• 제목/요약/키워드: Recovered Product

검색결과 155건 처리시간 0.025초

텍스트마이닝을 이용한 약물유해반응 보고자료 분석 (Analysis of Adverse Drug Reaction Reports using Text Mining)

  • 김현희;유기연
    • 한국임상약학회지
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    • 제27권4호
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    • pp.221-227
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    • 2017
  • Background: As personalized healthcare industry has attracted much attention, big data analysis of healthcare data is essential. Lots of healthcare data such as product labeling, biomedical literature and social media data are unstructured, extracting meaningful information from the unstructured text data are becoming important. In particular, text mining for adverse drug reactions (ADRs) reports is able to provide signal information to predict and detect adverse drug reactions. There has been no study on text analysis of expert opinion on Korea Adverse Event Reporting System (KAERS) databases in Korea. Methods: Expert opinion text of KAERS database provided by Korea Institute of Drug Safety & Risk Management (KIDS-KD) are analyzed. To understand the whole text, word frequency analysis are performed, and to look for important keywords from the text TF-IDF weight analysis are performed. Also, related keywords with the important keywords are presented by calculating correlation coefficient. Results: Among total 90,522 reports, 120 insulin ADR report and 858 tramadol ADR report were analyzed. The ADRs such as dizziness, headache, vomiting, dyspepsia, and shock were ranked in order in the insulin data, while the ADR symptoms such as vomiting, 어지러움, dizziness, dyspepsia and constipation were ranked in order in the tramadol data as the most frequently used keywords. Conclusion: Using text mining of the expert opinion in KIDS-KD, frequently mentioned ADRs and medications are easily recovered. Text mining in ADRs research is able to play an important role in detecting signal information and prediction of ADRs.

산 침출$Mg^{++}$액으로부터 $Mg(OH)_2$및 MgO 粉末의 製造 (Preparation of $Mg(OH)_2$and MgO from Acid Leaching $Mg^{++}$ Solution)

  • 최용각;이종현;원창환;이갑호
    • 자원리싸이클링
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    • 제10권5호
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    • pp.16-21
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    • 2001
  • 자전연소고온반응법(SHS)에 의한 고순도 분말의 제조시에 주로 얻어지는 $Mg^{++}$ 유 부산물로부터 초미분 $Mg(OH)_2$및 MgO분말을 제조하였다 $Mg(OH) _2$제조시 최적의 실험 조건은 0.7M의 $Mg^{++}$ 을 함유하는 pH 1.42의 산침출 용액중에 9M의 KOH를 pH조절제로 첨가한 경우이다. 이때 pH는 약 13.0을 나타내며, 모든 $Mg^{++}$$Mg(OH)_2$로 침전되었다. $Mg(OH)_2$의 탈수반응을 조사하기 위하여 DSC를 사용하였으며, 그 결과를 하소공정에 사용하였다. MgO분말은 건조된 Mg(OH)2 분말을 $400-450^{\circ}C$로 하소함으로써 제조되었으며, 제조된 $Mg(OH)_2$및 MgO분말의 크기 및 형상은 상용 분말과 유사하였다.

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Incapability of Utilizing Galactose by pgs1 Mutation Occurred on the Galactose Incorporation Step in Saccharomyces cerevisiae

  • Rho, Min-Suk;Su, Xuefeng;Lee, Yoon-Shik;Kim, Woo-Ho;Dowhan, William
    • Journal of Microbiology and Biotechnology
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    • 제16권1호
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    • pp.84-91
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    • 2006
  • A Saccharomyces cerevisiae pgs1 nulI mutant, which is deficient with phosphatidyl glycerol (PG) and cardiolipin (CL) biosynthesis, grows well on most fermentable carbon sources, but fails to grow on non-fermentable carbon sources such as glycerol, ethanol, and lactate. This mutant also cannot grow on galactose medium as the sole carbon source. We found that the incorporation of $[^{14}C]-galactose$, which is the first step of the galactose metabolic pathway (Leloir pathway), into the pgs 1 null mutant cell was extremely repressed. Exogenously expressed PGS1 (YCpPGS1) under indigenous promoter could completely restore the pgs1 growth defect on non-fermentable carbon sources, and dramatically recovered $[^{14}C]-galactose$ incorporation into the pgs1 mutant cell. However, PGS1 expression under the GALl promoter $(YEpP_{GAL1}-PGS1myc)$ could not complement pgs1 mutation, and the GAL2-lacZ fusion gene $(YEpP_{GAL2}-lacZ)$ also did not exhibit its $\beta-galactosidase$ activity in the pgs1 mutant. In wild-type yeast, antimycin $A(1\;{\mu}g/ml)$, which inhibits mitochondrial complex III, severely repressed not only the expression of the GAL2-lacZ fusion gene, but also uptake of $[^{14}C]-galactose$. However, exogenously expressed PGS1 partially relieved these inhibitory effects of antimycin A in both the pgs1 mutant and wild-type yeast, although it could not basically restore the growth defect on galactose by antimycin A. These results suggest that the PGSI gene product has an important role in utilization of galactose by Gal genes, and that intact mitochondrial function with PGS1 should be required for galactose incorporation into the Leloir pathway. The PGS1 gene might provide a clue to resolve the historic issue about the incapability of galactose with deteriorated mitochondrial function.

서비스 회복에 대한 기대-성과 불일치와 지각된 공정성이 패션 상품 고객의 만족도 및 충성도에 미치는 영향 (Potential Influence of Expectation-Performance Dis-Confirmation and Perceived Justice for Service Recovery upon Fashion-Product Consumers' Satisfaction and Loyalty)

  • 신수연;이정임
    • 복식문화연구
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    • 제18권3호
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    • pp.526-540
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    • 2010
  • Due to fierce competition, many domestic fashion businesses are suffering difficulty in securing and maintaining customers. Accordingly, fashion companies are devoting all their energy to secure customers by using high quality and diverse strategies for distribution and promotion, and to secure loyalty by satisfying customers with the offer of excellent service. Thus, it is very important to provide systematic service recovery strategy available for handling service failure effectively. Therefore, the purpose of this study is comprehensively analyzing influences of expectation dis-confirmation and perceived justice for service recovery upon consumers' satisfaction and loyalty. The findings are as follows. First, as for the service failure that customers experienced, the more consumers who expect it to be recovered led to the higher formation of expectation-compensation dis-confirmation. Second, it was indicated that the higher seriousness in service failure that customers experienced led to the lower satisfaction and loyalty to service recovery. Third, as a result of examining influence of expectation-compensation dis-confirmation for service-failure recovery upon consumer satisfaction and loyalty, the customers who showed more positive dis-confirmation to expectation-compensation were indicated to form the more satisfaction and loyalty. Fourth, as a result of examining the influence of the perceived justice in the process of service-failure recovery upon customer satisfaction, all in 3 dimensions of justice had effect on customer satisfaction.

살리실산이 오이 잎의 산화적 스트레스와 UV-B 내성에 미치는 영향 (Effects of Salicylic Acid on Oxidative Stress and UV-B Tolerance in Cucumber Leaves)

  • 홍정희;김태윤
    • 한국환경과학회지
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    • 제16권12호
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    • pp.1345-1353
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    • 2007
  • The effect of salicylic acid(SA) on antioxidant system and protective mechanisms against UV-B induced oxidative stress was investigated in cucumber(Cucumis sativus L.) leaves. UV-B radiation and SA were applied separately or in combination to first leaves of cucumber seedlings, and dry matter accumulation, lipid peroxidation and activities of antioxidant enzymes were measured in both dose and time-dependant manner. UV-B exposure showed reduced levels of fresh weight and dry matter production, whereas SA treatment significantly increased them. SA noticeably recovered the UV-B induced inhibition of biomass production. UV-B stress also affected lipid peroxidation and antioxidant enzyme defense system. Malondialdehyde(MDA), a product of lipid peroxidation, was greatly increased under UV-B stress, showing a significant enhancement of a secondary metabolites, which may have antioxidative properties in cucumber leaves exposed to UV-B radiation. Combined application of UV-B and SA caused a moderate increase in lipid peroxidation. These results suggest that SA may mediate protection against oxidative stress. UV-B exposure significantly increased SOD, APX, and GR activity compared with untreated control plants. Those plants treated with 1.0 mM SA showed a similar pattern of changes in activities of antioxidant enzymes. SA-mediated induction of antioxidant enzyme activity may involve a protective accumulation of $H_2O_2$ against UV-B stress. Moreover, their activities were stimulated with a greater increase by UV-B+SA treatment. The UV-B+SA plants always presented higher values than UV-B and SA plants, considering the adverse effects of UV-B on the antioxidant cell system. ABA and JA, second messengers in signaling in response to stresses, showed similar mode of action in UV-B stress, supporting that they may be important in acquired stress tolerance. Based on these results, it can be suggested that SA may participates in the induction of protective mechanisms involved in tolerance to UV-B induced oxidative stress.

질 성형을 위한 실리콘 액 주입 후 발생한 급성 호흡 곤란 증후군 1예 (A Case of Acute Respiratory Distress Syndrome Induced by Injection of Silicone Fluid for Colpoplasty)

  • 정창욱;전익수;장재영;박지은;송춘영;김성헌;강경우
    • Tuberculosis and Respiratory Diseases
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    • 제57권2호
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    • pp.193-196
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    • 2004
  • 저자들은 실리콘 액을 이용한 질 성형술 후에 급성호흡 곤란 증후군을 보인 환자에서 경기관지 폐생검으로 실리콘에 의한 것으로 생각되는 폐포 대식세포내의 봉입체를 확인하고 대증적인 치료로 호전된 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

재활용 가능한 고방열 고분자 복합소재 개발 (Recyclable Polymeric Composite with High Thermal Conductivity)

  • 신하은;김채빈;안석훈;김두헌;임종국;고문주
    • Composites Research
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    • 제32권6호
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    • pp.319-326
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    • 2019
  • 본 연구에서는 재활용이 가능하며 열가소성 특성을 지닌 신규 고분자 수지를 개발하고 합성하였다. 이렇게 개발된 수지와 판상형 질화붕소(h-BN) 사이의 계면 친화성이 좋음을 계산과학을 통하여 확인하고 열압기(hot press)를 이용하여 복합소재를 제조하였다. 고분자 수지와 필러 사이의 계면 친화성과 함께 복합소재 제조시 발생되는 전단력(shear force) 만으로도 매우 높은 필러 정렬도를 지닌 복합소재를 제조할 수 있었고, 이러한 이유로 복합소재는 최대 13.8 W/mK의 높은 열전도도를 갖는 것을 확인하였다. 또한, 개발된 수지가 화학적으로 분해 가능한 장점을 이용하여 제조된 복합소재로부터 물리/화학적 변성 없이 필러를 회수할 수 있었고 이렇게 회수된 필러는 향후 다양한 신규 복합소재 제조에 재활용이 가능하다.

Quatification of Flavonoid Contents in Chungsimyeonja-tang, a Multi-Herbal Decoction, and Its Protective Effect against Cisplatin-induced Nephrotoxicity

  • Kim, Young-Jung;Kim, Tae-Won;Seo, Chang-Seob;Park, So-Ra;Ha, Hyekyung;Shin, Hyeun-Kyoo;Jung, Ju-Young
    • Natural Product Sciences
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    • 제20권4호
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    • pp.251-257
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    • 2014
  • Chungsimyeonja-tang (CSYJT) is an herbal decoction that consists with 12 herbal medicines. CSYJT has been shown to have anti-stress, anti-allergic and anti-oxidant effects. The aim of this study was to determine flavonoid contents in CSYJT and evaluate its protective effect against cisplatin induced nephrotoxicity using both in vitro (porcine renal epithelial cell; PK15 cell) and in vivo (Sprague Dawley rat) experiments. In the present study, thee mean contents of baicalin, wogonoside and baicalein in CSYJT were 14.65, 5.27 and 0.02 mg/g, respectively. The CSYJT extract treatment attenuated the following alteration in porcine renal epithelial (PK15) cell: the increase in reactive oxygen species (ROS), the glutathione depletion and the increase in p53 expression induced by cisplatin treatment. In the in vivo study, rats were orally treated with CSYJT extract once a day for 28 days. Five days before the last treatment, cisplatin (5 mg/kg) was intraperitoneally injected to induce acute renal failure. Increased blood urea nitrogen (BUN) and creatinine (CRE) levels after cisplatin treatment were ameliorated by pretreatment of CSYJT extract. In addition, lipid peroxidation was decreased and antioxidant enzyme (glutathione) was recovered in CSYJT pretreated kidney tissue. In histopathological examination, CSYJT pretreated group showed ameliorated pathological alteration after cisplatin injection with decreased apoptosis. Taken together, pretreatment of CSYJT could ameliorate cisplatin-induced nephrotoxicity.

$^{99m}TcO^-{_4}$의 메틸-에틸-케톤-간편 추출법 (A Convenient Method on the Methyl-Ethyl-Ketone Extraction of $^{99m}TcO^-{_4}$)

  • 이종두;이병헌
    • Journal of Radiation Protection and Research
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    • 제9권2호
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    • pp.103-111
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    • 1984
  • 간편형으로 $^{99m}Tc$-메틸-에틸-케톤(MEK) 추출법을 개량하고 이동 가능형으로 $^{99m}Tc$추출 장치를 설계하였다. $^{99m}TcO^-{_4}$의 MEK 추출 및 상 분리를 한 용기에서 하도록 하여 조작을 간편하게 하였으며 $^{99}Mo$의 방사능 차폐를 한개의 납용기로 할 수 있도록 하였다. $^{99m}TcO^-{_4}({\gamma}_e=0.14\;MeV)$를 분리차폐를 하여 장치를 간소화하였다. $^{99m}Tc-MEK$ 추출액중의 $^{99m}TcO^-{_4}$를 흡착 및 용리만에 의하여 회수할 수 있도록 하며 방사능 휘발 가능성을 줄이었고 알루미나 칼람을 소형으로 하여 $^{99m}TcO^-{_4}$염 제품의 부피를 1 ml로 줄이고 칼람 조작시간을 단축하였다. $^{99m}Tc$ 분리시간을 30분대로 줄이고 조작을 차폐밖에서 할 수 있도록 하였다. 장치를 무균 조작할 수 있도록 설계하였다.

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교반 볼밀을 이용한 왕겨재의 건식 미세분쇄에 관한 연구 (Dry Fine Grinding of Rice Husk Ash using a Stirred Ball Mill)

  • 박승제;최연규;김명호;이종호
    • Journal of Biosystems Engineering
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    • 제25권1호
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    • pp.39-46
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    • 2000
  • This work was conducted to study the operating characteristics of a grinding system designed to obtain fine rice husk ash powder. To find better utilizing of rice husk, a valuable by-product from rice production, once the rice husk was incinerated and the thermal energy was recovered from the furnace, the ash was fed and pulverized in the grinding system resulting a fine powder to be used as a supplementary adding material to the portland cement manufacturing . The rice husk ash grinding system consisted of a high speed centrifugal fan for the preliminary coarse milling and a dry-type stirred ball mill for the subsequent fine grinding . Total grinding time 9 5, 15, 30, 45 min), impeller speed (250, 500, 750 rpm) , and mixed ratio (4.8, 7.9, 14.9) were three operating factors examined for the performance of a stirred ball mill used for the fine grinding of ash. With the stirred ball mill used in this study, the minimum attianable mean diameter of rice husk ash powder appeared to be 2 ${\mu}{\textrm}{m}$. During the find grinding, the difference in specific surface area of powder showed an increase and the grinding energy efficiency decreased with the increase in total grinding time, impeller speed ,and mixed ratio. For the operating conditions employed , the resulting mean diameter of fine ash powder, specific energy input, and grinding energy efficiency were in the range of 1.79 --16.04${\mu}{\textrm}{m}$, 0.072-5.226kWh/kg, an d1.11-12.15$m^2$/Wh, respectively. Grinding time of 30 min , impeller speed of 750 rpm, and mixed ratio of 4.8 were chosen as the best operating conditions of the stirred ball mill for fine grinding . At these conditions, mean particle diameter of the fine ash, grinding energy efficiency, grinding throughtput, and specific energy input were 2.73${\mu}{\textrm}{m}$, 3.95$m^2$/Wh, 0.25kg/h, and 1.22kWh/kg, respectively.

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