• Title/Summary/Keyword: Recurrent Aphthous Stomatitis(RAS)

Search Result 8, Processing Time 0.024 seconds

Case Report for a Refractory Recurrent Aphthous Stomatitis Treated with Jibaekpalmi-hwon

  • Son, Chang-Gue
    • The Journal of Korean Medicine
    • /
    • v.33 no.2
    • /
    • pp.73-77
    • /
    • 2012
  • Objectives: This report reports a clinical case of a patient with recurrent aphthous stomatitis (RAS) for 10 years who was completely cured using Korean medicine. Methods: A male patient with terribly severe RAS was hospitalized, and then treated with Jibaekpalmi-hwon, indirect moxibustion (KI 1 and CV 4) and acupuncture. The clinical outcome was observed by self-reported VAS measurement and macroscopy. Results: The severity of stomatitis became improved gradually and completely recovered during 17 hospital days, and RAS has not recurred for three months as an outpatient. The blood test including complement activity was in the normal range. Conclusions: This case report provides information about a therapeutic effect of Jibaekpalmi-hwon and Korean medicine on RAS.

A Case Report of Patient with Recurrent Aphthous Stomatitis and Pompholyx Treated with Modified Palmulgunja-tang (팔물군자탕 가미방으로 호전된 재발성 아프타성 구내염 및 한포진 환자 치험 1례)

  • Kim, Ji Hwan
    • Journal of Sasang Constitutional Medicine
    • /
    • v.32 no.2
    • /
    • pp.80-95
    • /
    • 2020
  • Introduction This study is the first case report to observe a significant improvement of clinical symptoms of both Recurrent Aphthous Stomatitis(RAS) and pompholyx treating with modified Palmulgunja-tang for Soeum-type. Case presentation A 37-year-old female patient complained of pain by ulcers on her mouth and tongue, and of itching caused by vesicles on her palms and soles was diagnosed with RAS, pompholyx, and, especially moderate pattern of 'Congestive Hyperpsychotic symptomatology' according to the theory of Sasang Constitutional Medicine(SCM). During inpatient and outpatient treatment, she took modified Palmulgunja-tang, and was treated with acupuncture, moxibustion, and cupping therapy. The effectiveness of these therapies was assessed with subjective Neumeral Rating Scale(NRS) and Dyshidotic Eczema Area and Severity Index(DASI). Conclusion After the treatment according to the theory of SCM, NRS, and DASI score about RAS and pompoholyx was decreased, and the general condition of the patient also has improved.

Screening of Antibiotics that Selectively Inhibit a Bacterial Species Associated with a Recurrent Aphthous Stomatitis Risk

  • Lee, Ahreum;Kim, Yunji;Choi, Youngnim
    • International Journal of Oral Biology
    • /
    • v.42 no.3
    • /
    • pp.123-128
    • /
    • 2017
  • Recurrent aphthous stomatitis (RAS) is a common oral mucosal disorder for which no curative treatment is available. We previously reported that decreased Streptococcus salivarius and increased Acinetobacter johnsonii on the oral mucosa are associated with RAS risk. The purpose of this study was to identify antibiotics that selectively inhibit A. johnsonii but minimally inhibit oral mucosal commensals. S. salivarius KCTC 5512, S. salivarius KCTC 3960, A. johnsonii KCTC 12405, Rothia mucilaginosa KCTC 19862, and Veillonella dispar KCOM 1864 were subjected to antibiotic susceptibility test using amoxicillin, cefotaxime, gentamicin, clindamycin, and metronidazole in liquid culture. The minimal inhibitory concentration (MIC) was defined as the concentration that inhibits 90% of growth. Only gentamicin presented a higher MIC for A. johnsonii than MICs for S. salivarius and several oral mucosal commensals. Interestingly, the growth of S. salivarius increased 10~200% in the presence of sub-MIC concentrations of gentamicin, which was independent of development of resistance to gentamicin. In conclusion, gentamicin may be useful to restore RAS-associated imbalance in oral microbiota by selectively inhibiting the growth of A. johnsonii but enhancing the growth of S. salivarius.

A Case Report of Recurrent Aphthous Stomatitis resulted from Cessation of smoking in Stroke Patient (중풍환자에서 금연 후 발생한 재발성 아프타성 구내염에 대한 증례보고)

  • Lee Hyung-Chul;Lee Sang-Wook;Bae Eun-Joo;Park Seong-Uk;Yoon Seong-Woo;Ko Chang-Nam
    • The Journal of Internal Korean Medicine
    • /
    • v.24 no.4_2
    • /
    • pp.967-974
    • /
    • 2003
  • Recurrent Aphthous Stomatitis(RAS) is inflammatory ulcerative condition of the oral mucosa. The lesions of RAS are self-limited and persist for 1 to 2 weeks, resolved with or without scarring and recurred after periods of remission. It is known that nicotine may protect oral mucosa from aphthous ulcers by keratinization of the oral mucosa. After quitting smoking, a stroke patient who suffered from RAS, used to relapse into RAS unless he didn't gargle with nicotine extract water. We diagnosed his case as heat in the stomach and treated with Chungwie-San(Qingwei-San). After medication with Chungwie-San, RAS was subsided and he stopped smoking during admission period.

  • PDF

A Follow-up Study of Clinical Characteristics of Recurrent Aphthous Stomatitis Patients Treated with Herbal Medicine (한약 치료를 시행한 재발성 아프타성 구내염 환자의 임상소견에 관한 추적 관찰 연구)

  • Ha, Na-yeon;Lee, Jae-hyung;Lee, Jung-eun;Nam, Seong-uk;Ko, Whee-hyoung;Hwang, Mi-ni;Kim, Jin-sung
    • The Journal of Internal Korean Medicine
    • /
    • v.38 no.5
    • /
    • pp.812-819
    • /
    • 2017
  • Objectives: The purpose of this study was to report the long-term efficacy of herbal medicine for treatment of patients with recurrent aphthous stomatitis (RAS). Methods: We reviewed the clinical records of 17 patients with RAS who visited the Oral Diseases Clinic of Kyung Hee University Korean Medicine Hospital from September 1st, 2014 to August 29th, 2017. The patients were treated with herbal medicine for more than 3 consecutive weeks, followed by a telephone survey. We evaluated the clinical characteristics of RAS, and compared the short-term and long-term efficacy of herbal medicine treatment. Results: After treatment with herbal medicine, the clinical characteristics improved in the 17 patients with RAS, especially in terms of the duration and interval of recurrence. Prolonged effects were reported upon the follow-up telephone survey. Conclusion: Herbal medicine treatment may have a long-term effect in patients with RAS.

A Case of Recurrent Aphthous Stomatitis Improved by Korean Medical Treatments - Focus on the effectiveness of Chungyeoldodam-tanggagam and Dangguisoo-san Plus Yuhyangjeongtong-sangagam (한방 치료로 호전된 재발성 아프타성 구내염 치험 1례 - 청열도담탕가감(淸熱導痰湯加減)과 당귀수산합유향정통산가감(當歸鬚散合乳香定痛散加減) 사용효과를 중점으로)

  • Kim, Tae-Jun;Kim, Yong-Min;Kim, Hee-Taek
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
    • /
    • v.33 no.2
    • /
    • pp.140-155
    • /
    • 2020
  • Objectives : The purpose of this study is to report the effectiveness of korean medical treatments on recurrent aphthous stomatitis(RAS) diagnosed as excess pattern(實證) based on symptoms of damum(痰飮), blood stasis(瘀血) and fire-heat(火熱). Methods : We treated a 61-year-old male patient who has RAS by korean medicine, pharmacopuncture and acupuncture treatment. These treatments were performed from 2020.01.22. to 2020.02.29. We have confirmed the improvement of ulcer lesions and pain. We recorded images that include change of symptoms. Results : After the treatments were done, the scores of numeric rating scale(NRS), oral health impact profile-14 (OHIP-14), oral assessment guide (OAG) and world health organization oral toxicity scale (WHO OTS) were decreased. The NRS score was decreased from 7 to 1. The OHIP-14 score was decreased from 30 to 14. The OAG score was decreased from 17 to 9. The WHO OTS score was decreased from 2 to 1. And ulcer lesions were clearly decreased. Conclusions : According to the result, korean medical treatments such as korean medicine, pharmacopuncture and acupuncture treatment, that are targeted at excess pattern(實證) caused by damum(痰飮), blood stasis(瘀血) and fire-heat(火熱) can be effective for the treatment of RAS.

Expression Pattern of T Lymphocyte Regulatory Factors in Unstimulated Whole Saliva of Erosive Oral Lichen Planus and Recurrent Aphthous Stomatitis Patients (미란형 구강편평태선과 재발성 아프타성 구내염 환자들의 비자극성 전타액내 T림프구 조절인자들의 발현 양상)

  • Yoon, Seon-Hack;Ko, Hyun-Mi;Park, Ji-Il;Kim, Jae-Hyung
    • Journal of Oral Medicine and Pain
    • /
    • v.34 no.4
    • /
    • pp.363-369
    • /
    • 2009
  • Erosive oral lichen planus (EOLP) and recurrent aphthous stomatitis (RAS) are T-cell mediated inflammatory immune disorders. It was investigated mRNA expression pattern of several regulatory factors, such as, CD28, CD45, CD152, CD154, CD279, which influence T lymphocyte in unstimulated whole saliva (UWS) of EOLP and RAS patients. It was collected unstimulated whole saliva during 10 minute in EOLP 18 people, RAS patients 12 people, healthy control 8 people. We investigated mRNA expression of T lymphocyte regulatory factors, such as, CD28, CD45, CD152, CD154, CD279, with real time reverse transcription polymerase chain reaction. In EOLP group, CD45, CD279 expressed higher and CD154 expressed lower than control. In RAS, CD45, CD270 expressed higher and CD28, CD154 expressed lower than control. In addition CD152 salivary mRNA expression of EOLP is higher than that of RAS. The above results were suggested that the mRNA expression of T lymphocyte regulatory factors in unstimulated whole saliva of EOLP and RAS contributes to diagnosis of diseases.

A literal study on the Gu-Chang (구창의 문헌연구)

  • Jung Han Sol;Park Jong Hoon;Ryuk Sang Won;Lee Kwang Gyu
    • Journal of Physiology & Pathology in Korean Medicine
    • /
    • v.16 no.1
    • /
    • pp.32-44
    • /
    • 2002
  • Gu-Chang is a disorder characterized by recurring ulcers confined to the oral mucosa. Despite much clinical and research attention, the causes remain poorly understood. In this paper, we will compare Gu-Chang with Recurrent Aphthous Stomatitis(RAS) in order to know what is the similiarity between Gu-Chang and RAS. So we will arrange various oriental and western medical literatures which are important. As a result of arrangement of the causes, symptoms and therapys of Gu-Chang, we can conclude through the studies as follows. 1. The etiologies of Gu-chang are following. In the Sthenia syndrome, there are evil heat of external factor, heat of heart and spleen, insomnia, heat of upper warmer, stress and diet, heat of lung and heart, excessive heat of upper warmer, inappropriate food intake, heat conveyance of organ, heat of stomach merdian, moistured heat of spleen and stomach and stasis of liver energy. In the Asthenia syndrome, there are deficiency of stomach energy, deficiency of upper warmer leading to heat, deficiency of middle warmer leading to cold, deficiency of lower warmer leading to heat, deficiency of middle energy, deficiency of blood, decreased fire and deficiency of soil, yin fire of lower warmer, deficiency of heart yin, deficiency of spleen yin and deficiency of qi and blood. 2. In western medicine the causes of RAS is presumed as local, microbial, systemic, nutritional, genetic, immunologic factors. 3. Once Gu-chang is compared with RAS, in the deficiency of yin leading to hyperactivity of fire, deficiency of yin leading to floating of fire and stasis of liver energy, recurring of Gu-chang is similar to RAS. Although recurring of Gu-chang due to tripple warmer of excessive fire has no recurrance, since there are the degree of Pain, site of lesion, dysphagia etc, it is similar to major RAS. It is may be believed that Sthenia Gu-chang is similar to major RAS, shape of recurring, site of lesion, degrree of Pain and white color of Asthenia Gu-chang are similar to minor RAS, but there is no similarity concerning herpes RAS in the literatures that describe the symptoms. 4. Generally, the treatment of Gu-chang is divided into Asthenia and Sthenia Syndrome. The method of cure to Sthenia syndrome is heat cleaning and purge fire, Asthenia syndrome is nourish yin to lower and adverse rising energy and strength the middle warmer and benefit vital energy. 5. Following is the medication for Sthenia syndrome. Heat of heart and spleen is Do Jok San, Yang Gyek San, Juk Yup Suk Go Tang, evil heat of external factor is Yang Gyek San Ga Gam, Stasis of liver energy is Chong Wi Fae Dok Yum, moistured heat of spleen and stomach is Chong Gi Sam Syep Tang. The medication for Asthenia Syndrome is following. Deficiency of upper warmer leading to heat is Bo Jung Ik Gi Tang, deficiency of middle warmer leading to cold is Bu Ja Lee Jung Tang, deficiency of lower warmer leading to heat is Yuk Mi Ji Hwang Tang, deficiency of yin leading to hyperactivity of fire is Ji Baek Ji Hwang Hwan, deficiency of yin leading to floating of fire is Lee Jung Tang Ga Bu Ja Medicine for external use were Yang Suk San, Boo Wyen San, Rok Po San, Yoo Hwa San ate. 6. In western medicine, there is no specific treatment for RAS, and management strategies depend on dinical presentation and symptoms and includes antibiotics, oral rinses, glucocorticoids, immunomodulatory drugs, vitamines, analgesics, laser and antiviral agents.