• Journal of information and communication convergence engineering
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• 제7권4호
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• pp.489-495
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• 2009

Geographic routing has attracted many researcers with no need for routing table to forward packet in mobile ad hoc networks. Previously, some literatures have mentioned how to improve the performance via simulation results. However, they didn't address the impact of various mobility models and beacon interval, which is used to maintain recent position information for nodes. In this paper, we introduce well-known geographic routing protocol called as GPSR and conduct simulation to identify the impact of these parameters. Even though GPSR shows acceptable performance in most cases, sometimes its performance becomes worse than what we expect.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2006년도 6th International Meeting on Information Display
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• pp.633-636
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• 2006

GE has developed a plastic substrate technology comprised of a superior high-heat polycarbonate substrate film and a unique transparent coating package that provides the ultrahigh barrier to moisture and oxygen, and chemical resistance to solvents used in device fabrication. This contribution will update recent progresses made at GEFlexible Ultra-high Gas Barrier Substrate for Organic Electronics on ultra-high barrier coated plastic substrate, both in batch mode and in roll-to-roll mode

• Clinical and Experimental Pediatrics
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• 제51권5호
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• pp.457-461
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• 2008

Kawasaki disease (KD) was first described by Dr. Tomisaku Kawasaki in his 1975 study, published in Pediatrics. Its pathogenesis is still not clearly understood. Early diagnosis and treatment are very important to preventing concomitant coronary artery complications. Most KD patients respond well to the standard treatment of aspirin and intravenous immunoglobulin; however, some of them are refractory to the standard treatment, and so adjuvant therapies with corticosteroids and anti-tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$) antibody are necessary. In this article, the author reviews and summarizes the most recent literature on the treatment of refractory KD.

• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3043-3051
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• 2016

Controlled remodeling of the extracellular matrix (ECM) is essential for cell growth, invasion and metastasis. Matrix metalloproteinases (MMPs) are a family of secreted, zinc-dependent endopeptidases capable of degradation of ECM components. The expression and activity of MMPs in a variety of human cancers have been intensively studied. They play important roles at different steps of malignant tumor formation and have central significance in embryogenesis, tissue remodeling, inflammation, angiogenesis and metastasis. However, increasing evidence demonstrates that MMPs are involved earlier in tumorigenesis. Recent studies also suggest that MMPs play complex roles in tumor progression. MMPs and membrane type (MT)-MMPs are potentially significant therapeutic targets in many cancers, so that designing of specific MMP inhibitors would be helpful for clinical trials. Here, we review the pleiotropic roles of the MMP system in hematological malignancies in-vitro and in-vivo models.

• Clinical and Experimental Pediatrics
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• 제58권3호
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• pp.84-88
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• 2015

Kawasaki disease (KD) is an acute systemic vasculitis that predominantly affects children, and can result in coronary artery lesions (CAL). A patient with KD who is resistant to treatment with intravenous immunoglobulin (IVIG) has a higher risk of developing CAL. Incomplete KD has increased in prevalence in recent years, and is another risk factor for the development of CAL. Although the pathogenesis of KD remains unclear, there has been increasing evidence for the role of genetic susceptibility to the disease since it was discovered in 1967. We retrospectively reviewed previous genetic research for known susceptibility genes in the pathogenesis of KD, IVIG resistance, and the development of CAL. This review revealed numerous potential susceptibility genes including genetic polymorphisms of ITPKC, CASP3, the transforming growth factor-${\beta}$ signaling pathway, B lymphoid tyrosine kinase, FCGR2A, KCNN2, and other genes, an imbalance of Th17/Treg, and a range of suggested future treatment options. The results of genetic research may improve our understanding of the pathogenesis of KD, and aid in the discovery of new treatment modalities for high-risk patients with KD.

• Clinical and Experimental Pediatrics
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• 제57권1호
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• pp.1-18
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• 2014

Channelopathies are a heterogeneous group of disorders resulting from the dysfunction of ion channels located in the membranes of all cells and many cellular organelles. These include diseases of the nervous system (e.g., generalized epilepsy with febrile seizures plus, familial hemiplegic migraine, episodic ataxia, and hyperkalemic and hypokalemic periodic paralysis), the cardiovascular system (e.g., long QT syndrome, short QT syndrome, Brugada syndrome, and catecholaminergic polymorphic ventricular tachycardia), the respiratory system (e.g., cystic fibrosis), the endocrine system (e.g., neonatal diabetes mellitus, familial hyperinsulinemic hypoglycemia, thyrotoxic hypokalemic periodic paralysis, and familial hyperaldosteronism), the urinary system (e.g., Bartter syndrome, nephrogenic diabetes insipidus, autosomal-dominant polycystic kidney disease, and hypomagnesemia with secondary hypocalcemia), and the immune system (e.g., myasthenia gravis, neuromyelitis optica, Isaac syndrome, and anti-NMDA [N-methyl-D-aspartate] receptor encephalitis). The field of channelopathies is expanding rapidly, as is the utility of molecular-genetic and electrophysiological studies. This review provides a brief overview and update of channelopathies, with a focus on recent advances in the pathophysiological mechanisms that may help clinicians better understand, diagnose, and develop treatments for these diseases.

• 한국정보과학회논문지:컴퓨팅의 실제 및 레터
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• 제14권3호
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• pp.296-300
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• 2008

최근에 개발된 Nonnegative tensor factorization(NTF)는 비음수 행렬 분해(NMF)의 multiway(multilinear) 확장형이다. NTF는 CANDECOMP/PARAFAC 모델에 비음수 제약을 가한 모델이다. 본 논문에서는 Tucker 모델에 비음수 제약을 가한 nonnegative Tucker decomposition(NTD)라는 새로운 텐서 분해 모델을 제안한다. 제안된 NTD 모델을 least squares, I-divergence, $\alpha$-divergence를 이용한 여러 목적함수에 대하여 fitting하는 multiplicative update rule을 유도하였다.

• 로봇학회논문지
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• 제4권3호
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• pp.169-176
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• 2009

Low-cost sensors have been widely used for mobile robot navigation in recent years. However, navigation performance based on low-cost sensors is not good enough to be practically used. Among many navigation techniques, building of an accurate map is a fundamental task for service robots, and mapping with low-cost IR sensors was investigated in this research. The robot's orientation uncertainty was considered for mapping by modifying the Bayesian update formula. Then, the data association scheme was investigated to improve the quality of a built map when the robot's pose uncertainty was large. Six low-cost IR sensors mounted on the robot could not give rich data enough to align the range data by the scan matching method, so a new sample-based method was proposed for data association. The real experiments indicated that the mapping method proposed in this research was able to generate a useful map for navigation.

• 한국에너지공학회:학술대회논문집
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• 한국에너지공학회 2004년도 춘계 학술발표회 논문집
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• pp.353-358
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• 2004

In recent, the trends in national energy Policy are established in the context of the integrated risk estimation for various national electricity generating options. The approach takes account of health, environmental, economic, and social aspects of electricity generation systems. In the present work, nuclear, coal, and LNG sources are chosen because these hold more than 90% of national total electricity generation in a descending order. A life cycle assessment (LCA) methodology is used for comparing environmental impacts of these options during the life cycle such as construction, operation as well as disposal stages. Here, the LCA consists of life cycle inventory analysis, classification/selection process of impact categories, characterization process, and normalization process of each category. LCA can be an useful tool for environmental impact assessment of future national energy options. At the planning stage of future energy Policies, the results of LCA would be taken into consideration. According to data update at the construction and disposal stages, the LCA needs to be conducted iteratively.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2001년도 가을 학술발표회 논문집
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• pp.183-190
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• 2001

Topology optimization. has been evolved into a very efficient conceptual design tool and has been utilized into design engineering processes in many industrial parts. In recent years, topology optimization has become the focus of structural optimization design and has been researched and widely applied both in academy and industry. Traditional topology optimization has been using homogenization method and optimality criteria method. Homogenization method provides relationship equation between structure which includes many holes and stiffness matrix in FEM. Optimality criteria method is used to update design variables while maintaining that volume fraction is uniform. Traditional topology optimization has advantage of good convergence but has disadvantage of too much convergency time and additive checkerboard prevention algorithm is needed. In one way to solve this problem, element remove method is presented. Then, it is applied to many examples. From the results, it is verified that the time of convergence is very improved and optimal designed results is obtained very similar to the results of traditional topology using 8 nodes per element.