• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4847-4851
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• 2013

Objectives: To evaluate accuracy of FDG-PET CT in prediction of persistent disease in head and neck cancer cases and to determine prognostic value of metabolic tumor response. Materials and Methods: Between 2009 and 2011, 46 patients with squamous cell carcinoma of head and neck receiving PET-CT were treated with definitive radiotherapy, with or without chemotherapy. There were 29 nasopharyngeal, 11 hypopharyngeal, 3 oropharyngeal and 3 laryngeal cancer patients, with a median age of 50.5 years (range 16-84), 32 males and 14 females. All patients were evaluated with PET-CT median 3-5 months (2.4-9.4) after completion of radiotherapy. Results: After a median 20 months of follow up, complete metabolic response was observed in 63% of patients. Suspicious residual uptake was present in 10.9% and residual metabolic uptake in 26.0% of patients. The overall sensitivity, specificity, positive predictive value and negative predictive value of FDG-PET-CT for detection of residual disease was 91% and 81%, 64% and 96% respectively. Two year LRC was 95% in complete responders while it was 34% in non-complete responders. Conclusions: FDG PET CT is a valuable tool for assessment of treatment response, especially in patients at high risk of local recurrence, and also as an indicator of prognosis. Definitely more precise criteria are required for assessment of response, there being no clear cut uptake value indicating residual disease. Futhermore, repair processes of normal tissue may consume glucose which appear as increased uptake in control FDG PET CT.

• Experimental and Molecular Medicine
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• 제50권11호
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• pp.7.1-7.12
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• 2018

Recent findings from The Cancer Genome Atlas project have provided a comprehensive map of genomic alterations that occur in hepatocellular carcinoma (HCC), including unexpected mutations in apolipoprotein B (APOB). We aimed to determine the clinical significance of this non-oncogenetic mutation in HCC. An Apob gene signature was derived from genes that differed between control mice and mice treated with siRNA specific for Apob (1.5-fold difference; P < 0.005). Human gene expression data were collected from four independent HCC cohorts (n = 941). A prediction model was constructed using Bayesian compound covariate prediction, and the robustness of the APOB gene signature was validated in HCC cohorts. The correlation of the APOB signature with previously validated gene signatures was performed, and network analysis was conducted using ingenuity pathway analysis. APOB inactivation was associated with poor prognosis when the APOB gene signature was applied in all human HCC cohorts. Poor prognosis with APOB inactivation was consistently observed through cross-validation with previously reported gene signatures (NCIP A, HS, high-recurrence SNUR, and high RS subtypes). Knowledge-based gene network analysis using genes that differed between low-APOB and high-APOB groups in all four cohorts revealed that low-APOB activity was associated with upregulation of oncogenic and metastatic regulators, such as HGF, MTIF, ERBB2, FOXM1, and CD44, and inhibition of tumor suppressors, such as TP53 and PTEN. In conclusion, APOB inactivation is associated with poor outcome in patients with HCC, and APOB may play a role in regulating multiple genes involved in HCC development.

• 한국항공운항학회지
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• 제26권4호
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• pp.36-42
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• 2018

Although continuous passenger injuries and physical damages are repeated due to the unexpected aviation turbulence encountered during operations, there is still exist the limitation for preventing recurrence of similar events because the lack of real-time information and delay in technological developments regarding various operating conditions and variable weather phenomena. The purpose of this study is to compare and analyze the meteorological data of the aviation turbulence occurred and actual flight data extracted from the Quick Access Recorder(QAR) to provide some precursors that the pilot can identify aviation turbulence early by referring thru the flight instrumentation indications. The case applied for this study was recent event, a scheduled flight from Incheon Airport, Korea to Narita Airport, Japan that suddenly encountered turbulence at an altitude of approximately 14,000 feet during approach. According to the Korea Meteorological Administration(KMA)'s Regional Data Assessment and Prediction System(RDAPS) data, it was observed that the strong amount of vorticity in the rear area of jet stream, which existed near Mount Fuji at that time. The QAR data analysis shows significant changes in the aircraft's parameters such as Pitch and Roll angle, Static Air Temperature(SAT), and wind speed and direction in tens of seconds to minutes before encounter the turbulence. If the accumulate reliability of the data in addition and verification of various parameters with continuous analysis of additional cases, it can be the precursors for the pilot's effective and pre-emptive action and conservative prevention measures against aviation turbulence to reduce subsequent passenger injuries in the aviation operations.

• 해양환경안전학회지
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• 제30권1호
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• pp.82-88
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• 2024

현대 해양 산업은 기술적 발전을 통해 신속한 발전을 이루고 있다. 이러한 발전을 주도하는 주요 기술 중 하나는 데이터 처리 기술이며, 이 중 자연어 처리 기법은 사람의 언어를 기계가 이해하고 처리할 수 있도록 하는 기술이다. 본 연구는 자연어 처리 기법을 통해 해양안전심판원의 재결서를 분석하여 이미 재결이 이루어진 선박 충돌사고의 원인 제공 비율을 학습한 후, 새로운 재결서를 입력하면 원인 제공 비율을 예측하는 모델을 개발하고자 하였다. 이 모델은 사고 당시 적용되는 항법과 원인 제공 비율에 영향을 주는 핵심 키워드의 가중치를 이용하여 사고의 원인 제공 비율을 계산하는 방식으로 구성하였다. 이 연구는 이러한 방식을 통해 제작한 모델의 정확도를 분석하고, 모델의 실무 적용 가능성을 검토함과 동시에 충돌사고 재발 방지 및 해양사고 당사자들의 분쟁 해결에 기여할 것으로 기대한다.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2006년도 Proceedings of ISRS 2006 PORSEC Volume II
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• pp.706-709
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• 2006

Cancer is one of the major causes of death; however, the survival rate can be increased if discovered at an early stage for timely treatment. According to the statistics of the World Health Organization of 2002, breast cancer was the most prevalent cancer for all cancers occurring in women worldwide, and it account for 16.8% of entire cancers inflicting Korean women today. In order to classify the type of breast cancer whether it is benign or malignant, this study was conducted with the use of the discriminant analysis and the decision tree of data mining with the breast cancer data disclosed on the web. The discriminant analysis is a statistical method to seek certain discriminant criteria and discriminant function to separate the population groups on the basis of observation values obtained from two or more population groups, and use the values obtained to allow the existing observation value to the population group thereto. The decision tree analyzes the record of data collected in the part to show it with the pattern existing in between them, namely, the combination of attribute for the characteristics of each class and make the classification model tree. Through this type of analysis, it may obtain the systematic information on the factors that cause the breast cancer in advance and prevent the risk of recurrence after the surgery.

• Nuclear Medicine and Molecular Imaging
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• 제42권sup1호
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• pp.101-109
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• 2008

Cervix cancer is one of common gynecological cancers in the world, and staged with FIGO or TNM system. However, these clinical staging systems lack information about lymph node or distant metastases, thus imaging modalities are considered to make an appropriate therapeutic plan and enhance overall survival rate. In this context, FDG PET is recommended to pre-treatment stating and prognosis prediction, for it could noninvasively evaluate the status of lymph nodes, especially abdominal paraaortic nodes which are closely related with prognosis. Moreover, the degree of FDG uptake is correlated with prognosis. Although there is no consistent method for surveillance of cervix cancer, FDG PET seems a very important tool in detecting tumor recurrence because it is much more advantageous than conventional imaging modalities such as MRI for discerning recurrent tumor from fibrosis caused by radiation or surgery. Furthermore, FDG PET could be used to evaluate treatment response. On the other hand, recently introduced PET/CT is expected to play an ancillary role to FIGO staging by adding anatomical information, and enhance diagnostic performance of PET by decreasing false positive findings.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.25-35
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• 2016

Lymph node metastasis (LNM) in papillary thyroid cancer (PTC) has been shown to be associated with increased risk of locoregional recurrence, poor prognosis and decreased survival, especially in older patients. Hence, there is a need for a reliable biomarker for the prediction of LNM in this cancer. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene translation or degradation and play key roles in numerous cellular functions including cell-cycle regulation, differentiation, apoptosis, invasion and migration. Various studies have demonstrated deregulation of miRNA levels in many diseases including cancers. While a large number of miRNAs have been identified from PTCs using various means, association of miRNAs with LNM in such cases is still controversial. Furthermore, studies linking most of the identified miRNAs to the mechanism of LNM have not been well documented. The aim of this review is to update readers on the current knowledge of miRNAs in relation to LNM in PTC.

• 한국지형학회지
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• 제28권2호
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• pp.59-70
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• 2021

This study aims to determine the sunlight exposure according to depositional environment to improve the accuracy of optically simulated luminescence (OSL) dating. Sufficient sunlight exposure during transportation of sediment is a basic assumption of the OSL dating, and if the process does not occur enough, the results may be overestimated compared to the actual depositional age. Therefore, the main purpose of this study is to establish a correction method by determining residual or unbleachable dose after sunlight exposure in the actual deposition process, not in the laboratory measurement. Four samples from two sites were collected according to the depositional environment from rivers and coasts, and various OSL signals, including the size of residual dose, degree of dispersion between grains, and OSL signal sensitivity, were measured. As a result, it was confirmed that sediments formed under temporarily high energy environments, such as floods and surges, had relatively high residual dose or large dispersion of residual dose between particles. In further studies, the OSL signal characteristics of river sediments by flow velocity will be identified and the relationship between energy and OSL signal characteristics will be identified in more detail. Moreover, a method of reconstructing the paleo-environment at the time of deposition for existing sediments will be devised. It is expected to provide important information for the frequency of disaster recurrence and prediction of future climate change.

• Korean Journal of Radiology
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• 제25권6호
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• pp.550-558
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• 2024

Hepatocellular carcinoma (HCC) is a biologically heterogeneous tumor characterized by varying degrees of aggressiveness. The current treatment strategy for HCC is predominantly determined by the overall tumor burden, and does not address the diverse prognoses of patients with HCC owing to its heterogeneity. Therefore, the prognostication of HCC using imaging data is crucial for optimizing patient management. Although some radiologic features have been demonstrated to be indicative of the biologic behavior of HCC, traditional radiologic methods for HCC prognostication are based on visually-assessed prognostic findings, and are limited by subjectivity and inter-observer variability. Consequently, artificial intelligence has emerged as a promising method for image-based prognostication of HCC. Unlike traditional radiologic image analysis, artificial intelligence based on radiomics or deep learning utilizes numerous image-derived quantitative features, potentially offering an objective, detailed, and comprehensive analysis of the tumor phenotypes. Artificial intelligence, particularly radiomics has displayed potential in a variety of applications, including the prediction of microvascular invasion, recurrence risk after locoregional treatment, and response to systemic therapy. This review highlights the potential value of artificial intelligence in the prognostication of HCC as well as its limitations and future prospects.

• 한국화재소방학회논문지
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• 제31권1호
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• pp.26-35
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• 2017

미국 노스리지 지진(1994)과 일본 고베지진(1995) 발생 이후 다양한 구조물 및 건축물을 설계 할 때 성능기반 내진설계 개념을 적용하고 있다. 최근 국내 소방시설물에 대해서도 내진설계기준이 제정되어 내진설계 규정에 따라 적합하게 설계되어야 한다. 성능기반 설계가 도입되면서 구조물 중요도에 따라 기능수행, 즉시복구, 인명보호, 붕괴방지 등 각각의 성능에 적합한 연발생빈도의 등재해도 스펙트럼이 요구되고 있다. 확률론적 방법을 적용하여 국내 주요 5개 도시에 대해 등재해도 스펙트럼(uniform hazard spectrum)을 분석하였다. 지진 및 지체구조 관련된 전문가 패널은 10인이며 전문가 패널이 제시한 다수의 지진지체구조구 모델 및 다양한 지진동 감쇠식을 적용하였다. 분석대상 진동수는 (0.5, 1.0, 2.0, 5.0, 10.0) Hz이고 또한 PGA(최대지반가속도) 결과를 이용하여 500년, 1,000년 및 2,500년 등 3개 주요 성능기준에 해당하는 재현주기에 대해 등재해도 스펙트럼을 분석하였다. 민감도 분석에 의하면 지진지체구조 구 모델 변수보다 지반진동 감쇠식 변수가 지진재해도에 보다 큰 영향을 주는 것으로 분석되었다. 일반적으로 등재해도 스펙트럼은 10 Hz에서 최대 지진재해도를 보여 주었고, 기존 연구 및 관련 기술기준에 제시된 등재해도 스펙트럼의 수준 및 모양 특성과 대단히 유사하였다.