• Title/Summary/Keyword: Re

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Preparation of IgG-$^{188}$Re Conjugate for Diagnosis of Abscess (농양진단을 위한 IgG-$^{188}$Re 표지화합물 제조)

  • 오옥두;최태현;임상무
    • Biomedical Science Letters
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    • v.3 no.2
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    • pp.131-138
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    • 1997
  • IgG-$^{188}$Re conjugate was prepared for the diagnosis of abscess. The IgG molecules reduced by 2-mercaptoethanol contained 1.5 free sulfhydryl groups per IgG molecule. The reduced IgG molecule was labelled with $^{188}$Re through chelate to 99% of labelling yield. The radiochemical purity of IgG-$^{188}$Re conjugate was maintained at 90% in the presence of human serum for 1 hour. The IgG-$^{188}$Re was intravenously administered into staphylococcal abscess-bearing rats and their biodistribution was monitored at 4 and 24 hours post injection. The IgG-$^{188}$Re conjugate was moderately localized in the abscess tissue. This result implies that the IgG-$^{188}$Re conjugate can be a tool for abscess diagnosis. This technique can be applied for the preparation of various monoclonal antibody labelled with $^{188}$Re.

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Mechanical Properties of 3D Printed Re-entrant Pattern/Neoprene Composite Textile by Pattern Tilting Angle of Pattern (3D 프린팅 Auxetic Re-entrant 패턴의 기울기 각도에 따른 네오프렌 복합 직물의 역학적 특성에 관한 연구)

  • Kim, Hyelim;Kabir, Shahbaj;Lee, Sunhee
    • Journal of the Korean Society of Clothing and Textiles
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    • v.45 no.1
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    • pp.106-122
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    • 2021
  • This study confirmed the mechanical properties of an auxetic re-entrant pattern prepared using 3D printing technology and its composite fabric with neoprene for the production of functional auxetic patterns/textiles for safety shoes. Samples were prepared by the tilt angle of a re-entrant pattern of 0°, 30°, 45°, 60° and 90°, and then analyzed using Poisson's ratio, bending, compression, and tensile properties. A 3D printed auxetic re-entrant pattern (3DP-RE) and its composite fabric (3DP-RE/NP) showed a negative Poisson's ratio in all tilting angles that indicated auxetic properties. The results of the bending property shown that strength of 3DP-RE/NP was 1.5 times lower than NP, but the strain improved 2.0 times. It was confirmed that the deformation of 3DP-RE/NP is possible with a low load. Each sample type of compression behavior indicated similar regardless of the tilting angles; in addition, the compression toughness of 3DP-RE/NP increased 1.2 times compared with NP. In the case of tensile properties, 3DP-RE and 3DP-RE/NP were affected by the tilting angle, samples with 90° (the opposite of load direction) showed best tensile property and toughness. 3DP-RE/NP indicated improved bending, compression, and tensile properties.

Quality Control of Tungsten-188/Rhenium-188 Generator (Tungsten-188/Rhenium-188 발생기의 정도관리)

  • Chang, Young-Soo;Jeong, Jae-Min;Lee, Dong-Soo;Chung, June-Key;Lee, Myung-Chul
    • The Korean Journal of Nuclear Medicine
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    • v.32 no.5
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    • pp.425-432
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    • 1998
  • Purpose: For the purpose of using Re-188 as a therapeutic radionuclide, we performed the quality control of the W-188/Re-188 generator system. Materials and Methods: Several quality control tests of the Re-188 eluate from generator were carried out for about 300 days. After elution of Re-188 with normal saline (20 ml), chromatogram and gamma-ray spectrum of Re-188 eluate were obtained. The presence of aluminum which was derived from the alumina bed of the generator was detected by using aluminum ion indicator kit. Re-188 eluate was allowed to decay for several days, and then W-188 breakthrough in the Re-188 eluate was measured by detecting gamma-ray at 227 keY and 290 keV. The pH and the pyrogenicity of the eluate were checked. The Re-188 bolus was concentrated with ion exchange columns. Results: The radioactivity of Re-188 eluate from the generator was $67.4{\pm}7.0%$ of W-188 during 270 days, and it was highest at third day after previous elution. Radiochemical purity of Re-188 eluate obtained from chromatogram was higher than 99%. Gamma-ray spectrum of Re-188 eluate showed a peak at 155 keV. Aluminum ion and W-188 contamination were not detected. The PH of Re-188 eluate was 3 and the concentration yield was 85%. Conclusion: Our experiments and results on quality control tests of Re-188 eluate from W-188/Re-188 generator may be useful for setting W-188/Re-188 generator in hospitals.

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Labeling and Biodistribution of Re-188-DTPA (Diethylenetriaminepentaaceticacid) (Re-188-DTPA (Diethylenetriaminepentaacetic acid)의 표지와 생체내 분포)

  • Lee, Jin;Kim, Young-Ju;Chang, Young-Soo;Jeong, Jae-Min;Shin, Seung-Ae;Chung, June-Key;Lee, Myung-Chul;Koh, Chang-Soon;Lee, Dong-Soo
    • The Korean Journal of Nuclear Medicine
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    • v.31 no.4
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    • pp.427-432
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    • 1997
  • Re-188 is useful candidate for therapeutic radionuclide because it has a physical half life of 17 hours, contains beta emissions suitable for therapy(maximum energy 2.12MeV) and emits a gamma ray that is suitable for quantitative diagnostic scanning(155keV). To use Re-188 as a radionuclide compound of angioplasty balloon radiotherapy, we investigated the labelling method and biodistribution of Re-188-DTPA We postulated that labeled Re-188-DTPA is preferable because it would be excreted via urinary system more easily than other compounds. To label Re-188 with DTPA, 1ml of 222MBq(6mCi) of Re-188 was added to DTPA solution(DTPA 20mg, $SnCl_2{\cdot}2H_2O$ 10mg, pH 3.5) and boiled at $100^{\circ}C$ for 120min in water bath. pH was adjusted to 5 with 2.3% sodium acetate. Labeling efficiency was measured using TLC-SG(acetone, saline). We evaluated biodistribution of Re-188-DTPA in sacrificed mice at 10 and 60 minutes after injection. We acquired images of kidneys, and drew time-activity curves in normal dogs and rats and calculated Tmax and Tl/2 in rats. The labelling efficiency was 95.7% on average. Labelling of Re-188-DTPA was.stable(90% after 5hours) in vitro at room temperature. According to time-activity curves of dogs and rats, it took 15 to 20 minutes after injection for Re-188-DTPA to be washed out through kidneys. In conclusion, Re-188-DTPA was successfully labeled, Re-188-DTPA was stable in vitro and was excreted early via kidneys in animals. We could recommend Re-188-DTPA as radionuclide of potential use in angioplasty balloon radiotherapy.

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The Influence of Practice Teaching Utilizing Content Representation on the Development of Student Teachers’ Pedagogical Content Knowledge (CoRe를 활용한 교육실습이 예비 교사들의 PCK 개발에 미치는 영향)

  • Jeong, Yoojeong;Lee, Kyunghee;Choi, Byungsoon
    • Journal of the Korean Chemical Society
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    • v.59 no.6
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    • pp.520-532
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    • 2015
  • The purposes of this study were to examine what kinds of educational activities were carried out during the practice teaching based on CoRe and to identify the role of CoRe and its influence on the development of expertise of student teachers. This study was performed as qualitative case study. The subjects of this study were one practice supervisor teacher and two student teachers. Data were collected through recording CoRe discussion process, student teachers' instructional scene, and semi-constructed interview, and analyzed by an inductive method. Student teachers noticed their own misconceptions, and clarified the concepts based on CoRe during the discussion with supervisor teacher. They also supplemented their lack of knowledge and made up new strategies through the process of sharing their ideas. During the discussion, the supervisor teacher conveyed his teaching experience based on his own orientations toward science teaching. In this course, CoRe plays roles as follows. Firstly, CoRe played a role as guiding supervisor teacher's coaching process. Secondly, CoRe helped for the supervisor teacher to recognize their own PCK. Thirdly, CoRe served as a tool of helping their communication. In turn CoRe proved to be a useful frame for teaching student teachers during practice teaching. Student teachers were provided with a useful framework for preparing lessons by developing CoRe for the topic they teach. Developing CoRe with supervisor teacher at the planning stage of lessons enhenced student-teachers' subject matter knowledge and their PCK including knowledge of science curricula and knowledge of student's understanding of science. Also student teachers understood the components of PCK and experienced the positive understanding toward students, teaching activities, and themselves as a science teacher.

Needs for the Improvement of Green Building Re-certification System (녹색건축 재인증제도의 개선방안에 관한 연구)

  • Wang, Jeong Joon;Kim, Jung Hyun;Kim, Byung Seon
    • KIEAE Journal
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    • v.13 no.6
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    • pp.67-75
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    • 2013
  • The present duration of 5 years in the Korea Green Building Certification(G-SEED) should be re-set taking into account with the needs for renewal of re-certification criteria. This study methods is to analyze the differences between the characteristics of the certification system of green building of domestic and foreign and to seek the improvement to derive the problem of detailed evaluation items of the examination. The purpose of this study is to identify some problems of re-certification criteria in the G-SEED System and to propose the renewal of certification system. Analysis of the rating criteria with a few re-certified examples of office buildings have been made. Some measures to improve the re-certification have been suggested as follows; (1) it is strongly suggested to establish re-certification rating systems that is not yet made, (2) the new criteria of re-certification bring into focus on whether buildings maintain the environmental performances of the initial status certified, and (3) thus the effective duration of re-certification needs to re-set flexibly in a way to confirm to the initial environmental performances and maintenance conditions certified.

Fabrication of PMMA-HfOx Organic-Inorganic Hybrid Resistive Switching Memory (PMMA-HfOx 유-무기 하이브리드 저항변화 메모리 제작)

  • Baek, Il-Jin;Cho, Won-Ju
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.29 no.3
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    • pp.135-140
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    • 2016
  • In this study, we developed the solution-processed PMMA-$HfO_x$ hybrid ReRAM devices to overcome the respective drawbacks of organic and inorganic materials. The performances of PMMA-$HfO_x$ hybrid ReRAM were compared to those of PMMA- and $HfO_x$-based ReRAMs. Bipolar resistive switching behavior was observed from these ReRAMs. The PMMA-$HfO_x$ hybrid ReRAMs showed a larger operation voltage margin and memory window than PMMA-based and $HfO_x$-based ReRAMs. The reliability and electrical instability of ReRAMs were remarkably improved by blending the $HfO_x$ into PMMA. An Ohmic conduction path was commonly generated in the LRS (low resistance state). In HRS (high resistance state), the PMMA-based ReRAM showed SCLC (space charge limited conduction). the PMMA-$HfO_x$ hybrid ReRAM and $HfO_x$-based ReRAM revealed the Pool-Frenkel conduction. As a result of flexibility test, serious defects were generated in $HfO_x$ film deposited on PI (polyimide) substrate. On the other hand, the PMMA and PMMA-$HfO_x$ films showed an excellent flexibility without defect generation.

A Review: Comparison of Fabrication and Characteristics of Flexible ReRAM and Multi-Insulating Graphene Oxide Layer ReRAM (산화 그래핀을 절연층으로 사용한 유연한 ReRAM과 다층 절연층 ReRAM의 제작 방법 및 결과 비교)

  • Kim, Dong-Kyun;Kim, Taeheon;Yoon, Taehwan;Pak, James Jungho
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.65 no.8
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    • pp.1369-1375
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    • 2016
  • A rapid progress of the next-generation non-volatile memory device has been made in recent years. Metal/insulator/Metal multi-layer structure resistive RAM(ReRAM) has attracted a great deal of attention because it has advantages of simple fabrication, low cost, low power consumption, and low operating voltage. This paper describes the working principle of the ReRAM device, a review of fabrication techniques, and characteristics of flexible ReRAM devices using graphene oxide as an insulating layer and ReRAM devices using multi-layered insulator. The switching characteristics of the above ReRAM devices have been compared. The oxidized graphene could be employed as an insulator of next generation ReRAM devices.

Comparative Economic Analysis of RE100 Implementation Methods in South Korea (국내 RE100 이행방안의 경제성 비교분석 연구)

  • An, Sang Hyo;Woo, JongRoul
    • Current Photovoltaic Research
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    • v.10 no.2
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    • pp.62-71
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    • 2022
  • The Global RE100 campaign is a one of the voluntary campaign, but it has a lot of influence on domestic companies that have not yet joined the Global RE100. Accordingly, the Korean government introduced the Korean RE100 (K-RE100) system to prepare an institutional mechanism for domestic companies to respond to RE100. However, in Korea, due to the high LCOE of renewable energy and institutional limitations of the power transaction system, there is a limit for companies to implement RE100 in various ways. Therefore, in this study, the implementation cost of RE100 for green tariff, REC purchase, third-party PPA, direct(or corporate) PPA, and self-generation was compared and analyzed to derive the order of implementation with the net present value (NPV) of costs incurred over 20 years. As a result, self-construction was analyzed as the most economical method, but the implementation through the green tariff seemed to be the most realistic implementation method so far. However, considering the gradually falling LCOE, third-party PPA and direct PPA could be secured competitiveness against green tariff in 2025 and 2026. Then it could allow the companies to have various portfolios for implementation of RE100.

A Single Re-encryption key based Conditional Proxy Re-Encryption Scheme (조건값의 개수에 독립적인 조건부 프록시 재암호화 기법)

  • Son, Junggab;Oh, Heekuck;Kim, SangJin
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.23 no.2
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    • pp.147-155
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    • 2013
  • Proxy re-encryption scheme has advantage where plaintext does not get exposed during re-encryption process. This scheme is popular for sharing server-saved data in case of cloud computing or mobile office that uses server to save data. Since previous proxy re-encryption schemes can use re-encryption key over and over again, it may abuse re-encryption. To solve this problem, conditional proxy re-encryption scheme was proposed. But, it is computationally expensive generate the same number of re-encryption key with the number of condition values. In this paper, we propose an efficient conditional proxy re-encryption scheme in terms of re-encryption key generation. The proposed scheme uses only encryption and decryption process. Therefore it has advantage to generate one re-encryption key for one person. The proposed scheme is secure against chosen-ciphertext attack.