• Journal of Biomedical Engineering Research
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• v.24 no.3
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• pp.159-165
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• 2003

We developed a 37-channel magnetoencephalogram (MEG) measurement system based on low-noise superconducting quantum interference device (SQUID) magnetometets, and operated the system to measure MEG signals. By using double relaxation oscillation SQUIDs with high flux-4o-voltage transfers, the SQUID outputs could be measured directly by room temperature preamplifiers and compact readout circuits were used for SQUID operation. The average field noise level of the magnetometers is about 3 fT/√Hz in the white region, low enough for MEG measurements when operated inside a magnetically shielded room. The 37 magnetometers were distributed on a hemispherical surface haying a radius of 125 mm. In addition to the 37 sensing channels. 11 reference channels were installed to pickup external noise and to form software gradiometers. A low-noise liquid helium dewar was fabricated with a liquid capacity of 30 L and boil-off rate of 4 L/d. The signal processing software consists of digital filtering, software gradiometer, isofield mapping and source localization. By using the developed system, we measured auditory-evoked fields and localized the current dipoles, demonstrating the effectiveness of the system.

• The Journal of the Korea Contents Association
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• v.15 no.11
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• pp.509-523
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• 2015

With the introduction of smart devices as a new channel of information distribution, the mass tourism that has been dominating the travel scene is being transformed into individual tourism. Therefore, it is more than important to establish an advanced smart tourism environment using cutting-edge ICT technologies in order to go into one of tourism developed countries. In line with that, this study draws both local and international cases to show where smart tourism stands now by mapping out problems and solutions by category. Firstly, in terms of infrastructure, establishing distribution platform and big data analyzing systems were suggested. Secondly, to fit the needs of consumers, converged tourism content and user experience based content development are in need. Lastly, in terms of governance forming public-private consultative body and incubating creative tourism companies are suggested. The study results will serve as a fruitful reference to those who want to establish business strategy related to smart tourism.

• Genomics & Informatics
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• v.17 no.3
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• pp.26.1-26.12
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• 2019

Identification of fusion gene is of prominent importance in cancer research field because of their potential as carcinogenic drivers. RNA sequencing (RNA-Seq) data have been the most useful source for identification of fusion transcripts. Although a number of algorithms have been developed thus far, most programs produce too many false-positives, thus making experimental confirmation almost impossible. We still lack a reliable program that achieves high precision with reasonable recall rate. Here, we present FusionScan, a highly optimized tool for predicting fusion transcripts from RNA-Seq data. We specifically search for split reads composed of intact exons at the fusion boundaries. Using 269 known fusion cases as the reference, we have implemented various mapping and filtering strategies to remove false-positives without discarding genuine fusions. In the performance test using three cell line datasets with validated fusion cases (NCI-H660, K562, and MCF-7), FusionScan outperformed other existing programs by a considerable margin, achieving the precision and recall rates of 60% and 79%, respectively. Simulation test also demonstrated that FusionScan recovered most of true positives without producing an overwhelming number of false-positives regardless of sequencing depth and read length. The computation time was comparable to other leading tools. We also provide several curative means to help users investigate the details of fusion candidates easily. We believe that FusionScan would be a reliable, efficient and convenient program for detecting fusion transcripts that meet the requirements in the clinical and experimental community. FusionScan is freely available at http://fusionscan.ewha.ac.kr/.

• Journal of the Korean Solar Energy Society
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• v.27 no.4
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• pp.1-9
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• 2007

Sensitivity analysis of wind resource micrositing has been performed through the application case at the Antarctic King Sejong station with the most representative micrositing softwares: WAsP, WindSim and Meteodyn WT. The wind data obtained from two met-masts separated 625m were applied as a climatology input condition of micro-scale wind mapping. A tower shading effect on the met-mast installed 20m apart from the warehouse has been assessed by the CFD software Fluent and confirmed a negligible influence on wind speed measurement. Theoretically, micro-scale wind maps generated by the two met-data located within the same wind system and strongly correlated meteor-statistically should be identical if nothing influenced on wind prediction but orography. They, however, show discrepancies due to nonlinear effects induced by surrounding complex terrain. From the comparison of sensitivity analysis, Meteodyn WT employing 1-equation turbulence model showed 68% higher RMSE error of wind speed prediction than that of WindSim using the ${\kappa}-{\epsilon}$ turbulence model, while a linear-theoretical model WAsP showed 21% higher error. Consequently, the CFD model WindSim would predict wind field over complex terrain more reliable and less sensitive to climatology input data than other micrositing models. The auto-validation method proposed in this paper and the evaluation result of the micrositing softwares would be anticipated a good reference of wind resource assessments in complex terrain.

• Korean Journal of Optics and Photonics
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• v.29 no.3
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• pp.99-103
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• 2018

Optical coherence elastography (OCE) is based on optical coherence tomography (OCT), which is a noninvasive, high-resolution, cross-sectional imaging technique. In this paper, we have developed dynamic optical coherence elastography to measure elasticity, a mechanical property of tissue, by phase difference. A piezoelectric actuator was used for sinusoidal mechanical loading of samples. Before applying this method to biomaterial, we assessed the feasibility of OCE with samples of sponge, eraser, and sharp lead. Cross-sectional and phase-difference images of the sample were obtained under sinusoidal loading. The strain rate was calculated from the phase-difference information. To obtain the envelope of the phase-difference oscillations along the horizontal direction, Hilbert transformation was performed at each depth. The elevation of the envelope was represented by color mapping, and we could measure the relative elasticity within the sample by comparing the elevations. Finally, there was an advantage when we calculated the shear rate using self-interference in the sample arm, instead of the interference between sample and reference arms.

• Journal of the Ergonomics Society of Korea
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• v.31 no.4
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• pp.515-523
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• 2012

Objective: The aim of this study is to investigate users' intuitive stereotypes on non-touch gestures and establish the gesture dictionary that can be applied to gesture-based interaction designs. Background: Recently, the interaction based on non-touch gestures is emerging as an alternative for natural interactions between human and systems. However, in order for non-touch gestures to become a universe interaction method, the studies on what kinds of gestures are intuitive and effective should be prerequisite. Method: In this study, as applicable domains of non-touch gestures, four devices(i.e. TV, Audio, Computer, Car Navigation) and sixteen basic operations(i.e. power on/off, previous/next page, volume up/down, list up/down, zoom in/out, play, cancel, delete, search, mute, save) were drawn from both focus group interview and survey. Then, a user participatory design was performed. The participants were requested to design three gestures suitable to each operation in the devices, and they evaluated intuitiveness, memorability, convenience, and satisfaction of their derived gestures. Through the participatory design, agreement scores, frequencies and planning times of each distinguished gesture were measured. Results: The derived gestures were not different in terms of four devices. However, diverse but common gestures were derived in terms of kinds of operations. In special, manipulative gestures were suitable for all kinds of operations. On the contrary, semantic or descriptive gestures were proper to one-shot operations like power on/off, play, cancel or search. Conclusion: The touchless gesture dictionary was established by mapping intuitive and valuable gestures onto each operation. Application: The dictionary can be applied to interaction designs based on non-touch gestures. Moreover, it will be used as a basic reference for standardizing non-touch gestures.

• Genomics & Informatics
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• v.8 no.3
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• pp.131-137
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• 2010

Genome-wide association studies (GWASs) have greatly contributed to the identification of common variants responsible for numerous complex traits. There are, however, unavoidable limitations in detecting causal and/or rare variants for traits in this approach, which depends on an LD-based tagging SNP microarray chip. In an effort to detect potential casual and/or rare variants for complex traits, such as type 2 diabetes (T2D) and triglycerides (TGs), we conducted a targeted resequencing of loci identified by the Korea Association REsource (KARE) GWAS. The target regions for resequencing comprised whole exons, exon-intron boundaries, and regulatory regions of genes that appeared within 1 Mb of the GWA signal boundary. From 124 individuals selected in population-based cohorts, a total of 0.7 Mb target regions were captured by the NimbleGen sequence capture 385K array. Subsequent sequencing, carried out by the Roche 454 Genome Sequencer FLX, generated about 110,000 sequence reads per individual. Mapping of sequence reads to the human reference genome was performed using the SSAHA2 program. An average of 62.2% of total reads was mapped to targets with an average 22X-fold coverage. A total of 5,983 SNPs (average 846 SNPs per individual) were called and annotated by GATK software, with 96.5% accuracy that was estimated by comparison with Affymetrix 5.0 genotyped data in identical individuals. About 51% of total SNPs were singletons that can be considered possible rare variants in the population. Among SNPs that appeared in exons, which occupies about 20% of total SNPs, 304 nonsynonymous singletons were tested with Polyphen to predict the protein damage caused by mutation. In total, we were able to detect 9 and 6 potentially functional rare SNPs for T2D and triglycerides, respectively, evoking a further step of replication genotyping in independent populations to prove their bona fide relevance to traits.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.9
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• pp.4587-4592
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• 2013

GPS is recognized the essential method to obtain the best result in the sphere of earth science that is setting of International Reference Frame, decision of the rotation coefficient about the earth rotation axis, detection of the crustal deformation, and observation of the diastrophism by high precision positioning except for navigation, geodetic survey and mapping. Therefore, in this study, it was attempted to build an expert service that enables non-experts to use high-precision GPS data processing. As a result, an Precise Point Positioning Solution that can maximize user convenience simply by entering the minimum required information for GPS data processing was developed, and the result of Precise Point Positioning Solution using GPS data provided by National Geographic Information Institute was compared with result of ITRF.

• Journal of the Korean Society for Nondestructive Testing
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• v.32 no.5
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• pp.545-550
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• 2012

Steam generator is one of the major components of nuclear power plant and steam generator tubes are the pressure boundary between primary and secondary side, which makes them critical for nuclear safety. As the operating time of nuclear power plant increases, not only damage mechanisms but also scaled deposits on steam generator tubes are known to be problematic causing tube support flow hole blockage and heat fouling. The ability to assess the extent and location of scaled deposits on tubes became essential for management and maintenance of steam generator and eddy current bobbin data can be utilized to measure thickness of scale on tubes. In this paper, tube reference standards with various thickness of scaled deposit has been set up to provide information about the overall deposit condition of steam generator tubes, providing essential tool for steam generator management and maintenance to predict and prevent future damages. Also, methodology to automatically measure scale thickness on tubes has been developed and applied to field data to estimate overall scale amount.

• Journal of Biomedical Engineering Research
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• v.26 no.1
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• pp.9-16
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• 2005

One of the most important roles of a brain atlas is providing a spatial reference system in which multiple images can be interpreted in a consistent way. The brain atlase based on Western populations such as the International Consortium for Brain Mapping's 452 T-1 Weighted Average Atlas was widely used; however, they may not be the optimal choice for use with brain images from other ethnic groups, because structural differences between occidental and oriental brains have been reported. Therefore, in this study, we created an average brain atlas from 100 healthy Koreans (100 cases (M/F=53/47), 39.0±17.0 years). The purpose of this study was to make a Korean average-brain atlas and to measure its differences from a widely accepted average brain atlas built on an occidental population. The average brain atlas for Koreans was developed using widely accepted tools and procedures. The comparison between the Korean and occidental averages was performed using tissue probability maps and a registration tool, and it was shown that the global pattern of differences between the two average brains found in this work agreed with previously reported differences: Korean brains are wider and shorter in size, and smaller in volume, yet no hemispheric volume asymmetry was found.