• Bulletin of the Korean Chemical Society
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• 제31권6호
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• pp.1561-1567
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• 2010

In this study, we have developed a new detection method using Si field effect transistor (FET)-type biosensors, which enables the direct monitoring of antigen-antibody binding within very high-ionic-strength solutions such as 1$\times$PBS and human serum. In the new method, as no additional dilution or desalting processes are required, the FET-type biosensors can be more suitable for ultrasensitive and real-time analysis of raw sample solutions. The new detection scheme is based on the observation that the strength of antigen-antibody-specific binding is significantly influenced by the ionic strength of the reaction solutions. For a prostate specific antigen (PSA), in some conditions, the binding reaction between PSA and anti-PSA in a low-ionic strength reaction solution such as 10 ${\mu}M$ phosphate buffer is weak (reversible), while that in high-ionic strength reaction solutions such as 1$\times$PBS or human serum is strong.

• Journal of Korean Society on Water Environment
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• 제26권2호
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• pp.356-364
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• 2010

The chemical and biological reaction of the aquatic organism is closely related with temperature variation and water temperature is one of the most important factors that should be considered in establishing sustainable reservoir operation scheme to minimize adverse environmental impacts related with dam construction. This paper investigates temperature variation in the downstream of Yongdam Reservoir using sampled data collected from total 8 temperature monitoring stations placed along the main river and the major tributaries. Using KoRiv1, 1-dimensional dynamic water quality simulation model, temperature variation in the downstream of Yongdam Reservoir has been simulated. The simulated results were compared with sampled data collected from May 15 to August 1 2008 by applying two different temperature modeling schemes, equilibrium temperature and full heat budget method. From the result of statistical analysis, seasonal temperature variation has been simulated by applying the equilibrium temperature scheme for comparison of the difference between the reservoir operation and the natural conditions.

• Proceedings of the KIEE Conference
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• 대한전기학회 2011년도 제42회 하계학술대회
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• pp.396-397
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• 2011

As moving away from fossil fuel makes rapid progress, new paradigm has arisen in the power industry area. Developing alternative energy source is progressing actively, the proportion of renewable energy in electricity production is expected to be increased. Because the output of wind farm depends on wind characteristic, minimizing the output fluctuation is a key to keep the power system controllable and stable. Various compensation scheme for stabilizing the output of wind farm has been developed. Considering some requirements such as reaction velocity, controllability, scalability and applicability, energy storage system is one of the effective methods for spreading of renewable energy. In this paper, method of compensating method with forecasting algorithm was simulated, and then the results was analyzed.

• Journal of Photoscience
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• 제3권3호
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• pp.167-169
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• 1996

Absorption of UV light induces photocleavage of polymer chains to produce free radicals which initiate photodegradation of the polymer molecules. Discoloration, cracking of surface, stiffening, and decreasing of mechanical properties of polymeric products occur as a result of photodegradation of the polymers. Photostabilizers are added to the polymer systems in order to minimize the unwanted effects of UV light. It is well known that Hindered Amine Light Stabilizers (HALS) are one of the most effective photostabilizer for polymers.' HALS have been used in a large number of commercial polymers and predominantly used in styrenic and engineering plastics. They are efficient and cost-effective in many applications despite their high prices. However, low molecular weight HALS vaporize easily, emitting harmful amines, and have poor extraction resistance, decreasing their photostabilization effect. They also decompose during processing and migrate within the polymers resulting in deposition on the polymer surfaces called 'blooming". These drawbacks of low molecular HALS can be overcome by use of the polymeric HALS. We have been studying photochemical reactions of the polymer systems. The present paper reports the preparation of a new polymeric photostabilizer containing HALS groups and their stabilization effects on photooxidation of polystyrene. The synthetic scheme for the preparation of polymeric photostabilizers containing HALS groups were shown at Scheme 1. N-[(Chloroformyl) phenyl]maleimide (CPMI) and N-[4-(chlorocarbonyl) phenyl]maleimide (CPMIC) were prepared by the known procedure. N[4-N'-(2,2,6,6-tetramethyl-4-piperidinyl)aminocarbonyl-phenyl] maleimide (TMPI) was prepared by the reaction of CPMI with 4-amino-2,2,6,6-tetramethylpiperidine (ATMP).

• Journal of the Korean Society for Aeronautical & Space Sciences
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• 제32권9호
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• pp.72-79
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• 2004

A method for thruster fault diagnosis for launch vehicle upper stage was developed. In order to protect the launch vehicle against the occurrence of faults, it is necessary to detect and identify the fault, as well as to reconfigure the controller of the vehicle. Considering the upper stage launch vehicle using reaction control system, an analytical method was adopted in order to detect the fault occurred in thruster. The fault detection scheme can be applied to the system regardless of the form of thruster fault occurred - leakage or lock-out. Results from processor-in-the-loop simulation are provided to demonstrate the validity of this fault detection and isolation scheme for the upper stage launch vehicle.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• 제21권1호
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• pp.175-182
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• 2023

APro, a modularized process-based total system performance assessment framework, was developed at the Korea Atomic Energy Research Institute (KAERI) to simulate radionuclide transport considering coupled thermal-hydraulic-mechanical-chemical processes occurring in a geological disposal system. For reactive transport simulation considering geochemical reactions, COMSOL and PHREEQC are coupled with MATLAB in APro using an operator splitting scheme. Conventionally, coupling is performed within a MATLAB interface so that COMSOL stops the calculation to deliver the solution to PHREEQC and restarts to continue the simulation after receiving the solution from PHREEQC at every time step. This is inefficient when the solution is frequently interchanged because restarting the simulation in COMSOL requires an unnecessary setup process. To overcome this issue, a coupling scheme that calls PHREEQC inside COMSOL was developed. In this technique, PHREEQC is called through the "MATLAB function" feature, and PHREEQC results are updated using the COMSOL "Pointwise Constraint" feature. For the one-dimensional advection-reaction-dispersion problem, the proposed coupling technique was verified by comparison with the conventional coupling technique, and it improved the computation time for all test cases. Specifically, the more frequent the link between COMSOL and PHREEQC, the more pronounced was the performance improvement using the proposed technique.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2003년도 ICCAS
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• pp.2719-2724
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• 2003

In this paper, we deal with the kinematic and dynamic modeling of hybrid robotic systems that are constructed by combination of parallel and serial modules or series of parallel modules. Previously, open-tree structure has been employed for dynamic modeling of hybrid robotic systems. Though this method is generally used, however, it requires expensive computation as the size of the system increases. Therefore, we propose an efficient dynamic modeling methodology for hybrid robotic systems. Initially, the dynamic model for the proximal module is obtained with respect to the independent joint coordinates. Then, in order to represent the operational dynamics of the proximal module, we model virtual joints attached at the top platform of the proximal module. The dynamic motion of the next module exerts dynamic forces to the virtual joints, which in fact is equivalent to the reaction forces exerted on the platform of the lower module by the dynamics of the upper module. Then, the dynamic forces at the virtual joints are distributed to the independent joints of the proximal module. For multiple modules, this scheme can be constructed as a recursive dynamic formulation, which results in reduction of the complexness of the open-tree structure method for modeling of hybrid robotic systems. Simulation for inverse dynamics is performed to validate the proposed modeling algorithm.

• Transactions of the Korean Society of Mechanical Engineers
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• 제15권6호
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• pp.2073-2082
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• 1991

The vaporization and combustion of liquid spray in a cylindrical shape combustor was studied numerically. Mixture of liquid drops and air was assumed to be ejected from the center-hole and assisting air from the concentric annulus with swirling. Eulerian-Lagrangian scheme was adopted for the two phase calculation, and the interactions between the phases were considered with the PSIC model. Also adopted were the infinite conductivity model for drop vaporization, the equation of Arrhenius and the eddy break-up model for reaction rate, and the k-epsilon model for turbulence calculations. Gas flow patterns, drop trajectories and contours of temperature and mass fractions of the gas species were predicted with swirl number, drop diameter, and equivalence ratio taken as parameters. Calculations show that the vaporization and the consequent combustion efficiency enhance with the increase of the swirl number and/or with the decrease of drop size, and the higher maximum temperature is attained with the higher equivalence ratio.

• Archives of Pharmacal Research
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• 제29권9호
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• pp.721-727
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• 2006

To continue exploration of structure activity relationship of novel 1-(indoline-5-sulfonyl)-4-phenylimidazolidinones (1) reported as anticancer agent with broad spectrum, three 1-(arylsulfonyl)-4-vinylimidazolidinones (2) were synthesized from methyl serinate (3) in 8 steps. Reaction of intermediate 2-phenoxycarbonylaminobut-3-enyl p-toluenesulfonate (10) with arylsulfonamide in the presence of potassium carbonate produced corresponding 2 and N-(4-vinyloxazolidin-2-yl)arylsulfonamide 11 in approximately equal ratio. This reaction is believed to undergo through urea intermediate 16 as shown in scheme 3. 1-Arylsufonyl-4-vinylimidazolidinones 2 show much reduced activity against human colon carcinoma (Colo205), human chronic myelogenous leukemia (K562), and human ovarian adenocarcinoma (SK-OV-3) and compatible activity against human lung carcinoma (A549) compared to 1. Therefore phenyl at 4-position should be the optimum planar motif for the activity of 1.

• Transactions of the Korean Society of Mechanical Engineers B
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• 제23권6호
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• pp.778-787
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• 1999

In this study, the autoignition process of liquid fuel, injected into hot and stagnant air in a 2-D axisymmetric confined cylindrical combustor, has been investigated. Eulerian-Lagrangian scheme was adopted to analyze the two-phase flow and combustion. The unsteady conservation equations were used to solve the transition of the gas field. Interactions between two phases were accounted by using the particle source in cell (PSI-Cell) model, which was used for detailed consideration of the finite rates of transports between phases. And infinite conduction model was adopted for the vaporization of droplets. The results have shown that the process of the autoignition consists of heating up of droplets, vaporization, mixing and ignition. The ignition criteria could be determined by the temporal variations of temperature, reaction rate and species mass fraction. And the effects of various parameters on ignition phenomena are examined. These have shown that the increasing the reaction rate and/or the vaporization rate can reduce the ignition delay time.