• YAKHAK HOEJI
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• v.51 no.6
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• pp.463-468
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• 2007

Chong Myung Tang is consisted of three medicinal herbs (Acori Graminei Rhizoma, Polygalae Radix and Hoelen cum Radix). It has been used as a medicine for the purpose of learning and memory improvement. In this paper, Chong Myung Tang was screened the biological activities for Alzheimer's disease. The extract (70% ethanol) of Acari Graminei Rhizoma (1 mg/ml) showed that acetylcholinesterase (AChE) and amyloid beta ($A{\beta}$) peptide aggregation inhibitory potency are 43.1% and 76.5%, respectively. The extract of Polygalae Radix showed inhibitory activity against $A{\beta}_{1-42}$ peptide aggregation (51.5%). To predict the drug-likeness, oral absorption ability; blood-brain barrier (BBB) penetraion rate, mutagenecity and carcinogenicity; in silico screening was performed against 16 compounds in the three medicinal herbs. According to the results, all compounds have appropriate chemical structures as medicines. The six compounds in Acori Graminei Rhizoma and the five compounds in Hoelen cum Radix showed excellent oral absorption rate and BBB penetration rate. The four compounds in Polygalae Radix showed excellent oral absorption rate, but their BBB penetration was presented low rate. And, the extract of Hoelen cum Radix didn't show AChE and $A{\beta}_{1-42}$ peptide aggregation inhibitory activities in vitro. Therefore, their activity in brain may be other mechanism. According to all of the results, in silico prediction technology is convenient and effective to determine biological active compounds in medicinal herbs.

• Proceedings of the Materials Research Society of Korea Conference
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• 2005.05a
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• pp.217-217
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• 2005

• Transactions of the Korean Society of Automotive Engineers
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• v.12 no.6
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• pp.60-65
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• 2004

Numerical simulations and experiments have been carried out to investigate the effect of fuel injection nozzles on the combustion and NOx formation processes in a medium-speed marine diesel engine. Spray visualization experiment was performed in the constant-volume high-pressure chamber to verify the numerical results on the spray characteristics such as spray angle and spray tip penetration. Time-resolved spray behaviors were captured by high-speed digital camera and analyzed to extract the information on the spray parameters. Spray and combustion phenomena were examined numerically using FIRE code. Wave breakup and Zeldovich models were adopted to describe the atomization characteristics and NOx formation processes. Numerical results were verified with experimental data such as cylinder pressure, heat release rate and NOx emission. Finally, the effects of fuel injection nozzles on the engine performance were investigated numerically to find the optimum nozzle parameters such as fuel injection angle, nozzle hole diameter and number of nozzle holes. From this study, the optimum fuel injection nozzle (nozzle hole diameter, 0.32 mm, number of nozzle holes, 8 and fuel injection angle, $148^{\circ}$) was selected to reduce both the fuel consumption and NOx emission. The reason for this selection could be explained from the highest fuel-air mixing in the early phase of injection due to the longest spray tip penetration and the highest heat release rate after $19^{\circ}$ ATDC due to the increased injection duration.

• Journal of Korean Tunnelling and Underground Space Association
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• v.20 no.4
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• pp.687-699
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• 2018

The construction of subsea tunnel differs from that of inland tunnel because of high water pressure due to sea water level and difficulties to reinforce the ground under construction. Therefore, it is very important to prevent trouble in advance when the subsea tunnel is constructed. In this paper, we established lots of databases about characteristics of geological and mechanical parameters on the construction of subsea tunnel using micro slurry TBM which depth is about 60 m. The correlation analysis is conducted to confirm the effect of thrust, torque and RPM among the excavation database on the net penetration rate. Also, An empirical formula is suggested to predict the net penetration rate through the correlation analysis between FPI (Field Penetration Index) and specific energy from the subsea tunnel excavation database.

• Korean Journal of Materials Research
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• v.1 no.3
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• pp.125-131
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• 1991

Boron penetration phenomenon of $p^{+}$ silicon gate with as-deposited amorphous or polycrystalline Si upon high temperature annealing was investigated using high frequency C-V (Capacitance-Volt-age) analysis, CCST(Constant Current Stress Test), TEM(Transmission Electron Microscopy) and SIMS(Secondary Ion Mass Spectroscopy), C-V analysis showed that an as-deposited amorphous Si gate resulted in smaller positive shifts in flatband voltage compared wish a polycrystalline Si gate, thus giving 60-80 percent higher charge-to-breakdown of gate oxides. The reduced boron penetration of amorphous Si gate may be attributed to the fewer grain boundaries available for boron diffusion into the gate oxide and the shallower projected range of $BF_2$ implantation. The relation between electron trapping rate and flatband voltage shift was also discussed.

• Journal of Advanced Marine Engineering and Technology
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• v.34 no.5
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• pp.645-652
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• 2010

The aim of this investigation was study on the non-evaporation diesel spray characteristics injected through a common-rail diesel injector under various ambient pressure. The diesel spray was investigated with observation of macroscopic characteristics such as spray tip penetration and spray cone angle by the shadowgraph and the image processing method. The numerical study was conducted using a computational fluid dynamics code, AVL-FIRE. The breakup models used were WAVE model and standard $k-{\varepsilon}$ turbulence model was applied. The numerical study used input data which spray cone angle and fuel injection rate was achieved by Zeuch's method. Comparison with experimental result such as spray tip penetration was good agreement. Distribution of droplet diameter were conducted on four planes where the axial distances were 5, 15, 39 and 49mm respectively downstream from the orifice exit.

• Reproductive and Developmental Biology
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• v.34 no.3
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• pp.223-227
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• 2010

These study was carried out to investigate the effects of the recovery time, diameter of oocytes on in vitro fertilization or intracytoplasmic sperm injection (ICSI). The in vitro maturation rates to MII stage of oocytes recovered at the inactive, follicular and luteal stages matured for 72 h were $1.4{\pm}0.0%$, $43.4{\pm}3.2%$ and $10.8{\pm}2.7%$, respectively. The fertilization rates of in vitro cultured oocytes recovered from ovaries at the in active, follicular and luteal stages were $0.0{\pm}0.0%$, $15.7{\pm}3.4%$ and $7.6{\pm}3.5%$, respectively. The in vitro maturation rate of oocytes recovered from ovaries at the follicular stage of the reproductive cycle was significantly higher than those at the inactive and luteal stages (p<0.05). The penetration rate determined that the percentages of oocytes with diameters in the < $100\;{\mu}m$, 100 to $100\;{\mu}m$ and 110 to $120\;{\mu}m$ ranges were $17.5{\pm}4.7%$, $43.9{\pm}4.5%$, $21.3{\pm}3.4%$, respectively. The penetration rate of oocytes with diameters between 100 to $100\;{\mu}m$ was significantly higher than that of oocytes whose diameters were < $100\;{\mu}m$ and $110{\sim}120\;{\mu}m$ (p<0.05). The penetration rate of oocytes determined that the percentages of ovaries with diameters between 1 to 5 mm and 6 to 10 mm were $32.9{\pm}3.2%$ and $17.5{\pm}3.7%$, respectively. Thus, the diameters of the ovaries were significantly higher at 1 to 5 mm (p<0.05). A total of 264 oocytes were fixed and stained after co-incubation with sperm, of which 72 had identifiable nuclear material. After in vitro fertilization for 20 hrs, 27.3% of oocytes were penetrated by spermatozoas. Oocytes were fixed and stained after ICSI, of which 38 oocytes contained identifiable nuclear material. After in vitro fertilization and ICSI for 20 hrs, to 27.3% and 67.9% of oocytes were penetrated by spermatozoas. The in vitro fertilization rates by ICSI was significantly higher than that in vitro fertilization method (p<0.05).

• Journal of Distribution Science
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• v.17 no.4
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• pp.51-57
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• 2019

Purpose - This study aims to improve the distribution structure of the OLED market and develop cost-effective optimization techniques. Specifically, it is a study on the optimization of ferric chloride to improve the etch of SUS MASK for OLED. Research design, data, and methodology - Applying the optimal conditions of the experiment, the final confirmation was evaluated for improvement by the Process Capability Index (Cpk). It is possible to derive social performance such as improvement of precision of SUS MASK manufacturing, economic performance such as defect rate, reduction of waste generation and treatment cost, technological achievement such as SUS MASK production technology, improvement of profit structure of technology development and process improvement do. Results - The improvement of the Cpk before the improvement was made was confirmed to be 0.57% with a defect estimate of 25.07% with a failure estimate of 0.57% after the improvement, and 8.84% with a failure estimate of 0.57% level after the improvement. Conclusions - If the conclusions obtained from the specimen experiment are applied to the manufacturing process of SUS MASK, it will be possible to expect excellent cost-effective competitiveness due to the improvement of precision and reduction of defect rate to enhance the OLED market penetration.

• Nuclear Engineering and Technology
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• v.31 no.6
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• pp.548-560
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• 1999

An experimental investigation has been peformed to examine the effects of various geometrical parameters and an initial operating condition on the air-water countercurrent How limitation (CCFL) in a simulated PWR hot leg. A total of 118 experimental data for the onset of CCFL and zero liquid penetration were obtained for various combinations of test parameters. It was observe that the CCFL can be classified into three different categories: (the onset of CCFL, (the partial liquid delivery, and (r) the zero liquid penetration. The observed mechanisms of the onset of CCFL were different depending on the inlet water flow rate. The parametric effects of pipe diameter, horizontal pipe length, horizontal pipe length-to-diameter (L/D) ratio, and initial water level in the horizontal pipe of the test section on the onset of air-water CCFL were also examined. An empirical correlation for the onset of CCFL in a horizontal pipe connected to an inclined riser was developed in terms of Wallis flooding parameters for the low inlet water flow rate region. Comparisons of the present empirical correlation with the air-water CCFL data of large pipe diameters show that the present correlation agrees more closely with the experimental data than the existing CCFL correlations.

• Computers and Concrete
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• v.19 no.2
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• pp.171-177
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• 2017

Water pressure test operation is used before the grouting to determine the rate of penetrability, the necessity and estimations related to grouting, by the penetration of water into the borehole. One of the parameters which have the highest effect is pressure of water penetration since the application of excessive pressure causes the hydraulic fracture to occur in the rock mass, and on the other hand, it must not be so small that prevents from seeing mechanical weaknesses and the rate of permeability. Mathematical modeling is used for the first time in this study to determine the optimum pressure. Thus, the joints that exist in the rock mass are simulated using cylindrical shell model. The joint surroundings are also modeled through Pasternak environment. To obtain equations governing the joints and the surroundings, energy method is used accompanied by Hamilton principle and an analytical solution method is used to obtain the maximum pressure. In order to validate the modeling, the pressure values obtained by the model were used in the sites of Seymareh and Aghbolagh dams and the relative error rates were measured considering the differences between calculated and actual pressures. Modeling in the sections of Seymareh dam showed 4.75, 3.93, 4.8 percent error rates and in the sections of Aghbolagh dam it rendered the values of 22.43, 5.22, 2.6 percent. The results indicate that this modeling can be used to estimate the amount of pressure for hydraulic fracture in water pressure test, to predict it and to prevent it.