• Journal of mucopolysaccharidosis and rare diseases
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• 제5권1호
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• pp.22-28
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• 2021

Mucopolysaccharidosis type III (MPS III) or Sanfilippo disease is an orphan-inherited lysosomal storage disease. It is one of the most common MPS subtypes. The classical presentation is an infantile-onset neurodegenerative disease characterized by intellectual regression, behavioral and sleep disturbances, loss of ambulation, and early death. Unlike other MPS, no disease-modifying therapy has been approved. Here, we review the curative therapy developed for MPS III, from historically ineffective hematopoietic stem cell transplantation and substrate reduction therapy to the promising enzyme replacement therapy or adeno-associated/lentiviral vector-mediated gene therapy. Preclinical studies are presented with recent translational first-in-man trials. We also present experimental research with preclinical mRNA and gene-editing strategies. Lessons from animal studies and clinical trials have highlighted the importance of early therapy before extensive neuronal loss. Disease-modifying therapy for MPS III will likely mandate the development of new early diagnosis strategies.

• Journal of Korean Society for Atmospheric Environment
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• 제19권E1호
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• pp.41-50
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• 2003

Greenhouse gases (GHG) could lead to global warming, which may bring about various disturbances to global ecosystem. Other than primary benefits that are too extensive, the ancillary benefit from GHG reduction has been estimated to provide justification for national actions. Five scenarios for 5 to 40％ reduction of GHG were evaluated for the benefit/cost efficiency, using the cost estimates from a previous study. Their benefits were also estimated using a European model. As a result of this study, it can be concluded that lower reduction scenarios (5∼10%) seem to be more efficient than higher reduction scenarios (30∼40％).

• Architectural research
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• 제7권2호
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• pp.69-79
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• 2005

There are no formal decision tools or guidelines to assist owners and contractors in choosing delivery systems and project strategies that would allow for a radical reduction in project cycle time - from the preplanning phase through project start up. Therefore, it is important to identify the state-of-practice and the state-of-art on methods of achieving radical reduction defined as a reduction of 25% or more in overall project cycle time. A comprehensive literature review, three questionnaire surveys, and the seven case studies were conducted and the data obtained from them were analyzed to establish the state-of-practice and state-of-art for project cycle time reduction techniques.

• 대한설비공학회지:설비저널
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• 제21권3호
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• pp.236-238
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• 1992

• 한국자동차공학회논문집
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• 제19권1호
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• pp.117-124
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• 2011

Automotive engines require strategies to fulfill the emission regulations in terms of NOx and PM. A dramatic reduction in NOx and PM emissions could be achieved with high pressure injection, innovative combustion strategies and EGR. Recently, Lean NOx Trap (LNT) and Urea-SCR are considered as more practical strategy to suppress the engine-out emissions substantially for copying with severe regulation. These systems need to reduce the reducing agent injection system which has a huge impact on NOx purification efficiency. In this paper, different three injectors have been used to investigate spray characteristics and engine emission test was conducted to clarify the effect of these injectors on the NOx reduction.

• 한국축산식품학회지
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• 제37권6호
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• pp.793-798
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• 2017

Salt is an essential ingredient for cheese production, and it influences various aspects of cheese, including the shelf life, enzyme activity, flavor, casein hydration, and microbial proliferation during ripening. Several consumers avoid cheese with high salt content, mainly due to health problems such as hypertension, cardiovascular disease (CVD), stroke, and heart attacks. Salt has been commonly used for several purposes in cheese production, including for obtaining the required flavor and texture, for its preservative properties, and as a taste enhancer. However, salt usage has been opposed by the public and governmental bodies, who have been advised by health authorities that salt should be reduced or avoided in cheese for healthier life. However, salt replacement or reduction in cheese manufacturing requires formulation of intensive strategies. This review provides information about several strategies and innovations for reduction and replacement of salt in cheese manufacturing without seriously affecting the quality, microbial safety, and sensory properties of cheeses.

• 한국안전학회지
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• 제29권1호
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• pp.64-69
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• 2014

Community-based disaster preparedness approaches are increasingly important elements of vulnerability reduction and disaster strategies. They are associated with a policy trend that values the knowledge and capacities of local people. In this research, we describe the community diagnosis method and develop Flood Disaster Risk Reduction Index(FDRRI) for assessment of flood vulnerability. FDRRI is composed of four indicators such as Flood Exposure Indicator(FEI), Sensitivity Indicator(SI), Risk Reduction Indicator(RRI), and Community Preparedness Indicator(CPI). We anticipate to present the guideline for selection national preparedness projects and uplift community's preparedness capacity.

• 경영과정보연구
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• 제34권1호
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• pp.211-225
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• 2015

본 연구의 목적은 부실기업에서 회생과정을 거쳐 정상기업으로 전환된 회생기업을 대상으로 기업부실 원인과 기업이 선택하는 회생전략 사이의 관련성을 확인하고, 기업이 추구하는 회생전략에 따라 회생성과가 어떻게 달라지는지를 확인하는 데 있다. 국내 상장된 제조기업 중 2000년부터 2012년까지 법원에 법정관리 및 화의신청을 한 기업과 워크아웃 기업중 기업회생에 성공한 113개 기업을 대상으로 설문조사를 실시하였고 회수된 55개 설문과 공시자료를 바탕으로 다중회귀모형에 의해 실증 분석한 결과를 요약하면 다음과 같다. 먼저, 내부부실원인은 자산감축과 비용절감, 즉 효율성제고전략에 긍정적인 영향을 미치는 것으로 나타났고, 반대로 외부부실원인은 수익창출전략(제품/서비스감축, 제품/서비스확대)에 긍정적인 영향을 미치는 것으로 나타났다. 다음으로, 기업이 추구하는 회생전략에 따라 회생성과가 달라지는 지를 실증 분석한 결과, 효율성제고전략(자산감축과 비용절감)은 부채비율감소에 긍정적인 영향을 미치고, 반대로 수익창출전략(제품/서비스감축과 제품/서비스확대)은 매출액증가율에 긍정적인 영향을 미치는 것으로 나타났다. 본 연구는 기존의 부실원인과 회생전략, 회생전략이 회생성과에 미치는 포괄적 분석모형을 넘어 회생원인에 따라 기업이 보다 주안점을 두는 회생전략이 어떻게 달라지며, 회생전략에 따라 회생성과도 달라질 수 있음을 실증적으로 규명해 보았다는데 연구의 의의를 찾을 수 있다.

• 인터넷정보학회논문지
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• 제18권5호
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• pp.103-112
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• 2017

Work engagement and job burnout are crucial problems in Korea, particularly in the business environment, and they also indicate people's motivation. Online-based teams in e-business also have these issues. Especially the role of the leader in this new type of teams is more crucial for members' motivation, behavior, and performance. Contingency leadership theories posit that different situations need different traits or behaviors of a leader. For an online-based team, which is internet-based team in e-business, a leader should use specific communication strategies to enhance a team's performance and members' motivation. In an online-based team and an offline-based team, the ways in which leaders motivate members will be different. This paper suggests particular communicative strategies for leaders of online situations. Online-based team members communicate using mobile phones or IT tools, and leaders mayinfluences members in virtual meetings. Moreover, online-based leadership needs to be more entrepreneurial and risk encouraging, and less conservative than offline-based leadership. In addition, online-based leadership should be energetic, decisive, adaptable, and inspiring, and furtherutilize communication tools such as being more gregarious/talkative, assertiveness, linguistic diversity and affect. This paper explains the roles of communicative elements such as coordination, expression, direction-giving/uncertainty reduction, empathy, meaning-making, satisfaction, and competence to decrease job burnout and to increase work engagement. The purpose of this study is to suggest communication strategies' differentiated influences on work engagement and job burnout in an online-based team.

• 한국디지털정책학회:학술대회논문집
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• 한국디지털정책학회 2007년도 춘계학술대회
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• pp.33-40
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• 2007

The Customs Administration, unlike other administrative service, should respond to constantly changing external environment. The Customs has to actively adapt itself to government policy changes, economic changes and international environment changes to facilitate the flow of trade logistics and maintain trading relations wi th other countries. The purpose of this paper is to explain policy directions of the Korea Customs Service which enforces various policies related to tariff and non-tariff barrier elimination for the trade liberalization while the Korean government is pursuing FTAs on a multi-track basis. This paper aims to seek ways to apply FTA policies to the Korean society and economy in a smooth manner. First of all, this paper examines changes in Customs administration brought by the proliferation of FTAs to such areas as FTA negotiations, import/export management, duties and taxes collection, drawback reduction/exempt ion of duty application area of preferential tariff rate and country of origin management. Then, the paper sets FTA missions of "supporting Customs Administration to lead the new trend of free trade environment" after analyzing the environment changes. To achieve the FTA mission mentioned above, the KCS designated 4 strategies and 40 implementation tasks. The 4 strategies are named "4C Strategies" taking initial letters from Client-oriented, Customized procedures, Cooperation and Constitution. "4C" also refers to Foresee(strategies to foresee the successful establishment of FTA policies) or For C(Customer or Customs). The KCS will continue to create new tasks through various channels and monitor their implementation process, and to help FTA regime successfully take root in Korea.