing astroglial and neuronal markers in vivo. Glia 39, 193-206 https://doi.org/10.1002/glia.10094
- Jackson, E.L., Garcia-Verdugo, J.M., Gil-Perotin, S., Roy, M., Quinones-Hinojosa, A., VandenBerg, S., and Alvarez-Buylla, A. (2006). PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling. Neuron 51, 187-199 https://doi.org/10.1016/j.neuron.2006.06.012
- Joo, K.M., Kim, S.Y., Jin, X., Song, S.Y., Kong, D.S., Lee, J.I., Jeon, J.W., Kim, M.H., Kang, B.G., Jung, Y., et al. (2008). Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas. Lab. Invest. 88, 808-815 https://doi.org/10.1038/labinvest.2008.57
- Kim, C.F., Jackson, E.L., Woolfenden, A.E., Lawrence, S., Babar, I., Vogel, S., Crowley, D., Bronson, R.T., and Jacks, T. (2005). Identification of bronchioalveolar stem cells in normal lung and lung cancer. Cell 121, 823-835 https://doi.org/10.1016/j.cell.2005.03.032
- Kreisl, T.N., Kim, L., Moore, K., Duic, P., Royce, C., Stroud, I., Garren, N., Mackey, M., Butman, J.A., Camphausen, K., et al. (2009). Phase II trial of ingle-agent bevacizumab followed by bevacizumab plus irinotecan at tumor rogression in recurrent glioblastoma. J. Clin. Oncol. 27, 740-745 https://doi.org/10.1200/JCO.2008.16.3055
- Kripke, M.L., Gruys, E., and Fidler, I.J. (1978). Metastatic heterogeneity of cells from an ultraviolet light-induced murine fibrosar coma of recent origin. Cancer Res. 38, 2962-2967
- Lagasse, E. (2008). Cancer stem cells with genetic instability: the best vehicle with the best engine for cancer. Gene Ther. 15, 136-142 https://doi.org/10.1038/sj.gt.3303068
- Lapidot, T., Sirard, C., Vormoor, J., Murdoch, B., Hoang, T., Caceres- Cortes, J., Minden, M., Paterson, B., Caligiuri, M.A., and Dick, J.E. (1994). A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 367, 645-648 https://doi.org/10.1038/367645a0
- Louis, D.N., Ohgaki, H., Wiestler, O.D., and Cavenee, W.K. (2007). WHO Classification of Tumours of the Central Nervous System; in World Classification of Tumours, International Agency for Research on Cancer (IARC), Lyon
- Marchuk, D.A., Saulino, A.M., Tavakkol, R., Swaroop, M., Wallace, M.R., Andersen, L.B., Mitchell, A.L., Gutmann, D.H., Boguski, M., and Collins, F.S. (1991). cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product. Genomics 11, 931-940 https://doi.org/10.1016/0888-7543(91)90017-9
- Miele, L., Golde, T., and Osborne, B. (2006). Notch signaling in cancer. Curr. Mol. Med. 6, 905-918 https://doi.org/10.2174/156652406779010830
- O’Brien, C.A., Pollett, A., Gallinger, S., and Dick, J.E. (2007). A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445, 106-110 https://doi.org/10.1038/nature05372
- Odoux, C., Fohrer, H., Hoppo, T., Guzik, L., Stolz, D.B., Lewis, D.W., Gollin, S.M., Gamblin, T.C., Geller, D.A., and Lagasse, E. (2008). A stochastic model for cancer stem cell origin in metastatic colon cancer. Cancer Res. 68, 6932-6941 https://doi.org/10.1158/0008-5472.CAN-07-5779
- Ogden, A.T., Waziri, A.E., Lochhead, R.A., Fusco, D., Lopez, K., Ellis, J.A., Kang, J., Assanah, M., McKhann, G.M., Sisti, M.B., et al. (2008). Identification of A2B5+CD133- tumor-initiating cells in adult human gliomas. Neurosurgery 62, 505-514; discussion 514-515 https://doi.org/10.1227/01.neu.0000316019.28421.95
- Osawa, M., Hanada, K., Hamada, H., and Nakauchi, H. (1996). Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 273, 242-245 https://doi.org/10.1126/science.273.5272.242
- Palmer, T.D., Willhoite, A.R., and Gage, F.H. (2000). Vascular niche for adult hippocampal neurogenesis. J. Comp. Neurol. 425, 479-494 https://doi.org/10.1002/1096-9861(20001002)425:4<479::AID-CNE2>3.0.CO;2-3
- Park, D.M., Li, J., Okamoto, H., Akeju, O., Kim, S.H., Lubensky, I., Vortmeyer, A., Dambrosia, J., Weil, R.J., Oldfield, E.H., et al. (2007). N-CoR pathway targeting induces glioblastoma derived cancer stem cell differentiation. Cell Cycle 6, 467-470 https://doi.org/10.4161/cc.6.4.3856
- Park, D.M., Hoeppner, D.J., Ravin, R., Androutsellis-Theotokis, A., Miller, J., Park, M.J., Soeda, A., and McKay, R.D. (2008). SSEA-1 is expressed by glioblastoma-derived cancer stem cells and identifies the highly proliferative fraction. Society for Neuroscience 2008 Annual Meeting Abstract 654.21/DD2
- Peiffer, J., and Kleihues, P. (1999). Hans-Joachim Scherer (1906-1945), pioneer in glioma research. Brain Pathol. 9, 241-245 https://doi.org/10.1111/j.1750-3639.1999.tb00222.x
- Quinones-Hinojosa, A., Sanai, N., Soriano-Navarro, M., Gonzalez-Perez, O., Mirzadeh, Z., Gil-Perotin, S., Romero-Rodriguez, R., Berger, M.S., Garcia-Verdugo, J.M., and Alvarez-Buylla, A. (2006). Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cells. J. Comp. Neurol. 494, 415-434 https://doi.org/10.1002/cne.20798
- Quintana, E., Shackleton, M., Sabel, M.S., Fullen, D.R., Johnson, T.M., and Morrison, S.J. (2008). Efficient tumour formation by single human melanoma cells. Nature 456, 593-598 https://doi.org/10.1038/nature07567
- Ravin, R., Hoeppner, D.J., Munno, D.M., Carmel, L., Sullivan, J., Levitt, D.L., Miller, J.L., Athaide, C., Panchision, D.M., and McKay, R.D. (2008). Potency and fate specification in CNS stem cell populations in vitro. Cell Stem Cell 3, 670-680 https://doi.org/10.1016/j.stem.2008.09.012
- Reya, T., Morrison, S.J., Clarke, M.F., and Weissman, I.L. (2001). Stem cells, cancer, and cancer stem cells. Nature 414, 105-111 https://doi.org/10.1038/35102167
- Rich, J.N., and Eyler, C.E. (2008). Cancer stem cells in brain tumor biology. Cold Spring Harbor symposia on quantitative biology 73, 411-420 https://doi.org/10.1101/sqb.2008.73.060
- Rizzo, P., Osipo, C., Foreman, K., Golde, T., Osborne, B., and Miele, L. (2008). Rational targeting of Notch signaling in cancer. Oncogene 27, 5124-5131 https://doi.org/10.1038/onc.2008.226
- Rosen, J.M., and Jordan, C.T. (2009). The increasing complexity of the cancer stem cell paradigm. Science 324, 1670-1673 https://doi.org/10.1126/science.1171837
- Samuelsen, S.O., Bakketeig, L.S., Tretli, S., Johannesen, T.B., and Magnus, P. (2006). Head circumference at birth and risk of brain cancer in childhood: a population-based study. Lancet Oncol. 7, 39-42 https://doi.org/10.1016/S1470-2045(05)70470-8
- Schulenburg, A., Ulrich-Pur, H., Thurnher, D., Erovic, B., Florian, S., Sperr, W.R., Kalhs, P., Marian, B., Wrba, F., Zielinski, C.C., et al. (2006). Neoplastic stem cells: a novel therapeutic target in clinical oncology. Cancer 107, 2512-2520 https://doi.org/10.1002/cncr.22277
- Shen, Q., Goderie, S.K., Jin, L., Karanth, N., Sun, Y., Abramova, N., Vincent, P., Pumiglia, K., and Temple, S. (2004). Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science 304, 1338-1340 https://doi.org/10.1126/science.1095505
- Singh, S.K., Clarke, I.D., Terasaki, M., Bonn, V.E., Hawkins, C., Squire, J., and Dirks, P.B. (2003). Identification of a cancer stem cell in human brain tumors. Cancer Res. 63, 5821-5828
- Singh, S.K., Hawkins, C., Clarke, I.D., Squire, J.A., Bayani, J., Hide, T., Henkelman, R.M., Cusimano, M.D., and Dirks, P.B. (2004). Identification of human brain tumour initiating cells. Nature 432, 396-401 https://doi.org/10.1038/nature03128
- Spangrude, G.J., Heimfeld, S., and Weissman, I.L. (1988). Purification and characterization of mouse hematopoietic stem cells. Science 241, 58-62 https://doi.org/10.1126/science.2898810
- Stupp, R., Mason, W.P., van den Bent, M.J., Weller, M., Fisher, B., Taphoorn, M.J., Belanger, K., Brandes, A.A., Marosi, C., Bogdahn, U., et al. (2005). Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 352, 987-996 https://doi.org/10.1056/NEJMoa043330
- Taipale, J., and Beachy, P.A. (2001). The Hedgehog and Wnt signalling pathways in cancer. Nature 411, 349-354 https://doi.org/10.1038/35077219
- Tohyama, T., Lee, V.M., Rorke, L.B., Marvin, M., McKay, R.D., and Trojanowski, J.Q. (1992). Nestin expression in embryonic human euroepithelium and in human neuroepithelial tumor cells. Lab. Invest. 66, 303-313
- Uchida, N., Buck, D.W., He, D., Reitsma, M.J., Masek, M., Phan, T.V., Tsukamoto, A.S., Gage, F.H., and Weissman, I.L. (2000). Direct isolation of human central nervous system stem cells. Proc. Natl. Acad. Sci. USA 97, 14720-14725 https://doi.org/10.1073/pnas.97.26.14720
- Uhrbom, L., Dai, C., Celestino, J.C., Rosenblum, M.K., Fuller, G.N., and Holland, E.C. (2002). Ink4a-Arf loss cooperates with KRas activation in strocytes and neural progenitors to generate glioblastomas of various morphologies depending on activated Akt. Cancer Res. 62, 5551-5558
- Valtz, N.L., Hayes, T.E., Norregaard, T., Liu, S.M., and McKay, R.D. (1991). An embryonic origin for medulloblastoma. New Biol. 3, 364-371
- Virchow, R. (1858). Cellular Pathology, Berlin
- Vredenburgh, J.J., Desjardins, A., Herndon, J.E., 2nd, Marcello, J., Reardon, D.A., Quinn, J.A., Rich, J.N., Sathornsumetee, S., Gururangan, S., Sampson, J., et al. (2007). Bevacizumab plus irinotecan in recurrent glioblastoma multiforme. J. Clin. Oncol. 25, 4722-4729 https://doi.org/10.1200/JCO.2007.12.2440
- Wang, J., Sakariassen, P.O., Tsinkalovsky, O., Immervoll, H., Boe, S.O., Svendsen, A., Prestegarden, L., Rosland, G., Thorsen, F., Stuhr, L., et al. (2008). CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. Int. J. Cancer 122, 761-768 https://doi.org/10.1002/ijc.23130
- Yuan, X., Curtin, J., Xiong, Y., Liu, G., Waschsmann-Hogiu, S., Farkas, D.L., Black, K.L., and Yu, J.S. (2004). Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene 23, 9392-9400 https://doi.org/10.1038/sj.onc.1208311
- Zhu, Y., Romero, M.I., Ghosh, P., Ye, Z., Charnay, P., Rushing, E.J., Marth, J.D., and Parada, L.F. (2001). Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes. Dev. 15, 859-876 https://doi.org/10.1101/gad.862101
- Zhu, Y., Guignard, F., Zhao, D., Liu, L., Burns, D.K., Mason, R.P., Messing, A., and Parada, L.F. (2005a). Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 8, 119-130 https://doi.org/10.1016/j.ccr.2005.07.004
- Zhu, Y., Harada, T., Liu, L., Lush, M.E., Guignard, F., Harada, C., Burns, D.K., Bajenaru, M.L., Gutmann, D.H., and Parada, L.F. (2005b). Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation. Development 132, 5577-5588 https://doi.org/10.1242/dev.02162
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- Nrf2 is required to maintain the self-renewal of glioma stem cells vol.13, pp.None, 2009, https://doi.org/10.1186/1471-2407-13-380
- Glioblastoma, a Brief Review of History, Molecular Genetics, Animal Models and Novel Therapeutic Strategies vol.61, pp.1, 2013, https://doi.org/10.1007/s00005-012-0203-0
- Cancer-Specific Requirement for BUB1B/BUBR1 in Human Brain Tumor Isolates and Genetically Transformed Cells vol.3, pp.2, 2009, https://doi.org/10.1158/2159-8290.cd-12-0353
- Akt and c-Myc Induce Stem-Cell Markers in Mature Primary p53 −/− Astrocytes and Render These Cells Gliomagenic in the Brain of Immunocompetent Mice vol.8, pp.2, 2009, https://doi.org/10.1371/journal.pone.0056691
- Side population in human glioblastoma is non-tumorigenic and characterizes brain endothelial cells vol.136, pp.5, 2009, https://doi.org/10.1093/brain/awt025
- Downregulation of miR-452 Promotes Stem-Like Traits and Tumorigenicity of Gliomas vol.19, pp.13, 2013, https://doi.org/10.1158/1078-0432.ccr-12-3794
- Cytomegalovirus pp71 Protein Is Expressed in Human Glioblastoma and Promotes Pro-Angiogenic Signaling by Activation of Stem Cell Factor vol.8, pp.7, 2009, https://doi.org/10.1371/journal.pone.0068176
- Correlation between the prognostic value and the expression of the stem cell marker CD133 and isocitrate dehydrogenase1 in glioblastomas vol.115, pp.3, 2013, https://doi.org/10.1007/s11060-013-1234-z
- Interleukin-6 is overexpressed and augments invasiveness of human glioma stem cells in vitro vol.30, pp.8, 2013, https://doi.org/10.1007/s10585-013-9599-0
- Angiopep-2-conjugated liposomes encapsulating γ-secretase inhibitor for targeting glioblastoma stem cells vol.44, pp.7, 2009, https://doi.org/10.1007/s40005-014-0151-2
- CD133 antibody-conjugated immunoliposomes encapsulating gemcitabine for targeting glioblastoma stem cells vol.2, pp.24, 2009, https://doi.org/10.1039/c4tb00185k
- A disintegrin and metalloproteinases 10 and 17 modulate the immunogenicity of glioblastoma-initiating cells vol.16, pp.3, 2014, https://doi.org/10.1093/neuonc/not232
- Silencing BMI1 eliminates tumor formation of pediatric glioma CD133+ cells not by affecting known targets but by down-regulating a novel set of core genes vol.2, pp.1, 2009, https://doi.org/10.1186/s40478-014-0160-4
- Brain Barriers and a Subpopulation of Astroglial Progenitors of Developing Human Forebrain Are Immunostained for the Glycoprotein YKL-40 vol.62, pp.5, 2009, https://doi.org/10.1369/0022155414528514
- The ID proteins: master regulators of cancer stem cells and tumour aggressiveness vol.14, pp.2, 2014, https://doi.org/10.1038/nrc3638
- Interferon-β Induces Loss of Spherogenicity and Overcomes Therapy Resistance of Glioblastoma Stem Cells vol.13, pp.4, 2009, https://doi.org/10.1158/1535-7163.mct-13-0772
- Knockdown of nuclear factor erythroid 2-related factor 2 by lentivirus induces differentiation of glioma stem-like cells vol.32, pp.3, 2009, https://doi.org/10.3892/or.2014.3320
- Selective Calcium Sensitivity in Immature Glioma Cancer Stem Cells vol.9, pp.12, 2014, https://doi.org/10.1371/journal.pone.0115698
- Expression of ZFX gene correlated with the central features of the neoplastic phenotype in human brain tumors with distinct phenotypes vol.4, pp.None, 2009, https://doi.org/10.4103/2277-9175.164000
- The Evidence of Glioblastoma Heterogeneity vol.5, pp.None, 2009, https://doi.org/10.1038/srep07979
- Expression of a-disintegrin and metalloproteinase 10 correlates with grade of malignancy in human glioma vol.9, pp.5, 2009, https://doi.org/10.3892/ol.2015.2993
- The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence vol.15, pp.7, 2015, https://doi.org/10.1586/14737175.2015.1051968
- The LIM-only transcription factor LMO2 determines tumorigenic and angiogenic traits in glioma stem cells vol.22, pp.9, 2015, https://doi.org/10.1038/cdd.2015.7
- Paramagnetic albumin decorated CuInS2/ZnS QDs for CD133+ glioma bimodal MR/fluorescence targeted imaging vol.4, pp.23, 2009, https://doi.org/10.1039/c6tb00834h
- An update on the epigenetics of glioblastomas vol.8, pp.9, 2009, https://doi.org/10.2217/epi-2016-0040
- Notch3 Signaling-Mediated Melanoma-Endothelial Crosstalk Regulates Melanoma Stem-Like Cell Homeostasis and Niche Morphogenesis vol.97, pp.6, 2009, https://doi.org/10.1038/labinvest.2017.1
- Hypoxia in the glioblastoma microenvironment: shaping the phenotype of cancer stem-like cells vol.19, pp.7, 2009, https://doi.org/10.1093/neuonc/now258
- The p38 signaling pathway mediates quiescence of glioma stem cells by regulating epidermal growth factor receptor trafficking vol.8, pp.20, 2017, https://doi.org/10.18632/oncotarget.16741
- TRIM 8 regulates stemness in glioblastoma through PIAS 3‐ STAT 3 vol.11, pp.3, 2017, https://doi.org/10.1002/1878-0261.12034
- Targetome Analysis Revealed Involvement of MiR-126 in Neurotrophin Signaling Pathway: A Possible Role in Prevention of Glioma Development vol.20, pp.2, 2009, https://doi.org/10.22074/cellj.2018.4901
- The Development and Applications of a Dual Optical Imaging System for Studying Glioma Stem Cells vol.18, pp.None, 2009, https://doi.org/10.1177/1536012119870899
- Dexamethasone in Glioblastoma Multiforme Therapy: Mechanisms and Controversies vol.12, pp.None, 2019, https://doi.org/10.3389/fnmol.2019.00065
- MMP-2 expression and correlation with pathology and MRI of glioma vol.17, pp.2, 2009, https://doi.org/10.3892/ol.2018.9806
- Retinoid receptor turnover mediated by sumoylation, ubiquitination and the valosin-containing protein is disrupted in glioblastoma vol.9, pp.1, 2009, https://doi.org/10.1038/s41598-019-52696-3
- Radiotherapy versus combination radiotherapy-bevacizumab for the treatment of recurrent high-grade glioma: a systematic review vol.163, pp.7, 2009, https://doi.org/10.1007/s00701-021-04794-3
- PIM1 Inhibition Affects Glioblastoma Stem Cell Behavior and Kills Glioblastoma Stem-like Cells vol.22, pp.20, 2009, https://doi.org/10.3390/ijms222011126