• Title/Summary/Keyword: Recovery of Pd

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A Biomechanical Gait Analysis of Patients with Parkinson's Disease by Auditory Cues Velocity (청각 신호 속도에 따른 파킨슨병 환자의 생역학적 보행 분석)

  • Kim, Eun-Jung;Han, Jin-Tae;Jung, Jae-Min
    • Journal of the Korean Society of Physical Medicine
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    • v.8 no.1
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    • pp.49-58
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    • 2013
  • PURPOSE: The purpose of this study was to determine if auditory cues velocity has a greater effect on the gait pattern of patients with Parkinson's disease (PD) than the cues applied individually. METHODS: The subjects were 15 elderly patients diagnosed with PD, 15 healthy elderly persons. Patients were measured of three conditions performed in random order: slow, general, fast. The auditory cue velocity consisted of a metronome beat ${\pm}20%$ than the subject's general gait speed. Using a motion analysis and a force platform measurement system, changes in spatiotemporal variables, kinetic and kinematic variables were compared to gait analysis. RESULTS: Comparison between the auditory cues velocity, there was a significant difference in the spatiotemporal variables with regard to the cadence, stride length, support time, step length, double support time (p<.05). Comparison between the auditory cues velocity, there was a significant increase general and fast velocity gait than slow velocity gait in the maximum flexion in swing phase of knee joint (p<.05). There appears to be the aspect of an increasing ground reaction force (GRF) on the first peak in the vertical axis (p<.05). CONCLUSION: Auditory cues velocity improved of spatio-temporal factors, kinematic and kinetic factors depending on the velocity of the faster. Therefore at the rehabilitation training of PD patients auditory cues velocity would be used for recovery and gait reeducation, may arise through the patients functional ability.

Ameliorative Effects of NXP031 on MPTP-Induced Neurotoxicity (MPTP로 유도된 신경 독성에 대한 NXP031의 개선 효과)

  • Lee, Joo Hee;Song, Min Kyung;Kim, Youn-Jung
    • Journal of Korean Biological Nursing Science
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    • v.23 no.3
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    • pp.199-207
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    • 2021
  • Purpose: The purpose of this study was to investigate effects of NXP031, an inhibitor of oxidation by specifically binding to the complex of DNA aptamer/vitamin C, on dopaminergic neurons loss and the reaction of microglia in an animal model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced subchronic Parkinson's disease (PD). Methods: A subchronic PD mouse model was induced via an intraperitoneal (IP) injection of MPTP 30 mg/kg per day for five days. NXP031 (vitamin C/aptamer at 200 mg/4 mg/kg) and vitamin C at 200 mg/kg were administered via IP injections at one hour after performing MPTP injection. This process was performed for five days. Motor function was then evaluated with pole and rotarod tests, after which an immunohistochemical analysis was performed. Results: NXP031 administration after MPTP injection significantly improved motor functions (via both pole and rotarod tests) compared to the control (MPTP injection only) (p<.001). NXP031 alleviated the loss of dopaminergic neurons in the substantia nigra (SN) and striatum caused by MPTP injection. It was found to have a neuroprotective effect by reducing microglia activity. Conclusion: NXP031 can improve impaired motor function, showing neuroprotective effects on dopaminergic neurons in the SN and striatum of MPTP-induced subchronic Parkinson's disease mouse model. Results of this study suggest that NXP031 has potential in future treatments for PD and interventions for nerve recovery.

Design of Carrier Recovery Circuit for High-Order QAM - Part II : Performance Analysis and Design of the Gear-shift PLL with ATC(Automatic Transfer-mode Controller) and Average-mode-change Circuit (High-Order QAM에 적합한 반송파 동기회로 설계 - II부. 자동모드전환시점 검출기 및 평균모드전환회로를 적용한 Gear-Shift PLL 설계 및 성능평가)

  • Kim, Ki-Yun;Kim, Sin-Jae;Choi, Hyung-Jin
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.38 no.4
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    • pp.18-26
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    • 2001
  • In this paper, we propose an ATC(Automatic Transfer mode Controller) algorithm and an average-mode-change method for use in Gear shift PLL which can automatically change loop gain. The proposed ATC algorithm accurately detects proper timing or the mode change and has a very simpler structure - than the conventional lock detector algorithm often used in QPSK. And the proposed average mode change method can obtain low errors of estimated frequency offset by averaging the loop filter output of frequency component in shift register. These algorithms are also useful in designing ASIC, since these algorithms occupy small circuit area and are adaptable for high speed digital processing. We also present phase tracking performance of proposed Gear-shift PLL, which is composed of polarity decision PD, ATC and average mode change circuit, and analyze the results by examining constellation at each mode.

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Determination of Fission Products in Simulated Nuclear Spent Fuels by Cation.Anion Exchange Chromatography and Inductively Coupled Plasma Atomic Emission Spectrometry (양.음이온교환 크로마토그래피와 유도결합플라스마 원자방출분광법을 이용한 모의 사용후핵연료 중 핵분열생성물 분석)

  • Choi, Kwang Soon;Sohn, Se Chul;Pyo, Hyung Yeol;Suh, Moo Yul;Kim, Do Yang;Park, Yang Soon;Jee, Kwang Yong
    • Analytical Science and Technology
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    • v.13 no.4
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    • pp.446-452
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    • 2000
  • The simulated nuclear spent fuel (SIMFUEL) containing the platinum group elements which will not be dissolved in a nitric acid was completely dissolved with a acid digestion bomb. The metallic elements separated in the SIMFUEL were measured by inductively coupled plasma atomic emission spectrometry (ICP-AES). Because the peaks of metallic elements were spectrally interfered by uranium spectrum, uranium and metallic elements were separated by cation exchange resin for Mo, Pd, Rh and Ru and by anion exchange resin for Ba, Ce, La, Nd, Rh, Sr, Y and Zr, respectively. The recovery of Mo, Pd, Rh and Ru after separation by cation exchange chromatography found to be 99-103% and anion exchange separation showed 96.5-107% of recovery except Y with the simulated solution whose concentration was similar to the spent nuclear fuel. The relative standard deviation of this method showed 1.3-6.7% in the SIMFUEL whose concentrations of metallic elements were between several $10^2-10^3$ppm.

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Synthesis of Iron Nanopowder from FeCl3 Solution by Chemical Reduction Method for Recycling of Spent Neodymium Magnet (네오디뮴 폐자석 재활용을 위한 화학환원법을 이용한 철 나노 분말 제조)

  • Ha, Yonghwang;Gang, Ryun-Ji;Choi, Seung-Hoon;Yoon, Ho-Sung;Ahn, Jong-Gwan
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.13 no.12
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    • pp.6187-6195
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    • 2012
  • Recycling process of iron should be developed for efficient recovery of neodymium(Nd), rare metal, from acid-leaching solution of neodymium magnet. In this study, $FeCl_3$ solution as iron source was used for synthesis of iron nanoparticle with the condition of various factors, etc, reductant, surfactant. $Na_4O_7P_2$ and polyvinylpyrrolidone(PVP) as surfactants, $NaBH_4$ as reductant, and palladium chloride($PdCl_2$) as a nucleation seed were used. Iron powder was analyzed with instruments of XRD, SEM and PSA for measuring shape and size. Iron nanoparticles were made at the ratio of 1 : 5(Fe (III) : $NaBH_4$) after 30 min of reduction time. Size and shape of iron particles synthesized were round-form and 50 nm ~ 100 nm size. Zeta-potential of iron at the 100 mg/L of $Na_4O_7P_2$ was negative value, which is good for dispersion of metal particle. When $Na_4O_7P_2$(100 mg/L), PVP($FeCl_3$ : PVP = 1 : 4, w/w) and Pd($FeCl_3$ : $PdCl_2$ = 1 : 0.001, w/w) were used, iron nanoparticles which are round-shape, well-dispersed, near 100 nm-sized can be made.

A Complete, Reductive Depolymerization of Concentrated Sulfuric Acid Hydrolysis Lignin into a High Calorific Bio-oil using Supercritical Ethanol

  • Riaz, Asim;Kim, Jaehoon
    • KEPCO Journal on Electric Power and Energy
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    • v.2 no.3
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    • pp.447-452
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    • 2016
  • It is imperative to develop an effective pathway to depolymerize lignin into liquid fuel that can be used as a bioheavy oil. Lignin can be converted into liquid products either by a solvent-free thermal cracking in the absence air, or thermo-chemical degradation in the presence of suitable solvents and chemicals. Here we show that the solvent-assisted liquefaction has produced promising results in the presence of metal-based catalysts. The supercritical ethanol is an efficient liquefaction solvent, which not only provides better solubility to lignin, but also scavenges the intermediate species. The concentrated sulfuric acid hydrolysis lignin (CSAHL) was completely liquefied in the presence of solid catalysts (Ni, Pd and Ru) with no char formation. The effective deoxy-liquefaction nature associated with scEtOH with aid hydrodeoxygenation catalysts, resulted in significant reduction in oxygen-to-carbon (O/C) molar ratio up to 61%. The decrease in oxygen content and increase in carbon and hydrogen contents increased the calorific value bio-oil, with higher heating value (HHV) of $34.6MJ{\cdot}Kg^{-1}$. The overall process is energetically efficient with 129.8% energy recovery (ER) and 70.8% energy efficiency (EE). The GC-TOF/MS analysis of bio-oil shows that the bio-oil mainly consists of monomeric species such as phenols, esters, furans, alcohols, and traces of aliphatic hydrocarbons. The bio-oil produced has better flow properties, low molecular weight, and high aromaticity.

Do some patients receive unnecessary parenteral nutrition after pancreatoduodenectomy? Results from an international multicentre study

  • Thomas B. Russell;Peter L. Labib;Paula Murphy;Fabio Ausania;Elizabeth Pando;Keith J. Roberts;Ambareen Kausar;Vasileios K. Mavroeidis;Gabriele Marangoni;Sarah C. Thomasset;Adam E. Frampton;Pavlos Lykoudis;Manuel Maglione;Nassir Alhaboob;Hassaan Bari;Andrew M. Smith;Duncan Spalding;Parthi Srinivasan;Brian R. Davidson;Ricky H. Bhogal;Daniel Croagh;Ismael Dominguez;Rohan Thakkar;Dhanny Gomez;Michael A. Silva;Pierfrancesco Lapolla;Andrea Mingoli;Alberto Porcu;Nehal S. Shah;Zaed Z. R. Hamady;Bilal Al-Sarrieh;Alejandro Serrablo;Somaiah Aroori
    • Annals of Hepato-Biliary-Pancreatic Surgery
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    • v.28 no.1
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    • pp.70-79
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    • 2024
  • Backgrounds/Aims: After pancreatoduodenectomy (PD), an early oral diet is recommended; however, the postoperative nutritional management of PD patients is known to be highly variable, with some centers still routinely providing parenteral nutrition (PN). Some patients who receive PN experience clinically significant complications, underscoring its judicious use. Using a large cohort, this study aimed to determine the proportion of PD patients who received postoperative nutritional support (NS), describe the nature of this support, and investigate whether receiving PN correlated with adverse perioperative outcomes. Methods: Data were extracted from the Recurrence After Whipple's study, a retrospective multicenter study of PD outcomes. Results: In total, 1,323 patients (89%) had data on their postoperative NS status available. Of these, 45% received postoperative NS, which was "enteral only," "parenteral only," and "enteral and parenteral" in 44%, 35%, and 21% of cases, respectively. Body mass index < 18.5 kg/m2 (p = 0.03), absence of preoperative biliary stenting (p = 0.009), and serum albumin < 36 g/L (p = 0.009) all correlated with receiving postoperative NS. Among those who did not develop a serious postoperative complication, i.e., those who had a relatively uneventful recovery, 20% received PN. Conclusions: A considerable number of patients who had an uneventful recovery received PN. PN is not without risk, and should be reserved for those who are unable to take an oral diet. PD patients should undergo pre- and postoperative assessment by nutrition professionals to ensure they are managed appropriately, and to optimize perioperative outcomes.

Preparation of Iron Nano-particle by Slurry Reduction Method from Leaching Solution of Spent Nd magnet (폐네오디뮴 자석 침출용액으로부터 Slurry 환원법을 이용한 철 Nano 분말 제조)

  • Ahn, Jong-Gwan;Gang, Ryunji;You, Haebin;Yoon, Ho-Sung
    • Resources Recycling
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    • v.23 no.6
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    • pp.22-29
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    • 2014
  • Recycling process of iron should be developed for efficient recovery of neodymium (Nd), rare metal, from acid-leaching solution of Nd magnet. In this study, $FeCl_3$ solution as iron source was used for preparation of iron nano particles with the condition of various factors, such as, reductant, and surfactant. $Na_4P_2O_7$ and Polyvinylpyrrolidone (PVP) as surfactants, $NaBH_4$ as reductant, and palladium chloride ($PdCl_2$) as a nucleation seed were used. Iron powder was analyzed by using XRD, SEM for measuring shape and size. Iron nano particles were prepared at the ratio of 1:5 (Fe (III) : $NaBH_4$). Size and shape of iron particles were round-form and 50 ~ 100 nm size. Zeta-potential of iron at the 100 mg/L of $Na_4P_2O_7$ was negative value, which was good for dispersion of metal particle. When $Na_4P_2O_7$ (100 mg/L), PVP($FeCl_3:PVP$ = 1 : 4, w/w) and Pd($FeCl_3:PdCl_2$ = 1 : 0.001, w/w) were used, iron nano particles which were round-shape, well-dispersed and near 100 nm-sized range. In this condition, $FeCl_3$ solution changed with spent Nd leachate solution, and then it is possible to be made round-formed iron nano particles at pH 9 and at the reaction bath over 20 L which is not include any surfactant.

Design of Optical Receiver with CDR using Delayed Data Topology (데이터 지연방식의 CDR을 이용한 광 송신기 설계)

  • Kim, Kyung-Min;Kang, Hyung-Won;Choi, Young-Wan
    • 한국정보통신설비학회:학술대회논문집
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    • 2005.08a
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    • pp.154-158
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    • 2005
  • In this paper, we design optical receiver composed of CDR(clock and data recovery), SA(sense amp), TIA(transimpe dence amplifier), and decision circuit. The optical receiver can be classified to two main block, one is Deserializer composed of CDR and SA, another is PD receiver composed of preamplifier(샴), peak detector, etc. In this paper, we propose CDR using delayed data topology that could improve defects of existing CDR. The optical receiver that is proposed in this paper has the role of translation a 1.25 Gb/s optical signal to $10{\times}125 Mb/s$ array electric signals. This optical receiver is verified by simulator(hspice) using 0.35 um CMOS technology.

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Assessment of Insulation Condition in Large Transformers (대형변압기 절연상태 평가)

  • Kim, Hee-Dong;Kong, Tae-Sik;Lee, Young-Jun;Park, Jae-Jun
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 2004.07a
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    • pp.499-502
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    • 2004
  • In order to detect of insulation problems an early, transformer has to be performed the several tests. The ac current and tan6 of transformer winding insulation were investigated by Schering bridge. Partial discharge(PD) tests are used to evaluate the insulation condition of transformer. The moisture content measurement was conducted using RVM(recovery voltage meter). The RVM test can show that the problem is affecting the paper insulation of transformer. The value of moisture content was 2.3% in main transformer. The insulations of four transformers were judged to be in good condition.

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