• BMB Reports
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• v.54 no.7
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• pp.335-343
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• 2021

Cancer stem cells (CSCs) are a subpopulation of cancer that can self-renew and differentiate into large tumor masses. Evidence accumulated to date shows that CSCs affect tumor proliferation, recurrence, and resistance to chemotherapy. Recent studies have shown that, like stem cells, CSCs maintain cells with self-renewal capacity by means of asymmetric division and promote cell proliferation by means of symmetric division. This cell division is regulated by fate determinants, such as the NUMB protein, which recently has also been confirmed as a tumor suppressor. Loss of NUMB expression leads to uncontrolled proliferation and amplification of the CSC pool, which promotes the Notch signaling pathway and reduces the expression of the p53 protein. NUMB genes are alternatively spliced to produce six functionally distinct isoforms. An interesting recent discovery is that the protein NUMB isoform produced by alternative splicing of NUMB plays an important role in promoting carcinogenesis. In this review, we summarize the known functions of NUMB and NUMB isoforms related to the proliferation and generation of CSCs.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.64 no.9
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• pp.1391-1397
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• 2015

Recently, various researches are conducted in the application of regenerative energy produced during the operation of an electric locomotive. Regenerative energy is produced by a generator in the brake procedure. The generator is operated by kinetic energy of an electric railroad using an electric motor. The process of producing regenerative energy varies with the current type of a railroad and its running condition. The quality of electric power can be improved and electric energy can be utilized effectively, especially in the use of an energy storage system (ESS). Thus, it is necessary to apply ESS into AC section and high speed railway. This study analyses the composition of the regenerative ESS equipment installed in Yong-Jeong sectioning post, operational principle, charge and discharge algorithm and energy efficiency. The analysis shows that CO2 emissions can be reduced about 0.5 ton per a day. In addition, ESS helps saving the energy and the compensation of the voltage drop caused by the operation of high speed train when it is installed at the end of the feeder section. The number of high speed train will be increased continuously related to the electrification rate. Therefore, applying the ESS to high speed railway is expected to solve the instability of the feeder voltage and the equipment capacity problem caused by the high speed trains.

• Animal cells and systems
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• v.3 no.3
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• pp.259-267
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• 1999

The expression of the neural cell adhesion molecule-180 (NCAM-180), which accumulates at contact sites between cells and may be responsible for the stabilization of cell contacts, was studied in the olfactory system and retina of developing and adult rats. From embryonic day 12 onwards, which was the earliest stage examined, the NCAM-180 pathway directing to the presumptive olfactory bulb was observed. In later stages, olfactory neurons and fasciculating axons in the olfactory epithelium and nerve fiber layer and glomeruli of the olfactory bulb expressed NCAM-180. From postnatal day 0, immunolabelling pattern of the olfactory epithelium and olfactory bulb were the same as that during later stages. NCAM-180 immunoreactivity was present on differentiating retinal cells and persisted on those cells throughout adulthood. However, contrary to the olfactory nerve which remained detectable in the adult, the optic nerve was only transiently expressed with NCAM-180 and was no longer detectable in the adult. The presence of NCAM-180 in olfactory tissues suggests their possible role in pathfinding, differentiation, fasciculation and synaptic plasticity. The continued presence of NCAM-180 in the olfactory system examined may underlie its continuous cell turnover and regenerative capacity. The continuous expression of NCAM-180 in ganglion cells, bipolar cells and photoreceptor cells, also suggests potential regenerating capability and some plastic functions for these cells in the adult. Since the expression of NCAM-180 by the optic nerve was restricted to the period of special histogenetic events, for example, during axonal growth and synaptogenesis, it is possible that the lack of NCAM-180 in the adult optic nerve might cause a nonpermissive environment for the regeneration and result in regenerative failure of this system.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.32 no.4
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• pp.67-72
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• 2004

A regenerative cooling system has been designed through empirical 1-D analysis for a liquid rocket engine of 30-ton-level thrust. The hot-gas-side wall temperature from 1-D analysis shows 100K difference compared to 3D CFD analysis. Two variations of design with same cooling performance are suggested for different maximum channel widths i.e., 4mm and 2mm. The coolant pressure drop of the latter design is higher by 20%. The maximum liner temperature is about 700K when TBC and the thermal resistance of carbon deposit are considered. So film cooling is recommended to increase the cooling capacity as the present cooling capacity is insufficient

• Proceedings of the SAREK Conference
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• 2005.11a
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• pp.359-364
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• 2005

In dehumidification evaporation cooling system. the regeneratie evaporative cooler(REC) makes an important role to reduce the sensible cooling load in the system through evaporative cooling, By this reason, many studies about increasing the cooling capacity of the REC were undertook. In this paper, we analyzed the cooling characteristics of the REC due to the structures of the REC and determined the best structure for the REC's effectiveness and cooling capacity. From the study. we could obtain some important results: at first. corrugated type has the benefit to expand the channel width of the REC, But because the type has some weak points about the size and weight. there is almost no benefit to improve the performance of the REC. Through these reasons. we decided that finned type is the best structure to improve the performance of the REC.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.62 no.7
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• pp.1045-1052
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• 2013

In this study we deal with design procedures for the flywheel energy storage system that has the capacity to store the regenerative energy produced from the railway vehicles. The flywheel energy storage system (FESS) stores the regenerative electrical energy into the high speed rotational flywheel, by conversion the electrical energy into the mechanical rotational energy. Thus the FESS is composed of the energy conversion components, such as the motor and generator, mechanical support components, such as the rotational rotor, the magnetic bearings to support the rotor, and the digital controller to control the air gap between the rotor and the magnetic bearings. In this paper the design procedures for the rotor operating at the rigid mode and the magnetic bearings to support the rotational rotor without contact are presented.

• The KSFM Journal of Fluid Machinery
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• v.17 no.2
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• pp.48-53
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• 2014

A low-noise regenerative blower is developed for fuel cell application by combining the FANDAS-Regen code and design optimization algorithm under several performance constraints for flow capacity, static pressure, efficiency and power consumption. The optimized blower design model is manufactured with some impeller modification based on low noise design concept and tested by using aerodynamic performance chamber facility and narrow-band noise measurement apparatus. The measured results of the optimized blower satisfy the performance requirements and are also compared favorably with the FANDAS-Regen prediction results within a few percent relative error. Furthermore, the present study shows the remarkable noise reduction by 26 dBA can be achieved through design optimization and low noise design concept.

• BMB Reports
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• v.47 no.3
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• pp.135-140
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• 2014

The mesenchymal stem cells (MSCs), which are derived from the mesoderm, are considered as a readily available source for tissue engineering. They have multipotent differentiation capacity and can be differentiated into various cell types. Many studies have demonstrated that the MSCs identified from amniotic membrane (AM-MSCs) and amniotic fluid (AF-MSCs) are shows advantages for many reasons, including the possibility of noninvasive isolation, multipotency, self-renewal, low immunogenicity, anti-inflammatory and nontumorigenicity properties, and minimal ethical problem. The AF-MSCs and AM-MSCs may be appropriate sources of mesenchymal stem cells for regenerative medicine, as an alternative to embryonic stem cells (ESCs). Recently, regenerative treatments such as tissue engineering and cell transplantation have shown potential in clinical applications for degenerative diseases. Therefore, amnion and MSCs derived from amnion can be applied to cell therapy in neuro-degeneration diseases. In this review, we will describe the potential of AM-MSCs and AF-MSCs, with particular focus on cures for neuronal degenerative diseases.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.28 no.8
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• pp.316-324
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• 2016

This study investigated a compact regenerative evaporative cooler (REC). To achieve practical applications of an REC, it is very important to consider the compactness as well as the cooling performance. Therefore, a prototype of the REC was designed and fabricated to improve the compactness by reducing the length through the insertion of fins in both the dry and wet channels. The REC prototype was tested in terms of performance evaluation under various operating conditions. An analytical model was also developed to analyze the effects of the axial conduction through the solid body of the REC, the wetness of the surface in the wet channel, and the thermal capacity of the evaporation water flow. The model was validated by comparing the results of a simulation with experimental data. The numerical simulation was based on the model to analyze the performance of the REC and to suggest methods to improve the cooling performance of the REC. Finally, the performance of the present REC was compared to that obtained in previous experimental studies. The results showed that the REC prototype in the present study is the most compact and achieves the highest cooling performance.

• BMB Reports
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• v.56 no.9
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• pp.502-507
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• 2023

Photobiomodulation therapy has been proposed as a promising therapeutic approach for retinal degenerative diseases. However, its effect on the regenerative capacity in mammalian retina and its intracellular signalling mechanisms remain unknown. Here, we show that photobiomodulation with 670 nm light stimulates Müller glia cell cycle re-entry and dedifferentiation into a progenitor-like state in both the uninjured and injured retina. We also find that 670 nm light treatment inhibits the Hippo pathway, which is activated in Müller glia following NaIO₃-induced retinal injury. YAP, a major downstream effector of the Hippo signalling pathway was translocated into the nucleus of Müller glia along with YAP dephosphorylation in retina treated with 670 nm light. Deficiency of YAP attenuated Müller glia cell cycle re-entry and dedifferentiation. Our data reveal that the Hippo-YAP signalling pathway is associated with the photostimulatory effect on regenerative response in mammalian retina, and suggest a potential therapeutic strategy for retinal degenerative diseases.