• 여성건강간호학회지
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• 제27권1호
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• pp.27-39
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• 2021

Purpose: This study aimed to review recent findings from birth cohort studies on maternal and child environmental health. Methods: Birth cohort studies regarding environmental health outcomes for mothers and their children were investigated through a systematic review. A literature search was conducted in PubMed, CINAHL, the Cochrane Library, Embase, and RISS to identify published studies using the keywords using a combination of the following keywords: maternal exposure, environmental exposure, health, cohort, and birth cohort. Articles were searched and a quality appraisal using the Newcastle-Ottawa Scale for cohort studies was done. Results: A review of the 14 selected studies revealed that prenatal and early life exposure to environmental pollutants had negative impacts on physical, cognitive, and behavioral development among mothers and children up to 12 years later. Environmental pollutants included endocrine disruptors, air pollution (e.g., particulate matter), and heavy metals. Conclusion: This systematic review demonstrated that exposure to environmental pollutants negatively influences maternal and children's environmental health outcomes from pregnancy to the early years of life. Therefore, maternal health care professionals should take steps to reduce mothers' and children's exposure to environmental pollutants.

• 방사성폐기물학회지
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• 제20권3호
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• pp.349-356
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• 2022

Nuclear power plant decommissioning generates significant concrete waste, which is slightly contaminated, and expected to be classified as clearance concrete waste. Clearance concrete waste is generally crushed into rubble at the site or a satellite treatment facility for practical disposal purposes. During the process, workers are exposed to radiation from the nuclides in concrete waste. The treatment processes consist of concrete cutting/crushing, transportation, and loading/unloading. Workers' radiation exposure during the process was systematically studied. A shielding package comprising a cylindrical and hexahedron structure was considered to reduce workers' radiation exposure, and improved the treatment process's efficiency. The shielding package's effect on workers' radiation exposure during the cutting and crushing process was also studied. The calculated annual radiation exposure of concrete treatment workers was below 1 mSv, which is the annual radiation exposure limit for members of the public. It was also found that workers involved in cutting and crushing were exposed the most.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2017년도 춘계학술대회
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• pp.179-182
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• 2017

뇌신경계 인터벤션시술은 장시간의 시술로 인해 피부의 수포 탈모 홍반등의 방사선 피폭으로 인한 위해가 빈번히 보고되어 지고 있다. 이에 CT(computed tomography) scan 시 피부 및 방사선 감수성이 예민한 인체의 전방부에 위치한 표적장기의 방사선 피폭을 감소시킬 목적으로 제작된 bismuth 차폐체를 인체공학적인 설계에 의하여 뇌혈관계 인터벤션 시술에 적용함으로써 방사선 감수성이 비교적 예민한 두피의 방사선 피폭 저감화를 위하여 연구를 제안 하고자 한다.

• BMB Reports
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• 제36권1호
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• pp.1-11
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• 2003

The causative role of polycyclic aromatic hydrocarbons (PAH) in human carcinogenesis is undisputed. Measurements of PAH-DNA adduct levels in easily accessible white blood cells therefore represent useful early endpoints in exposure intervention of chemoprevention studies. The successful applicability of DNA adducts as early endpoints depends on several criteria:i.adduct levels in easily accessible surrogate tissues should reflect adduct levels in target-tissues, ii. toxicokinetics and the temporal relevance should be properly defined.iii. sources of inter- and intra-individual variability must be known and controllable, and finally iv. adduct analyses must have advantages as compared to other markers of PAH-exposure. In general, higher DNA adduct levels or a higher proportion of subjects with detectable DNA adduct levels were found in exposed individuals as compared with non-exposed subjects, but saturation may occur at high exposures. Furthermore, DNA adduct levels varied according to changes in exposure, for example smoking cessation resulted in lower DNA adduct levels and adduct levels paralleled seasonal variations of air-pollution. Intra-individual variation during continuous exposure was low over a short period of time (weeks), but varied significantly when longer time periods (months) were investigated. Inter-individual variation is currently only partly explained by genetic polymorphisms in genes involved in PAH-metabolism and deserves further investigation. DNA adduct measurement may have three advantages over traditional exposure assessment: i. they can smooth the extreme variability in exposure which is typical for environmental toxicants and may integrate exposure over a longer period of time. Therefore, DNA adduct assessment may reduce the monitoring effort. ii. Biological monitoring of DNA adducts accounts for all exposure routes. iii. DNA adducts may account for inter-individual differences in uptake, elimination, distribution, metabolism and repair amongst exposed individuals. In conclusion, there is now a sufficiently large scientific basis to justify the application of DNA adduct measurement as biomarkers in exposure assessment and intervention studies. Their use in risk-assessment, however, requires further investigation.

• Asian Pacific Journal of Cancer Prevention
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• 제16권1호
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• pp.239-244
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• 2015

Background: One of the causes of acute leukemia can be exposure to certain chemicals such as pesticides. This study determined the relationship between exposure to pesticides and the occurrence of acute leukemia in Fars province, south of Iran. Materials and Methods: Between April 2011 and April 2013 in a case-control study conducted in Nemazee Hospital in Shiraz, Southern Iran; 314 subjects diagnosed with acute leukemia (94 pediatric cases and 220 adults) were enrolled to determine any correlation between exposure to pesticides and the occurrence. Controls (n=314) were matched by sex and age. Results: There was a history of exposure to pesticides among 85% of pediatric cases and 69% of their controls and 83% of adult cases and 75% of their controls while 87.5% of pediatric cases and 90% of adult cases reported exposure to intermediate and high doses of pesticides and among the controls, the exposure to low doses of pesticides was 70.5% and 65%, respectively. Exposure to indoor pesticides was seen among most of cases and controls. Being a farmer was at a significantly more increased risk of developing acute leukemia in comparison to other jobs, especially for their children. Conclusions: Exposure to pesticides was shown to be one of the most important causes of acute leukemia. It seems that there is a need to educate the people on public health importance of exposure to pesticides especially during school time to reduce the risk of malignancies during childhood.

• Journal of Yeungnam Medical Science
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• 제28권1호
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• pp.45-53
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• 2011

Background: Increasing numbers of young people go to clubs. In Korea, however, no studies have been conducted regarding the exposure of club patrons to secondhand smoke. The present study was conducted to evaluate the degree of club customers' exposure to secondhand smoke. Methods: The study subjects included 10 male and 12 female non-smokers. The investigational site was a club located in Daegu. Urine samples were collected before exposure to secondhand smoke in the club and 6 hours after a 3-hour exposure. The urine cotinine levels were measured via the LC -MS/MS method. A survey was conducted to collect data regarding the subjects' smoking experiences and the degree of exposure to secondhand smoke in their daily lives. Results: The average urine cotinine level increased from 1.09 ${\mu}g/L$ to 5.55 ${\mu}g/L$ ($p$<0.05). No significant difference existed in the change in urine cotinine level between the male and female subjects. In addition, there was no significant difference in the change in urine cotinine level by the degree of exposure to secondhand smoke in daily life. Conclusions: The average urine cotinine level in all the subjects significantly increased after exposure to secondhand smoke. This is the first study on exposure to secondhand smoke in clubs; these results can be used to craft measures that reduce exposure to secondhand smoke in public places, such as clubs.

• 한국방사선학회논문지
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• 제14권4호
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• pp.353-360
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• 2020

본 연구는 CBCT 장비의 표준 노출 조건(80 kV, 7 mA)을 기준으로 관전압과 관전류를 낮추어 촬영하면서 표준 노출 조건의 물리적 화질 요소값을 유지할 수 있는 노출 조건의 제시를 목표로 두고자한다. 영상의 물리적 화질 요소값의 측정을 위해 변조전달함수(MTF)가 분석되었고 선량 측정을 위해 선량-면적 곱(DAP)을 이용하였다. 관전압(80, 78, 76 kV)과 관전류(7, 6, 5, 4, 3 mA)의 15가지 조합의 노출 조건에서 Sedent ex IQ 팬텀 (Leeds Test Objects Ltd., Boroughbridge, UK)의 CBCT 영상을 얻었고 MTF 10이 각 조건에서 계산 되었다. 표준 노출 조건과 비교시 80 kV-6 mA, 80 kV-5 mA 노출 조건은 MTF 10에 있어 유의한 차이를 보이지 않았기에 본 연구에서 사용된 CBCT 장비의 경우, 80 kV-5 mA로 낮춘 노출 조건에서 물리적 화질요소값을 유지하면서 선량을 감소시킬 수 있는 것으로 판단되어진다.

• 방사선산업학회지
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• 제11권1호
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• pp.47-54
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• 2017

Compared to other occupations, there is a greater risk of exposure to radiation due to the use of radioisotopes in nuclear medicine for diagnostic evaluations and therapy. To consider ways to reduce exposure dose for those in nuclear medicine involved in injection work and elution work among radiation workers as well as for sanitation workers and trainees among frequent workers an investigation into exposure dose and situational analysis from changes in yearly exposure dose evaluations, changes in work environment and changes in forms of inspection were conducted. Exposure dose measurements were taken by using EPD MK2 worn during working hours for one injection worker, one elution worker, two sanitation workers, and one trainee at a general hospital in the Seoul area for three days from July 18th to 20th 2016. Radiation from radioisotopes which are a part of nuclear medicine can significantly affect not only radiation workers who deal with radioisotopes directly but also frequency works as well. According to this study the annual dose limit for elution workers and injection workers were considered safe as the amount of exposure was not large enough to have a significant effect. The limits of this study consist in the duration of this study and the quantity of participants. Also there was a limitation of the measurement device involving accumulated exposure, where the EPD MK2 cannot check the changes in exposure according to a particular activity.

• Safety and Health at Work
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• 제12권2호
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• pp.238-243
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• 2021

Objectives: The aim of this study was to provide baseline data for the assessment of exposure to indium and to prevent adverse health effects among workers engaged in the electronics and related industries in Republic of Korea. Methods: Total (n = 369) and respirable (n = 384) indium concentrations were monitored using personal air sampling in workers at the following 19 workplaces: six sputtering target manufacturing companies, four manufacturing companies of panel displays, two companies engaged in cleaning of sputtering components, two companies dedicated to the cleaning of sputtering target, and five indium recycling companies. Results: The level of exposure to total indium ranged from 0.9 to 609.3 ㎍/m³ for the sputtering target companies; from 0.2 to 2,782.0 ㎍/m³ for the panel display companies and from 0.5 to 2,089.9 ㎍/m³ for the indium recycling companies. The level of exposure to respirable indium was in the range of 0.02 to 448.6 ㎍/m³ for the sputtering target companies; 0.01 to 419.5 ㎍/m³ for the panel display companies; and 0.5 to 436.3 ㎍/m³ for the indium recycling companies. The indium recycling companies had the most samples exceeding the exposure standard for indium, followed by sputtering target companies and panel display companies. Conclusions: The main finding from this exposure assessment is that many workers who handle indium compounds in the electronics industry are exposed to indium levels that exceed the exposure standards for indium. Hence, it is necessary to continuously monitor the indium exposure of this workforce and take measures to reduce its exposure levels.

• 한국산업보건학회지
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• 제28권3호
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• pp.304-311
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• 2018

Objectives: The purpose of this study was to compare the self-reported symptoms of occupational asthma, occupational rhinitis, and respiratory symptoms between a direct exposure to flour dust group and a non-exposure group from the bakery industry. Methods: The participants were 62 workers directly exposed to flour dust and 30 non-exposed workers. The survey was composed of questions related to general characteristics. Korean self-reported respiratory symptoms(SNU-93), occupational asthma, and occupational rhinitis data was collected from April to July 2017. Results: The smoking rate among the direct exposure to flour dust workers was 67.7% and the mean of working hours(11-12) was 96.8%. The SNU-93 questionnaire revealed that respiratory symptoms in the chest and wheezing or whistling were significantly higher among the direct-exposure group than non-exposure group. The response for occupational asthma symptoms was significantly higher in the direct exposure group(2.4 points) than in the non-exposure group(1.6 points). Conclusion: In order to decrease the symptoms of these respiratory diseases among bakery workers exposed to flour dust, it is necessary to reduce working hours and the smoking rate. The performance of periodic medical examinations is needed to find abnormal respiratory diseases. In addition, workers who have been diagnosed with asthma and rhinitis should consider switching to a process that is not exposed to flour dust.