• Title/Summary/Keyword: Reduced resistance

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Improved Interpolating Equation for Industrial Platinum Resistance Thermometer (산업용 백금저항온도계를 위한 향상된 내삽식)

  • Yang, In-Seok;Kim, Yong-Gyoo;Gam, Kee-Sool;Lee, Young-Hee
    • Journal of Sensor Science and Technology
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    • v.21 no.2
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    • pp.109-113
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    • 2012
  • We propose an improved interpolating equation to express temperature-resistance characteristics for modern industrial platinum resistance thermometers (PRTs). Callendar-van Dusen equation which has been widely used for platinum resistance thermometer fails to fully describe temperature characteristics of high quality PRTs and leaves systematic residual when the calibration point include temperatures above $300^{\circ}C$. Expanding Callendar-van Dusen to higher-order polynomial drastically improves the uncertainty of the fitting even with reduced degrees of freedom of the fitting. We found that in the fourth-order polynomial fitting, the third-order and fourth-order coefficients have a strong correlation. Using the correlation, we suggest an improved interpolating equation in the form of fourth-order polynomial, but with three fitting parameters. Applying this interpolating equation reduced the uncertainty of the fitting to 32 % of that resulted from the traditional Callendar-van Dusen. This improvement was better than that from a simple third-order polynomial despite that the degrees of the freedom of the fitting was the same.

The Effects of Mori folium on Insulin Resistance and Adipose Tissue Inflammation in an Experimental Mouse Model of Obesity (상엽(桑葉)이 비만 유발 생쥐의 인슐린 저항성 및 지방세포 염증에 미치는 영향)

  • Ma, Young-hoon;Kim, Hyo-jae;Han, Yang-hee
    • The Journal of Internal Korean Medicine
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    • v.37 no.4
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    • pp.609-623
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    • 2016
  • Objective: This study was undertaken to investigate the effects of Mori folium on insulin resistance and adipose tissue inflammation in an experimental mouse model of obesity.Methods: Obesity was induced in C57BL/6 mice by feeding them a high-fat diet. The mice were divided into four groups (n=6): a normal diet, high-fat diet, high-fat diet with 40 mg of Mori folium, and high-fat diet with 800 mg of Mori folium groups. After 13 wk, the body weights, fasting blood glucose and fasting serum insulin levels, insulin resistance (homeostatic model assessment) levels, oral glucose tolerance test levels, epididymal fat and liver weights, and gene expression of tumor necrosis factor-α, interleukin-6, and interferon-γ were measured. In addition, adipose tissue macrophages were analyzed by fluorescence-activated cell sorting.Results: Mori folium significantly reduced blood glucose levels, oral glucose tolerance levels, and liver weights. It also reduced adipose tissue macrophage numbers and tumor necrosis factor receptor-α gene expression.Conclusions: These results show that Mori folium has insulin resistance reduction and anti-inflammatory effects in an experimental mouse model of obesity.

Urushiol V Suppresses Cell Proliferation and Enhances Antitumor Activity of 5-FU in Human Colon Cancer Cells by Downregulating FoxM1

  • Jeong, Ji Hye;Ryu, Jae-Ha
    • Biomolecules & Therapeutics
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    • v.30 no.3
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    • pp.257-264
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    • 2022
  • Colorectal cancer (CRC) is one of the most common malignant tumor. 5-FU is commonly used for the treatment of CRC. However, the development of drug resistance in tumor chemotherapy can seriously reduce therapeutic efficacy of 5-FU. Recent data show that FoxM1 is associated with 5-FU resistance in CRC. FoxM1 plays a critical role in the carcinogenesis and drug resistance of several malignancies. It has been reported that urushiol V isolated from the cortex of Rhus verniciflua Stokes is cytotoxic to several types of cancer cells. However, the underlying molecular mechanisms for its antitumor activity and its potential to attenuate the chemotherapeutic resistance in CRC cells remain unknown. Here, we found that urushiol V could inhibit the cell proliferation and induced S-phase arrest of SW480 colon cancer cells. It inhibited protein expression level of FoxM1 through activation of AMPK. We also investigated the combined effect of urushiol V and 5-FU. The combination treatment reduced FoxM1 expression and consequently reduced cell growth and colony formation in 5-FU resistant colon cancer cells (SW480/5-FUR). Taken together, these result suggest that urushiol V from Rhus verniciflua Stokes can suppress cell proliferation by inhibiting FoxM1 and enhance the antitumor capacity of 5-FU. Therefore, urushiol V may be a potential bioactive compound for CRC therapy.

A Study on Pull-out Capacity and Shear resistance strength change by grasses (초본류에 의한 인발저항력 및 전단저항력 변화에 관한 연구)

  • Kim, Taegyun;Chae, Soo Kwon;Chun, Seung Hoon
    • Journal of Wetlands Research
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    • v.15 no.4
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    • pp.431-440
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    • 2013
  • It was tested in field that a Pull-out Capacity and Shear resistance strength change of reed, common reed and sedge which were planted by mat-type turf and used for revegetation of bank. The testes were done for 9 weeks from end of May and the grasses were planted on sandy soil. Roots grew fastly after planted and increasement of a common reed and sedge root were reduced after 4 weeks but increasement of reed roots were not reduced. The difference of increasement of roots is due to a difference of propagation method. Sedge propagate by seed. Reed and commom reed propagate by seed and subterranean stem and reed has bigger subterranean stem than common reed. So increasement of common reed and sedge roots were slow than reed. By root growth pattern, increasement of pull-out capacity and shear resistance strength showed very similar way of root growth, those of common reed and sedge were fast in early stage of cultivation but were reduced. But increasement of pull-out capacity and shear resistance strength of reed was not reduced. A Maximum shear resistance strength called critical shear resistance strength of common reed and sedge can be Analyzed at 11 weeks after planted.

Wear Resistance Characteristics of Thermal Sprayed AlSiMg/SiC Composite Coatings on Aluminum Engine Cylinder Bores (Aluminum Engine Cylinder Bore 적용 AlSiMg/SiC 복합 용사피막의 내마모 특성)

  • 양병모;변응선;박경채
    • Journal of Welding and Joining
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    • v.17 no.6
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    • pp.62-69
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    • 1999
  • The advantages of Thermal sprayed coatings as a replacement for cast iron liners are reduced weight, better heat transfer and reduced cost. One of the most important performance attributes of a cylinder bore coating is its wear resistance, since it must survive the abrasive sliding of both the piston rings and the piston skirt. In this study, composite powders were prepared by ball milling of Al-13Si-3Mg(wt%) alloy with SiC particles. The concentrations of SiC were 40 and 60wt%. The composite powders were sprayed using Metco-9MB plasma torch. Plasma sprayed coatings were heat-treated at 500℃ for 3 hours. The wear resistances of the plasma sprayed coatings were found to improve with heat treatment and superior to the commercially available G.C.I.(gray cast iron). AlSiMg-40SiC heat-treated coatings showed the best wear resistance in this study.

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Induced Resistance in Tomato Plants Against Fusarium Wilt Invoked by Nonpathogenic Fusarium, Chitosan and Bion

  • Amini, J.
    • The Plant Pathology Journal
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    • v.25 no.3
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    • pp.256-262
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    • 2009
  • The potential of. nonpathogenic Fusarium oxysporum strain Avr5, either alone or in combination with chitosan and Bion, for inducing defense reaction in tomato plants inoculated with F. oxysporum f. sp lycopersici, was studied in vitro and glasshouse conditions. Application Bion at concentration of 5, 50, 100 and $500{\mu}g$/ml, and the highest concentration of chitosan reduced in vitro growth of the pathogen. Nonpathogenic F. oxysporum Avr5 reduced the disease severity of Fusarium wilt of tomato in split plants, significantly. Bion and chitosan applied on tomato seedlings at concentration $100{\mu}g$ a.i./plant; 15, 10 and 5 days before inoculation of pathogen. All treatments significantly reduced disease severity of Fusarium wilt of tomato relative to the infected control. The biggest disease reduction and increasing tomato growth belong to combination of nonpathogenic Fusarium and Bion. Growth rate of shoot and root markedly inhibited in tomato plants in response to tomato Fusarium wilt as compared with healthy control. These results suggest that reduction in disease incidence and promotion in growth parameters in tomato plants inoculated with nonpathogenic Fusarium and sprayed with elicitors could be related to the synergistic and cooperative effect between them, which lead to the induction and regulation of disease resistance. Combination of elicitors and non-pathogenic Fusarium synergistically inhibit the growth of pathogen and provide the first experimental support to the hypothesis that such synergy can contribute to enhanced fungal resistance in tomato. This chemical could provide a new approach for suppression of tomato Fusarium wilt, but its practical use needs further investigation.

The Effect of Load Direction and Pile Size on the Pile Bearing Capacity : Model Pile Tests (하중 방향(압축-인발)과 말뚝 직경이 말뚝의 지지력에 미치는 영향에 관한 연구 -실내모형시험-)

  • 이인모;백세환
    • Geotechnical Engineering
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    • v.8 no.3
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    • pp.13-22
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    • 1992
  • Model pile tests using calibration chamber are performed in !his paper in order to clarify the effect of the fundamental differences between the newly developed SPLT(Simple Pile Loading Test)and the conventional pile loading test on the pile bearing capacity. They are : (1) the direction of the applied load to mobilize the skin friction ; and (2) the use of reduced sifted sliding core. The conclusions obtained from the model pile tests are as follows : (1) The skin friction in tension loading is found to be somewhat smaller than that in compression loading. The average ration is 0.73 with the coefficient of variation (COV) of 0.18. (2) The ratio of the tip resistance rosin연 the reduced sized sliding core to that using the whole shoe shows wide scattering ; its average is 0.99 and the COV is 0.28. The aver - age of 0.99 means that there is no considerable difference in the tip resistance whether the reduced sized sliding core or the whole shoe is used, on condition that penetration depth ratio is larger than 4 : if the boundary effect of the chamber test is considered, the resistance of the whole shoe might be even larger.

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Electroplating on the Lead Frames Fabricated from Domestic Copper Plate (국산동판을 사용한 리드프레임 도금기술에 관한 연구)

  • Jang, Hyeon-Gu;Lee, Dae-Seung
    • Journal of the Korean institute of surface engineering
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    • v.19 no.3
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    • pp.92-108
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    • 1986
  • An electroplating on the lead frame fabricated from domestic copper plate was studied experimentally. In this study, nickel was plated on the thin copper lead frame and silver layer was coated on the nickel film in the cyanide electrolyte. The effect of process variables such as current density, plating time, coating thickness and flow rate of electrolytic solution on the properties of coating was investigated. Some samples on each step were fabricated during electroplating. The results obtained from polarization measurement, observation of SEM photograph, adhesion test of coating and microhardness test are as follows. On silver plating, polarization resistance of potentiostatic cathodic polarization curve is reduced as the flow rate of Ag electrolytic solution increases. And above resistance is also reduced when the minor chemicals of sodium cyanide and sodium carbonate are added in potassium silver cyanide bath. The reduced polarization resistance makes silver deposition on the cathode easy. An increase in the current density and the coating thickness causes the particle size of deposit to coarsen, and consequently the Knoop microhardness of the coating decreases. On selective plating an increase in the flow rate of plating solution lead to do high speed plating with high current density. In this case, the surface morphology of deposit is of fine microstructure with high Knoop hardness. An increasing trend of the adhesion of coating was shown with increasing the current density and flow rate of electrolytic solution.

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Molecular Mechanisms of Succinate Dehydrogenase Inhibitor Resistance in Phytopathogenic Fungi

  • Sang, Hyunkyu;Lee, Hyang Burm
    • Research in Plant Disease
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    • v.26 no.1
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    • pp.1-7
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    • 2020
  • The succinate dehydrogenase inhibitor (SDHI) is a class of fungicides, which is widely and rapidly used to manage fungal pathogens in the agriculture field. Currently, fungicide resistance to SDHIs has been developed in many different plant pathogenic fungi, causing diseases on crops, fruits, vegetables, and turf. Understanding the molecular mechanisms of fungicide resistance is important for effective prevention and resistance management strategies. Two different mechanisms have currently been known in SDHI resistance. The SDHI target genes, SdhB, SdhC, and SdhD, mutation(s) confer resistance to SDHIs. In addition, overexpression of ABC transporters is involved in reduced sensitivity to SDHI fungicides. In this review, the current status of SDHI resistance mechanisms in phytopathogenic fungi is discussed.

A Study on the Application of Gypsum Board through the Application of Fire Resistance Ceiling Structure (내화천장구조 적용을 통한 석고보드 활용 확대에 관한 연구)

  • Choi, Dong-ho
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2019.11a
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    • pp.217-218
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    • 2019
  • Fire resistance ceiling system is the structure of which the ceiling installed under the slave of the structure has the fire resistance performance. Because of having the fire resistance performance, fire resistive coatings on steel beams can be reduced and large span structures can be constructed. So, it have advantages of convenience for construction, shorten for construction time and cost reducing. In foreign country, it is general that one system consisting of slave and ceiling is constructed as a fire resistance system, in these cases, gypsum boards are mostly used as ceiling materials. The purpose of this study was to explain the possibility of expanding the use of gypsum boards by securing fire resistance performance of these ceilings.

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